BR112014018714A8 - Compostos de 4-(benzoimidazol-2-il)-tiazol e derivados de aza relacionados - Google Patents
Compostos de 4-(benzoimidazol-2-il)-tiazol e derivados de aza relacionadosInfo
- Publication number
- BR112014018714A8 BR112014018714A8 BR112014018714A BR112014018714A BR112014018714A8 BR 112014018714 A8 BR112014018714 A8 BR 112014018714A8 BR 112014018714 A BR112014018714 A BR 112014018714A BR 112014018714 A BR112014018714 A BR 112014018714A BR 112014018714 A8 BR112014018714 A8 BR 112014018714A8
- Authority
- BR
- Brazil
- Prior art keywords
- benzoimidazol
- aza derivatives
- thiazole compounds
- compounds
- related aza
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010061300 CXCR3 Receptors Proteins 0.000 abstract 1
- 102000011963 CXCR3 Receptors Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2012/050489 | 2012-02-02 | ||
| PCT/IB2013/050870 WO2013114332A1 (en) | 2012-02-02 | 2013-02-01 | 4-(benzoimidazol-2-yl)-thiazole compounds and related aza derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014018714A2 BR112014018714A2 (https=) | 2017-06-20 |
| BR112014018714A8 true BR112014018714A8 (pt) | 2017-12-26 |
Family
ID=48014121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014018714A BR112014018714A8 (pt) | 2012-02-02 | 2013-02-01 | Compostos de 4-(benzoimidazol-2-il)-tiazol e derivados de aza relacionados |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9266876B2 (https=) |
| EP (1) | EP2809668B1 (https=) |
| JP (1) | JP6073931B2 (https=) |
| KR (1) | KR101800607B1 (https=) |
| CN (1) | CN104093715B (https=) |
| AU (1) | AU2013216354B2 (https=) |
| BR (1) | BR112014018714A8 (https=) |
| CA (1) | CA2861020C (https=) |
| CL (1) | CL2014002048A1 (https=) |
| EA (1) | EA027595B1 (https=) |
| ES (1) | ES2632237T3 (https=) |
| IL (1) | IL233872A (https=) |
| MX (1) | MX352181B (https=) |
| MY (1) | MY170524A (https=) |
| NZ (1) | NZ629795A (https=) |
| PH (1) | PH12014501540A1 (https=) |
| PL (1) | PL2809668T3 (https=) |
| SG (1) | SG11201404144PA (https=) |
| UA (1) | UA113638C2 (https=) |
| WO (1) | WO2013114332A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA030067B1 (ru) | 2013-07-22 | 2018-06-29 | Идорсиа Фармасьютиклз Лтд | Производные 1-(пиперазин-1-ил)-2-([1,2,4]триазол-1-ил)этанона |
| US10087151B2 (en) | 2014-01-09 | 2018-10-02 | The J. David Gladstone Institutes, A Testimentary Trust Established Under The Will Of J. David Gladstone | Substituted benzoxazine and related compounds |
| AR099789A1 (es) | 2014-03-24 | 2016-08-17 | Actelion Pharmaceuticals Ltd | Derivados de 8-(piperazin-1-il)-1,2,3,4-tetrahidro-isoquinolina |
| AR103399A1 (es) * | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| JP6337218B2 (ja) * | 2015-01-15 | 2018-06-06 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ｃｘｃｒ３受容体調節剤としてのヒドロキシアルキル−ピペラジン誘導体 |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2018011265A1 (en) | 2016-07-13 | 2018-01-18 | Idorsia Pharmaceuticals Ltd | Hydroxyalkyl-piperazine derivatives as cxcr3 receptor modulators |
| FR3067028B1 (fr) | 2017-06-06 | 2019-07-12 | Adpuerivitam | Modulateurs de recepteurs nmda, compositions les comprenant et utilisation de ces composes dans le traitement de maladies impliquant le systeme nerveux central |
| AU2021324684A1 (en) * | 2020-08-11 | 2023-04-20 | Board Of Trustees Of Michigan State University | Proteasome enhancers and uses thereof |
| EP4228632A4 (en) * | 2020-10-16 | 2025-02-19 | Saint Louis University | Rev-erb agonists |
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| JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
| GB0229618D0 (en) * | 2002-12-19 | 2003-01-22 | Cancer Rec Tech Ltd | Pyrazole compounds |
| GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
| WO2005035534A1 (ja) | 2003-10-08 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 複素ビシクロ環および複素トリシクロ環化合物およびその医薬 |
| US20050124625A1 (en) | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
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| WO2011051243A1 (en) | 2009-10-29 | 2011-05-05 | Bayer Cropscience Ag | Active compound combinations |
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| BR112012027762B1 (pt) | 2010-04-28 | 2018-06-05 | Bayer Intellectual Property Gmbh | Derivados de cetoheteroarilpiperidina e - piperazina como fungicidas |
| US8815775B2 (en) | 2010-05-18 | 2014-08-26 | Bayer Cropscience Ag | Bis(difluoromethyl)pyrazoles as fungicides |
| BR112012026708A2 (pt) | 2010-05-20 | 2015-09-22 | Du Pont | composto selecionado, composição fungicida e método para controlar doenças vegetais |
| EP2576539B1 (de) | 2010-05-27 | 2017-12-13 | Bayer CropScience AG | Pyridinylcarbonsäure derivate als fungizide |
| US20120122928A1 (en) | 2010-08-11 | 2012-05-17 | Bayer Cropscience Ag | Heteroarylpiperidine and -Piperazine Derivatives as Fungicides |
| US8759527B2 (en) | 2010-08-25 | 2014-06-24 | Bayer Cropscience Ag | Heteroarylpiperidine and -piperazine derivatives as fungicides |
| EP2632922B1 (de) | 2010-10-27 | 2019-02-27 | Bayer CropScience Aktiengesellschaft | Heteroarylpiperidin und -piperazinderivate als fungizide |
| BR112013012621A2 (pt) | 2010-11-25 | 2016-07-12 | Syngenta Participations Ag | heterociclos microbicidas |
| CN103384470A (zh) | 2010-12-17 | 2013-11-06 | 纳幕尔杜邦公司 | 杀真菌偶氮环酰胺 |
| WO2012104273A1 (de) | 2011-02-01 | 2012-08-09 | Bayer Cropscience Ag | Heteroarylpiperidin und -piperazinderivate als fungizide |
| BR112013020419A2 (pt) | 2011-02-10 | 2016-07-12 | Syngenta Participations Ag | microbicidas derivados de pirazol |
| BR112013020270A2 (pt) | 2011-02-10 | 2016-07-12 | Syngenta Participations Ag | derivados de pirazol microbicidas |
| CN102827073A (zh) | 2011-06-17 | 2012-12-19 | 安吉奥斯医药品有限公司 | 治疗活性组合物和它们的使用方法 |
| US10004232B2 (en) | 2011-09-15 | 2018-06-26 | Bayer Intellectual Property Gmbh | Piperidine pyrazoles as fungicides |
| US20140243371A1 (en) | 2011-10-18 | 2014-08-28 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| CN103889982A (zh) | 2011-10-18 | 2014-06-25 | 先正达参股股份有限公司 | 杀微生物的吡唑衍生物 |
| US8642774B2 (en) | 2011-12-08 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Compounds |
| WO2013127808A1 (en) | 2012-03-02 | 2013-09-06 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| EP2820012A1 (en) | 2012-03-02 | 2015-01-07 | Syngenta Participations AG | Microbiocidal pyrazole derivatives |
| US10035790B2 (en) | 2012-10-19 | 2018-07-31 | Exelixis, Inc. | RORγ modulators |
| WO2014075874A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
| WO2014075873A1 (en) | 2012-11-13 | 2014-05-22 | Syngenta Participations Ag | Microbiocidal pyrazole derivatives |
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2013
- 2013-02-01 US US14/376,307 patent/US9266876B2/en active Active
- 2013-02-01 NZ NZ629795A patent/NZ629795A/en not_active IP Right Cessation
- 2013-02-01 EP EP13712913.6A patent/EP2809668B1/en active Active
- 2013-02-01 MY MYPI2014702122A patent/MY170524A/en unknown
- 2013-02-01 AU AU2013216354A patent/AU2013216354B2/en not_active Ceased
- 2013-02-01 EA EA201400854A patent/EA027595B1/ru not_active IP Right Cessation
- 2013-02-01 BR BR112014018714A patent/BR112014018714A8/pt not_active IP Right Cessation
- 2013-02-01 UA UAA201409420A patent/UA113638C2/uk unknown
- 2013-02-01 ES ES13712913.6T patent/ES2632237T3/es active Active
- 2013-02-01 JP JP2014555374A patent/JP6073931B2/ja not_active Expired - Fee Related
- 2013-02-01 WO PCT/IB2013/050870 patent/WO2013114332A1/en not_active Ceased
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- 2013-02-01 SG SG11201404144PA patent/SG11201404144PA/en unknown
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- 2013-02-01 CA CA2861020A patent/CA2861020C/en active Active
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- 2013-02-01 PL PL13712913T patent/PL2809668T3/pl unknown
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2014
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- 2014-07-30 IL IL233872A patent/IL233872A/en not_active IP Right Cessation
- 2014-07-31 CL CL2014002048A patent/CL2014002048A1/es unknown
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|---|---|
| AU2013216354A1 (en) | 2014-09-25 |
| MY170524A (en) | 2019-08-09 |
| MX2014009355A (es) | 2014-09-01 |
| PL2809668T3 (pl) | 2018-02-28 |
| CA2861020A1 (en) | 2013-08-08 |
| PH12014501540B1 (en) | 2014-09-22 |
| US9266876B2 (en) | 2016-02-23 |
| UA113638C2 (xx) | 2017-02-27 |
| CN104093715B (zh) | 2017-04-26 |
| SG11201404144PA (en) | 2014-10-30 |
| KR20140120364A (ko) | 2014-10-13 |
| EP2809668A1 (en) | 2014-12-10 |
| JP6073931B2 (ja) | 2017-02-01 |
| EA201400854A1 (ru) | 2015-04-30 |
| CA2861020C (en) | 2018-07-17 |
| ES2632237T3 (es) | 2017-09-12 |
| AU2013216354B2 (en) | 2017-08-31 |
| PH12014501540A1 (en) | 2014-09-22 |
| CL2014002048A1 (es) | 2014-11-14 |
| JP2015506957A (ja) | 2015-03-05 |
| EP2809668B1 (en) | 2017-04-12 |
| IL233872A (en) | 2017-05-29 |
| EA027595B1 (ru) | 2017-08-31 |
| MX352181B (es) | 2017-11-13 |
| CN104093715A (zh) | 2014-10-08 |
| KR101800607B1 (ko) | 2017-11-23 |
| WO2013114332A1 (en) | 2013-08-08 |
| NZ629795A (en) | 2016-06-24 |
| BR112014018714A2 (https=) | 2017-06-20 |
| US20140371204A1 (en) | 2014-12-18 |
| HK1203939A1 (en) | 2015-11-06 |
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