EA200301309A1 - Усовершенствованный фармакокинетический профиль гидрофобных веществ - Google Patents

Усовершенствованный фармакокинетический профиль гидрофобных веществ

Info

Publication number
EA200301309A1
EA200301309A1 EA200301309A EA200301309A EA200301309A1 EA 200301309 A1 EA200301309 A1 EA 200301309A1 EA 200301309 A EA200301309 A EA 200301309A EA 200301309 A EA200301309 A EA 200301309A EA 200301309 A1 EA200301309 A1 EA 200301309A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmacokinetic profile
improved pharmacokinetic
hydrophobic substances
hydrophobic substance
administration
Prior art date
Application number
EA200301309A
Other languages
English (en)
Other versions
EA006961B1 (ru
Inventor
Томас К. Пинкертон
Original Assignee
Фармация Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Корпорейшн filed Critical Фармация Корпорейшн
Publication of EA200301309A1 publication Critical patent/EA200301309A1/ru
Publication of EA006961B1 publication Critical patent/EA006961B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G23/00—Compounds of titanium
    • C01G23/04—Oxides; Hydroxides
    • C01G23/047—Titanium dioxide
    • C01G23/053—Producing by wet processes, e.g. hydrolysing titanium salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/46—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on titanium oxides or titanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Nanotechnology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Ceramic Engineering (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Environmental & Geological Engineering (AREA)
  • Materials Engineering (AREA)
  • Structural Engineering (AREA)
  • Geology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Раскрыт способ системного введения гидрофобного вещества млекопитающему. Способ включает доставку упомянутого гидрофобного вещества в дерму млекопитающего, благодаря чему получают улучшенное системное всасывание по сравнению со всасыванием, получаемым при подкожной доставке посредством введения ударной дозы.
EA200301309A 2001-06-29 2002-06-24 Усовершенствованный фармакокинетический профиль гидрофобных веществ EA006961B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/897,801 US20030073609A1 (en) 2001-06-29 2001-06-29 Enhanced pharmacokinetic profile of intradermally delivered substances
PCT/US2002/020080 WO2003002094A2 (en) 2001-06-29 2002-06-24 Enhanced pharmacokinetic profile of hydrophobic substances

Publications (2)

Publication Number Publication Date
EA200301309A1 true EA200301309A1 (ru) 2004-12-30
EA006961B1 EA006961B1 (ru) 2006-06-30

Family

ID=25408438

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200301307A EA006922B1 (ru) 2001-06-29 2001-12-26 Усиленное системное всасывание веществ, введённых интрадермальным путём
EA200301309A EA006961B1 (ru) 2001-06-29 2002-06-24 Усовершенствованный фармакокинетический профиль гидрофобных веществ
EA200301308A EA006578B1 (ru) 2001-06-29 2002-06-24 Гидрофобные агонисты допамина, введенные в дерму

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200301307A EA006922B1 (ru) 2001-06-29 2001-12-26 Усиленное системное всасывание веществ, введённых интрадермальным путём

Family Applications After (1)

Application Number Title Priority Date Filing Date
EA200301308A EA006578B1 (ru) 2001-06-29 2002-06-24 Гидрофобные агонисты допамина, введенные в дерму

Country Status (17)

Country Link
US (4) US20030073609A1 (ru)
EP (3) EP1399205A2 (ru)
JP (3) JP2004537540A (ru)
KR (3) KR20040022438A (ru)
CN (3) CN1610567A (ru)
AU (1) AU2002345813B2 (ru)
BR (2) BR0210665A (ru)
CA (3) CA2450354A1 (ru)
CO (2) CO5540369A2 (ru)
CZ (3) CZ20033059A3 (ru)
EA (3) EA006922B1 (ru)
IL (3) IL158651A0 (ru)
MX (3) MXPA03011931A (ru)
NO (3) NO20035580D0 (ru)
PL (3) PL365667A1 (ru)
WO (3) WO2003002175A2 (ru)
ZA (3) ZA200308385B (ru)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1048725B1 (en) 1999-04-27 2005-07-06 Transgene S.A. Process for production of mammalian cell lines
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
MXPA03009371A (es) * 2001-04-13 2004-11-12 Becton Dickinson Co Metodos y dispositivos para administrar sustancias en la capa intradermica de la piel para absorcion sistemica.
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
BR0210628A (pt) * 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
CN1655834A (zh) 2002-05-06 2005-08-17 贝克顿·迪金森公司 用于控制药代动力学的方法和装置
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
WO2004020014A2 (en) * 2002-08-30 2004-03-11 Becton, Dickinson And Company Method of controlling pharmacokinetics of immunomodulatory compounds
US7060059B2 (en) * 2002-10-11 2006-06-13 Becton, Dickinson And Company System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or multi-needle intradermal (ID) delivery device
EP1635876A4 (en) * 2003-06-13 2009-05-06 Becton Dickinson Co IMPROVED INTRADERMAL ADMINISTRATION OF BIOACTIVE AGENTS
CN1838968A (zh) 2003-08-08 2006-09-27 艾伯吉尼斯公司 针对甲状旁腺激素(pth)之抗体和其用途
US7318925B2 (en) 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
CA2535138C (en) * 2003-08-12 2013-01-08 Becton, Dickinson And Company Patch-like infusion device
MXPA06002159A (es) * 2003-08-26 2006-05-22 Becton Dickinson Co Metodos para la administracion intradermica de agentes terapeuticos.
WO2005091922A2 (en) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
US20050256182A1 (en) * 2004-05-11 2005-11-17 Sutter Diane E Formulations of anti-pain agents and methods of using the same
JP5037496B2 (ja) * 2005-05-13 2012-09-26 トラスティーズ オブ ボストン ユニバーシティ １型糖尿病用の完全自動制御システム
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
US8197435B2 (en) * 2006-05-02 2012-06-12 Emory University Methods and devices for drug delivery to ocular tissue using microneedle
US8025634B1 (en) * 2006-09-18 2011-09-27 Baxter International Inc. Method and system for controlled infusion of therapeutic substances
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
WO2008114220A2 (en) * 2007-03-19 2008-09-25 Insuline Medical Ltd. Device for drug delivery and associated connections thereto
CN104069567A (zh) * 2007-03-19 2014-10-01 茵苏莱恩医药有限公司 药物输送设备
WO2008115586A1 (en) * 2007-03-21 2008-09-25 Alza Corporation Apparatus and method for transdermal delivery of a triptan agonist
US8642062B2 (en) 2007-10-31 2014-02-04 Abbott Cardiovascular Systems Inc. Implantable device having a slow dissolving polymer
US20090143762A1 (en) * 2007-11-29 2009-06-04 Alltranz Inc. Methods and Compositions for Enhancing the Viability Of Microneedle Pores
US8409133B2 (en) 2007-12-18 2013-04-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
CN102245137A (zh) 2008-11-07 2011-11-16 茵苏莱恩医药有限公司 用于药物递送的装置和方法
US7828996B1 (en) 2009-03-27 2010-11-09 Abbott Cardiovascular Systems Inc. Method for the manufacture of stable, nano-sized particles
US9199034B2 (en) 2009-11-09 2015-12-01 Becton, Dickinson And Company Drug delivery devices, systems, and methods
KR100967900B1 (ko) * 2010-04-12 2010-07-06 대전광역시 교차로 정보제공 시스템
EP3520749A1 (en) 2010-10-15 2019-08-07 Clearside Biomedical, Inc. Device for ocular access
ES2755497T3 (es) 2010-10-31 2020-04-22 Univ Boston Sistema de control de glucosa en sangre
MX2015005839A (es) 2012-11-08 2015-12-17 Clearside Biomedical Inc Metodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos.
CN105246529B (zh) 2013-05-03 2019-06-14 科尼尔赛德生物医学公司 用于眼部注射的设备和方法
WO2014197317A1 (en) 2013-06-03 2014-12-11 Clearside Biomedical, Inc. Apparatus and methods for drug delivery using multiple reservoirs
CA2938078C (en) 2014-01-31 2019-06-11 Trustees Of Boston University Offline glucose control based on preceding periods
JP2017524419A (ja) 2014-06-20 2017-08-31 クリアサイド バイオメディカル，インコーポレイテッド 薬剤送達のための挿入深さを制御するための可変径カニューレ及び方法
CN114209707A (zh) * 2015-05-28 2022-03-22 瑞迪博士实验室有限公司 用于治疗疼痛的塞来昔布口服组合物
WO2017027459A1 (en) 2015-08-07 2017-02-16 Trustees Of Boston University Glucose control system with automatic adaptation of glucose target
WO2017139375A1 (en) 2016-02-10 2017-08-17 Clearside Biomedical, Inc. Ocular injection kit, packaging, and methods of use
WO2017192565A1 (en) 2016-05-02 2017-11-09 Clearside Biomedical, Inc. Systems and methods for ocular drug delivery
CN110177527B (zh) 2016-08-12 2022-02-01 科尼尔赛德生物医学公司 用于调节药剂递送用针的插入深度的装置和方法
WO2018204515A1 (en) 2017-05-02 2018-11-08 Georgia Tech Research Corporation Targeted drug delivery methods using a microneedle
DE112020003392T5 (de) 2019-07-16 2022-05-19 Beta Bionics, Inc. Blutzuckerkontrollsystem
CA3146872A1 (en) 2019-07-16 2021-01-21 Beta Bionics, Inc. Blood glucose control system
US11957876B2 (en) 2019-07-16 2024-04-16 Beta Bionics, Inc. Glucose control system with automated backup therapy protocol generation

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2619962A (en) * 1948-02-19 1952-12-02 Res Foundation Vaccination appliance
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
US4270537A (en) * 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
IE53703B1 (en) * 1982-12-13 1989-01-18 Elan Corp Plc Drug delivery device
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
CA1283827C (en) * 1986-12-18 1991-05-07 Giorgio Cirelli Appliance for injection of liquid formulations
US6056716A (en) * 1987-06-08 2000-05-02 D'antonio Consultants International Inc. Hypodermic fluid dispenser
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
IT1227626B (it) 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
US5273975A (en) * 1989-06-09 1993-12-28 The Upjohn Company Heterocyclic amines having central nervous system activity
US5098389A (en) * 1990-06-28 1992-03-24 Becton, Dickinson And Company Hypodermic needle assembly
US5156591A (en) * 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
TW279133B (ru) * 1990-12-13 1996-06-21 Elan Med Tech
US5279544A (en) * 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5527288A (en) * 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
SE9102652D0 (sv) * 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5298262A (en) 1992-12-04 1994-03-29 Sterling Winthrop Inc. Use of ionic cloud point modifiers to prevent particle aggregation during sterilization
US5346702A (en) 1992-12-04 1994-09-13 Sterling Winthrop Inc. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization
US5336507A (en) 1992-12-11 1994-08-09 Sterling Winthrop Inc. Use of charged phospholipids to reduce nanoparticle aggregation
US5279552A (en) * 1993-01-11 1994-01-18 Anton Magnet Intradermal injection device
CA2132277C (en) * 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
US5997501A (en) * 1993-11-18 1999-12-07 Elan Corporation, Plc Intradermal drug delivery device
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5582591A (en) * 1994-09-02 1996-12-10 Delab Delivery of solid drug compositions
IE72524B1 (en) * 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US5801057A (en) * 1996-03-22 1998-09-01 Smart; Wilson H. Microsampling device and method of construction
US6576636B2 (en) * 1996-05-22 2003-06-10 Protarga, Inc. Method of treating a liver disorder with fatty acid-antiviral agent conjugates
CA2257601A1 (en) * 1996-06-10 1997-12-18 Danon Haim Needle for subcutaneous delivery of fluids
US5871158A (en) * 1997-01-27 1999-02-16 The University Of Utah Research Foundation Methods for preparing devices having metallic hollow microchannels on planar substrate surfaces
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
IE970782A1 (en) * 1997-10-22 1999-05-05 Elan Corp An improved automatic syringe
US5957895A (en) * 1998-02-20 1999-09-28 Becton Dickinson And Company Low-profile automatic injection device with self-emptying reservoir
AU3973599A (en) * 1998-05-08 1999-11-29 Genetronics, Inc. Electrically induced vessel vasodilation
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
EP1086214B1 (en) * 1998-06-10 2009-11-25 Georgia Tech Research Corporation Microneedle devices and methods of their manufacture
US6589987B2 (en) * 1998-09-08 2003-07-08 Charlotte-Mecklenburg Hospital Authority Method of treating cancer using tetraethyl thiuram disulfide
US6455564B1 (en) 1999-01-06 2002-09-24 Pharmacia & Upjohn Company Method of treating sexual disturbances
EP1187653B1 (en) * 1999-06-04 2010-03-31 Georgia Tech Research Corporation Devices for enhanced microneedle penetration of biological barriers
DE19938823A1 (de) * 1999-08-19 2001-02-22 Boehringer Ingelheim Pharma Medikamentöse Behandlung des Restless Leg Syndroms
US6319224B1 (en) * 1999-08-20 2001-11-20 Bioject Medical Technologies Inc. Intradermal injection system for injecting DNA-based injectables into humans
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US6569143B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
AU3440601A (en) * 1999-11-24 2001-06-04 Elan Pharmaceuticals, Inc. Method and composition for protecting against radio-contrast medium-induced renal dysfunction
DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
BR0210628A (pt) * 2001-06-29 2004-08-10 Becton Dickinson Co Liberação intradérmica de vacinas e agentes terapêuticos genéticos via microcânula
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances

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EA200301307A1 (ru) 2004-06-24
US20040175401A1 (en) 2004-09-09
IL158651A0 (en) 2004-05-12
US20040170654A1 (en) 2004-09-02
MXPA03011931A (es) 2005-03-07
KR20040019024A (ko) 2004-03-04
EA006922B1 (ru) 2006-04-28
EA006961B1 (ru) 2006-06-30
WO2003002103A3 (en) 2003-04-10
PL365667A1 (en) 2005-01-10
NO20035731L (no) 2004-02-27
EP1399205A2 (en) 2004-03-24
BR0210665A (pt) 2004-10-05
US20030073609A1 (en) 2003-04-17
ZA200309125B (en) 2004-11-24
ZA200309151B (en) 2004-11-25
IL159025A0 (en) 2004-05-12
BR0210688A (pt) 2004-09-21
PL366635A1 (en) 2005-02-07
CZ20033364A3 (cs) 2004-08-18
WO2003002103A2 (en) 2003-01-09
EP1416915A1 (en) 2004-05-12
CA2452321A1 (en) 2003-01-09
KR20040029327A (ko) 2004-04-06
CA2452393A1 (en) 2003-01-09
CZ20033059A3 (cs) 2004-04-14
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CN1610567A (zh) 2005-04-27
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