MX2016000651A - Metodo para la parada, proteccion y conservacion de organos y reduccion de la lesion tisular. - Google Patents

Metodo para la parada, proteccion y conservacion de organos y reduccion de la lesion tisular.

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Publication number
MX2016000651A
MX2016000651A MX2016000651A MX2016000651A MX2016000651A MX 2016000651 A MX2016000651 A MX 2016000651A MX 2016000651 A MX2016000651 A MX 2016000651A MX 2016000651 A MX2016000651 A MX 2016000651A MX 2016000651 A MX2016000651 A MX 2016000651A
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Mexico
Prior art keywords
subject
organs
arrest
reducing
preservation
Prior art date
Application number
MX2016000651A
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English (en)
Inventor
Dobson Geoffrey
Original Assignee
Hibernation Therapeutics A Kf Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013902659A external-priority patent/AU2013902659A0/en
Application filed by Hibernation Therapeutics A Kf Llc filed Critical Hibernation Therapeutics A Kf Llc
Publication of MX2016000651A publication Critical patent/MX2016000651A/es

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    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05Phenols
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
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  • Neurology (AREA)
  • Neurosurgery (AREA)
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  • Rheumatology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La invención se refiere a composiciones y a métodos de inducción de la parada de órganos, mantenimiento de la parada y reanimación en un sujeto que ha padecido una enfermedad o lesión potencialmente mortal; preparación, extracción y conservación de órganos, tejidos y células; reducción de efectos perjudiciales de al menos uno de anestesia, cirugía, intervención clínica y derivación cardiopulmonar en la lesión de tejidos, órganos y células de un sujeto; o reducción de los efectos perjudiciales de la cirugía o intervención clínica en la lesión de órganos y cerebro en todo el organismo de un sujeto. La composición comprende (i) un compuesto seleccionado de al menos uno de un agente de apertura del canal de potasio, un agonista del canal de potasio y un agonista del receptor de adenosina; (ii) un agente antiarrítmico o un anestésico local; y (iii) citrato.
MX2016000651A 2013-07-17 2014-07-17 Metodo para la parada, proteccion y conservacion de organos y reduccion de la lesion tisular. MX2016000651A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AU2013902659A AU2013902659A0 (en) 2013-07-17 A method for treating haemorrhage, shock and brain injury
AU2013902657A AU2013902657A0 (en) 2013-07-17 A method for reducing infection, sepsis and injury
AU2013902658A AU2013902658A0 (en) 2013-07-17 A method for reducing inflammation, coagulation and adhesions
AU2013902656A AU2013902656A0 (en) 2013-07-17 A method for inducing whole body arrest
AU2013903644A AU2013903644A0 (en) 2013-09-23 A method for organ arrest, protection and preservation and reducing tissue injury
PCT/AU2014/050132 WO2015006830A1 (en) 2013-07-17 2014-07-17 A method for organ arrest, protection and preservation and reducing tissue injury

Publications (1)

Publication Number Publication Date
MX2016000651A true MX2016000651A (es) 2016-10-14

Family

ID=52345629

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016000651A MX2016000651A (es) 2013-07-17 2014-07-17 Metodo para la parada, proteccion y conservacion de organos y reduccion de la lesion tisular.
MX2016000649A MX2016000649A (es) 2013-07-17 2014-07-17 Un metodo para tratar la infeccion, sepsis y lesion.
MX2016000650A MX2016000650A (es) 2013-07-17 2014-07-17 Un metodo para tratar la hemorragia, choque y lesion cerebral.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2016000649A MX2016000649A (es) 2013-07-17 2014-07-17 Un metodo para tratar la infeccion, sepsis y lesion.
MX2016000650A MX2016000650A (es) 2013-07-17 2014-07-17 Un metodo para tratar la hemorragia, choque y lesion cerebral.

Country Status (8)

Country Link
US (3) US20160166598A1 (es)
EP (3) EP3021854A4 (es)
CN (3) CN105579045A (es)
AU (3) AU2014292827A1 (es)
BR (3) BR112016000898A2 (es)
CA (3) CA2917653A1 (es)
MX (3) MX2016000651A (es)
WO (5) WO2015006827A1 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011242697B2 (en) 2010-04-21 2015-01-22 Government Of The United States Fluoroscopy-independent, endovascular aortic occlusion system
US9474882B2 (en) 2013-02-26 2016-10-25 Prytime Medical Devices, Inc. Fluoroscopy-independent balloon guided occlusion catheter and methods
EP3424552B1 (en) 2013-09-09 2020-04-15 Prytime Medical Devices, Inc. Low-profile occlusion catheter
CA2941438C (en) 2014-06-10 2018-04-10 Prytime Medical Devices, Inc. Conduit guiding tip
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
WO2016149653A2 (en) 2015-03-19 2016-09-22 Prytime Medical Devices, Inc. System and method for low-profile occlusion balloon catheter
WO2017079725A1 (en) * 2015-11-06 2017-05-11 The Board Of Trustees Of The University Of Illinois Peptides and method for treatment of cardiac arrest
WO2017137528A1 (en) * 2016-02-12 2017-08-17 Charité - Universitätsmedizin Berlin Adenosine a1 receptor agonist for use in treatment of status epilepticus
CA3012017A1 (en) 2016-06-02 2017-12-07 Prytime Medical Devices, Inc. System and method for low-profile occlusion balloon catheter
US10707531B1 (en) 2016-09-27 2020-07-07 New Dominion Enterprises Inc. All-inorganic solvents for electrolytes
EP3568190B1 (en) 2017-01-12 2023-11-22 The Regents of the University of California Endovascular perfusion augmentation for critical care
CA3060519A1 (en) 2017-04-21 2018-10-25 The Regents Of The University Of California Aortic flow meter and pump for partial-aortic occlusion
WO2018226991A1 (en) 2017-06-07 2018-12-13 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
CN111556763B (zh) 2017-11-13 2023-09-01 施菲姆德控股有限责任公司 血管内流体运动装置、系统
EP3720343A4 (en) * 2017-12-05 2022-01-19 Neuroindex Ltd. SYSTEMS AND METHODS OF ANESTHESIA MANAGEMENT
EP4085965A1 (en) 2018-02-01 2022-11-09 Shifamed Holdings, LLC Intravascular blood pumps and methods of use and manufacture
CN108753683B (zh) * 2018-05-26 2022-02-15 温州医科大学 一种促进冻存组织器官和细胞活性复苏的溶液体系
CA3107489A1 (en) 2018-08-06 2020-02-13 Prytime Medical Devices, Inc. System and method for low profile occlusion balloon catheter
WO2020047539A1 (en) * 2018-08-31 2020-03-05 Louisiana Tech Research Corporation System and method for network analysis of a patient's neuro-cardio-respiratory system
CN110352951A (zh) * 2018-11-15 2019-10-22 崔磊 一种无血清无dmso组织工程骨冻存液及其制备和冻存方法
CN109248173A (zh) * 2018-11-23 2019-01-22 浙江省人民医院 一种心脏停搏液
WO2020122928A1 (en) * 2018-12-14 2020-06-18 National Taiwan University A stable cardioplegic solution for cardiac surgery
EP3908110A1 (en) * 2019-01-10 2021-11-17 Organ Assist B.V. An apparatus and a method for ex-vivo measurement of performance of a donor heart
EP3946379A4 (en) * 2019-03-29 2023-01-25 Virginia Commonwealth University POLYMER CARDIOPULMONARY RESUSCITATION AGENT
CN110057821B (zh) * 2019-04-16 2021-09-07 上海交通大学 用于人类配子快速冻融过程观测的低温显微成像系统
WO2020223462A1 (en) * 2019-04-30 2020-11-05 University Of Florida Research Foundation, Inc. Biomarker panel for sepsis encephalopathy
US11964145B2 (en) 2019-07-12 2024-04-23 Shifamed Holdings, Llc Intravascular blood pumps and methods of manufacture and use
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
US20220313144A1 (en) * 2019-09-12 2022-10-06 The General Hospital Corporation System amd method for determining treatment outcomes for neurological disorders based on functional connectivity parameters
KR20220072853A (ko) * 2019-09-24 2022-06-02 퍼넘브러, 인코퍼레이티드 주입 카테터 및 사용 방법들
EP4034192A4 (en) 2019-09-25 2023-11-29 Shifamed Holdings, LLC INTRAVASCULAR BLOOD PUMP SYSTEMS AND METHODS OF USE AND CONTROL THEREOF
CN110692580B (zh) * 2019-11-15 2021-11-02 苑春亭 一种刺参度夏池塘及安全通过夏眠的方法
CN113134116B (zh) * 2020-01-20 2022-09-06 山东威高宏瑞医学科技有限公司 内镜微创手术用的填充组合物及填充制剂
CA3171608A1 (en) 2020-03-16 2021-09-23 Certus Critical Care, Inc. Blood flow control devices, systems, and methods and error detection thereof
CN111407244A (zh) * 2020-03-30 2020-07-14 上海大学 基于svr算法的左心室收缩末期弹性预测方法及系统
CN111345293B (zh) * 2020-04-08 2021-08-27 江门海关技术中心 一种虫类标本用防蛀剂及其制备方法
CN111937861B (zh) * 2020-08-17 2021-10-26 南昌大学第二附属医院 一种七氟烷缺血再灌注装置及使用方法
CN112195151B (zh) * 2020-10-28 2022-06-21 范德里希(上海)生物科技有限公司 一种牙髓间充质干细胞复苏培养液、制备方法及复苏培养方法
CN112826463B (zh) * 2020-12-31 2023-11-10 苏州爱琴生物医疗电子有限公司 一种血压调控范围的确定装置和相关设备
CN117320620A (zh) * 2021-03-18 2023-12-29 华盛顿大学 血液稀释探测器
CN113854280B (zh) * 2021-09-06 2022-05-31 创芯国际生物科技(广州)有限公司 一种低温保存液及其制备方法和应用
WO2023154844A2 (en) * 2022-02-10 2023-08-17 Workman David Henry Compositions comprising nad+ and associated methods of treatment
WO2023245103A2 (en) * 2022-06-15 2023-12-21 Vascular Perfusion Solutions, Inc. Tissue perfusion and viability sensing system
WO2024050139A1 (en) * 2022-09-02 2024-03-07 AnaBios Corporation Therapeutic uses of cardiac myosin inhibitors

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3795581A (en) * 1971-11-01 1974-03-05 American Hospital Supply Corp Method of maintaining or restoring the 2,3-diphosphoglycerate content of human red cells
US4112070A (en) * 1977-06-08 1978-09-05 Research Corporation Blood preservation system
SU878297A1 (ru) 1978-05-03 1981-11-07 Научно-Исследовательский Институт Трансплантологии И Искусственных Органов Состав дл сохранени жизнеспособности оперируемого сердца
US4798824A (en) 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5006512A (en) 1987-10-02 1991-04-09 Tsuyoshi Ohnishi Therapeutic usages of inhibitors for a potassium efflux channel
US4968675A (en) * 1988-10-28 1990-11-06 Upjohn Non-hemolytic lazaroid parenteral formulation
US5256770A (en) 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
DE3926287A1 (de) 1989-08-09 1991-02-21 Bernhard Clasbrummel Medizinische anwendung von omega-conotoxin gvia oder omega-conotoxin gvia-analoga zur sympathikolyse
US5145771A (en) 1990-04-12 1992-09-08 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
US5206222A (en) 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
US5407793A (en) 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
RU2025973C1 (ru) 1992-02-10 1995-01-09 Научно-производственное предприятие "Биофарм" Раствор для консервации живых органов
US5370989A (en) 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
AU2690695A (en) * 1994-05-25 1995-12-18 Jerry I. Jacobson Method and apparatus for ameliorating aging process
US5679706A (en) 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
US5554497A (en) 1994-12-12 1996-09-10 Charlotte-Mecklenburg Hospital Authority Cardioplegic solution for arresting an organ
US5656420A (en) 1995-02-24 1997-08-12 University Of Kentucky Research Foundation Method for employing the delta opioid dadle to extend tissue survival time during ischemia
WO1997016169A1 (en) * 1995-11-01 1997-05-09 Chiron Corporation Treatment of a cardiovascular indication by delivery of therapeutics to the pericardial space
JP3875295B2 (ja) 1995-11-30 2007-01-31 功 竹内 心筋保護液
US5939394A (en) * 1996-01-18 1999-08-17 Fleming & Company Methods and compositions for the prevention and treatment of immunological disorders, inflammatory diseases and infections
US6043224A (en) 1996-09-05 2000-03-28 The Massachusetts Institute Of Technology Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
IT1297886B1 (it) 1997-02-28 1999-12-20 Carmine Antropoli Nifedipina per uso topico
WO1998057651A1 (en) 1997-06-18 1998-12-23 Discovery Therapeutics, Inc. Compositions and methods for preventing restenosis following revascularization procedures
CN1057192C (zh) 1997-09-10 2000-10-11 上海长征医院 一种配制多器官保存液的方法
US6011017A (en) 1998-04-15 2000-01-04 Cypros Pharmaceutical Corp. Method of reducing pulmonary hypertension and atrial fibrillation after surgery using cardiopulmonary bypass
CN1309562A (zh) 1998-07-16 2001-08-22 纪念斯隆-凯特林癌症中心 包括一种阿片样物质镇痛剂和一种nmda拮抗剂的局部给药组合物
KR100683603B1 (ko) 1998-10-23 2007-02-20 폴리힐 엘티디. 창상 치유용 미소구 조성물
US6358208B1 (en) 1998-11-21 2002-03-19 Philipp Lang Assessment of cardiovascular performance using ultrasound methods and devices that interrogate interstitial fluid
NZ514515A (en) 1999-03-23 2003-11-28 Global Cardiac Solutions Pty L Organ arrest, protection and preservation using a potassium channel operator and/or adenosine receptor and a local anaesthetic
US6586413B2 (en) 1999-11-05 2003-07-01 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
GB9930079D0 (en) * 1999-12-20 2000-02-09 Glaxo Group Ltd Medicaments
AU2001231189A1 (en) 2000-01-27 2001-08-07 Childrens Hospital Research Foundation Transdermal anesthetic and vasodilator composition and methods for topical administration
JP2001261575A (ja) 2000-03-13 2001-09-26 General Hospital Corp 血管収縮を調節する方法とその組成物
US6569615B1 (en) 2000-04-10 2003-05-27 The United States Of America As Represented By The Department Of Veteran's Affairs Composition and methods for tissue preservation
US6271228B1 (en) 2000-04-28 2001-08-07 Pfizer Inc. Blood pressure stabilization during hemodialysis
JP2004512260A (ja) 2000-04-28 2004-04-22 メモリアル スローン−ケッタリング キャンサー センター 局所麻酔/オピオイド製剤およびその使用方法
DE60121458T2 (de) 2000-09-26 2007-02-15 Medtronic, Inc., Minneapolis Medizinische vorrichtung zur blutstromsteuerung
CA2474316A1 (en) 2002-01-29 2003-08-07 Cognetix, Inc. Kappa-pviia-related conotoxins as organ protectants
CA2379211A1 (fr) 2002-03-28 2003-09-28 Institut De Cardiologie De Montreal Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase)
ATE418991T1 (de) 2002-04-18 2009-01-15 Cv Therapeutics Inc Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US20040229780A1 (en) 2002-09-20 2004-11-18 Olivera Baldomero M. KappaM-conopeptides as organ protectants
US6921633B2 (en) 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
US20040167226A1 (en) 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
GB2436255B (en) 2002-12-23 2007-11-28 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery
WO2004056181A1 (en) 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery (2)
US6992075B2 (en) 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
WO2004108666A2 (en) 2003-06-02 2004-12-16 Samaritan Pharmaceuticals, Inc. Neuroprotective benzoate and benzamide compounds
US7049309B2 (en) 2003-10-14 2006-05-23 Bristol-Myers Squibb Company 3-Thia-4-arylquinolin-2-one potassium channel modulators
JP2008525468A (ja) 2004-12-22 2008-07-17 エモリー・ユニバーシティ ポストコンディショニング臓器保護作用を増強する治療補助薬
US20070009880A1 (en) 2005-07-11 2007-01-11 Toledo Luis H Methods And Solutions For Storing Donor Organs
CN101500409A (zh) * 2006-05-29 2009-08-05 低温药理有限公司 改善的组织维持
JP2009538834A (ja) 2006-05-29 2009-11-12 ハイバーネイション セラピューティクス リミテッド 組織維持の改善
US20130122108A1 (en) * 2006-06-06 2013-05-16 Robert G Matheny Compositions for Regenerating Defective or Absent Myocardium
EP2139316B1 (en) * 2006-07-25 2015-03-18 Hibernation Therapeutics, a KF LLC Trauma therapy
US8389013B2 (en) * 2006-10-06 2013-03-05 Newsouth Innovations Pty Limited Process for producing particles via atomized rapid injection for solvent extraction
CA2717162A1 (en) * 2007-03-02 2008-09-12 Hibernation Therapeutics Limited Transplants
CN100423638C (zh) 2007-03-22 2008-10-08 南京吉脉生物技术有限公司 一种器官保存液及其制备方法
AU2008280836A1 (en) * 2007-07-25 2009-01-29 Hibernation Therapeutics, A Kf Llc Improved organ protection, preservation and recovery
CN101496512A (zh) * 2008-02-01 2009-08-05 扬子江药业集团上海海尼药业有限公司 一种器官保存液及其制备方法
US20090198145A1 (en) * 2008-02-06 2009-08-06 Chow Harrison Compositions, methods, and systems for rapid induction and maintenance of continuous rem sleep
WO2011075391A1 (en) 2009-12-15 2011-06-23 Schering Corporation Formulations of acadesine
CN102726366B (zh) 2011-04-07 2014-06-04 中国人民解放军第二军医大学 一种器官保存液及其配制方法

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