BR112013025274A2 - processo de aminação redutora para preparação de dronedarona usando composto intermediário de amina - Google Patents

processo de aminação redutora para preparação de dronedarona usando composto intermediário de amina

Info

Publication number
BR112013025274A2
BR112013025274A2 BR112013025274A BR112013025274A BR112013025274A2 BR 112013025274 A2 BR112013025274 A2 BR 112013025274A2 BR 112013025274 A BR112013025274 A BR 112013025274A BR 112013025274 A BR112013025274 A BR 112013025274A BR 112013025274 A2 BR112013025274 A2 BR 112013025274A2
Authority
BR
Brazil
Prior art keywords
preparation
dronedarone
amine intermediate
amination process
reducing amination
Prior art date
Application number
BR112013025274A
Other languages
English (en)
Inventor
Antal Friesz
Csaba Huszár
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BR112013025274A2 publication Critical patent/BR112013025274A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

resumo patente de invenção: "processo de aminação redutora para preparação de dronedarona usando composto intermediário de amina". a presente invenção refere-se a um novo processo de preparação de dronedarona de fórmula (i) e seus sais farmaceuticamente aceitáveis, caracterizado pelo fato de que um composto de fórmula (ii) é reagido na presença de um agente redutor com butiraldeído e/ou ácido butanóico, e separação do produto obtido e, se desejado, convertê-lo em um sal farmaceuticamente aceitável do mesmo. a invenção refere-se também a alguns novos compostos intermediários e sua preparação.
BR112013025274A 2011-03-29 2012-03-27 processo de aminação redutora para preparação de dronedarona usando composto intermediário de amina BR112013025274A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1100166A HUP1100166A2 (en) 2011-03-29 2011-03-29 Reductive amination process for preparation of dronedarone using amine intermediary compound
PCT/HU2012/000021 WO2012131410A1 (en) 2011-03-29 2012-03-27 Reductive amination process for preparation of dronedarone using amine intermediary compound

Publications (1)

Publication Number Publication Date
BR112013025274A2 true BR112013025274A2 (pt) 2016-07-19

Family

ID=89990231

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013025274A BR112013025274A2 (pt) 2011-03-29 2012-03-27 processo de aminação redutora para preparação de dronedarona usando composto intermediário de amina

Country Status (13)

Country Link
US (1) US9024046B2 (pt)
EP (1) EP2691381A1 (pt)
JP (1) JP2014514292A (pt)
CN (1) CN103562196A (pt)
AU (1) AU2012235911A1 (pt)
BR (1) BR112013025274A2 (pt)
CA (1) CA2831689A1 (pt)
HU (1) HUP1100166A2 (pt)
IL (1) IL228472A0 (pt)
MX (1) MX2013011259A (pt)
RU (1) RU2013148026A (pt)
SG (1) SG194021A1 (pt)
WO (1) WO2012131410A1 (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900759A2 (en) 2009-12-08 2011-11-28 Sanofi Aventis Novel process for producing dronedarone
HUP1000010A2 (en) 2010-01-08 2011-11-28 Sanofi Sa Process for producing dronedarone
FR2957079B1 (fr) 2010-03-02 2012-07-27 Sanofi Aventis Procede de synthese de derives de cetobenzofurane
FR2958290B1 (fr) 2010-03-30 2012-10-19 Sanofi Aventis Procede de preparation de derives de sulfonamido-benzofurane
FR2958291B1 (fr) 2010-04-01 2013-07-05 Sanofi Aventis Procede de preparation de derives d'amino-benzofurane
HUP1000330A2 (en) 2010-06-18 2011-12-28 Sanofi Sa Process for the preparation of dronedarone and the novel intermediates
FR2962731B1 (fr) 2010-07-19 2012-08-17 Sanofi Aventis Procede de preparation de derives d'amino-benzoyl-benzofurane
FR2963006B1 (fr) 2010-07-21 2013-03-15 Sanofi Aventis Procede de preparation de derives de nitro-benzofurane
HUP1000386A2 (en) 2010-07-22 2012-05-29 Sanofi Sa Novel process for producing dronedarone
HUP1100167A2 (en) 2011-03-29 2012-11-28 Sanofi Sa Process for preparation of dronedarone by mesylation
HUP1100165A2 (en) 2011-03-29 2012-12-28 Sanofi Sa Process for preparation of dronedarone by n-butylation
FR2983198B1 (fr) 2011-11-29 2013-11-15 Sanofi Sa Procede de preparation de derives de 5-amino-benzoyl-benzofurane
EP2617718A1 (en) 2012-01-20 2013-07-24 Sanofi Process for preparation of dronedarone by the use of dibutylaminopropanol reagent
US9221778B2 (en) 2012-02-13 2015-12-29 Sanofi Process for preparation of dronedarone by removal of hydroxyl group
WO2013121234A1 (en) 2012-02-14 2013-08-22 Sanofi Process for the preparation of dronedarone by oxidation of a sulphenyl group
US9382223B2 (en) 2012-02-22 2016-07-05 Sanofi Process for preparation of dronedarone by oxidation of a hydroxyl group
WO2013178337A1 (en) 2012-05-31 2013-12-05 Sanofi Process for preparation of dronedarone by grignard reaction
CN103716116B (zh) * 2012-09-28 2019-04-16 中兴通讯股份有限公司 信道状态信息反馈信令的配置方法、基站和终端
US10390254B2 (en) * 2013-10-10 2019-08-20 Lg Electronics Inc. Interference cancellation method and apparatus between terminals in wireless access system supporting full-duplex radio scheme
KR102598775B1 (ko) * 2016-10-27 2023-11-03 에스칼리에 바이오사이언시스, 비브이 Ｒｏｒ­감마 조절제

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06104663B2 (ja) 1986-07-02 1994-12-21 旭化成工業株式会社 芳香族環状酸無水物の製造法
FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
FR2817864B1 (fr) 2000-12-11 2003-02-21 Sanofi Synthelabo Derive de methanesulfonamido-benzofurane, son procede de preparation et son utilisation comme intermediaire de synthese
FR2817865B1 (fr) 2000-12-11 2005-02-18 Sanofi Synthelabo Derive aminoalkoxybenzoyle sous forme de sel, son procede de preparation et son utilisation comme intermediaire de synthese
IL146389A0 (en) 2001-11-08 2002-07-25 Isp Finetech Ltd Process for the preparation of dronedarone
CN101153012B (zh) * 2006-09-29 2010-06-23 北京德众万全药物技术开发有限公司 一种决奈达隆关键中间体的新的制备方法
US20120122971A1 (en) 2009-04-08 2012-05-17 Cambrex Karlskoga Ab New process for preparing hydroxylamines and medicaments
CN101838252B (zh) * 2010-05-27 2016-05-04 北京德众万全医药科技有限公司 2-正丁基-5-取代氨基苯并呋喃及其制备方法

Also Published As

Publication number Publication date
CN103562196A (zh) 2014-02-05
EP2691381A1 (en) 2014-02-05
US20140018554A1 (en) 2014-01-16
HUP1100166A2 (en) 2012-12-28
AU2012235911A1 (en) 2013-10-24
MX2013011259A (es) 2014-03-27
RU2013148026A (ru) 2015-05-10
JP2014514292A (ja) 2014-06-19
US9024046B2 (en) 2015-05-05
CA2831689A1 (en) 2012-10-04
SG194021A1 (en) 2013-11-29
WO2012131410A1 (en) 2012-10-04
IL228472A0 (en) 2013-12-31

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 3A E 4A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2386 DE 27-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.