BR112015025489A2 - fosfocetolases para produção melhorada de metabolitos derivados de acetil coenzima a, isopreno, precursores de isoprenoides, e isoprenoides - Google Patents
fosfocetolases para produção melhorada de metabolitos derivados de acetil coenzima a, isopreno, precursores de isoprenoides, e isoprenoidesInfo
- Publication number
- BR112015025489A2 BR112015025489A2 BR112015025489A BR112015025489A BR112015025489A2 BR 112015025489 A2 BR112015025489 A2 BR 112015025489A2 BR 112015025489 A BR112015025489 A BR 112015025489A BR 112015025489 A BR112015025489 A BR 112015025489A BR 112015025489 A2 BR112015025489 A2 BR 112015025489A2
- Authority
- BR
- Brazil
- Prior art keywords
- isoprene
- acetyl coenzyme
- precursors
- production
- phosphocetolases
- Prior art date
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 title abstract 10
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 title abstract 6
- 229940100228 acetyl coenzyme a Drugs 0.000 title abstract 3
- 239000002207 metabolite Substances 0.000 title abstract 3
- 239000002243 precursor Substances 0.000 title abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 150000003505 terpenes Chemical class 0.000 abstract 4
- KJTLQQUUPVSXIM-ZCFIWIBFSA-M (R)-mevalonate Chemical compound OCC[C@](O)(C)CC([O-])=O KJTLQQUUPVSXIM-ZCFIWIBFSA-M 0.000 abstract 2
- KJTLQQUUPVSXIM-UHFFFAOYSA-N DL-mevalonic acid Natural products OCCC(O)(C)CC(O)=O KJTLQQUUPVSXIM-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000037361 pathway Effects 0.000 abstract 2
- 108010004621 phosphoketolase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02009—Phosphoketolase (4.1.2.9)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361810696P | 2013-04-10 | 2013-04-10 | |
| US201361834359P | 2013-06-12 | 2013-06-12 | |
| PCT/US2014/033688 WO2014169144A2 (en) | 2013-04-10 | 2014-04-10 | Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015025489A2 true BR112015025489A2 (pt) | 2017-10-10 |
Family
ID=50877659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015025489A BR112015025489A2 (pt) | 2013-04-10 | 2014-04-10 | fosfocetolases para produção melhorada de metabolitos derivados de acetil coenzima a, isopreno, precursores de isoprenoides, e isoprenoides |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10246694B2 (enExample) |
| EP (2) | EP2984105B1 (enExample) |
| JP (2) | JP6530375B2 (enExample) |
| CN (1) | CN105555952A (enExample) |
| BR (1) | BR112015025489A2 (enExample) |
| ES (1) | ES2735331T3 (enExample) |
| SG (1) | SG11201508186XA (enExample) |
| WO (1) | WO2014169144A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| EP2984105B1 (en) | 2013-04-10 | 2019-05-22 | Danisco US Inc. | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
| BR112017005665A2 (pt) * | 2014-09-18 | 2017-12-12 | Genomatica Inc | organismos microbianos não naturais com eficiência energética melhorada |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2018176021A1 (en) * | 2017-03-24 | 2018-09-27 | Danisco Us Inc | Reduction of acetate and glycerol in modified yeast having an exogenous ethanol-producing pathway |
| CN107841523A (zh) * | 2017-10-19 | 2018-03-27 | 浙江大学 | 利用群体感应分子诱导从桦褐孔菌中提取三萜类物质方法 |
| CN111699247A (zh) | 2017-12-07 | 2020-09-22 | 齐默尔根公司 | 通过发酵产生(6e)-8-羟基香叶醇的经改造的生物合成途径 |
| WO2019126778A1 (en) | 2017-12-21 | 2019-06-27 | Zymergen Inc. | Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone |
| AU2019228730A1 (en) * | 2018-03-01 | 2020-08-27 | Totalenergies Onetech | Metabolic pathways with increased carbon yield |
| CN109929883A (zh) * | 2019-04-02 | 2019-06-25 | 烟台华康荣赞生物科技有限公司 | 重组酵母、构建方法和其在制备酪醇及衍生物中的应用 |
| WO2021063958A1 (en) * | 2019-09-30 | 2021-04-08 | Global Bioenergies | Improved means and methods for increasing the yield of acetyl-coa from glucose |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR669447A (fr) | 1929-02-09 | 1929-11-15 | Dispositif pour arrêter automatiquement un moteur d'automobile après une période de temps prédéterminée | |
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| EP1510583A1 (en) | 2002-05-10 | 2005-03-02 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| ATE493490T1 (de) | 2002-10-04 | 2011-01-15 | Du Pont | Verfahren zur biologischen herstellung von 1,3- propandiol mit hoher ausbeute |
| RU2004124226A (ru) * | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| EP1789547B1 (en) * | 2004-08-10 | 2010-04-07 | Ajinomoto Co., Inc. | The use of phosphoketolase for producing useful metabolites |
| EP2024504B2 (en) | 2006-05-26 | 2022-12-14 | Amyris, Inc. | Production of isoprenoids |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| WO2009005704A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| WO2009076676A2 (en) | 2007-12-13 | 2009-06-18 | Danisco Us Inc. | Compositions and methods for producing isoprene |
| US20110045563A1 (en) | 2008-02-06 | 2011-02-24 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| BRPI0911667A2 (pt) | 2008-04-23 | 2019-04-24 | Danisco Us Inc | variante de sintase de isopreno para produção microbiana aprimorada de isopreno |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| AU2009266938B2 (en) | 2008-07-02 | 2013-10-17 | Danisco Us Inc. | Compositions and methods for producing isoprene free of C5 hydrocarbons under decoupling conditions and/or safe operating ranges |
| HU3516U (en) | 2008-07-31 | 2008-11-28 | Zoltan Kuthi | Anti-theft protection of draining for fuel tanks |
| MY156562A (en) | 2008-09-15 | 2016-02-26 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
| SG169652A1 (en) | 2008-09-15 | 2011-04-29 | Danisco Us Inc | Reduction of carbon dioxide emission during isoprene production by fermentation |
| EP2340312A2 (en) | 2008-09-15 | 2011-07-06 | Danisco US Inc. | Conversion of prenyl derivatives to isoprene |
| DK2344629T3 (en) | 2008-09-15 | 2018-03-05 | Danisco Us Inc | SYSTEMS USING CELL CULTURE TO MAKE ISOPRENE |
| CA2737082A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| EP2382312A2 (en) | 2008-12-30 | 2011-11-02 | Danisco US Inc. | Methods of producing isoprene and a co-product |
| US8324442B2 (en) | 2009-03-03 | 2012-12-04 | Amyris, Inc. | Microbial derived isoprene and methods for making the same |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| SG10201501879PA (en) | 2009-04-23 | 2015-05-28 | Danisco Us Inc | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| WO2011034863A1 (en) | 2009-09-15 | 2011-03-24 | Sapphire Energy, Inc. | A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| WO2011075534A2 (en) | 2009-12-18 | 2011-06-23 | Danisco Us Inc. | Purification of isoprene from renewable resources |
| US8455236B2 (en) | 2009-12-23 | 2013-06-04 | Danisco Us Inc. | Compositions and methods of PGL for the increased production of isoprene |
| US8871488B2 (en) | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| BR112013010551A8 (pt) | 2010-10-27 | 2018-07-03 | Danisco Us Inc | variantes de isopreno sintase para produção aprimorada de isopreno |
| US8889383B2 (en) * | 2011-04-29 | 2014-11-18 | Danisco Us Inc. | Production of mevalonate, isoprene, and isoprenoids using genes encoding polypeptides having thiolase, HMG-CoA synthase and HMG-CoA reductase enzymatic activities |
| US9121038B2 (en) * | 2011-04-29 | 2015-09-01 | The Goodyear Tire & Rubber Company | Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids |
| CN103703123B (zh) | 2011-07-12 | 2016-08-17 | 财富科学家股份有限公司 | 用于产生有用代谢物的重组微生物 |
| SG11201401249PA (en) | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| CN104039974B (zh) * | 2011-11-09 | 2016-10-12 | 阿迈瑞斯公司 | 乙酰辅酶a衍生的类异戊二烯的生产 |
| US8741613B2 (en) | 2012-05-16 | 2014-06-03 | Glycos Biotechnologies, Inc. | Microorganisms and processes for the production of isoprene |
| EP2984105B1 (en) | 2013-04-10 | 2019-05-22 | Danisco US Inc. | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
-
2014
- 2014-04-10 EP EP14727659.6A patent/EP2984105B1/en active Active
- 2014-04-10 BR BR112015025489A patent/BR112015025489A2/pt not_active Application Discontinuation
- 2014-04-10 EP EP18175724.6A patent/EP3425049A1/en not_active Withdrawn
- 2014-04-10 CN CN201480032280.2A patent/CN105555952A/zh active Pending
- 2014-04-10 SG SG11201508186XA patent/SG11201508186XA/en unknown
- 2014-04-10 WO PCT/US2014/033688 patent/WO2014169144A2/en not_active Ceased
- 2014-04-10 ES ES14727659T patent/ES2735331T3/es active Active
- 2014-04-10 JP JP2016507665A patent/JP6530375B2/ja active Active
- 2014-04-10 US US14/783,391 patent/US10246694B2/en active Active
-
2019
- 2019-02-14 US US16/276,558 patent/US10988750B2/en active Active
- 2019-05-16 JP JP2019093057A patent/JP2019162130A/ja active Pending
-
2020
- 2020-09-24 US US16/948,592 patent/US11371035B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014169144A3 (en) | 2014-12-04 |
| US20160068831A1 (en) | 2016-03-10 |
| US20190367896A1 (en) | 2019-12-05 |
| US10246694B2 (en) | 2019-04-02 |
| EP2984105B1 (en) | 2019-05-22 |
| EP3425049A1 (en) | 2019-01-09 |
| SG11201508186XA (en) | 2015-11-27 |
| US20210139878A1 (en) | 2021-05-13 |
| WO2014169144A2 (en) | 2014-10-16 |
| EP2984105A2 (en) | 2016-02-17 |
| WO2014169144A8 (en) | 2015-10-15 |
| US11371035B2 (en) | 2022-06-28 |
| ES2735331T3 (es) | 2019-12-18 |
| JP6530375B2 (ja) | 2019-06-12 |
| JP2016519577A (ja) | 2016-07-07 |
| CN105555952A (zh) | 2016-05-04 |
| US10988750B2 (en) | 2021-04-27 |
| JP2019162130A (ja) | 2019-09-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B154 | Notification of filing of divisional application [chapter 15.50 patent gazette] |
Free format text: O PEDIDO FOI DIVIDIDO NO BR122023000309-8 PROTOCOLO 870230001753 EM 06/01/2023 15:34. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |