BR0108930A - Método de fornecimento de um agente ativo a um tipo celular de interesse, composição farmacêutica, pró-droga ativada por caspase, kit, método de tratamento de mamìferos, uso de um conjugado de caspase e uso de um pró-agente - Google Patents

Método de fornecimento de um agente ativo a um tipo celular de interesse, composição farmacêutica, pró-droga ativada por caspase, kit, método de tratamento de mamìferos, uso de um conjugado de caspase e uso de um pró-agente

Info

Publication number
BR0108930A
BR0108930A BR0108930-7A BR0108930A BR0108930A BR 0108930 A BR0108930 A BR 0108930A BR 0108930 A BR0108930 A BR 0108930A BR 0108930 A BR0108930 A BR 0108930A
Authority
BR
Brazil
Prior art keywords
caspase
agent
pro
interest
conjugate
Prior art date
Application number
BR0108930-7A
Other languages
English (en)
Inventor
Paul J Carter
Lewis Gazzard
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of BR0108930A publication Critical patent/BR0108930A/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

"MéTODO DE FORNECIMENTO DE UM AGENTE ATIVO A UM TIPO CELULAR DE INTERESSE, COMPOSIçãO FARMACêUTICA, PRó-DROGA ATIVADA POR CASPASE, KIT, MéTODO DE TRATAMENTO DE MAMìFEROS, USO DE UM CONJUGADO DE CASPASE E USO DE UM PRó-AGENTE". A presente invenção proporciona métodos inovadores para o fornecimento localizado de agentes farmacêuticos através da administração de um conjugado de caspase que se dirige a um tipo celular de interesse e da administração adicional de um pró-agente que é convertido localmente, na presença da caspase, em um agente ativo. A presente invenção proporciona, ainda, agentes direcionadores inovadores que compreendem uma caspase, bem como pró-drogas inovadoras que compreendem uma porção de pró-droga clivável por caspase. A presente invenção também fornece composições farmacêuticas, bem como métodos de tratamento que compreendem os conjugados de caspase e pró-drogas de acordo com a presente invenção
BR0108930-7A 2000-02-24 2001-02-22 Método de fornecimento de um agente ativo a um tipo celular de interesse, composição farmacêutica, pró-droga ativada por caspase, kit, método de tratamento de mamìferos, uso de um conjugado de caspase e uso de um pró-agente BR0108930A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18477900P 2000-02-24 2000-02-24
PCT/US2001/005709 WO2001062300A2 (en) 2000-02-24 2001-02-22 Caspase activated prodrugs therapy

Publications (1)

Publication Number Publication Date
BR0108930A true BR0108930A (pt) 2002-12-10

Family

ID=22678303

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108930-7A BR0108930A (pt) 2000-02-24 2001-02-22 Método de fornecimento de um agente ativo a um tipo celular de interesse, composição farmacêutica, pró-droga ativada por caspase, kit, método de tratamento de mamìferos, uso de um conjugado de caspase e uso de um pró-agente

Country Status (15)

Country Link
US (1) US20070104719A1 (pt)
EP (1) EP1257296A2 (pt)
JP (1) JP2003523407A (pt)
KR (1) KR20020082227A (pt)
CN (1) CN1406137A (pt)
AU (1) AU783679B2 (pt)
BR (1) BR0108930A (pt)
CA (1) CA2399255A1 (pt)
HU (1) HUP0300024A2 (pt)
IL (1) IL150992A0 (pt)
MX (1) MXPA02007939A (pt)
NZ (1) NZ520458A (pt)
PL (1) PL358187A1 (pt)
WO (1) WO2001062300A2 (pt)
ZA (1) ZA200206105B (pt)

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EP2300021A4 (en) * 2008-05-22 2014-10-08 Univ Ramot CONJUGATE OF A POLYMER, ANTI-ANGIOGENESE AGENT AND TARGETING REST, AND USES THEREOF FOR THE TREATMENT OF BONE-RELATED ANGIOGENESIS STATES
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MX2010014574A (es) 2008-07-08 2011-04-27 Abbott Lab Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
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JP6109952B2 (ja) 2012-11-01 2017-04-05 アッヴィ・インコーポレイテッド 抗ｖｅｇｆ／ｄｌｌ４二重可変ドメイン免疫グロブリンおよびこれらの使用
JP2016522793A (ja) 2013-03-15 2016-08-04 アッヴィ・インコーポレイテッド ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質
ES2857192T3 (es) * 2014-06-03 2021-09-28 Jiaray Pharmaceuticals Inc Conjugado de mitomicina
US10125105B2 (en) 2014-06-11 2018-11-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Triazabutadienes as cleavable cross-linkers
US9593080B1 (en) 2014-06-11 2017-03-14 The Arizona Board Of Regents On Behalf Of The University Of Arizona Triazabutadienes as cleavable cross-linkers
US10047061B2 (en) 2014-06-11 2018-08-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Water-soluble triazabutadienes
US9775914B2 (en) * 2014-11-20 2017-10-03 Pharosgen Co., Ltd. Prodrugs activated by caspase
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
US10954195B2 (en) 2015-08-11 2021-03-23 Arizona Board Of Regents On Behalf Of The University Of Arizona Substituted triazenes protected from degradation by carboxylation of N1
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Also Published As

Publication number Publication date
WO2001062300A3 (en) 2002-04-25
CN1406137A (zh) 2003-03-26
AU4166701A (en) 2001-09-03
CA2399255A1 (en) 2001-08-30
PL358187A1 (en) 2004-08-09
NZ520458A (en) 2005-02-25
WO2001062300A2 (en) 2001-08-30
KR20020082227A (ko) 2002-10-30
US20070104719A1 (en) 2007-05-10
EP1257296A2 (en) 2002-11-20
IL150992A0 (en) 2003-02-12
HUP0300024A2 (en) 2003-05-28
MXPA02007939A (es) 2003-02-10
AU783679B2 (en) 2005-11-24
ZA200206105B (en) 2003-07-31
JP2003523407A (ja) 2003-08-05

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A,10A E 11A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012.

B15K Others concerning applications: alteration of classification

Ipc: C07K 16/32 (2006.01), A61K 47/68 (2017.01), B82Y 5