BR112014010204A2 - composto, métodos para tratar aterosclerose, para aumentar o hdl-c, para reduzir p ldl-c e para tratar dislipidemia em um paciente, e, uso do composto, composição fermacêutica - Google Patents

composto, métodos para tratar aterosclerose, para aumentar o hdl-c, para reduzir p ldl-c e para tratar dislipidemia em um paciente, e, uso do composto, composição fermacêutica

Info

Publication number
BR112014010204A2
BR112014010204A2 BR112014010204A BR112014010204A BR112014010204A2 BR 112014010204 A2 BR112014010204 A2 BR 112014010204A2 BR 112014010204 A BR112014010204 A BR 112014010204A BR 112014010204 A BR112014010204 A BR 112014010204A BR 112014010204 A2 BR112014010204 A2 BR 112014010204A2
Authority
BR
Brazil
Prior art keywords
compound
treating
ldl
patient
reducing
Prior art date
Application number
BR112014010204A
Other languages
English (en)
Portuguese (pt)
Inventor
Sha Deyou
Ye Feng
Liu Jian
Patrick Shao Pengcheng
Vachal Petr
Reddy Katipally Revathi
Sun Wanying
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of BR112014010204A2 publication Critical patent/BR112014010204A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR112014010204A 2011-10-28 2012-10-25 composto, métodos para tratar aterosclerose, para aumentar o hdl-c, para reduzir p ldl-c e para tratar dislipidemia em um paciente, e, uso do composto, composição fermacêutica BR112014010204A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161552592P 2011-10-28 2011-10-28
PCT/US2012/061842 WO2013063217A1 (en) 2011-10-28 2012-10-25 Fused bicyclic oxazolidinone cetp inhibitor

Publications (1)

Publication Number Publication Date
BR112014010204A2 true BR112014010204A2 (pt) 2017-05-09

Family

ID=47143312

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014010204A BR112014010204A2 (pt) 2011-10-28 2012-10-25 composto, métodos para tratar aterosclerose, para aumentar o hdl-c, para reduzir p ldl-c e para tratar dislipidemia em um paciente, e, uso do composto, composição fermacêutica

Country Status (41)

Country Link
US (2) US8871738B2 (https=)
EP (1) EP2771345B1 (https=)
JP (1) JP5658427B2 (https=)
KR (1) KR101686308B1 (https=)
CN (1) CN103958524B (https=)
AR (1) AR088565A1 (https=)
AU (1) AU2012328759B2 (https=)
BR (1) BR112014010204A2 (https=)
CA (1) CA2852743C (https=)
CL (1) CL2014001090A1 (https=)
CO (1) CO6940419A2 (https=)
CR (1) CR20140256A (https=)
CY (1) CY1118464T1 (https=)
DK (1) DK2771345T3 (https=)
DO (1) DOP2014000086A (https=)
EA (1) EA026123B1 (https=)
EC (1) ECSP14002458A (https=)
ES (1) ES2604953T3 (https=)
GE (1) GEP20166434B (https=)
HR (1) HRP20161541T1 (https=)
HU (1) HUE030568T2 (https=)
IL (1) IL232130A (https=)
IN (1) IN2014CN03073A (https=)
JO (1) JO3210B1 (https=)
LT (1) LT2771345T (https=)
MA (1) MA35643B1 (https=)
ME (1) ME02557B (https=)
MX (1) MX345222B (https=)
NI (1) NI201400034A (https=)
PE (1) PE20141230A1 (https=)
PH (1) PH12014500890A1 (https=)
PL (1) PL2771345T3 (https=)
PT (1) PT2771345T (https=)
RS (1) RS55420B1 (https=)
SG (1) SG11201401884PA (https=)
SI (1) SI2771345T1 (https=)
TN (1) TN2014000158A1 (https=)
TW (1) TWI601731B (https=)
UA (1) UA114612C2 (https=)
WO (1) WO2013063217A1 (https=)
ZA (2) ZA201403091B (https=)

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TN2014000158A1 (en) 2015-09-30
DK2771345T3 (en) 2017-01-09
JP5658427B2 (ja) 2015-01-28
US20140378493A1 (en) 2014-12-25
CA2852743A1 (en) 2013-05-02
CL2014001090A1 (es) 2014-08-01
CR20140256A (es) 2014-07-15
CO6940419A2 (es) 2014-05-09
TWI601731B (zh) 2017-10-11
AR088565A1 (es) 2014-06-18
EP2771345A1 (en) 2014-09-03
SG11201401884PA (en) 2014-09-26
EA201490889A1 (ru) 2015-05-29
AU2012328759A1 (en) 2014-05-01
TW201321388A (zh) 2013-06-01
HRP20161541T1 (hr) 2016-12-30
LT2771345T (lt) 2016-11-25
US20130109649A1 (en) 2013-05-02
CA2852743C (en) 2016-08-02
PT2771345T (pt) 2016-11-30
SI2771345T1 (sl) 2016-12-30
MA35643B1 (fr) 2014-11-01
NZ625435A (en) 2015-12-24
KR101686308B1 (ko) 2016-12-13
PE20141230A1 (es) 2014-09-28
IL232130A0 (en) 2014-05-28
NI201400034A (es) 2014-10-10
ZA201403091B (en) 2015-04-29
ME02557B (me) 2017-02-20
WO2013063217A1 (en) 2013-05-02
EA026123B1 (ru) 2017-03-31
US9346825B2 (en) 2016-05-24
ES2604953T3 (es) 2017-03-10
JO3210B1 (ar) 2018-03-08
JP2014532652A (ja) 2014-12-08
HUE030568T2 (en) 2017-05-29
UA114612C2 (uk) 2017-07-10
DOP2014000086A (es) 2014-07-15
IL232130A (en) 2017-07-31
RS55420B1 (sr) 2017-04-28
IN2014CN03073A (https=) 2015-07-31
AU2012328759B2 (en) 2015-09-10
US8871738B2 (en) 2014-10-28
ZA201406833B (en) 2016-02-24
EP2771345B1 (en) 2016-09-21
MX2014005074A (es) 2014-08-01
KR20140094571A (ko) 2014-07-30
CY1118464T1 (el) 2017-07-12
GEP20166434B (en) 2016-02-10
PL2771345T3 (pl) 2017-04-28
MX345222B (es) 2017-01-20
CN103958524B (zh) 2016-04-06
ECSP14002458A (es) 2015-11-30
CN103958524A (zh) 2014-07-30
HK1195558A1 (zh) 2014-11-14
PH12014500890A1 (en) 2014-06-09

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