BR112013025300A2 - processo de preparação de dronedarona através de n-butilação - Google Patents

processo de preparação de dronedarona através de n-butilação

Info

Publication number
BR112013025300A2
BR112013025300A2 BR112013025300A BR112013025300A BR112013025300A2 BR 112013025300 A2 BR112013025300 A2 BR 112013025300A2 BR 112013025300 A BR112013025300 A BR 112013025300A BR 112013025300 A BR112013025300 A BR 112013025300A BR 112013025300 A2 BR112013025300 A2 BR 112013025300A2
Authority
BR
Brazil
Prior art keywords
butylation
dronedarone
preparation process
compound
formula
Prior art date
Application number
BR112013025300A
Other languages
English (en)
Inventor
Antal Friesz
Zsolt Dombrády
Zsolt Párkányi
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112013025300A2 publication Critical patent/BR112013025300A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

resumo patente de invenção: "processo de preparação de dronedarona através de n-butilação". a invenção refere-se a um novo processo de preparação de dronedarona (i) e seus sais farmaceuticamente aceitáveis, onde o composto de fórmula (ii) ou sal dele é reagido com um composto de fórmula l-(ch2)3-ch3 (iii), onde l é um grupo de saída, e separação do produto obtido e, se desejado, converte-lo em um sal farmaceuticamente aceitável dele. a invenção refere-se também a alguns novos produtos intermediários e a preparação deles.
BR112013025300A 2011-03-29 2012-03-27 processo de preparação de dronedarona através de n-butilação BR112013025300A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1100165A HUP1100165A2 (en) 2011-03-29 2011-03-29 Process for preparation of dronedarone by n-butylation
PCT/HU2012/000020 WO2012131409A1 (en) 2011-03-29 2012-03-27 Process for preparation of dronedarone by n-butylation

Publications (1)

Publication Number Publication Date
BR112013025300A2 true BR112013025300A2 (pt) 2016-07-19

Family

ID=89990230

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013025300A BR112013025300A2 (pt) 2011-03-29 2012-03-27 processo de preparação de dronedarona através de n-butilação

Country Status (14)

Country Link
US (2) US9174959B2 (pt)
EP (1) EP2691380A1 (pt)
JP (1) JP2014509640A (pt)
KR (1) KR20140015503A (pt)
CN (1) CN103562195A (pt)
AU (1) AU2012235910A1 (pt)
BR (1) BR112013025300A2 (pt)
CA (1) CA2831504A1 (pt)
HU (1) HUP1100165A2 (pt)
IL (1) IL228471A0 (pt)
MX (1) MX2013011257A (pt)
RU (1) RU2013147998A (pt)
SG (1) SG194019A1 (pt)
WO (1) WO2012131409A1 (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction
CN114014876A (zh) * 2021-12-17 2022-02-08 浙江东邦药业有限公司 一种甲氧基甲基头孢妥仑匹酯的制备方法

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3350450A (en) 1963-08-12 1967-10-31 Uniroyal Inc Process of preparing aromatic amines by the catalytic hydrogenation of aromatic nitro compounds
US3577441A (en) 1967-03-07 1971-05-04 Warner Lambert Pharmaceutical Nitro substituted benzofurans
US3657350A (en) 1967-05-09 1972-04-18 Sterling Drug Inc Process and compositions
DE2337396A1 (de) 1973-07-23 1975-02-13 Hoechst Ag Verfahren zur herstellung aromatischer 1,3-diketone
IE45765B1 (en) 1976-08-19 1982-11-17 Ici Ltd Triazoles and imidazoles useful as plant fungicides and growth regulating agents
US4666931A (en) 1984-12-29 1987-05-19 Kaken Pharmaceutical Co., Ltd. Benzofuran derivatives useful in treating diabetic complications
JPH06104663B2 (ja) 1986-07-02 1994-12-21 旭化成工業株式会社 芳香族環状酸無水物の製造法
US5066803A (en) 1989-12-07 1991-11-19 Sterling Drug Inc. 2- and 3-aminomethyl-6-arylcarbonyl-2,3-dihydropyrrolo[1,2,3-de]-1,4-benzoxazines
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
GB9416219D0 (en) 1994-08-11 1994-10-05 Karobio Ab Receptor ligands
IT1275997B1 (it) 1995-03-31 1997-10-24 Great Lakes Chemical Italia Enammine come accelleranti di vulcanizzazione per gomme naturali o sintetiche
JP2003512365A (ja) 1999-10-21 2003-04-02 ロデイア・シミ ベンゾフラン化合物あるいはベンゾチオフェン化合物を調製する方法
FR2800067B1 (fr) 1999-10-21 2004-12-17 Rhodia Chimie Sa Intermediaires de fabrication d'un derive de type benzofurane ou benzothiophene nitre en position 5 et leurs utilisations
FR2813306B1 (fr) 2000-08-23 2005-10-21 Sanofi Synthelabo Aminoalkybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation et les compositions les contenant
FR2813308B1 (fr) 2000-08-23 2005-07-01 Sanofi Synthelabo Aminoalkoxybenzoyl-benzofurannes ou benzothiophenes, leur procede de preparation ainsi que les compositions les contenant
FR2817864B1 (fr) * 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
FR2833262A1 (fr) 2001-12-06 2003-06-13 Rhodia Chimie Sa Procede de monosulfonylation d'un compose de type aminobenzofuranne ou aminobenzothiophene
FR2833263A1 (fr) * 2001-12-06 2003-06-13 Rhodia Chimie Sa Procede de preparation d'un compose de type aminobenzofuranne ou aminobenzothiophene
FR2833259B1 (fr) 2001-12-10 2004-08-27 Oreal Procede de preparation de 2-arylbenzofuranes, composes intermediaires, 2-arylbenzofuranes et compositions les comprenant
DE10237819A1 (de) 2002-08-19 2004-03-04 Bayer Ag 5-Nitrobenzofurane
BR0318383A (pt) 2003-07-03 2006-07-25 Aventis Pharma Inc derivados de pirazoloisoquinolina como inibidores de cinase
EP1784380A1 (de) 2004-08-24 2007-05-16 Basf Aktiengesellschaft Verfahren zur herstellung quartärer ammoniumverbindungen hoher reinheit
WO2006093801A1 (en) 2005-02-25 2006-09-08 Abbott Laboratories Thiadiazine derivatives useful as anti-infective agents
EP1931632A4 (en) 2005-08-18 2011-05-11 Microbia Inc USEFUL INDOOR CONNECTIONS
BRPI0708507A2 (pt) 2006-03-03 2011-05-31 Torrent Pharmaceuticals Ltd Novos antagonistas de receptores de dupla ação (dara) para os receptores at1 eta
ES2285934B1 (es) 2006-04-10 2008-12-16 Universidad Politecnica De Valencia Procedimiento para preparar compuestos amino utilizando catalizadores de oro.
US20120088746A1 (en) 2006-05-10 2012-04-12 Pfizer Inc. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
GB0611210D0 (en) 2006-06-07 2006-07-19 Cambrex Karlskoga Ab Process
CN101153012B (zh) * 2006-09-29 2010-06-23 北京德众万全药物技术开发有限公司 一种决奈达隆关键中间体的新的制备方法
GB0719180D0 (en) 2007-10-02 2007-11-14 Cambrex Karlskoga Ab New process
CN102171200B (zh) 2008-10-02 2015-09-30 坎布雷卡尔斯库加公司 用于制备二酮类和药物的方法
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
CN102171199A (zh) 2008-10-10 2011-08-31 隆萨有限公司 制备2-烷基-3-芳酰基-5-硝基-苯并呋喃类的方法
JP5788381B2 (ja) 2009-04-08 2015-09-30 カンブレックス カルルスクーガ アクチ ボラケットＣａｍｂｒｅｘ Ｋａｒｌｓｋｏｇａ Ａｂ ヒドロキシルアミンおよび薬剤を調製するための新規のプロセス
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
UY32656A (es) 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
TW201111354A (en) 2009-05-27 2011-04-01 Sanofi Aventis Process for the production of Dronedarone intermediates
CN101993427B (zh) 2009-08-26 2012-10-10 成都伊诺达博医药科技有限公司 一种制备决奈达隆的方法
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
AU2011213921A1 (en) 2010-02-10 2012-08-09 Mapi Pharma Limited Preparation of benzofurans and use thereof as synthetic intermediates
IT1398317B1 (it) 2010-02-23 2013-02-22 Chimico Internaz Spa Lab Nuovo procedimento per la preparazione del dronedarone.
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958289B1 (fr) 2010-03-30 2012-06-15 Sanofi Aventis Procede de preparation de derives de 3-ceto-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
CN101838252B (zh) * 2010-05-27 2016-05-04 北京德众万全医药科技有限公司 2-正丁基-5-取代氨基苯并呋喃及其制备方法
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
WO2012004658A2 (en) 2010-07-09 2012-01-12 Frichem Private Limited Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
WO2012032545A1 (en) 2010-09-08 2012-03-15 Cadila Healthcare Limited Processes for preparing dronedarone and its intermediates
EP2447256A1 (en) 2010-10-21 2012-05-02 Laboratorios Lesvi, S.L. Process for obtaining dronedarone
FR2973027A1 (fr) 2011-03-24 2012-09-28 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
HUP1100166A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Reductive amination process for preparation of dronedarone using amine intermediary compound
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
WO2013014478A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive amination process for preparation of dronedarone using carboxyl intermediary compound
WO2013014480A1 (en) 2011-07-26 2013-01-31 Sanofi Process for preparation of dronedarone using amide intermediary compound
WO2013014479A1 (en) 2011-07-26 2013-01-31 Sanofi Reductive animation process for preparation of dronedarone using aldehyde intermediary compound
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
US9249119B2 (en) 2012-02-14 2016-02-02 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
US9238636B2 (en) 2012-05-31 2016-01-19 Sanofi Process for preparation of dronedarone by Grignard reaction

Also Published As

Publication number Publication date
MX2013011257A (es) 2014-03-27
CA2831504A1 (en) 2012-10-04
RU2013147998A (ru) 2015-05-10
US9611242B2 (en) 2017-04-04
CN103562195A (zh) 2014-02-05
US20140114081A1 (en) 2014-04-24
AU2012235910A1 (en) 2013-10-24
JP2014509640A (ja) 2014-04-21
EP2691380A1 (en) 2014-02-05
WO2012131409A1 (en) 2012-10-04
HUP1100165A2 (en) 2012-12-28
SG194019A1 (en) 2013-11-29
US9174959B2 (en) 2015-11-03
KR20140015503A (ko) 2014-02-06
IL228471A0 (en) 2013-12-31
US20160009679A1 (en) 2016-01-14

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 3A E 4A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.