BR112014020821A2 - molécula de ligação a antígeno para promoção de desaparecimento de antígeno através de fcyriib - Google Patents

molécula de ligação a antígeno para promoção de desaparecimento de antígeno através de fcyriib

Info

Publication number
BR112014020821A2
BR112014020821A2 BR112014020821A BR112014020821A BR112014020821A2 BR 112014020821 A2 BR112014020821 A2 BR 112014020821A2 BR 112014020821 A BR112014020821 A BR 112014020821A BR 112014020821 A BR112014020821 A BR 112014020821A BR 112014020821 A2 BR112014020821 A2 BR 112014020821A2
Authority
BR
Brazil
Prior art keywords
antigen
binding
molecule
binding activity
fcrn
Prior art date
Application number
BR112014020821A
Other languages
English (en)
Other versions
BR112014020821B1 (pt
Inventor
Maeda Atsuhiko
Mimoto Futa
Katada Hitoshi
Haraya Kenta
Kadono Shojiro
Igawa Tomoyuki
Iwayanagi Yuki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2012/054624 external-priority patent/WO2012115241A1/ja
Priority claimed from PCT/JP2012/075092 external-priority patent/WO2013047752A1/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR112014020821A2 publication Critical patent/BR112014020821A2/pt
Publication of BR112014020821B1 publication Critical patent/BR112014020821B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303—Liver or Pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

abstract the present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an fc?-binding domain having fc? riib-selective binding activity, and (iii) an fcrn-binding domain having fcrn-binding activity under an acidic ph range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule. tradução do resumo resumo patente de invenção: "molécula de ligação a antígeno para promoção de desaparecimento de antígeno através de fc?riib". a presente invenção refere-se a moléculas de ligação a antígeno contendo (i) um domínio de ligação a antígeno cuja atividade de ligação a antígeno varia dependendo das condições de concentração de íons, (ii) um domínio de ligação a fc? tendo atividade de ligação seletiva ao fc?riib e (iii) um domínio de ligação a fcrn tendo atividade de ligação ao fcrn sob uma condição de faixa de ph ácido e métodos de diminuição da concentração plasmática de antígeno quando comparado com antes da administração da molécula, os quais incluem a etapa de administração da molécula.
BR112014020821-2A 2012-02-24 2013-02-22 Composição farmacêutica e método de produção de uma molécula de ligação a antígeno BR112014020821B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
PCT/JP2012/054624 WO2012115241A1 (ja) 2011-02-25 2012-02-24 FcγRIIb特異的Fc抗体
JPPCT/JP2012/054624 2012-02-24
JP2012-185866 2012-08-24
JP2012185866 2012-08-24
PCT/JP2012/075092 WO2013047752A1 (ja) 2011-09-30 2012-09-28 抗原の消失を促進する抗原結合分子
JPPCT/JP2012/075092 2012-09-28
PCT/JP2013/054461 WO2013125667A1 (ja) 2012-02-24 2013-02-22 FcγRIIBを介して抗原の消失を促進する抗原結合分子

Publications (2)

Publication Number Publication Date
BR112014020821A2 true BR112014020821A2 (pt) 2017-07-04
BR112014020821B1 BR112014020821B1 (pt) 2022-11-16

Family

ID=49005844

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014020821-2A BR112014020821B1 (pt) 2012-02-24 2013-02-22 Composição farmacêutica e método de produção de uma molécula de ligação a antígeno

Country Status (16)

Country Link
US (2) US20160046693A1 (pt)
EP (2) EP3738980A1 (pt)
JP (5) JP6138108B2 (pt)
KR (3) KR102219987B1 (pt)
CN (2) CN107266564A (pt)
AU (3) AU2013223087B2 (pt)
BR (1) BR112014020821B1 (pt)
CA (1) CA2865158C (pt)
DK (1) DK2818183T3 (pt)
ES (1) ES2795419T3 (pt)
HK (1) HK1201476A1 (pt)
MX (2) MX370668B (pt)
RU (1) RU2736349C2 (pt)
SG (2) SG11201405137QA (pt)
TW (4) TWI682939B (pt)
WO (1) WO2013125667A1 (pt)

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