BR0206586A - Processo para a produção de pantotenato aumentada, produto, composição, e, microorganismo recombinante para a produção de pantotenato aumentada - Google Patents
Processo para a produção de pantotenato aumentada, produto, composição, e, microorganismo recombinante para a produção de pantotenato aumentadaInfo
- Publication number
- BR0206586A BR0206586A BR0206586-0A BR0206586A BR0206586A BR 0206586 A BR0206586 A BR 0206586A BR 0206586 A BR0206586 A BR 0206586A BR 0206586 A BR0206586 A BR 0206586A
- Authority
- BR
- Brazil
- Prior art keywords
- increased
- production
- pantothenate production
- composition
- product
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 6
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 title abstract 5
- 244000005700 microbiome Species 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 229940014662 pantothenate Drugs 0.000 title abstract 4
- 235000019161 pantothenic acid Nutrition 0.000 title abstract 4
- 239000011713 pantothenic acid Substances 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- QYNUQALWYRSVHF-ABLWVSNPSA-N 5,10-methylenetetrahydrofolic acid Chemical class C1N2C=3C(=O)NC(N)=NC=3NCC2CN1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-ABLWVSNPSA-N 0.000 abstract 2
- 230000001851 biosynthetic effect Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- OTOIIPJYVQJATP-BYPYZUCNSA-M (R)-pantoate Chemical compound OCC(C)(C)[C@@H](O)C([O-])=O OTOIIPJYVQJATP-BYPYZUCNSA-M 0.000 abstract 1
- PKVVTUWHANFMQC-UHFFFAOYSA-N 2-dehydropantoic acid Chemical compound OCC(C)(C)C(=O)C(O)=O PKVVTUWHANFMQC-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
- C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/02—Hydroxymethyl-, formyl- and related transferases (2.1.2)
- C12Y201/02011—3-Methyl-2-oxobutanoate hydroxymethyltransferase (2.1.2.11), i.e. ketopantoate hydroxymethyltransferase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01011—Aspartate 1-decarboxylase (4.1.1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
- C12Y603/02001—Pantoate-beta-alanine ligase (6.3.2.1)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26299501P | 2001-01-19 | 2001-01-19 | |
| US26305301P | 2001-01-19 | 2001-01-19 | |
| US34763802P | 2002-01-11 | 2002-01-11 | |
| PCT/US2002/000925 WO2002061108A2 (en) | 2001-01-19 | 2002-01-18 | Microorganisms and processes for enhanced production of pantothenate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0206586A true BR0206586A (pt) | 2006-01-24 |
Family
ID=27401561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0206586-0A BR0206586A (pt) | 2001-01-19 | 2002-01-18 | Processo para a produção de pantotenato aumentada, produto, composição, e, microorganismo recombinante para a produção de pantotenato aumentada |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7244593B2 (enEXAMPLES) |
| EP (1) | EP1390519B1 (enEXAMPLES) |
| JP (1) | JP4229700B2 (enEXAMPLES) |
| KR (1) | KR20030075163A (enEXAMPLES) |
| CN (1) | CN100529068C (enEXAMPLES) |
| AT (1) | ATE347589T1 (enEXAMPLES) |
| BR (1) | BR0206586A (enEXAMPLES) |
| CA (1) | CA2434626A1 (enEXAMPLES) |
| CZ (1) | CZ20031886A3 (enEXAMPLES) |
| DE (1) | DE60216581T2 (enEXAMPLES) |
| HU (1) | HU227432B1 (enEXAMPLES) |
| IL (1) | IL156708A0 (enEXAMPLES) |
| IN (2) | IN2003CH01278A (enEXAMPLES) |
| MX (1) | MXPA03006343A (enEXAMPLES) |
| NO (1) | NO20033240L (enEXAMPLES) |
| PL (1) | PL369009A1 (enEXAMPLES) |
| WO (1) | WO2002061108A2 (enEXAMPLES) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8232081B2 (en) * | 1999-09-21 | 2012-07-31 | Basf Se | Methods and microorganisms for production of panto-compounds |
| RU2003125653A (ru) | 2001-01-19 | 2005-03-10 | БАСФ Акциенгезельшафт (DE) | Способы улучшенного получения пантотената |
| DE10106461A1 (de) * | 2001-02-13 | 2002-08-14 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen |
| EP1385975B1 (de) | 2001-02-21 | 2007-01-03 | Basf Aktiengesellschaft | Verfahren zur herstellung von d-pantothensäure und/oder salze als zusatz zu tierfuttermitteln |
| DE10108223A1 (de) | 2001-02-21 | 2002-10-10 | Basf Ag | Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln |
| EP1247868A3 (de) * | 2001-04-03 | 2002-10-30 | Degussa AG | Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen |
| WO2003004672A1 (en) * | 2001-07-03 | 2003-01-16 | Degussa Ag | Process for the fermentative preparation of d-pantothenic acid and/or salts thereof |
| DE10132178A1 (de) | 2001-07-03 | 2003-01-23 | Degussa | Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen |
| CN100455669C (zh) * | 2002-07-03 | 2009-01-28 | 巴斯福股份公司 | 用于提高泛酸产量的微生物和方法 |
| WO2004005525A2 (en) | 2002-07-03 | 2004-01-15 | Basf Aktiengesellschaft | Microorganisms and processes for enhanced production of pantothenate |
| JP4713469B2 (ja) * | 2003-06-18 | 2011-06-29 | ディーエスエム アイピー アセッツ ビー．ブイ． | 胞子形成できない微生物を用いたパントテネート（Ｐａｎｔｏｔｈｅｎａｔｅ）の製造 |
| DE10331291A1 (de) | 2003-07-10 | 2005-02-17 | Consortium für elektrochemische Industrie GmbH | Varianten der 3-Phosphoglyceratdehydrogenase mit reduzierter Hemmung durch L-Serin und dafür codierende Gene |
| DE102004026152A1 (de) * | 2004-05-28 | 2005-12-15 | Basf Ag | Fermentative Herstellung von Feinchemikalien |
| DE112007001179T5 (de) | 2006-05-16 | 2009-04-02 | Dsm Ip Assets B.V. | Verfahren zur Herstellung von Panthenol |
| EP2157174A1 (en) | 2008-08-12 | 2010-02-24 | DSM IP Assets B.V. | Increased production of pantothenate (vitamin B5) |
| CN104928336B (zh) | 2009-10-26 | 2020-05-08 | 弗·哈夫曼-拉罗切有限公司 | 用于生产糖基化免疫球蛋白的方法 |
| CN102311966B (zh) * | 2010-06-30 | 2016-04-13 | 中国科学院青岛生物能源与过程研究所 | 用于合成脂肪醇的构建体，载体，蓝细菌，以及在蓝细菌中生产脂肪醇的方法 |
| EP2723878B1 (en) | 2011-06-21 | 2020-05-20 | DSM IP Assets B.V. | Vitamin b5 production |
| WO2012175574A1 (en) | 2011-06-21 | 2012-12-27 | Dsm Ip Assets B.V. | Increased pantothenate (vitamin b5) production |
| EP2809771B1 (en) | 2012-01-30 | 2017-12-27 | Myriant Corporation | Production of muconic acid from genetically engineered microorganisms |
| WO2014087184A1 (en) * | 2012-12-03 | 2014-06-12 | Metabolic Explorer | Neopentyl glycol fermentative production by a recombinant microorganism |
| KR20240005196A (ko) | 2016-03-02 | 2024-01-11 | 피티티 글로벌 케미컬 퍼블릭 컴퍼니 리미티드 | 유전자 조작된 미생물로부터 개선된 뮤콘산 생산 |
| CN108456701B (zh) * | 2018-03-23 | 2020-10-16 | 精晶药业股份有限公司 | 一种d-泛解酸内酯的制备方法 |
| CN111534562A (zh) * | 2020-06-19 | 2020-08-14 | 南京欧信医药技术有限公司 | 一种d-泛解酸的制备方法 |
| CN112195143B (zh) * | 2020-09-24 | 2022-10-14 | 浙江工业大学 | 一种用于发酵法生产d-泛酸的菌株及发酵法生产d-泛酸的方法 |
| CN113416744B (zh) * | 2021-06-04 | 2022-05-20 | 浙江工业大学 | 一种d-泛解酸生产菌、构建方法及应用 |
| CN116024278B (zh) * | 2022-12-16 | 2024-05-07 | 黑龙江新和成生物科技有限公司 | 一种发酵法制备d-泛酸的方法 |
| WO2025113965A1 (en) * | 2023-11-29 | 2025-06-05 | Unilever Ip Holdings B.V. | Use of l-aspartate for improving production of pantothenate |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6787334B1 (en) * | 1998-10-09 | 2004-09-07 | Degussa Ag | Process for the preparation of pantothenic acid by amplification of nucleotide sequences which code for the ketopantoate reductase |
| DE19846499A1 (de) * | 1998-10-09 | 2000-04-20 | Degussa | Verfahren zur Herstellung von Pantothensäure durch Verstärkung von für Ketopantoat-Reduktase kodierenden Nukleotidsequenzen |
| DE19855314A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentiven Herstellung von D-Pantothensäure unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| DE19855313A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen |
| DE19855312A1 (de) * | 1998-12-01 | 2000-06-08 | Degussa | Verfahren zur fermentativen Herstellung von D-Pantothensäure unter Verwendung coryneformer Bakterien |
| AU7708700A (en) * | 1999-09-21 | 2001-04-24 | Basf Aktiengesellschaft | Methods and microorganisms for production of panto-compounds |
| RU2003125653A (ru) * | 2001-01-19 | 2005-03-10 | БАСФ Акциенгезельшафт (DE) | Способы улучшенного получения пантотената |
| EP1247868A3 (de) * | 2001-04-03 | 2002-10-30 | Degussa AG | Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen |
| WO2003004672A1 (en) * | 2001-07-03 | 2003-01-16 | Degussa Ag | Process for the fermentative preparation of d-pantothenic acid and/or salts thereof |
-
2002
- 2002-01-18 HU HU0501185A patent/HU227432B1/hu not_active IP Right Cessation
- 2002-01-18 WO PCT/US2002/000925 patent/WO2002061108A2/en active IP Right Grant
- 2002-01-18 CN CNB028038576A patent/CN100529068C/zh not_active Expired - Fee Related
- 2002-01-18 IL IL15670802A patent/IL156708A0/xx unknown
- 2002-01-18 CA CA002434626A patent/CA2434626A1/en not_active Abandoned
- 2002-01-18 KR KR20037009544A patent/KR20030075163A/ko not_active Withdrawn
- 2002-01-18 PL PL02369009A patent/PL369009A1/xx not_active Application Discontinuation
- 2002-01-18 CZ CZ20031886A patent/CZ20031886A3/cs unknown
- 2002-01-18 US US10/466,641 patent/US7244593B2/en not_active Expired - Lifetime
- 2002-01-18 DE DE60216581T patent/DE60216581T2/de not_active Expired - Lifetime
- 2002-01-18 MX MXPA03006343A patent/MXPA03006343A/es unknown
- 2002-01-18 BR BR0206586-0A patent/BR0206586A/pt active Search and Examination
- 2002-01-18 JP JP2002561662A patent/JP4229700B2/ja not_active Expired - Fee Related
- 2002-01-18 AT AT02709018T patent/ATE347589T1/de not_active IP Right Cessation
- 2002-01-18 EP EP02709018A patent/EP1390519B1/en not_active Expired - Lifetime
- 2002-01-19 IN IN1278CH2003 patent/IN2003CH01278A/en unknown
-
2003
- 2003-07-17 NO NO20033240A patent/NO20033240L/no not_active Application Discontinuation
- 2003-08-14 IN IN1280CH2003 patent/IN2003CH01280A/en unknown
-
2007
- 2007-07-16 US US11/879,143 patent/US20080166777A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002243526A (en) | 2002-08-12 |
| JP4229700B2 (ja) | 2009-02-25 |
| EP1390519A2 (en) | 2004-02-25 |
| CN1571837A (zh) | 2005-01-26 |
| EP1390519B1 (en) | 2006-12-06 |
| US7244593B2 (en) | 2007-07-17 |
| IN2003CH01280A (enEXAMPLES) | 2005-11-18 |
| PL369009A1 (en) | 2005-04-18 |
| US20040091979A1 (en) | 2004-05-13 |
| US20080166777A1 (en) | 2008-07-10 |
| WO2002061108A3 (en) | 2003-12-11 |
| CA2434626A1 (en) | 2002-08-08 |
| MXPA03006343A (es) | 2003-10-06 |
| IN2003CH01278A (enEXAMPLES) | 2005-11-18 |
| NO20033240L (no) | 2003-09-17 |
| DE60216581D1 (de) | 2007-01-18 |
| IL156708A0 (en) | 2004-01-04 |
| DE60216581T2 (de) | 2007-09-27 |
| JP2004533213A (ja) | 2004-11-04 |
| HUP0501185A2 (en) | 2006-10-28 |
| ATE347589T1 (de) | 2006-12-15 |
| HU227432B1 (hu) | 2011-06-28 |
| NO20033240D0 (no) | 2003-07-17 |
| WO2002061108A2 (en) | 2002-08-08 |
| CN100529068C (zh) | 2009-08-19 |
| CZ20031886A3 (cs) | 2003-10-15 |
| KR20030075163A (ko) | 2003-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 24, 25 E 10 (IX) DA LPI. |
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| B12B | Appeal against refusal [chapter 12.2 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |