SG11201806348PA - Steroid derivative fxr agonist - Google Patents

Steroid derivative fxr agonist

Info

Publication number
SG11201806348PA
SG11201806348PA SG11201806348PA SG11201806348PA SG11201806348PA SG 11201806348P A SG11201806348P A SG 11201806348PA SG 11201806348P A SG11201806348P A SG 11201806348PA SG 11201806348P A SG11201806348P A SG 11201806348PA SG 11201806348P A SG11201806348P A SG 11201806348PA
Authority
SG
Singapore
Prior art keywords
fxr agonist
steroid derivative
fxr
steroid
derivative
Prior art date
Application number
SG11201806348PA
Inventor
Haiying He
Hualing Xiao
Peng Li
Chunyan Du
Zhi Luo
Shuhui Chen
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201610061293 priority Critical
Priority to CN201610331759 priority
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority to PCT/CN2017/072567 priority patent/WO2017129125A1/en
Publication of SG11201806348PA publication Critical patent/SG11201806348PA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/58Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J33/00Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J43/00Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J9/00Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Abstract

The present invention relates to a compound represented by formula (I), a tautomer thereof a acceptable thereof, relates applications thereof in the preparation of drugs for treating FXR related diseases.
SG11201806348PA 2016-01-28 2017-01-25 Steroid derivative fxr agonist SG11201806348PA (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201610061293 2016-01-28
CN201610331759 2016-05-18
PCT/CN2017/072567 WO2017129125A1 (en) 2016-01-28 2017-01-25 Steroid derivative fxr agonist

Publications (1)

Publication Number Publication Date
SG11201806348PA true SG11201806348PA (en) 2018-08-30

Family

ID=59397430

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201806348PA SG11201806348PA (en) 2016-01-28 2017-01-25 Steroid derivative fxr agonist

Country Status (12)

Country Link
EP (1) EP3409684A1 (en)
JP (1) JP2019503392A (en)
KR (1) KR20180100703A (en)
CN (1) CN109071593A (en)
AU (1) AU2017213032A1 (en)
BR (1) BR112018015474A2 (en)
CA (1) CA3012396A1 (en)
CL (1) CL2018002009A1 (en)
MX (1) MX2018009175A (en)
PH (1) PH12018550120A1 (en)
SG (1) SG11201806348PA (en)
WO (1) WO2017129125A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170094184A (en) 2014-11-06 2017-08-17 이난타 파마슈티칼스, 인코포레이티드 Bile acid analogs as fxr/tgr5 agonists and methods of use thereof
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
CA2975257A1 (en) 2015-02-11 2016-08-18 Enanta Pharmaceuticals, Inc. Bile acid analogs as fxr/tgr5 agonists and methods of use thereof
WO2017147174A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof
WO2017147137A1 (en) 2016-02-23 2017-08-31 Enanta Pharmaceuticals, Inc. Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof
WO2019020067A1 (en) * 2017-07-26 2019-01-31 正大天晴药业集团股份有限公司 Method for preparing steroid derivative fxr agonist
WO2019020068A1 (en) * 2017-07-26 2019-01-31 正大天晴药业集团股份有限公司 Crystalline or amorphous form of steroid derivative fxr agonist, preparation method therefor and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2389100A (en) 1998-12-23 2000-07-12 Glaxo Group Limited Assays for ligands for nuclear receptors
DE60205891T2 (en) * 2001-03-12 2006-06-22 Intercept Pharmaceuticals, Inc. Steroids as agonists for fxr
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
US10208081B2 (en) * 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
WO2016086134A1 (en) * 2014-11-26 2016-06-02 Enanta Pharmaceuticals, Inc. Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
RU2017134013A (en) * 2015-03-31 2019-04-30 Энанта Фармасьютикалс, Инк. Derivative Acid Derivatives As Agronists FXR / TGR5 AND METHODS OF THEIR APPLICATION
CN107250150A (en) * 2015-04-28 2017-10-13 江苏豪森药业集团有限公司 Cholic acid derivative, and preparation method and medical use thereof
CN106083978A (en) * 2015-04-28 2016-11-09 上海迪诺医药科技有限公司 Sulphonylaminocarbonyl derivatives, and pharmaceutical compositions and use thereof

Also Published As

Publication number Publication date
JP2019503392A (en) 2019-02-07
CN109071593A (en) 2018-12-21
CA3012396A1 (en) 2017-08-03
AU2017213032A1 (en) 2018-08-30
KR20180100703A (en) 2018-09-11
PH12018550120A1 (en) 2019-03-18
BR112018015474A2 (en) 2018-12-18
EP3409684A1 (en) 2018-12-05
WO2017129125A1 (en) 2017-08-03
MX2018009175A (en) 2018-11-29
CL2018002009A1 (en) 2018-11-05

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