MX2021008800A - Barrera hematoencefalica humana in vitro. - Google Patents
Barrera hematoencefalica humana in vitro.Info
- Publication number
- MX2021008800A MX2021008800A MX2021008800A MX2021008800A MX2021008800A MX 2021008800 A MX2021008800 A MX 2021008800A MX 2021008800 A MX2021008800 A MX 2021008800A MX 2021008800 A MX2021008800 A MX 2021008800A MX 2021008800 A MX2021008800 A MX 2021008800A
- Authority
- MX
- Mexico
- Prior art keywords
- brain barrier
- blood brain
- human blood
- vitro human
- ibbb
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5058—Neurological cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5064—Endothelial cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/28—Vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Abstract
La presente descripción proporciona, en algunas modalidades, una barrera hematoencefálica in vitro (iBBB) que tiene propiedades funcionales de BBB in vivo así como métodos para identificar los compuestos capaces de atravesar la iBBB; también se describen los compuestos capaces de atravesar la iBBB y usos terapéuticos de dichos compuestos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962795520P | 2019-01-22 | 2019-01-22 | |
PCT/US2020/014572 WO2020154374A1 (en) | 2019-01-22 | 2020-01-22 | In vitro human blood brain barrier |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021008800A true MX2021008800A (es) | 2021-11-12 |
Family
ID=69724092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021008800A MX2021008800A (es) | 2019-01-22 | 2020-01-22 | Barrera hematoencefalica humana in vitro. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20220090021A1 (es) |
EP (1) | EP3914694A1 (es) |
JP (1) | JP2022523051A (es) |
KR (1) | KR20210131335A (es) |
CN (1) | CN113614222A (es) |
AU (1) | AU2020211961A1 (es) |
CA (1) | CA3127452A1 (es) |
IL (1) | IL285062A (es) |
MX (1) | MX2021008800A (es) |
WO (1) | WO2020154374A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114276983A (zh) * | 2021-12-31 | 2022-04-05 | 广州市第一人民医院(广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院) | 一种3d共培养4种细胞体外建立人血脑屏障模型的方法 |
WO2023205460A1 (en) * | 2022-04-22 | 2023-10-26 | Children’S Hospital Medical Center | Vascularized brain organoids and methods of making and use |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US9932559B2 (en) * | 2012-11-16 | 2018-04-03 | The Johns Hopkins University | Platform for creating an artificial blood brain barrier |
US11136362B2 (en) | 2016-03-10 | 2021-10-05 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide modulators of specific calcineurin protein-protein interactions |
EP3494213A4 (en) * | 2016-08-04 | 2020-01-08 | Wake Forest University Health Sciences | MODEL FOR BLOOD BRAIN CABINETS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
US20180064527A1 (en) * | 2016-09-07 | 2018-03-08 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Modeling Blood-Brain Barrier in Vitro |
US10451637B2 (en) * | 2017-03-24 | 2019-10-22 | The University Of British Columbia | Synthetic blood vessels and uses thereof |
-
2020
- 2020-01-22 CN CN202080022493.2A patent/CN113614222A/zh active Pending
- 2020-01-22 CA CA3127452A patent/CA3127452A1/en active Pending
- 2020-01-22 WO PCT/US2020/014572 patent/WO2020154374A1/en unknown
- 2020-01-22 MX MX2021008800A patent/MX2021008800A/es unknown
- 2020-01-22 JP JP2021543231A patent/JP2022523051A/ja active Pending
- 2020-01-22 KR KR1020217026482A patent/KR20210131335A/ko unknown
- 2020-01-22 AU AU2020211961A patent/AU2020211961A1/en not_active Abandoned
- 2020-01-22 US US17/424,529 patent/US20220090021A1/en active Pending
- 2020-01-22 EP EP20707921.1A patent/EP3914694A1/en not_active Withdrawn
-
2021
- 2021-07-22 IL IL285062A patent/IL285062A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2020211961A1 (en) | 2021-09-09 |
EP3914694A1 (en) | 2021-12-01 |
JP2022523051A (ja) | 2022-04-21 |
KR20210131335A (ko) | 2021-11-02 |
US20220090021A1 (en) | 2022-03-24 |
CN113614222A (zh) | 2021-11-05 |
CA3127452A1 (en) | 2020-07-30 |
IL285062A (en) | 2021-09-30 |
WO2020154374A1 (en) | 2020-07-30 |
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