BR1100154B1 - Antifungicos de tetraidrofurano - Google Patents

Antifungicos de tetraidrofurano

Info

Publication number
BR1100154B1
BR1100154B1 BR1100154A BR1100154A BR1100154B1 BR 1100154 B1 BR1100154 B1 BR 1100154B1 BR 1100154 A BR1100154 A BR 1100154A BR 1100154 A BR1100154 A BR 1100154A BR 1100154 B1 BR1100154 B1 BR 1100154B1
Authority
BR
Brazil
Prior art keywords
independently
tetrahydrofuran
ester
anti fungals
fungals
Prior art date
Application number
BR1100154A
Other languages
English (en)
Portuguese (pt)
Inventor
Anil K Saksena
Viyyoor M Girijavallabhan
Raymond G Lovey
Russell E Pike
Hayan Wang
Yi-Tsung Liu
Ashit K Ganguly
Frank Bennett
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22622452&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR1100154(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of BR1100154B1 publication Critical patent/BR1100154B1/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Dental Preparations (AREA)
  • Lubricants (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
BR1100154A 1993-12-21 1997-03-06 Antifungicos de tetraidrofurano BR1100154B1 (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17108393A 1993-12-21 1993-12-21

Publications (1)

Publication Number Publication Date
BR1100154B1 true BR1100154B1 (pt) 2013-11-26

Family

ID=22622452

Family Applications (1)

Application Number Title Priority Date Filing Date
BR1100154A BR1100154B1 (pt) 1993-12-21 1997-03-06 Antifungicos de tetraidrofurano

Country Status (28)

Country Link
EP (1) EP0736030B1 (enExample)
JP (1) JP2834889B2 (enExample)
KR (1) KR0179990B1 (enExample)
CN (1) CN1064685C (enExample)
AT (1) ATE204875T1 (enExample)
AU (1) AU681753B2 (enExample)
BR (1) BR1100154B1 (enExample)
CA (1) CA2179396C (enExample)
CO (1) CO4520281A1 (enExample)
CZ (1) CZ294823B6 (enExample)
DE (2) DE69428125T2 (enExample)
DK (1) DK0736030T3 (enExample)
ES (1) ES2159623T3 (enExample)
FI (1) FI118470B (enExample)
FR (1) FR06C0009I2 (enExample)
HU (1) HU225062B1 (enExample)
IL (1) IL112081A (enExample)
LU (1) LU91216I2 (enExample)
MY (1) MY130217A (enExample)
NL (1) NL300219I2 (enExample)
NO (2) NO316173B1 (enExample)
NZ (1) NZ278713A (enExample)
PL (1) PL181193B1 (enExample)
PT (1) PT736030E (enExample)
SK (1) SK283035B6 (enExample)
TW (1) TW377349B (enExample)
WO (1) WO1995017407A1 (enExample)
ZA (1) ZA9410142B (enExample)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT741737E (pt) * 1994-01-24 2000-04-28 Janssen Pharmaceutica Nv Antifungicos do tipo azole soluveis em agua
ES2199291T3 (es) * 1995-06-02 2004-02-16 Schering Corporation Antifungicos de tetrahidrofurano.
US5698557A (en) * 1995-06-19 1997-12-16 Schering Corporation Hydroxy-substituted antifungals
WO1997000255A1 (en) * 1995-06-19 1997-01-03 Schering Corporation Tetrahydrofuran antifungals
PL327142A1 (en) * 1995-12-20 1998-11-23 Schering Corp Method of obtaining hydrazides
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability
ZA974428B (en) 1996-05-24 1997-11-24 Schering Corp Antifungal composition with enhanced bioavailability.
US5846971A (en) * 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
NZ333514A (en) * 1996-06-28 2000-05-26 Schering Corp Oral pharmaceutical composition comprising a triazole antifungal compound
JP2000514057A (ja) * 1996-06-28 2000-10-24 シェーリング コーポレイション 増強されたバイオアベイラビリティを有する抗真菌剤の固溶体
US5972381A (en) * 1996-06-28 1999-10-26 Schering Corporation Solid solution of an antifungal agent with enhanced bioavailability
EP0938484A1 (en) * 1996-11-12 1999-09-01 Sepracor, Inc. 2r,4s,r,r- and 2s,4r,r,r-hydroxyitraconazole
EP0937071A1 (en) 1996-11-12 1999-08-25 Sepracor, Inc. 2r,4s,s,s- and 2s,4r,s,s-hydroxyitraconazole
CN1237172A (zh) * 1996-11-12 1999-12-01 塞普拉科公司 2r,4s,r,s-和2s,4r,r,s-羟基伊曲康唑-和羟基沙波康唑衍生物
CA2269616A1 (en) * 1996-11-12 1998-05-22 Gerald J. Tanoury 2r,4s,s,r- and 2s,4r,s,r-hydroxyitraconazole
US5684197A (en) * 1996-12-12 1997-11-04 Schering Corporation Process for preparation of hydrazides
EE03876B1 (et) 1997-02-11 2002-10-15 Janssen Pharmaceutica N.V. Aminohappe estrit sisaldavad asool-antimükootikumid, nende valmistamine ja kasutamine ning neid sisaldavad farmatseutilised kompositsioonid
US6043245A (en) * 1997-09-25 2000-03-28 Schering Corporation Tetrahydrofuran antifungal phosphate
HUP0004616A3 (en) * 1997-09-25 2002-04-29 Schering Corp Hydroxy ester of tetrahydrofurane derivative as prodrug for the corresponding antifungal agent
DK1021439T3 (da) * 1997-10-07 2004-05-10 Schering Corp Krystallinsk antifungal polymorf form
WO1999018111A1 (en) * 1997-10-07 1999-04-15 Schering Corporation Crystalline antifungal glycine ester polymorph
US6713481B1 (en) * 1997-10-17 2004-03-30 David R. Andrews Crystalline antifungal polymorph
US5883097A (en) * 1998-04-16 1999-03-16 Schering Corporation Soluble azole antifungal salt
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
US6147077A (en) * 1999-04-29 2000-11-14 Sepracor Inc. 2R,4S-hydroxyitraconazole isomers
CZ20013866A3 (cs) * 1999-05-04 2002-06-12 Janssen Pharmaceutica N. V. Antifungální ethery
US6362172B2 (en) 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
US6448401B1 (en) 2000-11-20 2002-09-10 Bristol-Myers Squibb Company Process for water soluble azole compounds
KR100607742B1 (ko) 2001-04-03 2006-08-01 쉐링 코포레이션 안정한 액상 현탁제, 및 이를 함유하는, 생체 이용율이 증진된 항진균성 조성물
US7446107B2 (en) 2002-02-15 2008-11-04 Transform Pharmaceuticals, Inc. Crystalline forms of conazoles and methods of making and using the same
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
WO2003074474A2 (en) 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
US7790905B2 (en) 2002-02-15 2010-09-07 Mcneil-Ppc, Inc. Pharmaceutical propylene glycol solvate compositions
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
EP1511490A4 (en) 2002-05-31 2009-03-11 Transform Pharmaceuticals Inc NOVEL CONAZOLE CRYSTALLINE FORMS AND RELATED METHODS, PHARMACEUTICAL COMPOSITIONS AND METHODS
EP1515703A1 (en) 2002-06-21 2005-03-23 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US8183290B2 (en) 2002-12-30 2012-05-22 Mcneil-Ppc, Inc. Pharmaceutically acceptable propylene glycol solvate of naproxen
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
US8084445B2 (en) * 2004-08-13 2011-12-27 Schering-Plough Animal Health Corporation Pharmaceutical formulation
JO2691B1 (en) * 2005-05-03 2013-03-03 ايساي آر آند دي مانجمنت كو.، ليمتد Monolysine salts for azole compounds
EP2130540A1 (en) 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) * 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2011003992A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
WO2011158248A2 (en) * 2010-05-12 2011-12-22 Glenmark Generics Limited Process for preparation of posaconazole and crystalline polymorphic form v of posaconazole
CA2798002C (en) * 2010-05-19 2019-12-03 Sandoz Ag Process for the preparation of chiral triazolones
CA2798010C (en) 2010-05-19 2018-09-25 Sandoz Ag Purification of posaconazole and of posaconazole intermediates
WO2011144656A1 (en) * 2010-05-19 2011-11-24 Sandoz Ag Preparation of posaconazole intermediates
RU2588570C2 (ru) * 2010-05-19 2016-07-10 Сандоз Аг Способ получения хиральных гидразидов
RS62583B1 (sr) 2010-06-29 2021-12-31 Merck Sharp & Dohme Formulacije intravenskog rastvora sa posakonazolom, stabilisane supstituisanim beta-ciklodekstrinom
CA2838051C (en) * 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound
EP2789610A1 (en) 2013-04-10 2014-10-15 Sandoz Ag Purification of Posaconazole Intermediates
EP3024828B1 (en) * 2013-07-25 2017-05-17 Sandoz AG Improved process for the preparation of crystalline form iv of posaconazole
ITMI20132114A1 (it) 2013-12-18 2015-06-19 Djada Pharmaceutical Sa Una forma cristallina di posaconazolo
CN105287403A (zh) * 2014-08-02 2016-02-03 陕西合成药业股份有限公司 一种泊沙康唑前体药物的冻干组合物及其制备方法和用途
CN104370894A (zh) * 2014-10-21 2015-02-25 江苏恒盛药业有限公司 无定型泊沙康唑的制备工艺
PT3227277T (pt) 2014-12-05 2020-04-14 Pulmocide Ltd Composto antimicótico
JP6811727B2 (ja) * 2015-05-21 2021-01-20 プルモシデ リミテド 抗真菌性の4−(4−(4−(((3r,5r)−5−((1h−1,2,4−トリアゾール−1−イル)メチル)−5−(2,4−ジフルオロフェニル)テトラヒドロフラン−3−イル)メトキシ)−3−メチルフェニル)ピペラジン−1−イル)−n−(2−ヒドロキシシクロヘキシル)ベンズアミド、又はその医薬として許容し得る塩
CN106317032A (zh) * 2015-06-15 2017-01-11 重庆圣华曦药业股份有限公司 一种制备高纯度的泊沙康唑的方法
CN106432338A (zh) * 2015-08-08 2017-02-22 陕西合成药业股份有限公司 泊沙康唑衍生物、合成和在长效制剂中的用途
ES2946734T3 (es) * 2015-09-23 2023-07-25 Biocon Ltd Formas cristalinas del intermedio de posaconazol y procedimiento para la preparación de posaconazol amorfo
CN105606736A (zh) * 2016-01-27 2016-05-25 重庆华邦制药有限公司 分离测定泊沙康唑中间体z1及其有关物质的方法
DK3424911T3 (da) * 2016-03-04 2021-10-11 Zhejiang Ausun Pharmaceutical Co Ltd Posaconazol, sammensætning, intermediat, fremstillingsfremgangsmåde derfor og anvendelser deraf
CN105949278B (zh) * 2016-03-30 2019-12-06 南京曼杰生物科技有限公司 一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (en) 2016-07-08 2017-03-02 Synthon B.V. Pharmaceutical composition comprising amorphous posaconazole
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
TR201620462A2 (tr) 2016-12-31 2018-07-23 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
CN106967054A (zh) * 2017-03-30 2017-07-21 成都绿林科技有限公司 一种泊沙康唑的制备方法
CN106883221A (zh) * 2017-04-17 2017-06-23 兰州大学 一种无定形泊沙康唑及其制备方法
CN108341754A (zh) * 2018-03-12 2018-07-31 扬子江药业集团有限公司 泊沙康唑杂质及其制备方法和用途
CN110938093B (zh) * 2018-09-21 2022-08-19 华创合成制药股份有限公司 一种泊沙康唑磷酸酯单胆碱盐及其制备方法和用途
CN112778369B (zh) * 2019-11-05 2024-01-26 华创合成制药股份有限公司 一种三唑类衍生物及其制备方法和用途
GB201917867D0 (en) 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
CN113666915B (zh) * 2021-08-27 2022-08-16 江苏海洋大学 一种泊沙康唑中间体的制备方法
CN114315811B (zh) * 2021-11-19 2024-04-30 江苏恒盛药业有限公司 一种三氮唑类似物化合物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles
EP0318214B1 (en) * 1987-11-20 1994-12-14 Schering Corporation Tri- and tetra-substituted-oxetanes and -tetrahydrofurans and intermediates thereof
US5039676A (en) 1990-05-11 1991-08-13 Schering Corporation Tri- and tetra-substituted-oxetanes and tetrahydrofurans and intermediates thereof
IL103558A0 (en) * 1991-10-30 1993-03-15 Schering Corp Tri-substituted tetrahydrofuran antifungals

Also Published As

Publication number Publication date
NL300219I1 (nl) 2006-04-03
CO4520281A1 (es) 1997-10-15
AU1512795A (en) 1995-07-10
NO962616L (no) 1996-08-07
CA2179396A1 (en) 1995-06-29
SK82696A3 (en) 1997-03-05
FR06C0009I2 (enExample) 2006-12-29
CN1064685C (zh) 2001-04-18
ATE204875T1 (de) 2001-09-15
DE69428125T2 (de) 2002-05-02
NZ278713A (en) 1997-12-19
NO962616D0 (no) 1996-06-20
DE122006000004I2 (de) 2007-03-29
PT736030E (pt) 2002-01-30
FI962577A0 (fi) 1996-06-20
ES2159623T3 (es) 2001-10-16
LU91216I2 (en) 2006-03-27
JPH09500658A (ja) 1997-01-21
JP2834889B2 (ja) 1998-12-14
HU225062B1 (en) 2006-05-29
DE122006000004I1 (de) 2006-04-27
WO1995017407A1 (en) 1995-06-29
FI118470B (fi) 2007-11-30
IL112081A0 (en) 1995-03-15
CN1142828A (zh) 1997-02-12
NL300219I2 (nl) 2006-05-01
NO316173B1 (no) 2003-12-22
IL112081A (en) 2001-08-26
HUT75879A (en) 1997-05-28
NO2006002I2 (no) 2011-03-07
NO2006002I1 (no) 2006-02-20
FI962577L (fi) 1996-06-20
DK0736030T3 (da) 2001-10-29
AU681753B2 (en) 1997-09-04
SK283035B6 (sk) 2003-02-04
ZA9410142B (en) 1996-05-02
EP0736030A1 (en) 1996-10-09
TW377349B (en) 1999-12-21
PL181193B1 (pl) 2001-06-29
MY130217A (en) 2007-06-29
FR06C0009I1 (enExample) 2006-05-19
HK1008820A1 (en) 1999-05-21
CZ180596A3 (en) 1997-01-15
CZ294823B6 (cs) 2005-03-16
KR0179990B1 (en) 1999-03-20
DE69428125D1 (de) 2001-10-04
CA2179396C (en) 2001-04-17
EP0736030B1 (en) 2001-08-29
PL315169A1 (en) 1996-10-14
HU9601709D0 (en) 1996-08-28

Similar Documents

Publication Publication Date Title
BR1100154B1 (pt) Antifungicos de tetraidrofurano
MX9701229A (es) Antifungicos de tetrahidrofurano.
ATE306261T1 (de) Antithrombosemittel
CA2150287A1 (en) Agent for treating hepato-biliary diseases
IL133623A0 (en) Antithrombotic agents
DE69629474D1 (de) Antifungale tetrahydrofurane
AU8889998A (en) Water soluble analogs and prodrugs of paclitaxel
ES2140531T3 (es) Inhibidor de la interleucina-1.
ES2161870T3 (es) Esteres de benzoilacetato como fotoprotectores quelantes no sensibilizantes.
CA2304624A1 (en) Tetrahydrofuran phosphate- and hydroxy esters, as prodrugs for the corresponding antifungal agent
DE69528984D1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten
AR003437A1 (es) Un compuesto antifungico de tetrahidrofurano, una composicion farmaceutica que los contiene, su uso para preparar un medicamento antifungico y una sal deester aminoacido del mismo
CO4770982A1 (es) Nuevas formulaciones