BR0008804A - 4-oxo-4, 7-dihidrotieno [2,3-b] piridina-5-carboxamidas como agentes antivirais - Google Patents
4-oxo-4, 7-dihidrotieno [2,3-b] piridina-5-carboxamidas como agentes antiviraisInfo
- Publication number
- BR0008804A BR0008804A BR0008804-8A BR0008804A BR0008804A BR 0008804 A BR0008804 A BR 0008804A BR 0008804 A BR0008804 A BR 0008804A BR 0008804 A BR0008804 A BR 0008804A
- Authority
- BR
- Brazil
- Prior art keywords
- carboxamides
- oxo
- pyridine
- dihydrothieno
- antiviral agents
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- FGQULDOAAIVPCO-UHFFFAOYSA-N 4-oxo-7h-thieno[2,3-b]pyridine-5-carboxamide Chemical class O=C1C(C(=O)N)=CNC2=C1C=CS2 FGQULDOAAIVPCO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
"4-OXO-4,7-DIHIDROTIENO[2,3-b]PIRIDINA-5-CARBOXAMIDAS COMO AGENTES ANTIVIRAIS".A invenção fornece um composto de fórmula I, onde R^ 1^, R^ 2^, R^ 3^ e R^ 4^ possuem qualquer um dos valores definidos na especificação, ou um sal farmaceuticamente aceitável deste, assim como processos e intermediários úteis para preparar tais compostos ou sais, e métodos de impedir ou tratar uma infecção virótica herpética usando tais compostos ou sais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12366099P | 1999-03-09 | 1999-03-09 | |
PCT/US2000/005937 WO2000053610A2 (en) | 1999-03-09 | 2000-03-07 | 4-OXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0008804A true BR0008804A (pt) | 2002-04-16 |
Family
ID=22410054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0008804-8A BR0008804A (pt) | 1999-03-09 | 2000-03-07 | 4-oxo-4, 7-dihidrotieno [2,3-b] piridina-5-carboxamidas como agentes antivirais |
Country Status (25)
Country | Link |
---|---|
US (2) | US6239142B1 (pt) |
EP (1) | EP1159279B1 (pt) |
JP (1) | JP2002539130A (pt) |
KR (1) | KR20010102543A (pt) |
CN (1) | CN1347417A (pt) |
AT (1) | ATE226208T1 (pt) |
AU (1) | AU759875B2 (pt) |
BR (1) | BR0008804A (pt) |
CA (1) | CA2366609A1 (pt) |
CZ (1) | CZ20013028A3 (pt) |
DE (1) | DE60000611T2 (pt) |
DK (1) | DK1159279T3 (pt) |
EA (1) | EA003607B1 (pt) |
ES (1) | ES2184705T3 (pt) |
HK (1) | HK1045518A1 (pt) |
HU (1) | HUP0200324A3 (pt) |
IL (1) | IL145005A0 (pt) |
NO (1) | NO20014363L (pt) |
NZ (1) | NZ513758A (pt) |
PL (1) | PL350651A1 (pt) |
PT (1) | PT1159279E (pt) |
SK (1) | SK12582001A3 (pt) |
TW (1) | TWI222451B (pt) |
WO (1) | WO2000053610A2 (pt) |
ZA (1) | ZA200107255B (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6559145B2 (en) | 2000-07-12 | 2003-05-06 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US6562822B2 (en) | 2000-07-12 | 2003-05-13 | Pharmacia & Upjohn Company | Heterocyle carboxamides as antiviral agents |
US6730682B2 (en) | 2000-07-12 | 2004-05-04 | Pharmacia & Upjohn Company | Heterocycle carboxamides as antiviral agents |
US8101629B2 (en) | 2001-08-13 | 2012-01-24 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile |
US7638522B2 (en) | 2001-08-13 | 2009-12-29 | Janssen Pharmaceutica N.V. | Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
WO2003020728A1 (en) * | 2001-08-30 | 2003-03-13 | Pharmacia & Upjohn Company | 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS |
MXPA04001797A (es) | 2001-08-30 | 2004-07-08 | Pharmacia & Upjhon Company | 4-tioxo-4,7-dihidro-teno[2,3-b]piridin-5-carboxamidas como agentes antivirales. |
CN1620439A (zh) * | 2001-12-20 | 2005-05-25 | Osi药物公司 | 胰脂肪酶抑制剂化合物、其合成方法和应用 |
AR038118A1 (es) * | 2002-01-14 | 2004-12-29 | Upjohn Co | Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales |
AR038294A1 (es) | 2002-01-14 | 2005-01-12 | Upjohn Co | Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales |
AR038117A1 (es) * | 2002-01-14 | 2004-12-29 | Upjohn Co | Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida |
AU2003222077A1 (en) * | 2002-04-22 | 2003-11-03 | Pharmacia And Upjohn Company | A trifluoroacetic acid process to prepare (2,3-b)pyridine intermediates |
BR0313545B1 (pt) | 2002-08-09 | 2021-07-27 | Janssen Pharmaceutica Nv | processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila |
WO2004019932A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
WO2004019939A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
WO2004019933A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
WO2004019940A1 (en) * | 2002-08-30 | 2004-03-11 | Pharmacia & Upjohn Company | Method of preventing or treating atherosclerosis or restenosis |
AU2003265385A1 (en) * | 2002-09-04 | 2004-03-29 | Pharmacia & Upjohn Company Llc | Aryl-ethanolamine derivatives as antiviral agents |
AU2003304151A1 (en) * | 2002-09-04 | 2005-01-21 | Pharmacia And Upjohn Company | Heteroaryl-ethanolamine derivatives as antiviral agents |
AU2003269950A1 (en) * | 2002-09-04 | 2004-03-29 | Pharmacia & Upjohn Company Llc | Heteroaryl-ethanolamine derivatives as antiviral agents |
WO2004022566A1 (en) * | 2002-09-04 | 2004-03-18 | Pharmacia & Upjohn Company Llc | 4-OXO-4,7-DIHYDROTHIENO[2,3-b]PYRIDINE-5-CARBOXAMIDES AS ANTIVIRAL AGENTS |
WO2005003140A1 (en) * | 2003-07-02 | 2005-01-13 | Pharmacia & Upjohn Company Llc | 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents |
EP1756082A1 (en) * | 2004-04-13 | 2007-02-28 | Astex Therapeutics Limited | 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators |
SE0401578D0 (sv) | 2004-06-18 | 2004-06-18 | Active Biotech Ab | Novel compounds |
WO2006093518A2 (en) * | 2004-06-25 | 2006-09-08 | Apath, Llc | Thienyl compounds for treating virus-related conditions |
AP3069A (en) * | 2009-02-27 | 2014-12-31 | Siga Technologies Inc | Thienopyridine derivatives for the treatment and prvention of dengue virus infection |
JP2019504901A (ja) | 2016-02-16 | 2019-02-21 | ヴァンダービルト ユニバーシティー | ムスカリン性アセチルコリン受容体m1のポジティブアロステリックモジュレーター |
WO2018063552A1 (en) * | 2016-09-30 | 2018-04-05 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
CN112996789A (zh) | 2018-09-12 | 2021-06-18 | 诺华股份有限公司 | 抗病毒吡啶并吡嗪二酮化合物 |
AU2020353055B2 (en) | 2019-09-26 | 2024-03-07 | Gilead Sciences, Inc. | Antiviral pyrazolopyridinone compounds |
CN115073489B (zh) * | 2021-03-15 | 2023-11-28 | 同济大学 | 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物 |
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CA2036618C (en) * | 1990-02-22 | 2002-10-29 | Akira Morimoto | Fused thiophene derivatives, their production and use |
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US5219864A (en) | 1991-03-12 | 1993-06-15 | Kyowa Hakko Kogyo Co., Ltd. | Thienopyridine derivatives |
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JPH0776586A (ja) | 1993-07-16 | 1995-03-20 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物 |
TW449600B (en) | 1994-04-19 | 2001-08-11 | Takeda Chemical Industries Ltd | Condensed-ring thiophene derivatives, their production and use |
WO1996018617A1 (en) | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-acylamino-pyridines as inhibitors of nitric oxide synthase |
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JPH08301849A (ja) | 1995-05-01 | 1996-11-19 | Takeda Chem Ind Ltd | ヘテロ環化合物およびその製造法 |
JPH09208496A (ja) | 1996-01-30 | 1997-08-12 | Takeda Chem Ind Ltd | Lh−rh拮抗物質含有組成物 |
CA2250908C (en) | 1996-04-30 | 2012-03-13 | Takeda Chemical Industries, Ltd. | Combined use of gnrh agonist and antagonist |
EP0927164A1 (en) * | 1996-09-10 | 1999-07-07 | PHARMACIA & UPJOHN COMPANY | 8-hydroxy-7-substituted quinolines as anti-viral agents |
SK18542000A3 (sk) | 1998-06-04 | 2001-12-03 | Abbott Laboratories | Protizápalové zlúčeniny inhibujúce bunkovú adhéziu |
-
2000
- 2000-03-07 SK SK1258-2001A patent/SK12582001A3/sk unknown
- 2000-03-07 PL PL00350651A patent/PL350651A1/xx unknown
- 2000-03-07 KR KR1020017011447A patent/KR20010102543A/ko not_active Application Discontinuation
- 2000-03-07 CN CN00806238A patent/CN1347417A/zh active Pending
- 2000-03-07 ES ES00913786T patent/ES2184705T3/es not_active Expired - Lifetime
- 2000-03-07 AU AU35162/00A patent/AU759875B2/en not_active Ceased
- 2000-03-07 CA CA002366609A patent/CA2366609A1/en not_active Abandoned
- 2000-03-07 JP JP2000604046A patent/JP2002539130A/ja active Pending
- 2000-03-07 IL IL14500500A patent/IL145005A0/xx unknown
- 2000-03-07 CZ CZ20013028A patent/CZ20013028A3/cs unknown
- 2000-03-07 DE DE60000611T patent/DE60000611T2/de not_active Expired - Fee Related
- 2000-03-07 US US09/521,027 patent/US6239142B1/en not_active Expired - Fee Related
- 2000-03-07 PT PT00913786T patent/PT1159279E/pt unknown
- 2000-03-07 EP EP00913786A patent/EP1159279B1/en not_active Expired - Lifetime
- 2000-03-07 BR BR0008804-8A patent/BR0008804A/pt not_active IP Right Cessation
- 2000-03-07 EA EA200100955A patent/EA003607B1/ru not_active IP Right Cessation
- 2000-03-07 HU HU0200324A patent/HUP0200324A3/hu unknown
- 2000-03-07 WO PCT/US2000/005937 patent/WO2000053610A2/en not_active Application Discontinuation
- 2000-03-07 AT AT00913786T patent/ATE226208T1/de not_active IP Right Cessation
- 2000-03-07 DK DK00913786T patent/DK1159279T3/da active
- 2000-03-07 NZ NZ513758A patent/NZ513758A/en unknown
- 2000-03-09 TW TW089104265A patent/TWI222451B/zh not_active IP Right Cessation
-
2001
- 2001-04-02 US US09/824,334 patent/US6495683B2/en not_active Expired - Fee Related
- 2001-08-31 ZA ZA200107255A patent/ZA200107255B/en unknown
- 2001-09-07 NO NO20014363A patent/NO20014363L/no not_active Application Discontinuation
-
2002
- 2002-09-26 HK HK02107054.6A patent/HK1045518A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU3516200A (en) | 2000-09-28 |
ATE226208T1 (de) | 2002-11-15 |
EP1159279B1 (en) | 2002-10-16 |
NO20014363L (no) | 2001-11-08 |
NZ513758A (en) | 2001-09-28 |
US20020006937A1 (en) | 2002-01-17 |
EA003607B1 (ru) | 2003-06-26 |
ES2184705T3 (es) | 2003-04-16 |
IL145005A0 (en) | 2002-06-30 |
AU759875B2 (en) | 2003-05-01 |
TWI222451B (en) | 2004-10-21 |
PL350651A1 (en) | 2003-01-27 |
EA200100955A1 (ru) | 2002-02-28 |
CN1347417A (zh) | 2002-05-01 |
US6495683B2 (en) | 2002-12-17 |
WO2000053610A2 (en) | 2000-09-14 |
HUP0200324A2 (en) | 2002-06-29 |
DK1159279T3 (da) | 2003-02-17 |
WO2000053610A3 (en) | 2001-01-25 |
DE60000611D1 (en) | 2002-11-21 |
JP2002539130A (ja) | 2002-11-19 |
US6239142B1 (en) | 2001-05-29 |
CA2366609A1 (en) | 2000-09-14 |
CZ20013028A3 (cs) | 2002-03-13 |
HUP0200324A3 (en) | 2003-07-28 |
EP1159279A2 (en) | 2001-12-05 |
NO20014363D0 (no) | 2001-09-07 |
ZA200107255B (en) | 2002-12-02 |
HK1045518A1 (zh) | 2002-11-29 |
PT1159279E (pt) | 2003-02-28 |
DE60000611T2 (de) | 2003-06-26 |
SK12582001A3 (sk) | 2002-02-05 |
KR20010102543A (ko) | 2001-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A , 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 NA RPI2003 DE 26/05/2009. |