JP6530375B2 - アセチル補酵素ａ由来代謝産物、イソプレン、イソプレノイド前駆体、およびイソプレノイドの改善された生産のためのホスホケトラーゼ - Google Patents

アセチル補酵素ａ由来代謝産物、イソプレン、イソプレノイド前駆体、およびイソプレノイドの改善された生産のためのホスホケトラーゼ Download PDF

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JP6530375B2
JP6530375B2 JP2016507665A JP2016507665A JP6530375B2 JP 6530375 B2 JP6530375 B2 JP 6530375B2 JP 2016507665 A JP2016507665 A JP 2016507665A JP 2016507665 A JP2016507665 A JP 2016507665A JP 6530375 B2 JP6530375 B2 JP 6530375B2
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phosphoketolase
polypeptide
recombinant cell
seq
coa
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JP2016519577A5 (enExample
JP2016519577A (ja
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ベック、ザカリー・キュー
ムニョス、ジェフリー・ダブリュー
ウェルス、デレク・エイチ
ヤオ、ジエン
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Goodyear Tire and Rubber Co
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/02—Aldehyde-lyases (4.1.2)
    • C12Y401/02009—Phosphoketolase (4.1.2.9)

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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
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  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2016507665A 2013-04-10 2014-04-10 アセチル補酵素ａ由来代謝産物、イソプレン、イソプレノイド前駆体、およびイソプレノイドの改善された生産のためのホスホケトラーゼ Active JP6530375B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361810696P 2013-04-10 2013-04-10
US61/810,696 2013-04-10
US201361834359P 2013-06-12 2013-06-12
US61/834,359 2013-06-12
PCT/US2014/033688 WO2014169144A2 (en) 2013-04-10 2014-04-10 Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids

Related Child Applications (1)

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JP2019093057A Division JP2019162130A (ja) 2013-04-10 2019-05-16 アセチル補酵素ａ由来代謝産物、イソプレン、イソプレノイド前駆体、およびイソプレノイドの改善された生産のためのホスホケトラーゼ

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JP2016519577A JP2016519577A (ja) 2016-07-07
JP2016519577A5 JP2016519577A5 (enExample) 2017-06-08
JP6530375B2 true JP6530375B2 (ja) 2019-06-12

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JP2019093057A Pending JP2019162130A (ja) 2013-04-10 2019-05-16 アセチル補酵素ａ由来代謝産物、イソプレン、イソプレノイド前駆体、およびイソプレノイドの改善された生産のためのホスホケトラーゼ

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US (3) US10246694B2 (enExample)
EP (2) EP2984105B1 (enExample)
JP (2) JP6530375B2 (enExample)
CN (1) CN105555952A (enExample)
BR (1) BR112015025489A2 (enExample)
ES (1) ES2735331T3 (enExample)
SG (1) SG11201508186XA (enExample)
WO (1) WO2014169144A2 (enExample)

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US10246694B2 (en) 2019-04-02
SG11201508186XA (en) 2015-11-27
US11371035B2 (en) 2022-06-28
US20190367896A1 (en) 2019-12-05
WO2014169144A2 (en) 2014-10-16
US20210139878A1 (en) 2021-05-13
BR112015025489A2 (pt) 2017-10-10
US10988750B2 (en) 2021-04-27
EP2984105A2 (en) 2016-02-17
EP2984105B1 (en) 2019-05-22
EP3425049A1 (en) 2019-01-09
WO2014169144A3 (en) 2014-12-04
US20160068831A1 (en) 2016-03-10
JP2019162130A (ja) 2019-09-26
WO2014169144A8 (en) 2015-10-15
ES2735331T3 (es) 2019-12-18
JP2016519577A (ja) 2016-07-07
CN105555952A (zh) 2016-05-04

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