BR112013032232A2 - método de caracterização de câncer através do uso de biomarcador de ácido nucleico - Google Patents

método de caracterização de câncer através do uso de biomarcador de ácido nucleico

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Publication number
BR112013032232A2
BR112013032232A2 BR112013032232A BR112013032232A BR112013032232A2 BR 112013032232 A2 BR112013032232 A2 BR 112013032232A2 BR 112013032232 A BR112013032232 A BR 112013032232A BR 112013032232 A BR112013032232 A BR 112013032232A BR 112013032232 A2 BR112013032232 A2 BR 112013032232A2
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Brazil
Prior art keywords
disease
biomarkers
stages
condition
nucleic acid
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BR112013032232A
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English (en)
Inventor
David Spetzler
Kirk Brown
Traci Pawlowski
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Caris Life Sciences Switzerland Holdings S A R L
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Application filed by Caris Life Sciences Switzerland Holdings S A R L filed Critical Caris Life Sciences Switzerland Holdings S A R L
Publication of BR112013032232A2 publication Critical patent/BR112013032232A2/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95
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    • G01N2800/00—Detection or diagnosis of diseases
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Abstract

biomarker compositions and methods abstract biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. these include nucleic acids, protein, and circulating structures such as vesicles, and nucleic acid-protein complexes. tradução: resumo patente de invenção: "biomarcadores de circulação para cân-cer". biomarcadores podem ser avaliados para métodos de diagnós-tico, relacionados à terapia ou prognóstico para identificar fenótipos, tal como uma condição ou doença, ou o estágio ou progressão de uma doença, selecionar regimes de tratamento candidatos para doenças, condições, es-tágios de doença e estágios de uma condição e determinar eficácia do tra-tamento. biomarcadores de circulação de um fluido corporal podem ser usa-dos no traçado do perfil de estados fisiológicos ou determinação de fenótipos. esses incluem ácidos nucléicos, proteína e estruturas de circulação tais como vesículas e complexos de ácido nucleico-proteína.
BR112013032232A 2011-06-16 2012-06-14 método de caracterização de câncer através do uso de biomarcador de ácido nucleico BR112013032232A2 (pt)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201161497895P 2011-06-16 2011-06-16
US201161499138P 2011-06-20 2011-06-20
US201161501680P 2011-06-27 2011-06-27
US201161506019P 2011-07-08 2011-07-08
US201161506606P 2011-07-11 2011-07-11
US201161506598P 2011-07-11 2011-07-11
US201161507989P 2011-07-14 2011-07-14
US201161511455P 2011-07-25 2011-07-25
US201161523763P 2011-08-15 2011-08-15
US201161526623P 2011-08-23 2011-08-23
PCT/US2012/042519 WO2012174282A2 (en) 2011-06-16 2012-06-14 Biomarker compositions and methods

Publications (1)

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BR112013032232A2 true BR112013032232A2 (pt) 2016-09-20

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US (1) US20140220580A1 (pt)
EP (1) EP2721179A4 (pt)
JP (1) JP2014519340A (pt)
KR (1) KR20140072014A (pt)
CN (1) CN103797131A (pt)
AU (1) AU2012271516A1 (pt)
BR (1) BR112013032232A2 (pt)
CA (1) CA2839530A1 (pt)
WO (1) WO2012174282A2 (pt)

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