BR112016000898A2 - Método para parada, proteção e preservação de órgão e redução de lesão de tecido - Google Patents
Método para parada, proteção e preservação de órgão e redução de lesão de tecidoInfo
- Publication number
- BR112016000898A2 BR112016000898A2 BR112016000898A BR112016000898A BR112016000898A2 BR 112016000898 A2 BR112016000898 A2 BR 112016000898A2 BR 112016000898 A BR112016000898 A BR 112016000898A BR 112016000898 A BR112016000898 A BR 112016000898A BR 112016000898 A2 BR112016000898 A2 BR 112016000898A2
- Authority
- BR
- Brazil
- Prior art keywords
- organ
- reducing
- subject
- protecting
- stopping
- Prior art date
Links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
MÉTODO PARA PARADA, PROTEÇÃO E PRESERVAÇÃO DE ÓRGÃO E REDUÇÃO DE LESÃO DE TECIDO. Trata-se de composições e métodos para induzir a parada de órgão, manter a parada e reanimação em um sujeito que sofreu uma doença ou lesão de risco de vida; preparar, coletar, armazenar órgãos, tecidos e células; reduzir os efeitos nocivos de pelo menos um dentre anestesia, cirurgia, intervenção clínica e desvio cardiopulmonar na lesão dos tecidos, órgãos e células de um sujeito; ou reduzir os efeitos nocivos de cirurgia ou intervenção clínica na lesão dos órgãos e cérebro no corpo inteiro de um sujeito. A composição compreende (i) um composto selecionado a partir de pelo menos um dentre um abridor de canal de potássio, um agonista de canal de potássio e um agonista de receptor de adenosina; (ii) um agente antiarrítmico ou um anestésico local; e (iii) citrato.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2013902656A AU2013902656A0 (en) | 2013-07-17 | A method for inducing whole body arrest | |
AU2013902658A AU2013902658A0 (en) | 2013-07-17 | A method for reducing inflammation, coagulation and adhesions | |
AU2013902659A AU2013902659A0 (en) | 2013-07-17 | A method for treating haemorrhage, shock and brain injury | |
AU2013902657A AU2013902657A0 (en) | 2013-07-17 | A method for reducing infection, sepsis and injury | |
AU2013903644A AU2013903644A0 (en) | 2013-09-23 | A method for organ arrest, protection and preservation and reducing tissue injury | |
PCT/AU2014/050132 WO2015006830A1 (en) | 2013-07-17 | 2014-07-17 | A method for organ arrest, protection and preservation and reducing tissue injury |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016000898A2 true BR112016000898A2 (pt) | 2017-08-22 |
Family
ID=52345629
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016000804A BR112016000804A2 (pt) | 2013-07-17 | 2014-07-17 | Método para tratar hemorragia, choque e lesão cerebral |
BR112016000809A BR112016000809A2 (pt) | 2013-07-17 | 2014-07-17 | Método para tratar infecção, sepsia e lesão |
BR112016000898A BR112016000898A2 (pt) | 2013-07-17 | 2014-07-17 | Método para parada, proteção e preservação de órgão e redução de lesão de tecido |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016000804A BR112016000804A2 (pt) | 2013-07-17 | 2014-07-17 | Método para tratar hemorragia, choque e lesão cerebral |
BR112016000809A BR112016000809A2 (pt) | 2013-07-17 | 2014-07-17 | Método para tratar infecção, sepsia e lesão |
Country Status (8)
Country | Link |
---|---|
US (3) | US20160166598A1 (pt) |
EP (3) | EP3021854A4 (pt) |
CN (3) | CN105579045A (pt) |
AU (3) | AU2014292826A1 (pt) |
BR (3) | BR112016000804A2 (pt) |
CA (3) | CA2917653A1 (pt) |
MX (3) | MX2016000649A (pt) |
WO (5) | WO2015006829A1 (pt) |
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WO2017137528A1 (en) * | 2016-02-12 | 2017-08-17 | Charité - Universitätsmedizin Berlin | Adenosine a1 receptor agonist for use in treatment of status epilepticus |
JP6408176B2 (ja) | 2016-06-02 | 2018-10-17 | プリタイム・メディカル・デバイシーズ・インコーポレイテッドPrytime Medical Devices,Inc. | 低プロファイル閉塞バルーンカテーテル用のシステムおよび方法 |
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CA3049539C (en) | 2017-01-12 | 2022-09-20 | The Regents Of The University Of California | Endovascular perfusion augmentation for critical care |
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CN108753683B (zh) * | 2018-05-26 | 2022-02-15 | 温州医科大学 | 一种促进冻存组织器官和细胞活性复苏的溶液体系 |
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CN110057821B (zh) * | 2019-04-16 | 2021-09-07 | 上海交通大学 | 用于人类配子快速冻融过程观测的低温显微成像系统 |
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2014
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- 2014-07-17 CN CN201480051003.6A patent/CN105579045A/zh active Pending
- 2014-07-17 WO PCT/AU2014/050131 patent/WO2015006829A1/en active Application Filing
- 2014-07-17 EP EP14825914.6A patent/EP3021854A4/en not_active Withdrawn
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- 2014-07-17 AU AU2014292825A patent/AU2014292825A1/en not_active Abandoned
- 2014-07-17 EP EP14826665.3A patent/EP3021855A4/en not_active Withdrawn
- 2014-07-17 CA CA2917653A patent/CA2917653A1/en not_active Abandoned
- 2014-07-17 MX MX2016000649A patent/MX2016000649A/es unknown
- 2014-07-17 WO PCT/AU2014/050133 patent/WO2015006831A1/en active Application Filing
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