MX353550B - Uso de moleculas de enlace a semaforina-4d para la modulacion de la permeabilidad de la barrera sangre-cerebro. - Google Patents

Uso de moleculas de enlace a semaforina-4d para la modulacion de la permeabilidad de la barrera sangre-cerebro.

Info

Publication number
MX353550B
MX353550B MX2014004457A MX2014004457A MX353550B MX 353550 B MX353550 B MX 353550B MX 2014004457 A MX2014004457 A MX 2014004457A MX 2014004457 A MX2014004457 A MX 2014004457A MX 353550 B MX353550 B MX 353550B
Authority
MX
Mexico
Prior art keywords
semaphorin
brain barrier
modulation
barrier permeability
binding molecules
Prior art date
Application number
MX2014004457A
Other languages
English (en)
Other versions
MX2014004457A (es
Inventor
S Smith Ernest
Zauderer Maurice
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of MX2014004457A publication Critical patent/MX2014004457A/es
Publication of MX353550B publication Critical patent/MX353550B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a una cantidad eficaz de un anticuerpo aislado o fragmento del mismo que se une a antígeno, que se une específicamente a semaforina-4D (SEMA4D) para usarse como un medicamento para disminuir la permeabilidad de la barrera hematoencefálica (BBB) en un sujeto con permeabilidad BBB aumentada y un trastorno neuroinflamatorio, donde el anticuerpo o fragmento del mismo que se une a antígeno inhibe específicamente la interacción de semaforina 4D (SEMA4D) con el resceptor de SEMA4D, plexina B1.
MX2014004457A 2011-10-11 2012-10-11 Uso de moleculas de enlace a semaforina-4d para la modulacion de la permeabilidad de la barrera sangre-cerebro. MX353550B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161545809P 2011-10-11 2011-10-11
US201161555726P 2011-11-04 2011-11-04
US201261593641P 2012-02-01 2012-02-01
PCT/US2012/059757 WO2013055922A1 (en) 2011-10-11 2012-10-11 Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability

Publications (2)

Publication Number Publication Date
MX2014004457A MX2014004457A (es) 2014-06-05
MX353550B true MX353550B (es) 2018-01-18

Family

ID=48082436

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004457A MX353550B (es) 2011-10-11 2012-10-11 Uso de moleculas de enlace a semaforina-4d para la modulacion de la permeabilidad de la barrera sangre-cerebro.

Country Status (16)

Country Link
US (2) US20130095118A1 (es)
EP (1) EP2766093B1 (es)
JP (2) JP6395606B2 (es)
KR (1) KR101999872B1 (es)
CN (2) CN104168956A (es)
AU (1) AU2012322721B2 (es)
BR (1) BR112014008885B1 (es)
CA (1) CA2851805C (es)
DK (1) DK2766093T3 (es)
EA (1) EA029023B1 (es)
ES (1) ES2669209T3 (es)
IL (1) IL232072B (es)
MX (1) MX353550B (es)
PT (1) PT2766093T (es)
SG (1) SG11201401458UA (es)
WO (1) WO2013055922A1 (es)

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Publication number Publication date
SG11201401458UA (en) 2014-07-30
WO2013055922A1 (en) 2013-04-18
CN104168956A (zh) 2014-11-26
BR112014008885B1 (pt) 2021-02-17
MX2014004457A (es) 2014-06-05
IL232072A0 (en) 2014-05-28
KR101999872B1 (ko) 2019-07-12
US20190358321A1 (en) 2019-11-28
EP2766093A4 (en) 2015-03-25
CA2851805A1 (en) 2013-04-18
DK2766093T3 (en) 2018-06-06
JP6395606B2 (ja) 2018-09-26
JP2017193569A (ja) 2017-10-26
EP2766093A1 (en) 2014-08-20
ES2669209T3 (es) 2018-05-24
AU2012322721B2 (en) 2016-05-05
NZ623856A (en) 2016-04-29
AU2012322721A1 (en) 2013-05-16
PT2766093T (pt) 2018-05-18
EP2766093B1 (en) 2018-02-21
EA201490768A1 (ru) 2014-09-30
EA029023B1 (ru) 2018-01-31
CN110105452A (zh) 2019-08-09
KR20140076616A (ko) 2014-06-20
IL232072B (en) 2021-01-31
US11534488B2 (en) 2022-12-27
US20130095118A1 (en) 2013-04-18
JP2014530239A (ja) 2014-11-17
CA2851805C (en) 2021-12-28
BR112014008885A2 (pt) 2017-04-18

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