BR0210688A - Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme - Google Patents

Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme

Info

Publication number
BR0210688A
BR0210688A BR0210688-4A BR0210688A BR0210688A BR 0210688 A BR0210688 A BR 0210688A BR 0210688 A BR0210688 A BR 0210688A BR 0210688 A BR0210688 A BR 0210688A
Authority
BR
Brazil
Prior art keywords
hydrophobic
dermis
pharmacokinetic profile
improved pharmacokinetic
dopamine agonists
Prior art date
Application number
BR0210688-4A
Other languages
English (en)
Inventor
Thomas C Pinkerton
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BR0210688A publication Critical patent/BR0210688A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G23/00—Compounds of titanium
    • C01G23/04—Oxides; Hydroxides
    • C01G23/047—Titanium dioxide
    • C01G23/053—Producing by wet processes, e.g. hydrolysing titanium salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/46—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on titanium oxides or titanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ceramic Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Psychology (AREA)
  • Structural Engineering (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Environmental & Geological Engineering (AREA)
  • Materials Engineering (AREA)
  • Geology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PERFIL FARMACOCINéTICO MELHORADO DE AGONISTAS HIDRóFOBOS DE DOPAMINA ADMINISTRADOS à DERME". A presente invenção refere-se a um método para administração sistêmica de um agonista de dopamina hidrófobo a um mamífero. O método envolve distribuir o agonista de dopamina hidrófobo para a derme do mamífero, com o que se obtém absorção sistêmica melhorada comparada com a absorção produzida após distribuição subcutânea da substância por administração de bolo.
BR0210688-4A 2001-06-29 2002-06-24 Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme BR0210688A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/897,801 US20030073609A1 (en) 2001-06-29 2001-06-29 Enhanced pharmacokinetic profile of intradermally delivered substances
PCT/US2002/019918 WO2003002103A2 (en) 2001-06-29 2002-06-24 Hydrophobic dopamine agonists administered to the dermis

Publications (1)

Publication Number Publication Date
BR0210688A true BR0210688A (pt) 2004-09-21

Family

ID=25408438

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0210665-5A BR0210665A (pt) 2001-06-29 2002-06-24 Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme
BR0210688-4A BR0210688A (pt) 2001-06-29 2002-06-24 Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0210665-5A BR0210665A (pt) 2001-06-29 2002-06-24 Perfil farmacocinético melhorado de agonistas hidrófobos de dopamina administrados à derme

Country Status (17)

Country Link
US (4) US20030073609A1 (pt)
EP (3) EP1399205A2 (pt)
JP (3) JP2004537540A (pt)
KR (3) KR20040022438A (pt)
CN (3) CN1610567A (pt)
AU (1) AU2002345813B2 (pt)
BR (2) BR0210665A (pt)
CA (3) CA2450354A1 (pt)
CO (2) CO5540369A2 (pt)
CZ (3) CZ20033059A3 (pt)
EA (3) EA006922B1 (pt)
IL (3) IL158651A0 (pt)
MX (3) MXPA03011931A (pt)
NO (3) NO20035580D0 (pt)
PL (3) PL365667A1 (pt)
WO (3) WO2003002175A2 (pt)
ZA (3) ZA200308385B (pt)

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Also Published As

Publication number Publication date
US20040028707A1 (en) 2004-02-12
IL159025A0 (en) 2004-05-12
EP1416915A1 (en) 2004-05-12
ZA200308385B (en) 2004-10-28
KR20040022438A (ko) 2004-03-12
EA200301309A1 (ru) 2004-12-30
WO2003002175A3 (en) 2003-03-20
CA2450354A1 (en) 2003-01-09
CN1723052A (zh) 2006-01-18
WO2003002103A2 (en) 2003-01-09
NO20035580D0 (no) 2003-12-15
WO2003002175A8 (en) 2003-07-10
PL365667A1 (en) 2005-01-10
JP2005502613A (ja) 2005-01-27
NO20035782L (no) 2004-02-24
BR0210665A (pt) 2004-10-05
NO20035731L (no) 2004-02-27
EA006578B1 (ru) 2006-02-24
EA200301308A1 (ru) 2004-08-26
WO2003002103A3 (en) 2003-04-10
MXPA03011710A (es) 2004-12-06
MXPA03011931A (es) 2005-03-07
CZ20033059A3 (cs) 2004-04-14
WO2003002175A2 (en) 2003-01-09
CN1522139A (zh) 2004-08-18
ZA200309125B (en) 2004-11-24
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US20040170654A1 (en) 2004-09-02
CO5540369A2 (es) 2005-07-29
KR20040029327A (ko) 2004-04-06
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PL366370A1 (en) 2005-01-24
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NO20035731D0 (no) 2003-12-19
US20040175401A1 (en) 2004-09-09
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US20030073609A1 (en) 2003-04-17
CA2452321A1 (en) 2003-01-09
WO2003002094A2 (en) 2003-01-09
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WO2003002094A8 (en) 2005-10-20

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