BR112015002131B1 - Vírus vaccinia ankara modificado (mva) recombinante, composição farmacêutica e uso do referido mva recombinante - Google Patents
Vírus vaccinia ankara modificado (mva) recombinante, composição farmacêutica e uso do referido mva recombinante Download PDFInfo
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- BR112015002131B1 BR112015002131B1 BR112015002131-0A BR112015002131A BR112015002131B1 BR 112015002131 B1 BR112015002131 B1 BR 112015002131B1 BR 112015002131 A BR112015002131 A BR 112015002131A BR 112015002131 B1 BR112015002131 B1 BR 112015002131B1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261678367P | 2012-08-01 | 2012-08-01 | |
| EP12005594 | 2012-08-01 | ||
| US61/678,367 | 2012-08-01 | ||
| EP12005594.2 | 2012-08-01 | ||
| PCT/EP2013/055483 WO2014019718A1 (en) | 2012-08-01 | 2013-03-15 | Recombinant modified vaccinia virus ankara (mva) respiratory syncytial virus (rsv) vaccine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112015002131A2 BR112015002131A2 (pt) | 2017-11-07 |
| BR112015002131A8 BR112015002131A8 (pt) | 2022-08-23 |
| BR112015002131B1 true BR112015002131B1 (pt) | 2022-11-01 |
Family
ID=46614287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015002131-0A BR112015002131B1 (pt) | 2012-08-01 | 2013-03-15 | Vírus vaccinia ankara modificado (mva) recombinante, composição farmacêutica e uso do referido mva recombinante |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9480738B2 (enExample) |
| EP (2) | EP3656396A1 (enExample) |
| JP (2) | JP6523955B2 (enExample) |
| KR (3) | KR102435054B1 (enExample) |
| CN (2) | CN104540520B (enExample) |
| AU (1) | AU2013298915B2 (enExample) |
| BR (1) | BR112015002131B1 (enExample) |
| CA (2) | CA2879915C (enExample) |
| CY (1) | CY1122717T1 (enExample) |
| EA (2) | EA201891945A3 (enExample) |
| IL (1) | IL236744B (enExample) |
| IN (1) | IN2015DN01448A (enExample) |
| MX (3) | MX362511B (enExample) |
| MY (1) | MY171498A (enExample) |
| NZ (1) | NZ704005A (enExample) |
| SG (1) | SG11201500696VA (enExample) |
| SI (1) | SI2879702T1 (enExample) |
| WO (1) | WO2014019718A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2767324T3 (es) * | 2012-08-01 | 2020-06-17 | Bavarian Nordic As | Vacuna de virus vaccinia modificado de Ankara (MVA) recombinante para el virus sincicial respiratorio (VRS) |
| AU2014231229A1 (en) * | 2013-03-15 | 2015-09-17 | Bavarian Nordic A/S | Single high dose of MVA induces a protective immune response in neonates and infants |
| MX384992B (es) | 2014-06-13 | 2025-03-14 | Glaxosmithkline Biologicals Sa | Combinaciones inmunógenas. |
| US9630994B2 (en) | 2014-11-03 | 2017-04-25 | University Of Washington | Polypeptides for use in self-assembling protein nanostructures |
| KR102535670B1 (ko) | 2015-06-12 | 2023-05-22 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 아데노바이러스 폴리뉴클레오티드 및 폴리펩티드 |
| FR3042121A1 (fr) | 2015-10-08 | 2017-04-14 | Jean-Marc Limacher | Composition anti-tumorale |
| MX2019011869A (es) | 2017-04-04 | 2020-01-09 | Univ Washington | Nanoestructuras proteicas auto-ensamblables que muestran proteinas f de paramixovirus y/o neumovirus y su uso. |
| JP7406377B2 (ja) | 2017-05-15 | 2023-12-27 | ヤンセン ファッシンズ アンド プリベンション ベーフェー | 安定なウイルス含有組成物 |
| EP3624851A1 (en) | 2017-05-15 | 2020-03-25 | Janssen Vaccines & Prevention B.V. | Stable virus-containing composition |
| AU2018392884B2 (en) | 2017-12-20 | 2021-11-11 | Glaxosmithkline Biologicals Sa | Epstein-Barr Virus antigen constructs |
| US11771755B2 (en) | 2018-02-28 | 2023-10-03 | University Of Washington | Self-asssembling nanostructure vaccines |
| JP7437385B2 (ja) * | 2018-09-06 | 2024-02-22 | バヴァリアン・ノルディック・アクティーゼルスカブ | 保管が改善されたポックスウイルス組成物 |
| EP3956351A1 (en) * | 2019-04-18 | 2022-02-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Biological and synthetic molecules inhibiting respiratory syncytial virus infection |
| KR20220047332A (ko) * | 2019-08-13 | 2022-04-15 | 알티뮨 인크. | 치료제 효과 및 이의 투여 경로 |
| CN115243717A (zh) | 2020-03-12 | 2022-10-25 | 巴法里安诺迪克有限公司 | 改善痘病毒稳定性的组合物 |
| KR20240051214A (ko) | 2021-09-03 | 2024-04-19 | 버베리안 노딕 에이/에스 | 변형 백시니아 바이러스 앙카라(mva)에 의한 세포독성 전이유전자 발현의 하향조절을 위한 마이크로rna의 활용 |
| AU2024236322A1 (en) | 2023-03-10 | 2025-08-21 | Bavarian Nordic A/S | Methods of isolating poxviruses from avian cell cultures |
| CN120731268A (zh) | 2023-03-10 | 2025-09-30 | 巴法里安诺迪克有限公司 | 从鹌鹑细胞培养物产生痘病毒 |
| WO2024188801A1 (en) | 2023-03-10 | 2024-09-19 | Bavarian Nordic A/S | Use of quail cell lines for poxvirus production |
| FR3160186A1 (fr) | 2024-03-13 | 2025-09-19 | Odimma Therapeutics | Vecteur non-viral pour transcription augmentee |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US5110587A (en) | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5149650A (en) | 1986-01-14 | 1992-09-22 | University Of North Carolina At Chapel Hill | Vaccines for human respiratory virus |
| US5639853A (en) | 1987-09-29 | 1997-06-17 | Praxis Biologics, Inc. | Respiratory syncytial virus vaccines |
| US5223254A (en) | 1987-09-29 | 1993-06-29 | Praxis Biologics, Inc. | Respiratory syncytial virus: vaccines |
| DE3878468T2 (de) | 1987-12-23 | 1993-06-09 | Upjohn Co | Chimarenglykoproteine, enthaltend immunogene segmente des humanen respiratorischen synzytialvirus. |
| CA1341245C (en) | 1988-01-12 | 2001-06-05 | F. Hoffmann-La Roche Ag | Recombinant vaccinia virus mva |
| NZ239084A (en) | 1990-07-24 | 1994-09-27 | Uab Research Foundation | Bovine respiratory virus (brs) f glycoprotein and vaccine therefrom |
| US6730305B1 (en) | 2000-05-08 | 2004-05-04 | The Uab Research Foundation | Nucleotide sequences encoding bovine respiratory syncytial virus immunogenic proteins |
| GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| FR2718452B1 (fr) | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
| JPH10512846A (ja) | 1994-08-25 | 1998-12-08 | インスティテゥート ヴォー ディールホウデレイ エン ディーゲゾントヘイド (イーデー−デーエルオー) | 呼吸器系合胞体ウィルス(rsv)感染の型または亜型−特異的診断のためのrsvのgタンパク質に由来する抗原ペプチド |
| FR2726471B1 (fr) | 1994-11-07 | 1997-01-31 | Pf Medicament | Procede pour ameliorer l'immunogenicite d'un compose immunogene ou d'un haptene et application a la preparation de vaccins |
| US6083925A (en) | 1995-06-07 | 2000-07-04 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
| US6180398B1 (en) | 1996-07-12 | 2001-01-30 | Virogeneitics Corporation | Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
| US6020182A (en) | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| FR2751229B1 (fr) | 1996-07-19 | 1998-11-27 | Rhone Merieux | Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins |
| US6699478B1 (en) | 1997-09-19 | 2004-03-02 | Wyeth Holdings Corporation | Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus |
| FR2798857B1 (fr) * | 1999-09-23 | 2003-06-06 | Pf Medicament | Utilisation d'une proteine de membrane ompa d'enterobacterie associee a un peptide immunogene du vrs pour la preparation de vaccins administrables par voie nasale |
| US6651655B1 (en) | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
| GB0024089D0 (en) * | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
| SG106639A1 (en) | 2000-10-10 | 2004-10-29 | Gen Electric | Apparatus and method for introducing small amounts of refractory elements into a vapor deposition coating |
| ATE412666T1 (de) | 2000-10-18 | 2008-11-15 | Us Gov Health & Human Serv | Zusammensetzungen und verfahren zur modulierung von rsv-infektionen und -immunität |
| UA76731C2 (uk) | 2000-11-23 | 2006-09-15 | Баваріан Нордік А/С | Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації |
| US6855493B2 (en) | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| FR2827605B1 (fr) | 2001-07-20 | 2004-07-16 | Pf Medicament | Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin |
| CN1602316A (zh) | 2001-12-04 | 2005-03-30 | 巴法里安诺迪克有限公司 | 黄病毒ns1亚单位疫苗 |
| DK1506301T3 (da) | 2002-05-16 | 2014-07-21 | Bavarian Nordic As | Rekombinant poxvirus, der udtrykker homologe gener, der er indsat i poxvirusgenomet |
| US7368537B2 (en) | 2003-07-15 | 2008-05-06 | Id Biomedical Corporation Of Quebec | Subunit vaccine against respiratory syncytial virus infection |
| WO2006023029A2 (en) | 2004-06-16 | 2006-03-02 | The Johns Hopkins University | The cysteine-rich region of respiratory syncytial virus and methods of use therefor |
| MX2007002372A (es) * | 2004-08-27 | 2007-05-08 | Panacea Biotec Ltd | Vacuna para la poliomielitis inactivada derivada de la cepa sabin del virus de la polio. |
| WO2008115199A2 (en) * | 2006-08-18 | 2008-09-25 | The University Of North Carolina At Chapel Hill | Chimeric virus vaccines |
| US8772256B2 (en) * | 2006-11-30 | 2014-07-08 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Codon modified immunogenic compositions and methods of use |
| DE102006060799A1 (de) | 2006-12-21 | 2008-06-26 | RUHR-UNIVERSITäT BOCHUM | RSV F-Protein und seine Verwendung |
| CA2684578A1 (en) * | 2007-03-21 | 2008-09-25 | Id Biomedical Corporation Of Quebec | Chimeric antigens |
| KR100938105B1 (ko) * | 2007-09-21 | 2010-01-21 | 이화여자대학교 산학협력단 | 호흡기 신시치아 바이러스 백신 |
| EP4206231A1 (en) | 2007-12-24 | 2023-07-05 | ID Biomedical Corporation of Quebec | Recombinant rsv antigens |
| US8580270B2 (en) | 2008-09-30 | 2013-11-12 | University Of Massachusetts | Respiratory synctial virus (RSV) sequences for protein expression and vaccines |
| WO2010059689A2 (en) | 2008-11-18 | 2010-05-27 | Ligocyte Pharmaceuticals, Inc. | Rsv f vlps and methods of manufacture and use thereof |
| US8999637B2 (en) | 2008-11-21 | 2015-04-07 | Bavarian Nordic A/S | Vector comprising multiple homologous nucleotide sequences |
| SG10201500161XA (en) | 2008-12-09 | 2015-03-30 | Novavax Inc | Modified rsv f proteins and methods of their use |
| US20110318376A1 (en) | 2008-12-24 | 2011-12-29 | University Of Rochester | Recombinant expression of self-folding neutralizing epitope-bearing subdomains of the respiratory syncytial virus attachment and fusion proteins |
| WO2010149743A2 (en) | 2009-06-24 | 2010-12-29 | Id Biomedical Corporation Of Quebec | Vaccine |
| ES2583257T3 (es) | 2009-06-24 | 2016-09-20 | Glaxosmithkline Biologicals S.A. | Antígenos recombinantes del VSR |
| ES2563730T3 (es) * | 2009-07-15 | 2016-03-16 | Glaxosmithkline Biologicals S.A. | Composiciones de proteína RSV F y procedimientos de fabricación de las mismas |
| AU2010279492B2 (en) | 2009-08-04 | 2015-04-09 | The Government Of The United States Of America, As Represented By The Secretary, Department Of The Health And Human Services, Centers For Disease Control And Prevention | Anti-RSV immunogens and methods of immunization |
| WO2011030218A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| WO2011046925A1 (en) | 2009-10-12 | 2011-04-21 | Technovax, Inc. | Respiratory syncytial virus (rsv) virus-like particles (vlps) |
| WO2011057401A1 (en) | 2009-11-12 | 2011-05-19 | Trojan Technologies | Cleaning apparatus. radiation source module and fluid treatment system |
| JP5783642B2 (ja) | 2010-01-28 | 2015-09-24 | バヴァリアン・ノルディック・アクティーゼルスカブ | Mvaの主なゲノム欠失を含むワクシニアウイルス変異体 |
| JP5890407B2 (ja) * | 2010-07-07 | 2016-03-22 | アーティフィシャル セル テクノロジーズ インコーポレイテッド | 呼吸器合胞体ウイルス抗原組成物および方法 |
| EP2651771A1 (en) * | 2010-12-17 | 2013-10-23 | Philip Morris Products S.a.s. | Container having interacting surface elements including design element |
| WO2012085936A2 (en) * | 2010-12-20 | 2012-06-28 | Panacea Biotech Ltd | Recombinant respiratory syncytial virus plasmids and vaccines |
| WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
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