BRPI0412496A - fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármaco - Google Patents
fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármacoInfo
- Publication number
- BRPI0412496A BRPI0412496A BRPI0412496-0A BRPI0412496A BRPI0412496A BR PI0412496 A BRPI0412496 A BR PI0412496A BR PI0412496 A BRPI0412496 A BR PI0412496A BR PI0412496 A BRPI0412496 A BR PI0412496A
- Authority
- BR
- Brazil
- Prior art keywords
- active drug
- delivery
- prodrug
- periocular
- eye
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 7
- 229940079593 drug Drugs 0.000 title abstract 6
- 229940002612 prodrug Drugs 0.000 title abstract 6
- 239000000651 prodrug Substances 0.000 title abstract 6
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"FORNECIMENTO DE UM FáRMACO ATIVO PARA A PARTE POSTERIOR DO OLHO ATRAVéS DO FORNECIMENTO SUBCONJUNTIVAL OU PERIOCULAR DE UM PRó-FáRMACO". A presente invenção refere-se a um método de fornecimento sustentado de um fármaco ativo para uma parte posterior de um olho de um mamífero para tratar ou evitar uma doença ou condição afetando o referido mamífero, no qual a referida doença ou condição pode ser tratada ou evitada por ação do respectivo fármaco ativo sobre a referida parte posterior do olho, compreendendo a administração de uma quantidade eficaz de um éster ou pró-fármaco do fármaco ativo subconjuntivamente ou periocularmente. De preferência, o fármaco ativo é mais do que cerca de 10 vezes mais ativo do que o pró-fármaco. Outros aspectos desta invenção lidam com o tratamento de certas doenças pelo fornecimento periocular ou subconjuntival de um éster pró-fármaco, e certos produtos farmacêuticos contendo éster pró-fármaco para administração periocular ou subconjuntival.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/617,468 US20050009910A1 (en) | 2003-07-10 | 2003-07-10 | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
PCT/US2004/021938 WO2005011741A2 (en) | 2003-07-10 | 2004-07-07 | Delivery of a drug via subconjuctival or periocular delivery of a prodrug in a polymeric microparticle |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412496A true BRPI0412496A (pt) | 2006-09-19 |
Family
ID=33564972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412496-0A BRPI0412496A (pt) | 2003-07-10 | 2004-07-07 | fornecimento de um fármaco ativo para a parte posterior do olho através do fornecimento subconjuntival ou periocular de um pró-fármaco |
Country Status (16)
Country | Link |
---|---|
US (2) | US20050009910A1 (pt) |
EP (1) | EP1644047A2 (pt) |
JP (1) | JP2007528851A (pt) |
KR (1) | KR20060033008A (pt) |
CN (1) | CN1882362A (pt) |
AU (1) | AU2004260645B2 (pt) |
BR (1) | BRPI0412496A (pt) |
CA (1) | CA2531753A1 (pt) |
IL (1) | IL172583A (pt) |
MX (1) | MXPA06000408A (pt) |
NO (1) | NO20056174L (pt) |
NZ (2) | NZ544027A (pt) |
PL (1) | PL380169A1 (pt) |
RU (1) | RU2353393C2 (pt) |
WO (1) | WO2005011741A2 (pt) |
ZA (1) | ZA200510129B (pt) |
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CA2867203C (en) | 2012-03-16 | 2016-09-20 | The Johns Hopkins University | Non-linear multiblock copolymer-drug conjugates for the delivery of active agents |
US9827191B2 (en) | 2012-05-03 | 2017-11-28 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
KR102140989B1 (ko) | 2012-05-03 | 2020-08-04 | 칼라 파마슈티컬스, 인크. | 개선된 점막 수송을 나타내는 제약 나노입자 |
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US11596599B2 (en) | 2012-05-03 | 2023-03-07 | The Johns Hopkins University | Compositions and methods for ophthalmic and/or other applications |
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CN111902141A (zh) | 2018-03-26 | 2020-11-06 | C4医药公司 | 用于ikaros降解的羟脑苷脂结合剂 |
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-
2003
- 2003-07-10 US US10/617,468 patent/US20050009910A1/en not_active Abandoned
-
2004
- 2004-07-07 JP JP2006518912A patent/JP2007528851A/ja active Pending
- 2004-07-07 PL PL380169A patent/PL380169A1/pl not_active Application Discontinuation
- 2004-07-07 MX MXPA06000408A patent/MXPA06000408A/es unknown
- 2004-07-07 RU RU2006104983/14A patent/RU2353393C2/ru not_active IP Right Cessation
- 2004-07-07 WO PCT/US2004/021938 patent/WO2005011741A2/en active Application Filing
- 2004-07-07 CA CA002531753A patent/CA2531753A1/en not_active Abandoned
- 2004-07-07 NZ NZ544027A patent/NZ544027A/en not_active IP Right Cessation
- 2004-07-07 AU AU2004260645A patent/AU2004260645B2/en not_active Ceased
- 2004-07-07 EP EP04777796A patent/EP1644047A2/en not_active Withdrawn
- 2004-07-07 NZ NZ582376A patent/NZ582376A/en not_active IP Right Cessation
- 2004-07-07 KR KR1020067000591A patent/KR20060033008A/ko active Search and Examination
- 2004-07-07 CN CNA2004800195540A patent/CN1882362A/zh active Pending
- 2004-07-07 BR BRPI0412496-0A patent/BRPI0412496A/pt not_active IP Right Cessation
-
2005
- 2005-12-13 ZA ZA200510129A patent/ZA200510129B/en unknown
- 2005-12-14 IL IL172583A patent/IL172583A/en not_active IP Right Cessation
- 2005-12-23 NO NO20056174A patent/NO20056174L/no not_active Application Discontinuation
-
2012
- 2012-02-29 US US13/407,906 patent/US20120157499A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1644047A2 (en) | 2006-04-12 |
RU2006104983A (ru) | 2006-06-27 |
CN1882362A (zh) | 2006-12-20 |
IL172583A0 (en) | 2006-04-10 |
PL380169A1 (pl) | 2007-01-08 |
WO2005011741A2 (en) | 2005-02-10 |
NO20056174L (no) | 2006-01-25 |
NZ544027A (en) | 2010-07-30 |
WO2005011741A3 (en) | 2005-04-14 |
RU2353393C2 (ru) | 2009-04-27 |
US20050009910A1 (en) | 2005-01-13 |
JP2007528851A (ja) | 2007-10-18 |
AU2004260645B2 (en) | 2010-03-11 |
US20120157499A1 (en) | 2012-06-21 |
NZ582376A (en) | 2012-02-24 |
CA2531753A1 (en) | 2005-02-10 |
MXPA06000408A (es) | 2006-03-17 |
ZA200510129B (en) | 2007-02-28 |
AU2004260645A1 (en) | 2005-02-10 |
KR20060033008A (ko) | 2006-04-18 |
IL172583A (en) | 2011-02-28 |
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