SG11201508186XA - Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids - Google Patents
Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoidsInfo
- Publication number
- SG11201508186XA SG11201508186XA SG11201508186XA SG11201508186XA SG11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA SG 11201508186X A SG11201508186X A SG 11201508186XA
- Authority
- SG
- Singapore
- Prior art keywords
- phosphoketolases
- isoprenoids
- isoprene
- improved production
- acetyl coenzyme
- Prior art date
Links
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 title 2
- ZSLZBFCDCINBPY-ZSJPKINUSA-N acetyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 ZSLZBFCDCINBPY-ZSJPKINUSA-N 0.000 title 2
- 150000003505 terpenes Chemical class 0.000 title 2
- 229940100228 acetyl coenzyme a Drugs 0.000 title 1
- 239000002207 metabolite Substances 0.000 title 1
- 108010004621 phosphoketolase Proteins 0.000 title 1
- 239000002243 precursor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/02—Aldehyde-lyases (4.1.2)
- C12Y401/02009—Phosphoketolase (4.1.2.9)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361810696P | 2013-04-10 | 2013-04-10 | |
| US201361834359P | 2013-06-12 | 2013-06-12 | |
| PCT/US2014/033688 WO2014169144A2 (en) | 2013-04-10 | 2014-04-10 | Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201508186XA true SG11201508186XA (en) | 2015-11-27 |
Family
ID=50877659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201508186XA SG11201508186XA (en) | 2013-04-10 | 2014-04-10 | Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10246694B2 (enExample) |
| EP (2) | EP2984105B1 (enExample) |
| JP (2) | JP6530375B2 (enExample) |
| CN (1) | CN105555952A (enExample) |
| BR (1) | BR112015025489A2 (enExample) |
| ES (1) | ES2735331T3 (enExample) |
| SG (1) | SG11201508186XA (enExample) |
| WO (1) | WO2014169144A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| ES2735331T3 (es) | 2013-04-10 | 2019-12-18 | Goodyear Tire & Rubber | Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides |
| EP3741865B1 (en) * | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US20200377559A1 (en) * | 2017-03-24 | 2020-12-03 | Danisco Us Inc | Reduction of acetate and glycerol in modified yeast having an exogenous ethanol-producing pathway |
| CN107841523A (zh) * | 2017-10-19 | 2018-03-27 | 浙江大学 | 利用群体感应分子诱导从桦褐孔菌中提取三萜类物质方法 |
| CA3084263A1 (en) | 2017-12-07 | 2019-06-13 | Zymergen Inc. | Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation |
| CN111868047A (zh) | 2017-12-21 | 2020-10-30 | 齐默尔根公司 | 荆芥内半缩醛氧化还原酶、荆芥内半缩醛合酶和能够产生荆芥内酯的微生物 |
| US11634701B2 (en) | 2018-03-01 | 2023-04-25 | Total Raffinage Chimie | Metabolic pathways with increased carbon yield |
| CN109929883A (zh) * | 2019-04-02 | 2019-06-25 | 烟台华康荣赞生物科技有限公司 | 重组酵母、构建方法和其在制备酪醇及衍生物中的应用 |
| WO2021063958A1 (en) * | 2019-09-30 | 2021-04-08 | Global Bioenergies | Improved means and methods for increasing the yield of acetyl-coa from glucose |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR669447A (fr) | 1929-02-09 | 1929-11-15 | Dispositif pour arrêter automatiquement un moteur d'automobile après une période de temps prédéterminée | |
| DE19629568C1 (de) | 1996-07-15 | 1998-01-08 | Fraunhofer Ges Forschung | Verfahren zur Herstellung von Isopren |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| US20050287655A1 (en) | 2002-05-10 | 2005-12-29 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing mevalonic acid |
| AU2003287028B2 (en) | 2002-10-04 | 2008-09-04 | E.I. Du Pont De Nemours And Company | Process for the biological production of 1,3-propanediol with high yield |
| WO2006016705A1 (en) * | 2004-08-10 | 2006-02-16 | Ajinomoto Co., Inc. | The use of phosphoketolase for producing useful metabolites |
| RU2004124226A (ru) | 2004-08-10 | 2006-01-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Использование фосфокетолазы для продукции полезных метаболитов |
| CA2651747C (en) | 2006-05-26 | 2017-10-24 | Amyris Biotechnologies, Inc. | Production of isoprenoids |
| JP4986547B2 (ja) | 2006-09-04 | 2012-07-25 | 株式会社Ａｄｅｋａ | 新規なアセトアセチルＣｏＡ合成酵素、それをコードするＤＮＡ配列、当該酵素の製造方法および当該酵素を利用したメバロン酸の製造方法 |
| WO2009005704A1 (en) * | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| BRPI0823506A8 (pt) | 2007-12-13 | 2018-05-15 | Danisco Us Inc Genencor Div | composições e métodos para a produção de isoprene |
| WO2009100231A2 (en) | 2008-02-06 | 2009-08-13 | The Regents Of The University Of California | Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi |
| JP2011518564A (ja) | 2008-04-23 | 2011-06-30 | ダニスコ・ユーエス・インク | 改良された微生物によるイソプレン産出用のイソプレンシンターゼ変異体 |
| US7632995B2 (en) | 2008-05-09 | 2009-12-15 | Monsanto Technology Llc | Plants and seeds of hybrid corn variety CH852179 |
| EP2310490B1 (en) | 2008-07-02 | 2019-01-02 | Danisco US Inc. | Methods for producing isoprene |
| HU3516U (en) | 2008-07-31 | 2008-11-28 | Zoltan Kuthi | Anti-theft protection of draining for fuel tanks |
| WO2010031079A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Systems using cell culture for production of isoprene |
| MY156562A (en) | 2008-09-15 | 2016-02-26 | Danisco Us Inc | Increased isoprene production using the archaeal lower mevalonate pathway |
| CA2737223A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Reduction of carbon dioxide emission during isoprene production by fermentation |
| CA2737082A1 (en) | 2008-09-15 | 2010-03-18 | Danisco Us Inc. | Increased isoprene production using mevalonate kinase and isoprene synthase |
| BRPI0918936A2 (pt) | 2008-09-15 | 2019-09-24 | Danisco Us Inc | conversão de derivados de prenila em isopreno |
| CN102333866B (zh) | 2008-12-30 | 2015-04-29 | 丹尼斯科美国公司 | 生产异戊二烯和共同产物的方法 |
| US8324442B2 (en) | 2009-03-03 | 2012-12-04 | Amyris, Inc. | Microbial derived isoprene and methods for making the same |
| US20100297749A1 (en) | 2009-04-21 | 2010-11-25 | Sapphire Energy, Inc. | Methods and systems for biofuel production |
| EP2421966A2 (en) | 2009-04-23 | 2012-02-29 | Danisco US Inc. | Three-dimensional structure of isoprene synthase and its use thereof for generating variants |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| TW201412988A (zh) | 2009-06-17 | 2014-04-01 | Danisco Us Inc | 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造 |
| TWI434921B (zh) | 2009-06-17 | 2014-04-21 | Danisco Us Inc | 從生物異戊二烯組合物製造燃料成分之方法及系統 |
| CA2773675A1 (en) | 2009-09-15 | 2011-03-24 | Sapphire Energy, Inc. | A system for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp. |
| CN102884028B (zh) | 2009-12-18 | 2015-08-19 | 丹尼斯科美国公司 | 从可再生资源中纯化异戊二烯 |
| AU2010336342B2 (en) | 2009-12-23 | 2015-02-26 | Danisco Us Inc. | Compositions and methods for the increased production of isoprene and other products with 6 - phosphogluconolactonase (PGL) |
| US8871488B2 (en) * | 2010-06-18 | 2014-10-28 | Butamax Advanced Biofuels Llc | Recombinant host cells comprising phosphoketolases |
| JP2014502148A (ja) | 2010-10-27 | 2014-01-30 | ダニスコ・ユーエス・インク | イソプレン生産の向上を目的としたイソプレン合成酵素変異体 |
| JP2014519811A (ja) * | 2011-04-29 | 2014-08-21 | ダニスコ・ユーエス・インク | チオラーゼ、ＨＭＧ−ＣｏＡ合成酵素及びＨＭＧ−ＣｏＡ還元酵素活性を有するポリペプチドをコードしている遺伝子を使用するメバロン酸、イソプレン、及びイソプレノイドの生産 |
| US9121038B2 (en) * | 2011-04-29 | 2015-09-01 | The Goodyear Tire & Rubber Company | Recombinant microorganisms for enhanced production of mevalonate, isoprene, and isoprenoids |
| SG2014012520A (en) | 2011-07-12 | 2014-06-27 | Scientist Of Fortune Sa | Recombinant microorganism for the production of useful metabolites |
| SG11201401249PA (en) * | 2011-10-07 | 2014-05-29 | Danisco Us Inc | Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene |
| DK2776571T3 (en) * | 2011-11-09 | 2017-06-26 | Amyris Inc | PREPARATION OF ACETYL-COENZYM A-DERIVED ISOPRENOIDS |
| KR20150014941A (ko) | 2012-05-16 | 2015-02-09 | 글리코스 바이오테크놀로지스, 인코포레이티드 | 아이소프렌의 생산을 위한 미생물유기체 및 방법 |
| ES2735331T3 (es) | 2013-04-10 | 2019-12-18 | Goodyear Tire & Rubber | Fosfocetolasas para mejorar la producción de metabolitos derivados de acetil-coenzima A, isopreno, precursores de isoprenoides e isoprenoides |
-
2014
- 2014-04-10 ES ES14727659T patent/ES2735331T3/es active Active
- 2014-04-10 EP EP14727659.6A patent/EP2984105B1/en active Active
- 2014-04-10 JP JP2016507665A patent/JP6530375B2/ja active Active
- 2014-04-10 US US14/783,391 patent/US10246694B2/en active Active
- 2014-04-10 WO PCT/US2014/033688 patent/WO2014169144A2/en not_active Ceased
- 2014-04-10 CN CN201480032280.2A patent/CN105555952A/zh active Pending
- 2014-04-10 SG SG11201508186XA patent/SG11201508186XA/en unknown
- 2014-04-10 EP EP18175724.6A patent/EP3425049A1/en not_active Withdrawn
- 2014-04-10 BR BR112015025489A patent/BR112015025489A2/pt not_active Application Discontinuation
-
2019
- 2019-02-14 US US16/276,558 patent/US10988750B2/en active Active
- 2019-05-16 JP JP2019093057A patent/JP2019162130A/ja active Pending
-
2020
- 2020-09-24 US US16/948,592 patent/US11371035B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20160068831A1 (en) | 2016-03-10 |
| ES2735331T3 (es) | 2019-12-18 |
| WO2014169144A3 (en) | 2014-12-04 |
| WO2014169144A8 (en) | 2015-10-15 |
| US10988750B2 (en) | 2021-04-27 |
| JP6530375B2 (ja) | 2019-06-12 |
| BR112015025489A2 (pt) | 2017-10-10 |
| JP2019162130A (ja) | 2019-09-26 |
| US20210139878A1 (en) | 2021-05-13 |
| US10246694B2 (en) | 2019-04-02 |
| EP2984105B1 (en) | 2019-05-22 |
| EP3425049A1 (en) | 2019-01-09 |
| CN105555952A (zh) | 2016-05-04 |
| US20190367896A1 (en) | 2019-12-05 |
| EP2984105A2 (en) | 2016-02-17 |
| JP2016519577A (ja) | 2016-07-07 |
| WO2014169144A2 (en) | 2014-10-16 |
| US11371035B2 (en) | 2022-06-28 |
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