BR0302584A - Combinação de brimonidina e timolol para uso oftálmico tópico - Google Patents
Combinação de brimonidina e timolol para uso oftálmico tópicoInfo
- Publication number
- BR0302584A BR0302584A BR0302584-5A BR0302584A BR0302584A BR 0302584 A BR0302584 A BR 0302584A BR 0302584 A BR0302584 A BR 0302584A BR 0302584 A BR0302584 A BR 0302584A
- Authority
- BR
- Brazil
- Prior art keywords
- brimonidine
- topical ophthalmic
- timolol
- ophthalmic use
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/001—Arrangement of electric circuit elements in or on lighting devices the elements being electrical wires or cables
- F21V23/002—Arrangements of cables or conductors inside a lighting device, e.g. means for guiding along parts of the housing or in a pivoting arm
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/003—Arrangement of electric circuit elements in or on lighting devices the elements being electronics drivers or controllers for operating the light source, e.g. for a LED array
- F21V23/004—Arrangement of electric circuit elements in or on lighting devices the elements being electronics drivers or controllers for operating the light source, e.g. for a LED array arranged on a substrate, e.g. a printed circuit board
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V23/00—Arrangement of electric circuit elements in or on lighting devices
- F21V23/02—Arrangement of electric circuit elements in or on lighting devices the elements being transformers, impedances or power supply units, e.g. a transformer with a rectifier
- F21V23/023—Power supplies in a casing
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/0001—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems
- G02B6/0011—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form
- G02B6/0066—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings specially adapted for lighting devices or systems the light guides being planar or of plate-like form characterised by the light source being coupled to the light guide
- G02B6/0073—Light emitting diode [LED]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Abstract
"COMBINAçãO DE BRIMONIDINA E TIMOLOL PARA USO OFTáLMICO TóPICO". A presente invenção refere-se a composições farmacêuticas compreendendo brimonidina e timolol para distribuição oftálmica tópica e um método de tratamento compreendendo administrar a referida composição quando indicada para glaucoma e patologias associadas tal como pressão intra-ocular alta nos olhos de seres humanos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/126,790 US7030149B2 (en) | 2002-04-19 | 2002-04-19 | Combination of brimonidine timolol for topical ophthalmic use |
PCT/US2003/010885 WO2003088973A1 (en) | 2002-04-19 | 2003-04-09 | Combination of brimonidine and timolol for topical ophthalmic use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0302584A true BR0302584A (pt) | 2004-03-09 |
Family
ID=29215107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0302584-5A BR0302584A (pt) | 2002-04-19 | 2003-04-09 | Combinação de brimonidina e timolol para uso oftálmico tópico |
Country Status (18)
Country | Link |
---|---|
US (16) | US7030149B2 (pt) |
EP (2) | EP1496912B9 (pt) |
JP (1) | JP2005523316A (pt) |
KR (1) | KR100723189B1 (pt) |
CN (2) | CN100558364C (pt) |
BR (1) | BR0302584A (pt) |
CA (1) | CA2440764C (pt) |
CY (1) | CY1114048T1 (pt) |
DK (1) | DK1496912T3 (pt) |
ES (1) | ES2399045T3 (pt) |
HK (1) | HK1067549A1 (pt) |
MX (2) | MX368377B (pt) |
NO (1) | NO326579B1 (pt) |
NZ (1) | NZ528945A (pt) |
PT (1) | PT1496912E (pt) |
SI (1) | SI1496912T1 (pt) |
TW (1) | TWI351959B (pt) |
WO (1) | WO2003088973A1 (pt) |
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US20050026924A1 (en) * | 2000-07-14 | 2005-02-03 | Allergan, Inc. | Compositions containing alpha-2-adrenergic agonist components |
US7030149B2 (en) * | 2002-04-19 | 2006-04-18 | Allergan, Inc. | Combination of brimonidine timolol for topical ophthalmic use |
US20050244458A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular neuropathies |
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US7534795B2 (en) | 2005-10-25 | 2009-05-19 | Allergan, Inc. | Compounds and their use related to compositions for treating disease |
US20070238732A1 (en) * | 2006-04-10 | 2007-10-11 | Allergan, Inc. | Brimonidine and timolol compositions |
US20080051406A1 (en) * | 2006-08-25 | 2008-02-28 | Richard Graham | Brimonidine and timolol compositions |
WO2008024846A2 (en) * | 2006-08-25 | 2008-02-28 | Allergan, Inc. | Brimonidine and timolol compositions |
MX2007010025A (es) * | 2007-08-17 | 2009-02-25 | Arturo Jimenez Bayardo | Composición farmacéutica para tratamiento de hipertensión ocular. |
MX2007011165A (es) * | 2007-09-12 | 2009-03-11 | Arturo Jimenez Bayardo | Composición farmacéutica estable de timolol, dorzolamida y brimonidina. |
US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
PT2320911E (pt) | 2008-08-01 | 2014-11-11 | Eye Therapies Llc | Composições de vasoconstrição e métodos de utilização |
JP5218167B2 (ja) | 2009-03-11 | 2013-06-26 | 日立電線株式会社 | コネクタ |
US20100298335A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and Methods for Ameliorating or Reducing Presbyopia |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
US8317973B2 (en) * | 2009-11-11 | 2012-11-27 | Kemira Chemical, Inc. | Polyester surfactants for deinking |
US20110152271A1 (en) * | 2009-12-17 | 2011-06-23 | Gerald Horn | Compositions and methods for ophthalmic delivery of nasal decongestants |
US9522153B2 (en) | 2009-12-22 | 2016-12-20 | Allergan, Inc. | Compositions and methods for lowering intraocular pressure |
PE20160904A1 (es) * | 2009-12-22 | 2016-09-16 | Allergan Inc | Combinacion triple para reduccion de presion intraocular |
ES2709180T3 (es) | 2010-07-29 | 2019-04-15 | Allergan Inc | Soluciones de brimonidina y timolol sin conservantes |
US8445526B2 (en) | 2011-02-03 | 2013-05-21 | Glaucoma & Nasal Therapies Llc | Compositions and methods for treatment of glaucoma |
US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
EP2790673B1 (en) * | 2011-12-16 | 2017-07-05 | Allergan, Inc. | Ophthalmic compositions comprising polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers (soluplus) |
US8999938B2 (en) | 2013-06-21 | 2015-04-07 | Gnt Llc | Ophthalmic lipophilic drug delivery vehicle formulations |
CN107427460A (zh) * | 2015-03-19 | 2017-12-01 | 阿勒根公司 | 溴莫尼定和噻吗洛尔的固定剂量组合 |
KR102275012B1 (ko) | 2016-08-12 | 2021-07-07 | 실크 테크놀로지스 리미티드 | 염증 치료용 실크 유래 단백질 |
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US20200108064A1 (en) * | 2017-06-08 | 2020-04-09 | Eye Therapies, Llc | Low-dose brimonidine combinations and uses thereof |
KR20200018580A (ko) * | 2017-06-08 | 2020-02-19 | 아이 쎄러피스 엘엘씨 | 저용량 브리모니딘 조합 및 그의 용도 |
KR20200059254A (ko) * | 2017-09-25 | 2020-05-28 | 유니버시티 오브 플로리다 리서치 파운데이션, 아이엔씨. | 친수성 약물을 함유하는 점안액으로부터의 방부제 제거 |
US20190134051A1 (en) * | 2017-11-06 | 2019-05-09 | Rheostasis, Llc | Composition for treating ocular disorders such as macular degeneration, retinopathy and glaucoma |
KR20200136403A (ko) * | 2018-03-28 | 2020-12-07 | 노바리크 게엠베하 | 티몰롤을 포함하는 약제학적 조성물 |
US11871308B2 (en) * | 2019-07-29 | 2024-01-09 | TapText llc | System and method for link-initiated dynamic-mode communications |
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-
2002
- 2002-04-19 US US10/126,790 patent/US7030149B2/en not_active Expired - Lifetime
-
2003
- 2003-02-03 US US10/357,622 patent/US7323463B2/en not_active Expired - Lifetime
- 2003-04-09 SI SI200332241T patent/SI1496912T1/sl unknown
- 2003-04-09 ES ES03726234T patent/ES2399045T3/es not_active Expired - Lifetime
- 2003-04-09 CA CA002440764A patent/CA2440764C/en not_active Expired - Lifetime
- 2003-04-09 CN CNB038004682A patent/CN100558364C/zh not_active Expired - Lifetime
- 2003-04-09 PT PT37262342T patent/PT1496912E/pt unknown
- 2003-04-09 EP EP03726234.2A patent/EP1496912B9/en not_active Revoked
- 2003-04-09 DK DK03726234.2T patent/DK1496912T3/da active
- 2003-04-09 WO PCT/US2003/010885 patent/WO2003088973A1/en active Application Filing
- 2003-04-09 MX MX2014003586A patent/MX368377B/es unknown
- 2003-04-09 JP JP2003585725A patent/JP2005523316A/ja active Pending
- 2003-04-09 EP EP20100171064 patent/EP2241319A1/en not_active Ceased
- 2003-04-09 NZ NZ528945A patent/NZ528945A/en not_active IP Right Cessation
- 2003-04-09 BR BR0302584-5A patent/BR0302584A/pt not_active Application Discontinuation
- 2003-04-09 CN CN200910174400A patent/CN101664414A/zh active Pending
- 2003-04-09 KR KR1020037015881A patent/KR100723189B1/ko active IP Right Review Request
- 2003-04-09 MX MXPA03008401A patent/MXPA03008401A/es active IP Right Grant
- 2003-04-18 TW TW092109050A patent/TWI351959B/zh not_active IP Right Cessation
- 2003-10-14 US US10/685,941 patent/US7320976B2/en not_active Expired - Lifetime
-
2004
- 2004-10-19 NO NO20044450A patent/NO326579B1/no not_active IP Right Cessation
-
2005
- 2005-01-03 HK HK05100007.6A patent/HK1067549A1/xx not_active IP Right Cessation
-
2007
- 2007-11-28 US US11/946,828 patent/US8133890B2/en not_active Expired - Fee Related
-
2011
- 2011-11-30 US US13/308,507 patent/US8354409B2/en not_active Expired - Lifetime
-
2012
- 2012-12-26 US US13/727,106 patent/US20130116255A1/en not_active Abandoned
-
2013
- 2013-03-01 CY CY20131100193T patent/CY1114048T1/el unknown
- 2013-03-13 US US13/801,252 patent/US20130196995A1/en not_active Abandoned
- 2013-08-01 US US13/957,287 patent/US8748425B2/en not_active Expired - Lifetime
-
2014
- 2014-04-28 US US14/263,740 patent/US20150087647A1/en not_active Abandoned
-
2016
- 2016-06-24 US US15/192,729 patent/US9474751B1/en not_active Expired - Lifetime
-
2017
- 2017-02-22 US US15/439,112 patent/US9770453B2/en not_active Expired - Lifetime
- 2017-08-02 US US15/667,248 patent/US20180042932A1/en not_active Abandoned
- 2017-11-02 US US15/802,229 patent/US9907802B1/en not_active Expired - Lifetime
- 2017-11-02 US US15/802,179 patent/US9907801B1/en not_active Expired - Lifetime
-
2019
- 2019-05-07 US US16/405,813 patent/US20200129520A1/en not_active Abandoned
-
2021
- 2021-02-05 US US17/168,513 patent/US20210405280A1/en not_active Abandoned
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