NO20056174L - Levering av et aktivt legemiddel til den posteriore del av oyet via subkonjunktiv eller periokular levering av et prolegemiddel - Google Patents

Levering av et aktivt legemiddel til den posteriore del av oyet via subkonjunktiv eller periokular levering av et prolegemiddel

Info

Publication number
NO20056174L
NO20056174L NO20056174A NO20056174A NO20056174L NO 20056174 L NO20056174 L NO 20056174L NO 20056174 A NO20056174 A NO 20056174A NO 20056174 A NO20056174 A NO 20056174A NO 20056174 L NO20056174 L NO 20056174L
Authority
NO
Norway
Prior art keywords
delivery
active drug
periocular
prodrug
posterior portion
Prior art date
Application number
NO20056174A
Other languages
English (en)
Inventor
Orest Olejnik
Patrick M Hughes
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of NO20056174L publication Critical patent/NO20056174L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Foreliggende oppfinnelse vedrører en fremgangsmåte for vedvarende levering av et aktivt legemiddel til en bakre del av øyet til et pattedyr for å behandle eller forhindre en sykdom eller tilstand som påvirker det nevnte pattedyr, hvor den nevnte sykdom eller tilstand kan behandles eller forhindres av virkningen av det nevnte aktive legemiddel på den nevnte bakre del av øyet, som omfatter å adminisfrere en effektiv mengde av et ester-prolegemiddel av det aktive legemiddel subkonjunktivalt eller periokulært. Fortrinnsvis er det aktive legemiddel mer enn omtrent 10 ganger så aktivt som prolegemidlet. Andre aspekter av denne oppfinnelsen dreier seg om behandling av visse sykdommer ved periokulær eller subkonjunktival levering av et ester-prolegemiddel, og visse farmasøytiske produkter inneholdende ester- prolegemidler for periokulær eller subkonjunktival adminisfrering.
NO20056174A 2003-07-10 2005-12-23 Levering av et aktivt legemiddel til den posteriore del av oyet via subkonjunktiv eller periokular levering av et prolegemiddel NO20056174L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/617,468 US20050009910A1 (en) 2003-07-10 2003-07-10 Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
PCT/US2004/021938 WO2005011741A2 (en) 2003-07-10 2004-07-07 Delivery of a drug via subconjuctival or periocular delivery of a prodrug in a polymeric microparticle

Publications (1)

Publication Number Publication Date
NO20056174L true NO20056174L (no) 2006-01-25

Family

ID=33564972

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20056174A NO20056174L (no) 2003-07-10 2005-12-23 Levering av et aktivt legemiddel til den posteriore del av oyet via subkonjunktiv eller periokular levering av et prolegemiddel

Country Status (16)

Country Link
US (2) US20050009910A1 (no)
EP (1) EP1644047A2 (no)
JP (1) JP2007528851A (no)
KR (1) KR20060033008A (no)
CN (1) CN1882362A (no)
AU (1) AU2004260645B2 (no)
BR (1) BRPI0412496A (no)
CA (1) CA2531753A1 (no)
IL (1) IL172583A (no)
MX (1) MXPA06000408A (no)
NO (1) NO20056174L (no)
NZ (2) NZ582376A (no)
PL (1) PL380169A1 (no)
RU (1) RU2353393C2 (no)
WO (1) WO2005011741A2 (no)
ZA (1) ZA200510129B (no)

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Also Published As

Publication number Publication date
CA2531753A1 (en) 2005-02-10
ZA200510129B (en) 2007-02-28
MXPA06000408A (es) 2006-03-17
AU2004260645A1 (en) 2005-02-10
CN1882362A (zh) 2006-12-20
KR20060033008A (ko) 2006-04-18
WO2005011741A2 (en) 2005-02-10
NZ544027A (en) 2010-07-30
EP1644047A2 (en) 2006-04-12
AU2004260645B2 (en) 2010-03-11
NZ582376A (en) 2012-02-24
WO2005011741A3 (en) 2005-04-14
IL172583A (en) 2011-02-28
PL380169A1 (pl) 2007-01-08
JP2007528851A (ja) 2007-10-18
BRPI0412496A (pt) 2006-09-19
US20120157499A1 (en) 2012-06-21
IL172583A0 (en) 2006-04-10
RU2353393C2 (ru) 2009-04-27
US20050009910A1 (en) 2005-01-13
RU2006104983A (ru) 2006-06-27

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