BR112014004313A2 - composto glicosídeo, métodos de produção de um tioéter, de éter e de composto glicosídeo, e, éter. - Google Patents

composto glicosídeo, métodos de produção de um tioéter, de éter e de composto glicosídeo, e, éter.

Info

Publication number
BR112014004313A2
BR112014004313A2 BR112014004313A BR112014004313A BR112014004313A2 BR 112014004313 A2 BR112014004313 A2 BR 112014004313A2 BR 112014004313 A BR112014004313 A BR 112014004313A BR 112014004313 A BR112014004313 A BR 112014004313A BR 112014004313 A2 BR112014004313 A2 BR 112014004313A2
Authority
BR
Brazil
Prior art keywords
ether
glycoside compound
thioether
producing
methods
Prior art date
Application number
BR112014004313A
Other languages
English (en)
Other versions
BR112014004313A8 (pt
Inventor
Itoh Akihiro
Aoki Eriko
Suzuki Hiroshi
Original Assignee
Bonac Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bonac Corp filed Critical Bonac Corp
Publication of BR112014004313A2 publication Critical patent/BR112014004313A2/pt
Publication of BR112014004313A8 publication Critical patent/BR112014004313A8/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/16Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by addition of hydrogen sulfide or its salts to unsaturated compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06Pyrimidine radicals
    • C07H19/067Pyrimidine radicals with ribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/167Purine radicals with ribosyl as the saccharide radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR112014004313A 2011-08-25 2012-08-24 Composto glicosídeo, métodos de produção de um tioéter, de éter e de composto glicosídeo, e, éter. BR112014004313A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011184196 2011-08-25
PCT/JP2012/071517 WO2013027843A1 (ja) 2011-08-25 2012-08-24 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法

Publications (2)

Publication Number Publication Date
BR112014004313A2 true BR112014004313A2 (pt) 2017-03-28
BR112014004313A8 BR112014004313A8 (pt) 2023-02-07

Family

ID=47746578

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112014004313A BR112014004313A8 (pt) 2011-08-25 2012-08-24 Composto glicosídeo, métodos de produção de um tioéter, de éter e de composto glicosídeo, e, éter.
BR122020014853A BR122020014853B8 (pt) 2011-08-25 2012-08-24 Éter, e, método de produção de um éter

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122020014853A BR122020014853B8 (pt) 2011-08-25 2012-08-24 Éter, e, método de produção de um éter

Country Status (14)

Country Link
US (2) US9481702B2 (pt)
EP (2) EP2749565B1 (pt)
JP (2) JP5554881B2 (pt)
KR (1) KR101761103B1 (pt)
CN (2) CN103906758B (pt)
AU (1) AU2012297612B9 (pt)
BR (2) BR112014004313A8 (pt)
CA (1) CA2846572C (pt)
ES (2) ES2638147T3 (pt)
HK (1) HK1199456A1 (pt)
IL (2) IL231089A (pt)
MX (2) MX348971B (pt)
TW (2) TWI586683B (pt)
WO (1) WO2013027843A1 (pt)

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JP6459852B2 (ja) * 2014-08-29 2019-01-30 住友化学株式会社 エーテル化合物の製造方法
US10377788B2 (en) 2015-04-02 2019-08-13 Bonac Corporation Method for producing glycoside compounds
CN108473988A (zh) 2015-12-29 2018-08-31 国立大学法人北海道大学 抑制肾素原基因或肾素原受体基因表达的单链核酸分子及其用途
EP3450439B8 (en) 2016-04-26 2021-06-30 Sumitomo Chemical Company, Limited Method for producing monomer for single-stranded nucleic acid molecule
JPWO2018070543A1 (ja) 2016-10-14 2019-07-25 株式会社ボナック 新規な配糖体化合物及びその製造方法
EP3604528A4 (en) 2017-03-31 2021-01-13 Bonac Corporation CYCLIC NUCLEIC ACID MOLECULE HAVING A GENE EXPRESSION CONTROL FUNCTION
SG11201913541QA (en) 2017-07-28 2020-02-27 Kyorin Pharmaceutical Co Ltd Therapeutic agent for fibrosis
TWI830718B (zh) 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
CN111819280A (zh) 2018-03-30 2020-10-23 东丽株式会社 发夹型单链rna分子的制备方法
JP6817493B2 (ja) 2018-03-30 2021-01-20 住友化学株式会社 一本鎖rnaの製造方法
JP7280248B2 (ja) * 2018-04-24 2023-05-23 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
US20210355153A1 (en) * 2018-09-07 2021-11-18 Sumitomo Chemical Company, Limited Method for producing glycoside compound
JP7241098B2 (ja) 2019-01-25 2023-03-16 杏林製薬株式会社 線維症治療剤
US20220213134A1 (en) 2019-03-29 2022-07-07 Sumitomo Chemical Company, Limited Method for producing rna
WO2020202951A1 (ja) 2019-03-29 2020-10-08 住友化学株式会社 無機多孔質担体、及びこれを用いた核酸の製造方法
WO2020202950A1 (ja) 2019-03-29 2020-10-08 住友化学株式会社 無機多孔質担体及びこれを用いた核酸の製造方法
US20220177319A1 (en) 2019-03-29 2022-06-09 Sumitomo Chemical Company, Limited Inorganic porous support and method for producing nucleic acid using same
US20220193648A1 (en) 2019-03-29 2022-06-23 Sumitomo Chemical Company, Limited Inorganic porous carrier, and production method for nucleic acid using same
US20230022212A1 (en) * 2019-10-08 2023-01-26 Sumitomo Chemical Company, Limited Method for producing glycoside compound
EP4043473A4 (en) * 2019-10-11 2024-03-27 Sumitomo Chemical Co METHOD FOR PRODUCING NUCLEIC ACID OLIGOMERS
US20230024003A1 (en) 2019-10-23 2023-01-26 Sumitomo Chemical Company, Limited Glycoside compound, amidite compound, and production method for polynucleotide using said compounds
CN115003680A (zh) * 2020-01-29 2022-09-02 住友化学株式会社 制备核酸寡聚物的方法
EP4098655A4 (en) * 2020-01-29 2024-02-28 Sumitomo Chemical Co PROCESS FOR THE PRODUCTION OF NUCLEIC ACID OLIGOMERS
KR20220160010A (ko) 2020-03-27 2022-12-05 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법
CN115362163A (zh) 2020-04-14 2022-11-18 住友化学株式会社 核酸寡聚物的制造方法
KR20220167282A (ko) 2020-04-14 2022-12-20 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머를 포함하는 조성물
JPWO2021230293A1 (pt) 2020-05-13 2021-11-18
US20230242570A1 (en) 2020-07-09 2023-08-03 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
EP4206325A1 (en) 2020-08-25 2023-07-05 Bonac Corporation Novel nucleic acid molecule inhibiting expression of target gene
EP4219520A1 (en) 2020-09-24 2023-08-02 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer
EP4271695A2 (en) * 2020-12-31 2023-11-08 Alnylam Pharmaceuticals, Inc. 2'-modified nucleoside based oligonucleotide prodrugs
WO2023282120A1 (ja) 2021-07-06 2023-01-12 住友化学株式会社 核酸オリゴマーを含む組成物
JPWO2023054350A1 (pt) 2021-09-28 2023-04-06
US11897914B2 (en) 2021-11-29 2024-02-13 Hongene Biotech Corporation Synthesis of 2′ protected nucleosides
WO2023182274A1 (ja) * 2022-03-23 2023-09-28 住友化学株式会社 核酸オリゴマーの製造方法
WO2024019137A1 (ja) * 2022-07-22 2024-01-25 住友化学株式会社 オリゴヌクレオチドの製造方法
WO2024024766A1 (ja) * 2022-07-25 2024-02-01 東レ株式会社 アルキルハライド、それを用いたアルキル化剤及びヌクレオシド誘導体の製造方法

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NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
CA2129288C (en) 1993-08-17 2000-05-16 Jerzy Golik Phosphonooxymethyl esters of taxane derivatives
US5955600A (en) * 1996-12-27 1999-09-21 Isis Pharmaceuticals, Inc. Method for the synthesis of nucleotide or oligonucleotide phosphoramidites
US6610842B1 (en) * 1999-05-06 2003-08-26 Isis Pharmaceuticals, Inc. Processes for the synthesis of oligomers using phosphoramidite compositions
WO2005085271A1 (ja) * 2004-03-04 2005-09-15 Japan Science And Technology Agency 2 ‘水酸基を修飾された新規人工rna
JP5157168B2 (ja) * 2004-08-26 2013-03-06 日本新薬株式会社 ホスホロアミダイト化合物及びオリゴrnaの製法
JP4797156B2 (ja) * 2005-03-09 2011-10-19 国立大学法人東京工業大学 リボヌクレオシドの2’水酸基の脱保護方法
JP2008174524A (ja) 2007-01-22 2008-07-31 Nippon Shinyaku Co Ltd リボ核酸化合物の製造方法

Also Published As

Publication number Publication date
EP3098230A1 (en) 2016-11-30
TWI586684B (zh) 2017-06-11
BR122020014853B1 (pt) 2021-09-21
HK1199456A1 (en) 2015-07-03
TW201636357A (zh) 2016-10-16
EP2749565B1 (en) 2017-05-31
US9481702B2 (en) 2016-11-01
IL242889A (en) 2017-09-28
KR20140067062A (ko) 2014-06-03
MX370398B (es) 2019-12-11
JP5554881B2 (ja) 2014-07-23
WO2013027843A1 (ja) 2013-02-28
ES2638147T3 (es) 2017-10-18
CN107253926B (zh) 2019-10-25
US9988415B2 (en) 2018-06-05
US20160176810A1 (en) 2016-06-23
MX2014002229A (es) 2015-01-15
IL231089A (en) 2016-10-31
IL231089A0 (en) 2014-03-31
JP2014055147A (ja) 2014-03-27
MX348971B (es) 2017-07-05
AU2012297612A1 (en) 2014-03-20
ES2802996T3 (es) 2021-01-22
EP2749565A1 (en) 2014-07-02
KR101761103B1 (ko) 2017-07-25
CA2846572A1 (en) 2013-02-28
CN103906758A (zh) 2014-07-02
JP5554873B2 (ja) 2014-07-23
TWI586683B (zh) 2017-06-11
EP3098230B1 (en) 2020-05-06
TW201313734A (zh) 2013-04-01
AU2012297612B9 (en) 2017-08-03
CN107253926A (zh) 2017-10-17
CN103906758B (zh) 2017-05-10
AU2012297612B2 (en) 2017-02-23
CA2846572C (en) 2019-12-31
JPWO2013027843A1 (ja) 2015-03-23
EP2749565A4 (en) 2015-08-05
BR122020014853B8 (pt) 2023-02-28
US20140206856A1 (en) 2014-07-24
BR112014004313A8 (pt) 2023-02-07

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25A Requested transfer of rights approved

Owner name: SUMITOMO CHEMICAL COMPANY, LIMITED (JP)