TR200103235T2 - Organ tutma, koruma ve saklama. - Google Patents

Organ tutma, koruma ve saklama.

Info

Publication number
TR200103235T2
TR200103235T2 TR2001/03235T TR200103235T TR200103235T2 TR 200103235 T2 TR200103235 T2 TR 200103235T2 TR 2001/03235 T TR2001/03235 T TR 2001/03235T TR 200103235 T TR200103235 T TR 200103235T TR 200103235 T2 TR200103235 T2 TR 200103235T2
Authority
TR
Turkey
Prior art keywords
protection
storage
agonist
organ
organ retention
Prior art date
Application number
TR2001/03235T
Other languages
English (en)
Inventor
Phillip Dobson Geoffrey
Original Assignee
James Cook University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPP9414A external-priority patent/AUPP941499A0/en
Priority claimed from AUPQ4199A external-priority patent/AUPQ419999A0/en
Application filed by James Cook University filed Critical James Cook University
Publication of TR200103235T2 publication Critical patent/TR200103235T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331—Preservative, buffer, anticoagulant or diluent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Packages (AREA)
  • Materials For Medical Uses (AREA)
  • Saccharide Compounds (AREA)
  • Processing Of Solid Wastes (AREA)

Abstract

Bu bulus, etkili miktarlarda (I) bir potasyum kanal açici veya agonisti ve/veya bir adenozin reseptör agonisti ve (ii) denege gerektiginde bir lokal anestezik uygulanarak bir organin durdurulmasi, korunmasi ve/veya muhafaza edilmesini saglayan bir yöntem ile ilgilidir. Bu bulus ayrica, etkili miktarlarda (I) bir potasyum kanal açici veya agonisti ve/veya bir adenozin reseptör agonisti ve (ii) bir lokal anestezik içeren bir bilesimin ilave edilmesiyle bir organin durdurulmasi, korunmasi ve/veya muhafaza edilmesi için bir yöntem ile ilgilidir. Bu bulus ayrica, Etkili miktarlarda (I) bir potasyum kanal açici veya agonisti ve/veya bir adenozin reseptör agonisti ve (ii) bir lokal anestezik içeren bir farmasötik bilesim veya veterinerlik bilesimi ile ilgilidir.
TR2001/03235T 1999-03-23 2000-03-22 Organ tutma, koruma ve saklama. TR200103235T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPP9414A AUPP941499A0 (en) 1999-03-23 1999-03-23 Organ arrest, protection and preservation
AUPQ4199A AUPQ419999A0 (en) 1999-11-23 1999-11-23 Organ arrest, protection and preservation

Publications (1)

Publication Number Publication Date
TR200103235T2 true TR200103235T2 (tr) 2002-01-21

Family

ID=25646014

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03235T TR200103235T2 (tr) 1999-03-23 2000-03-22 Organ tutma, koruma ve saklama.

Country Status (18)

Country Link
US (7) US6955814B1 (tr)
EP (3) EP1168912B1 (tr)
JP (1) JP4949558B2 (tr)
KR (1) KR20020001797A (tr)
CN (1) CN1344135A (tr)
AT (1) ATE361667T1 (tr)
BR (1) BR0010653A (tr)
CA (1) CA2364687C (tr)
DE (1) DE60034778T2 (tr)
ES (1) ES2287001T3 (tr)
HK (1) HK1161035A1 (tr)
IL (1) IL145552A0 (tr)
MX (1) MXPA01009552A (tr)
NO (2) NO331669B1 (tr)
NZ (1) NZ514515A (tr)
PL (1) PL351484A1 (tr)
TR (1) TR200103235T2 (tr)
WO (1) WO2000056145A1 (tr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1168912B1 (en) * 1999-03-23 2007-05-09 Hibernation Therapeutics Limited Organ arrest, protection and preservation
AU2003208525B9 (en) 2002-02-04 2009-08-27 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Amend the invention title to read Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US20040170950A1 (en) * 2002-09-12 2004-09-02 Prien Samuel D. Organ preservation apparatus and methods
AU2003291847B2 (en) * 2002-12-23 2010-12-02 Hibernation Therapeutics, A Kf Llc Organ preconditioning, arrest, protection, preservation and recovery
CA2551169A1 (en) * 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
US20080056993A1 (en) * 2006-03-31 2008-03-06 Adenobio N.V. Compositions, Methods and Kits Using Adenosine and Inosine in Combination for Diagnosis and Treatment
WO2007137321A1 (en) * 2006-05-29 2007-12-06 Hibernation Therapeutics Limited Improved tissue maintenance
CN104107431A (zh) * 2006-05-29 2014-10-22 低温药理有限公司 改善的组织维持
US7811549B2 (en) * 2006-07-05 2010-10-12 Adenobio N.V. Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects
KR101490836B1 (ko) * 2006-07-25 2015-02-09 하이버네이션 테라퓨틱스, 어 케이에프 엘엘씨 외상 치료법
EP2173353B1 (en) * 2007-03-02 2015-05-06 Hibernation Therapeutics, a KF LLC Composition including Adenosine and Lignocaine
WO2008134740A1 (en) * 2007-04-30 2008-11-06 The Trustees Of The University Of Pennsylvania System and method of resuscitation of a mammal
CN103493799A (zh) * 2007-07-25 2014-01-08 低温药理有限公司 改进的器官保护、维护和康复
DE102007035642A1 (de) * 2007-07-30 2009-02-12 Grietje Beck Substanzen zur Protektion von Zellen und Geweben gegen Schädigung durch ungünstige Bedingungen
US20090185973A1 (en) * 2008-01-22 2009-07-23 Adenobio N.V. Methods, compositions, unit dosage forms, and kits for pharmacologic stress testing with reduced side effects
US20120046354A1 (en) * 2010-08-18 2012-02-23 Ehrenpreis Eli D Anti-oxidant lozenges for the prevention and treatment of radiation induced mucositis, precancerous lesions, oral cancer and other oral cavity mucosal disorders
EP2699242B1 (en) 2011-04-19 2017-11-01 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
EP2734235B1 (en) 2011-07-21 2017-03-22 Alfama, Inc. Ruthenium carbon monoxide releasing molecules and uses thereof
WO2014063134A1 (en) 2012-10-19 2014-04-24 New York University Methods for inhibiting osteolysis
WO2015006828A1 (en) 2013-07-17 2015-01-22 Hts Therapeutics Pty Ltd A method for treating haemorrhage, shock and brain injury
JP2013234200A (ja) * 2013-08-19 2013-11-21 Hibernation Therapeutics Ltd 組織維持の改善
US10092591B2 (en) 2014-02-27 2018-10-09 University Of Alaska Fairbanks Methods and compositions for the treatment of ischemic injury to tissue using therapeutic hypothermia
CN103893205B (zh) * 2014-04-15 2016-03-09 青岛大学附属医院 一种包含利多卡因和腺苷的心脏停搏液及其制备方法
CA2947711A1 (en) * 2014-05-01 2015-11-05 Catherine E. Berry A modified single dose, microplegic approach to cardioplegia for the adult heart
US9501418B2 (en) * 2014-06-26 2016-11-22 HGST Netherlands B.V. Invalidation data area for cache
US9913903B2 (en) * 2015-08-06 2018-03-13 Grifols Worldwide Operations Limited Method for the treatment or prevention of infection-related immune conditions using a composition comprising IgM
CN109769797B (zh) * 2017-11-13 2024-09-10 合肥华琪生物工程有限公司 一种器官保存液

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU878297A1 (ru) 1978-05-03 1981-11-07 Научно-Исследовательский Институт Трансплантологии И Искусственных Органов Состав дл сохранени жизнеспособности оперируемого сердца
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5006512A (en) 1987-10-02 1991-04-09 Tsuyoshi Ohnishi Therapeutic usages of inhibitors for a potassium efflux channel
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
DE3926287A1 (de) * 1989-08-09 1991-02-21 Bernhard Clasbrummel Medizinische anwendung von omega-conotoxin gvia oder omega-conotoxin gvia-analoga zur sympathikolyse
US5145771A (en) * 1990-04-12 1992-09-08 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
US5206222A (en) 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
CN1057192A (zh) 1991-06-30 1991-12-25 汪庆富 风油精聚胺酯海绵的制备工艺
US5407793A (en) 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
RU2025973C1 (ru) * 1992-02-10 1995-01-09 Научно-производственное предприятие "Биофарм" Раствор для консервации живых органов
US5370989A (en) * 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
US5554497A (en) * 1994-12-12 1996-09-10 Charlotte-Mecklenburg Hospital Authority Cardioplegic solution for arresting an organ
US5656420A (en) * 1995-02-24 1997-08-12 University Of Kentucky Research Foundation Method for employing the delta opioid dadle to extend tissue survival time during ischemia
JP3875295B2 (ja) * 1995-11-30 2007-01-31 功 竹内 心筋保護液
CA2279651A1 (en) 1996-09-05 1998-03-12 Massachusetts Institute Of Technology Compositions and methods for treatment of neurological disorders and neurodegenerative diseases
IT1297886B1 (it) * 1997-02-28 1999-12-20 Carmine Antropoli Nifedipina per uso topico
WO1998057651A1 (en) 1997-06-18 1998-12-23 Discovery Therapeutics, Inc. Compositions and methods for preventing restenosis following revascularization procedures
CN1057192C (zh) 1997-09-10 2000-10-11 上海长征医院 一种配制多器官保存液的方法
US6011017A (en) 1998-04-15 2000-01-04 Cypros Pharmaceutical Corp. Method of reducing pulmonary hypertension and atrial fibrillation after surgery using cardiopulmonary bypass
BR9912827A (pt) 1998-07-16 2001-05-02 Sloan Kettering Inst Cancer Composições tópicas compreendendo um analgésico opióide e um antagonista de nmda
KR100269540B1 (ko) 1998-08-28 2000-10-16 윤종용 웨이퍼 상태에서의 칩 스케일 패키지 제조 방법
EP1041970B1 (en) 1998-10-23 2013-07-03 Polyheal Ltd. Compositions of microspheres for wound healing
US6358208B1 (en) 1998-11-21 2002-03-19 Philipp Lang Assessment of cardiovascular performance using ultrasound methods and devices that interrogate interstitial fluid
EP1168912B1 (en) * 1999-03-23 2007-05-09 Hibernation Therapeutics Limited Organ arrest, protection and preservation
US6586413B2 (en) * 1999-11-05 2003-07-01 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
WO2001054679A2 (en) 2000-01-27 2001-08-02 Children's Hospital Research Foundation Transdermal composition containing an anesthetic and a vasodilator agent
JP2001261575A (ja) 2000-03-13 2001-09-26 General Hospital Corp 血管収縮を調節する方法とその組成物
US6569615B1 (en) 2000-04-10 2003-05-27 The United States Of America As Represented By The Department Of Veteran's Affairs Composition and methods for tissue preservation
WO2001082914A2 (en) 2000-04-28 2001-11-08 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
EP1324709B1 (en) 2000-09-26 2006-07-12 Medtronic, Inc. Medical device for directing blood flow
GB0028414D0 (en) 2000-11-22 2001-01-03 Univ Leeds Flush preservation solution
CA2474316A1 (en) 2002-01-29 2003-08-07 Cognetix, Inc. Kappa-pviia-related conotoxins as organ protectants
EP1494685B1 (en) 2002-04-18 2008-12-31 Cv Therapeutics, Inc. Method of treating arrhythmias comprising administration of an a1 adenosine agonist with a beta blocker
AUPS312602A0 (en) 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US20040229780A1 (en) * 2002-09-20 2004-11-18 Olivera Baldomero M. KappaM-conopeptides as organ protectants
US6921633B2 (en) 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
US20040167226A1 (en) 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
CA2551169A1 (en) 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
GB2436255B (en) 2002-12-23 2007-11-28 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery
US6992075B2 (en) 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
CA2561452A1 (en) 2003-06-02 2004-12-16 Samaritan Pharmaceuticals, Inc. Neuroprotective benzoate and benzamide compounds
US7049309B2 (en) * 2003-10-14 2006-05-23 Bristol-Myers Squibb Company 3-Thia-4-arylquinolin-2-one potassium channel modulators
AU2005319144A1 (en) 2004-12-22 2006-06-29 Emory University Therapeutic adjuncts to enhance the organ protective effects of postconditioning
US20070009880A1 (en) 2005-07-11 2007-01-11 Toledo Luis H Methods And Solutions For Storing Donor Organs
WO2007137321A1 (en) 2006-05-29 2007-12-06 Hibernation Therapeutics Limited Improved tissue maintenance
KR101490836B1 (ko) 2006-07-25 2015-02-09 하이버네이션 테라퓨틱스, 어 케이에프 엘엘씨 외상 치료법
EP2173353B1 (en) 2007-03-02 2015-05-06 Hibernation Therapeutics, a KF LLC Composition including Adenosine and Lignocaine
CN100423638C (zh) 2007-03-22 2008-10-08 南京吉脉生物技术有限公司 一种器官保存液及其制备方法
CN103493799A (zh) 2007-07-25 2014-01-08 低温药理有限公司 改进的器官保护、维护和康复

Also Published As

Publication number Publication date
US20160263141A1 (en) 2016-09-15
CA2364687C (en) 2014-11-18
DE60034778D1 (de) 2007-06-21
NO20014557D0 (no) 2001-09-19
IL145552A0 (en) 2002-06-30
DE60034778T2 (de) 2008-01-31
EP2359688A1 (en) 2011-08-24
NO20110807L (no) 2001-11-07
KR20020001797A (ko) 2002-01-09
US6955814B1 (en) 2005-10-18
WO2000056145A1 (en) 2000-09-28
NZ514515A (en) 2003-11-28
NO331669B1 (no) 2012-02-20
US7749522B2 (en) 2010-07-06
ATE361667T1 (de) 2007-06-15
EP1168912B1 (en) 2007-05-09
US20050171050A1 (en) 2005-08-04
EP2359688B1 (en) 2015-05-27
US20090298789A1 (en) 2009-12-03
EP1168912A4 (en) 2002-07-31
EP1790223A1 (en) 2007-05-30
BR0010653A (pt) 2002-02-05
US20100298254A1 (en) 2010-11-25
NO20014557L (no) 2001-11-07
US9320753B2 (en) 2016-04-26
US7223413B2 (en) 2007-05-29
ES2287001T3 (es) 2007-12-16
US20130184231A1 (en) 2013-07-18
JP4949558B2 (ja) 2012-06-13
EP1168912A1 (en) 2002-01-09
US20070270372A1 (en) 2007-11-22
MXPA01009552A (es) 2003-08-19
CN1344135A (zh) 2002-04-10
CA2364687A1 (en) 2000-09-28
PL351484A1 (en) 2003-04-22
JP2002539224A (ja) 2002-11-19
HK1161035A1 (en) 2012-08-24

Similar Documents

Publication Publication Date Title
TR200103235T2 (tr) Organ tutma, koruma ve saklama.
AR002007A1 (es) UNA COMPOSICION TERAPEUTICA DE APLICACION TOPICA QUE CONTIENE UN ANTAGONISTA DE SUSTANCIA P Y UTILIZACION DE DICHO ANTAGONISTA PARA LAPREPARACIóN DE DICHA COMPOSICION PARA DISMINUIR Y/O ELIMINAR UN EFECTO SECUNDARIO IRRITANTE DE UN PRODUCTO CONTENIDO EN LA MISMA.
UY25794A1 (es) Procedimiento para la preparacion de compuestos derivados de adeninas, que son agonistas del receptor de la adenosina a2a
GT200000053A (es) Moduladores del receptor glucocorticoide.
PE20011122A1 (es) DERIVADOS DE PURINA-2-ILCARBOXAMIDA COMO AGONISTAS SELECTIVOS DEL RECEPTOR A2a DE LA ADENOSINA
GT199700009A (es) Terapia combinada para la osteoporosis.
BR0207917A (pt) Dispositivo de mecha para obter e armazenar uma amostra de material genético, e, método de armazenar uma amostra de material genético sobre um dispositivo de mecha
ES2180626T3 (es) Composiciones que comprenden un agente bloqueante de la desgranulacion de celulas cebadas para el tratamiento de estados gastrointestinales dolorosos endogenos de origen no inflamatorio y no ulcerativo.
BR0016166A (pt) Compostos de diidropirimidina heterocìclicos
MX9202407A (es) Composicion farmaceutica que contiene un compuesto de alilamina como el agente activo y proceso para su preparacion.
BR0308854A (pt) Benzazolas substituìdas e seus usos como inibidoras de quinase raf
DE69923471D1 (de) Injizierbare propofol-formulierungen
TR200002855T2 (tr) Raloksifenin solunum yolu ile veya burundan uygulanması.
AR021370A1 (es) Composiciones farmaceuticas inyectables estabilizadas que contienen agentes anti-neoplasicos taxoides
BR9914901A (pt) Agonistas do receptor 5ht1 e metoclopramida para o tratamento de enxaqueca
ATE357928T1 (de) Pharmazeutische zusammensetzung für thrombinpeptidderivaten
BR0007201A (pt) Composições incluindo agentes de preservação demalto-oligossacarìdeos reduzidos, e métodospara preservar um material
ZA958173B (en) Use of a serotonin agoinist in combination with a tachykinin receptor antaonist in the treatment or prevention of migraine
BRPI0408136A (pt) derivados heterocìclicos contendo nitrogênio tendo estirila 2,6-dissubstituìda
PT671174E (pt) Formulacao para o aumento de peso do gado que compreende um ionoforo e selenio
PT92647A (pt) Processo para a preparacao de 5-cloro-2-< { (3,4-dimetoxi-2-piridinil)-metil}-sulfinil>-1h-benzimidazol e de composicoes farmaceuticas que o contem
AR029648A1 (es) El uso de un agonista de rar
ES2118087T3 (es) Composiciones inmunosupresoras.
DE60124694D1 (de) Verbesserte lipidzusammensetzungen und darin enthaltene derivate des 3-methoxybenzylthioharnstoffs
GB2363573A (en) Organ arrest, protection and preservation