BR0210665A - Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme - Google Patents
Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à dermeInfo
- Publication number
- BR0210665A BR0210665A BR0210665-5A BR0210665A BR0210665A BR 0210665 A BR0210665 A BR 0210665A BR 0210665 A BR0210665 A BR 0210665A BR 0210665 A BR0210665 A BR 0210665A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrophobic
- dermis
- pharmacokinetic profile
- improved pharmacokinetic
- dopamine agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G23/00—Compounds of titanium
- C01G23/04—Oxides; Hydroxides
- C01G23/047—Titanium dioxide
- C01G23/053—Producing by wet processes, e.g. hydrolysing titanium salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
- C04B35/46—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on titanium oxides or titanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Anesthesiology (AREA)
- Manufacturing & Machinery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Radiology & Medical Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ceramic Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- Diabetes (AREA)
- Inorganic Chemistry (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Psychology (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Geology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"PERFIL FARMACOCINéTICO MELHORADO DE AGONISTAS HIDRóFOBOS DE DOPAMINA ADMINISTRADOS à DERME". A invenção refere-se a um método para administração sistêmica de uma substância hidrófoba a um mamífero. O método envolve distribuir a substância hidrófoba para a derme do mamífero, com o que se obtém absorção sistêmica melhorada comparada com a absorção produzida após distribuição subcutânea da substância por administração de bolo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/897,801 US20030073609A1 (en) | 2001-06-29 | 2001-06-29 | Enhanced pharmacokinetic profile of intradermally delivered substances |
PCT/US2002/020080 WO2003002094A2 (en) | 2001-06-29 | 2002-06-24 | Enhanced pharmacokinetic profile of hydrophobic substances |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0210665A true BR0210665A (pt) | 2004-10-05 |
Family
ID=25408438
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210688-4A BR0210688A (pt) | 2001-06-29 | 2002-06-24 | Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme |
BR0210665-5A BR0210665A (pt) | 2001-06-29 | 2002-06-24 | Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0210688-4A BR0210688A (pt) | 2001-06-29 | 2002-06-24 | Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme |
Country Status (17)
Country | Link |
---|---|
US (4) | US20030073609A1 (pt) |
EP (3) | EP1399205A2 (pt) |
JP (3) | JP2004537540A (pt) |
KR (3) | KR20040022438A (pt) |
CN (3) | CN1610567A (pt) |
AU (1) | AU2002345813B2 (pt) |
BR (2) | BR0210688A (pt) |
CA (3) | CA2450354A1 (pt) |
CO (2) | CO5540369A2 (pt) |
CZ (3) | CZ20033059A3 (pt) |
EA (3) | EA006922B1 (pt) |
IL (3) | IL158651A0 (pt) |
MX (3) | MXPA03011931A (pt) |
NO (3) | NO20035580D0 (pt) |
PL (3) | PL365667A1 (pt) |
WO (3) | WO2003002175A2 (pt) |
ZA (3) | ZA200308385B (pt) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1048725T3 (da) | 1999-04-27 | 2005-08-22 | Transgene Sa | Fremgangsmåde til fremstilling af pattedyrcellelinjer |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US20020156453A1 (en) * | 1999-10-14 | 2002-10-24 | Pettis Ronald J. | Method and device for reducing therapeutic dosage |
US8465468B1 (en) * | 2000-06-29 | 2013-06-18 | Becton, Dickinson And Company | Intradermal delivery of substances |
US20040175360A1 (en) * | 2000-06-29 | 2004-09-09 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US20050008683A1 (en) * | 2000-06-29 | 2005-01-13 | Becton Dickinson And Company | Method for delivering interferons to the intradermal compartment |
DE10043321B4 (de) * | 2000-08-24 | 2005-07-28 | Neurobiotec Gmbh | Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung |
DE10064453A1 (de) * | 2000-12-16 | 2002-07-04 | Schering Ag | Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen |
MXPA03009371A (es) * | 2001-04-13 | 2004-11-12 | Becton Dickinson Co | Metodos y dispositivos para administrar sustancias en la capa intradermica de la piel para absorcion sistemica. |
US20030073609A1 (en) * | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
EP1416986A4 (en) * | 2001-06-29 | 2005-12-14 | Becton Dickinson Co | INTRADERMIC DISTRIBUTION OF VACCINES AND GENE THERAPEUTIC AGENTS VIA MICROCANNULE |
US20040120964A1 (en) * | 2001-10-29 | 2004-06-24 | Mikszta John A. | Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses |
US20060264886A9 (en) * | 2002-05-06 | 2006-11-23 | Pettis Ronald J | Method for altering insulin pharmacokinetics |
US7722595B2 (en) | 2002-05-06 | 2010-05-25 | Becton, Dickinson And Company | Method and device for controlling drug pharmacokinetics |
CA2497086A1 (en) * | 2002-08-30 | 2004-03-11 | Becton, Dickinson And Company | Method of controlling pharmacokinetics of immunomodulatory compounds |
CN1859943B (zh) * | 2002-10-11 | 2010-09-29 | 贝克顿·迪金森公司 | 用于控制患者体内葡萄糖的浓度的系统 |
BRPI0411428A (pt) * | 2003-06-13 | 2006-07-25 | Becton Dickinson Co | distribuição intradérmica de agentes biologicamente ativos |
US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
CN1838968A (zh) | 2003-08-08 | 2006-09-27 | 艾伯吉尼斯公司 | 针对甲状旁腺激素(pth)之抗体和其用途 |
DK3395396T3 (da) | 2003-08-12 | 2020-09-28 | Becton Dickinson Co | Plaster-lignende infusionsindretning |
CA2536669A1 (en) * | 2003-08-26 | 2005-03-17 | Becton, Dickinson And Company | Methods for intradermal delivery of therapeutics agents |
US20050256499A1 (en) * | 2004-03-03 | 2005-11-17 | Pettis Ronald J | Methods and devices for improving delivery of a substance to skin |
US20050256182A1 (en) * | 2004-05-11 | 2005-11-17 | Sutter Diane E | Formulations of anti-pain agents and methods of using the same |
US7806854B2 (en) * | 2005-05-13 | 2010-10-05 | Trustees Of Boston University | Fully automated control system for type 1 diabetes |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
US8025634B1 (en) * | 2006-09-18 | 2011-09-27 | Baxter International Inc. | Method and system for controlled infusion of therapeutic substances |
US9220837B2 (en) | 2007-03-19 | 2015-12-29 | Insuline Medical Ltd. | Method and device for drug delivery |
CN104069567A (zh) * | 2007-03-19 | 2014-10-01 | 茵苏莱恩医药有限公司 | 药物输送设备 |
EP2136863A2 (en) * | 2007-03-19 | 2009-12-30 | Insuline Medical Ltd. | Device for drug delivery and associated connections thereto |
US8622991B2 (en) | 2007-03-19 | 2014-01-07 | Insuline Medical Ltd. | Method and device for drug delivery |
WO2008115586A1 (en) * | 2007-03-21 | 2008-09-25 | Alza Corporation | Apparatus and method for transdermal delivery of a triptan agonist |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
CA2705131C (en) * | 2007-11-29 | 2016-06-28 | Alltranz Inc. | Methods and compositions for enhancing the viability of microneedle pores |
US8409133B2 (en) | 2007-12-18 | 2013-04-02 | Insuline Medical Ltd. | Drug delivery device with sensor for closed-loop operation |
RU2532893C2 (ru) | 2008-11-07 | 2014-11-10 | Инсьюлин Медикал Лтд. | Устройство и способ доставки лекарственных средств |
US7828996B1 (en) | 2009-03-27 | 2010-11-09 | Abbott Cardiovascular Systems Inc. | Method for the manufacture of stable, nano-sized particles |
US9199034B2 (en) * | 2009-11-09 | 2015-12-01 | Becton, Dickinson And Company | Drug delivery devices, systems, and methods |
KR100967900B1 (ko) * | 2010-04-12 | 2010-07-06 | 대전광역시 | 교차로 정보제공 시스템 |
JP5996544B2 (ja) | 2010-10-15 | 2016-09-21 | クリアサイド・バイオメディカル・インコーポレーテッドClearside Biomedical Incorporated | 眼球アクセス用装置 |
CA2816314C (en) | 2010-10-31 | 2018-03-06 | Trustees Of Boston University | Blood glucose control system |
KR20210133321A (ko) | 2012-11-08 | 2021-11-05 | 클리어사이드 바이오메디컬, 인코포레이드 | 인간 대상체에서 안구 질병을 치료하기 위한 방법 및 장치 |
EP4378444A3 (en) | 2013-05-03 | 2024-07-03 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
CN112515665B (zh) | 2014-01-31 | 2024-03-29 | 波士顿大学董事会 | 血糖水平控制系统 |
CN106794321A (zh) | 2014-06-20 | 2017-05-31 | 科尼尔赛德生物医学公司 | 可变直径插管以及用于控制对药剂递送的插入深度的方法 |
JP6605047B2 (ja) * | 2015-05-28 | 2019-11-13 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 疼痛治療のためのセレコキシブの経口用組成物 |
WO2017027459A1 (en) | 2015-08-07 | 2017-02-16 | Trustees Of Boston University | Glucose control system with automatic adaptation of glucose target |
EP3413851B1 (en) | 2016-02-10 | 2023-09-27 | Clearside Biomedical, Inc. | Packaging |
EP3452165A1 (en) | 2016-05-02 | 2019-03-13 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
IL305537A (en) | 2016-08-12 | 2023-10-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
EP4000075A4 (en) | 2019-07-16 | 2023-10-04 | Beta Bionics, Inc. | BLOOD GLUCOSE CONTROL SYSTEM |
US11957876B2 (en) | 2019-07-16 | 2024-04-16 | Beta Bionics, Inc. | Glucose control system with automated backup therapy protocol generation |
CN114760918A (zh) | 2019-07-16 | 2022-07-15 | 贝塔仿生公司 | 血糖控制系统 |
Family Cites Families (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2619962A (en) * | 1948-02-19 | 1952-12-02 | Res Foundation | Vaccination appliance |
US3964482A (en) * | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
BE795384A (fr) * | 1972-02-14 | 1973-08-13 | Ici Ltd | Pansements |
US4270537A (en) * | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
IE53703B1 (en) * | 1982-12-13 | 1989-01-18 | Elan Corp Plc | Drug delivery device |
US4826689A (en) | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
CA1283827C (en) * | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
US6056716A (en) * | 1987-06-08 | 2000-05-02 | D'antonio Consultants International Inc. | Hypodermic fluid dispenser |
AU614092B2 (en) * | 1987-09-11 | 1991-08-22 | Paul Max Grinwald | Improved method and apparatus for enhanced drug permeation of skin |
IT1227626B (it) | 1988-11-28 | 1991-04-23 | Vectorpharma Int | Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione |
US5273975A (en) * | 1989-06-09 | 1993-12-28 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
US5098389A (en) * | 1990-06-28 | 1992-03-24 | Becton, Dickinson And Company | Hypodermic needle assembly |
TW279133B (pt) * | 1990-12-13 | 1996-06-21 | Elan Med Tech | |
US5527288A (en) * | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
US5156591A (en) * | 1990-12-13 | 1992-10-20 | S. I. Scientific Innovations Ltd. | Skin electrode construction and transdermal drug delivery device utilizing same |
US5279544A (en) * | 1990-12-13 | 1994-01-18 | Sil Medics Ltd. | Transdermal or interdermal drug delivery devices |
SE9102652D0 (sv) * | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
US5298262A (en) | 1992-12-04 | 1994-03-29 | Sterling Winthrop Inc. | Use of ionic cloud point modifiers to prevent particle aggregation during sterilization |
US5346702A (en) | 1992-12-04 | 1994-09-13 | Sterling Winthrop Inc. | Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization |
US5336507A (en) | 1992-12-11 | 1994-08-09 | Sterling Winthrop Inc. | Use of charged phospholipids to reduce nanoparticle aggregation |
US5279552A (en) * | 1993-01-11 | 1994-01-18 | Anton Magnet | Intradermal injection device |
CA2132277C (en) * | 1993-10-22 | 2005-05-10 | Giorgio Cirelli | Injection device |
US5997501A (en) * | 1993-11-18 | 1999-12-07 | Elan Corporation, Plc | Intradermal drug delivery device |
US5591139A (en) * | 1994-06-06 | 1997-01-07 | The Regents Of The University Of California | IC-processed microneedles |
US5582591A (en) * | 1994-09-02 | 1996-12-10 | Delab | Delivery of solid drug compositions |
IE72524B1 (en) * | 1994-11-04 | 1997-04-23 | Elan Med Tech | Analyte-controlled liquid delivery device and analyte monitor |
US5983130A (en) * | 1995-06-07 | 1999-11-09 | Alza Corporation | Electrotransport agent delivery method and apparatus |
US5801057A (en) * | 1996-03-22 | 1998-09-01 | Smart; Wilson H. | Microsampling device and method of construction |
US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
ATE232116T1 (de) * | 1996-06-10 | 2003-02-15 | Elan Corp Plc | Nadel zur subkutanen verabreichung von flüssigkeiten |
US5871158A (en) * | 1997-01-27 | 1999-02-16 | The University Of Utah Research Foundation | Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces |
US5783705A (en) * | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
US5928207A (en) * | 1997-06-30 | 1999-07-27 | The Regents Of The University Of California | Microneedle with isotropically etched tip, and method of fabricating such a device |
IE970782A1 (en) * | 1997-10-22 | 1999-05-05 | Elan Corp | An improved automatic syringe |
US5957895A (en) * | 1998-02-20 | 1999-09-28 | Becton Dickinson And Company | Low-profile automatic injection device with self-emptying reservoir |
CA2331532A1 (en) * | 1998-05-08 | 1999-11-18 | Genetronics, Inc. | Electrically induced vessel vasodilation |
US6503231B1 (en) * | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
JP2002517300A (ja) * | 1998-06-10 | 2002-06-18 | ジョージア テック リサーチ コーポレイション | 微小針デバイスおよび製造方法ならびにそれらの使用 |
US6589987B2 (en) * | 1998-09-08 | 2003-07-08 | Charlotte-Mecklenburg Hospital Authority | Method of treating cancer using tetraethyl thiuram disulfide |
US6455564B1 (en) | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
ATE462468T1 (de) * | 1999-06-04 | 2010-04-15 | Georgia Tech Res Inst | Vorrichtungen zur vergrösserten penetration von mikronadeln in biologischen hautschichten |
DE19938823A1 (de) * | 1999-08-19 | 2001-02-22 | Boehringer Ingelheim Pharma | Medikamentöse Behandlung des Restless Leg Syndroms |
US6319224B1 (en) * | 1999-08-20 | 2001-11-20 | Bioject Medical Technologies Inc. | Intradermal injection system for injecting DNA-based injectables into humans |
US7113821B1 (en) * | 1999-08-25 | 2006-09-26 | Johnson & Johnson Consumer Companies, Inc. | Tissue electroperforation for enhanced drug delivery |
US20020095134A1 (en) * | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
US6569143B2 (en) * | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
US6843781B2 (en) * | 1999-10-14 | 2005-01-18 | Becton, Dickinson And Company | Intradermal needle |
US6776776B2 (en) * | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
AU3440601A (en) * | 1999-11-24 | 2001-06-04 | Elan Pharmaceuticals, Inc. | Method and composition for protecting against radio-contrast medium-induced renal dysfunction |
DE10001785A1 (de) * | 2000-01-18 | 2001-07-19 | Boehringer Ingelheim Pharma | NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms |
US20030073609A1 (en) * | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
EP1416986A4 (en) * | 2001-06-29 | 2005-12-14 | Becton Dickinson Co | INTRADERMIC DISTRIBUTION OF VACCINES AND GENE THERAPEUTIC AGENTS VIA MICROCANNULE |
-
2001
- 2001-06-29 US US09/897,801 patent/US20030073609A1/en not_active Abandoned
- 2001-12-26 EA EA200301307A patent/EA006922B1/ru not_active IP Right Cessation
- 2001-12-26 CA CA002450354A patent/CA2450354A1/en not_active Abandoned
- 2001-12-26 JP JP2003508413A patent/JP2004537540A/ja not_active Withdrawn
- 2001-12-26 IL IL15865101A patent/IL158651A0/xx unknown
- 2001-12-26 PL PL01365667A patent/PL365667A1/xx not_active Application Discontinuation
- 2001-12-26 CN CNA018234062A patent/CN1610567A/zh active Pending
- 2001-12-26 EP EP01991616A patent/EP1399205A2/en not_active Withdrawn
- 2001-12-26 WO PCT/US2001/050862 patent/WO2003002175A2/en not_active Application Discontinuation
- 2001-12-26 KR KR10-2003-7017079A patent/KR20040022438A/ko not_active Application Discontinuation
- 2001-12-26 CZ CZ20033059A patent/CZ20033059A3/cs unknown
- 2001-12-26 MX MXPA03011931A patent/MXPA03011931A/es not_active Application Discontinuation
-
2002
- 2002-06-24 WO PCT/US2002/020080 patent/WO2003002094A2/en active Search and Examination
- 2002-06-24 US US10/480,975 patent/US20040175401A1/en not_active Abandoned
- 2002-06-24 JP JP2003508342A patent/JP2005502613A/ja not_active Withdrawn
- 2002-06-24 KR KR10-2003-7017082A patent/KR20040019024A/ko not_active Application Discontinuation
- 2002-06-24 IL IL15902502A patent/IL159025A0/xx unknown
- 2002-06-24 JP JP2003508333A patent/JP2005503359A/ja not_active Withdrawn
- 2002-06-24 CZ CZ20033364A patent/CZ20033364A3/cs unknown
- 2002-06-24 CA CA002452393A patent/CA2452393A1/en not_active Abandoned
- 2002-06-24 BR BR0210688-4A patent/BR0210688A/pt not_active IP Right Cessation
- 2002-06-24 CZ CZ20033363A patent/CZ20033363A3/cs unknown
- 2002-06-24 EP EP02753349A patent/EP1416915A1/en not_active Ceased
- 2002-06-24 EA EA200301308A patent/EA006578B1/ru not_active IP Right Cessation
- 2002-06-24 EA EA200301309A patent/EA006961B1/ru unknown
- 2002-06-24 PL PL02366370A patent/PL366370A1/xx unknown
- 2002-06-24 PL PL02366635A patent/PL366635A1/xx not_active Application Discontinuation
- 2002-06-24 BR BR0210665-5A patent/BR0210665A/pt not_active IP Right Cessation
- 2002-06-24 WO PCT/US2002/019918 patent/WO2003002103A2/en not_active Application Discontinuation
- 2002-06-24 IL IL15902402A patent/IL159024A0/xx unknown
- 2002-06-24 MX MXPA03011710A patent/MXPA03011710A/es unknown
- 2002-06-24 CA CA002452321A patent/CA2452321A1/en not_active Abandoned
- 2002-06-24 MX MXPA03011794A patent/MXPA03011794A/es unknown
- 2002-06-24 AU AU2002345813A patent/AU2002345813B2/en not_active Expired - Fee Related
- 2002-06-24 US US10/480,973 patent/US20040170654A1/en not_active Abandoned
- 2002-06-24 CN CNA028131746A patent/CN1522139A/zh active Pending
- 2002-06-24 CN CNA028130502A patent/CN1723052A/zh active Pending
- 2002-06-24 EP EP02744560A patent/EP1399206A2/en not_active Withdrawn
- 2002-06-24 KR KR10-2003-7017081A patent/KR20040029327A/ko not_active Application Discontinuation
-
2003
- 2003-05-22 US US10/443,361 patent/US20040028707A1/en not_active Abandoned
- 2003-10-28 ZA ZA200308385A patent/ZA200308385B/en unknown
- 2003-11-24 ZA ZA200309125A patent/ZA200309125B/en unknown
- 2003-11-25 ZA ZA200309151A patent/ZA200309151B/en unknown
- 2003-12-15 NO NO20035580A patent/NO20035580D0/no not_active Application Discontinuation
- 2003-12-19 NO NO20035731A patent/NO20035731L/no not_active Application Discontinuation
- 2003-12-22 NO NO20035782A patent/NO20035782L/no not_active Application Discontinuation
- 2003-12-24 CO CO03112352A patent/CO5540369A2/es not_active Application Discontinuation
- 2003-12-24 CO CO03112342A patent/CO5640074A2/es not_active Application Discontinuation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0210665A (pt) | Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme | |
CO2022002685A2 (es) | Nanopartículas lipídicas mejoradas para el suministro de ácidos nucleicos | |
BR0114628A (pt) | Membro de retenção em microprojeção para aplicador de impacto | |
BR0312268A (pt) | Dispositivos transdermais para liberação de droga que têm microprotrusões revestidas | |
BRPI0414907A (pt) | formulações farmacêuticas com liberação sustentada injetáveis, orais ou tópicas | |
CY1111874T1 (el) | Ενεσιμη χορηγηση αριπιπραζολης | |
BR0311867A (pt) | Forma de ministração adesiva a mucosa em forma de pelìcula e uso de um extrato ou de um óleo de cannabis para a produção de uma forma de ministração adesiva a mucosa em forma de pelìcula | |
BRPI0416042A (pt) | composição e aparelho para suprimento transdérmico | |
AR057946A1 (es) | Formulacion de zonisamida de liberacion sostenidda | |
DE122011100049I1 (de) | Stabile pharmazeutische Losungsformulierungen fur unter Druck stehende Inhaliergerate fur die Verabreichung abgemessener Dosen. | |
PA8588601A1 (es) | Administracion combinada de una indolinona junto a un agente quimioterapeutico para el tratamiento de enfermedades de proliferacion celular | |
BRPI0615860B8 (pt) | composição farmacêutica de liberação prolongada monolítica sólida | |
BR0108930A (pt) | Método de fornecimento de um agente ativo a um tipo celular de interesse, composição farmacêutica, pró-droga ativada por caspase, kit, método de tratamento de mamìferos, uso de um conjugado de caspase e uso de um pró-agente | |
NO20030915L (no) | Fremgangsmåte for bedövelse | |
AR049985A1 (es) | Tratamiento de combinacion para enfermedades malignas no hematologicas | |
BR0207726A (pt) | Sais farmacêuticos | |
ECSP056076A (es) | Sistema de suministro para droga y terapia celular | |
CR7362A (es) | Formulaciones farmaceuticas de derivado de platino | |
ITMI20022323A1 (it) | Composizioni farmaceutiche atte al trattamento di malattie oftalmiche. | |
BR0107958A (pt) | Composição farmacêutica contendo pemetrexado juntamente com l-cisteìna monotrioglicerol ou ácido tioglicólico | |
BR0107899A (pt) | Processo para produzir uma preparação de ingrediente ativo compreendendo ibuprofeno, preparação de ingrediente ativo, uso da mesma, preparação farmacêutica, uso da mesma, processo para produzir formas de dosagem sólidas, e, forma de dosagem sólida | |
ECSP034740A (es) | Conjugados de pregabalina-lactosa | |
BR0311642A (pt) | Formulação de divalproex de sódio de liberação aumentada | |
BR0107160A (pt) | Uso de um éter cìclico para o preparo de medicamentos que afetam a tolerância à glicose | |
BR0013563A (pt) | Preparação farmacêutica sólida, utilização de uma preparação farmacêutica e processo para a produção de uma preparação farmacêutica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010. |