ES2184705T3 - 4-oxo-4,7-dihidro-tieno(2,3-b)piridina-5-carboxamidas como agentes antivirales. - Google Patents

4-oxo-4,7-dihidro-tieno(2,3-b)piridina-5-carboxamidas como agentes antivirales.

Info

Publication number
ES2184705T3
ES2184705T3 ES00913786T ES00913786T ES2184705T3 ES 2184705 T3 ES2184705 T3 ES 2184705T3 ES 00913786 T ES00913786 T ES 00913786T ES 00913786 T ES00913786 T ES 00913786T ES 2184705 T3 ES2184705 T3 ES 2184705T3
Authority
ES
Spain
Prior art keywords
oxo
antiviral agents
carboxamids
piridina
tieno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00913786T
Other languages
English (en)
Inventor
Mark E Schnute
Michele M Cudahy
Allen Scott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of ES2184705T3 publication Critical patent/ES2184705T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención suministra derivados de 4 - oxo - 4, 7 - dihidrotieno[2, 3 - b]piridin - 5 - carboxamida, más concretamente, derivados de 5 - bencilaminocarbonil - 4 - oxo - 4, 7 - dihidrotieno[2, 3 - b]piridina de fórmula (I), que son útiles como agentes antivirales (por ejemplo, como agentes contra virus de la familia del herpes).
ES00913786T 1999-03-09 2000-03-07 4-oxo-4,7-dihidro-tieno(2,3-b)piridina-5-carboxamidas como agentes antivirales. Expired - Lifetime ES2184705T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12366099P 1999-03-09 1999-03-09

Publications (1)

Publication Number Publication Date
ES2184705T3 true ES2184705T3 (es) 2003-04-16

Family

ID=22410054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00913786T Expired - Lifetime ES2184705T3 (es) 1999-03-09 2000-03-07 4-oxo-4,7-dihidro-tieno(2,3-b)piridina-5-carboxamidas como agentes antivirales.

Country Status (25)

Country Link
US (2) US6239142B1 (es)
EP (1) EP1159279B1 (es)
JP (1) JP2002539130A (es)
KR (1) KR20010102543A (es)
CN (1) CN1347417A (es)
AT (1) ATE226208T1 (es)
AU (1) AU759875B2 (es)
BR (1) BR0008804A (es)
CA (1) CA2366609A1 (es)
CZ (1) CZ20013028A3 (es)
DE (1) DE60000611T2 (es)
DK (1) DK1159279T3 (es)
EA (1) EA003607B1 (es)
ES (1) ES2184705T3 (es)
HK (1) HK1045518A1 (es)
HU (1) HUP0200324A3 (es)
IL (1) IL145005A0 (es)
NO (1) NO20014363L (es)
NZ (1) NZ513758A (es)
PL (1) PL350651A1 (es)
PT (1) PT1159279E (es)
SK (1) SK12582001A3 (es)
TW (1) TWI222451B (es)
WO (1) WO2000053610A2 (es)
ZA (1) ZA200107255B (es)

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US6562822B2 (en) 2000-07-12 2003-05-13 Pharmacia & Upjohn Company Heterocyle carboxamides as antiviral agents
US6559145B2 (en) 2000-07-12 2003-05-06 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US6730682B2 (en) 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
US8101629B2 (en) 2001-08-13 2012-01-24 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile
US7638522B2 (en) 2001-08-13 2009-12-29 Janssen Pharmaceutica N.V. Salt of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino] benzonitrile
JO3429B1 (ar) 2001-08-13 2019-10-20 Janssen Pharmaceutica Nv مشتقات برميدينات مثبطة فيروس الايدز
MXPA04001797A (es) 2001-08-30 2004-07-08 Pharmacia & Upjhon Company 4-tioxo-4,7-dihidro-teno[2,3-b]piridin-5-carboxamidas como agentes antivirales.
WO2003020728A1 (en) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS
EP1467978A4 (en) * 2001-12-20 2005-11-02 Osi Pharm Inc "COMPOUNDS THAT CONTAIN VACCINATES DRUG LIPASE, THEIR SYNTHESIS AND USE"
AR038117A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Agentes antivirales derivados de la 4- oxo-4,7 -dihidrofuro [2,3-b]piridin-5-carboxamida
AR038118A1 (es) * 2002-01-14 2004-12-29 Upjohn Co Compuestos derivados de la bencinamida del acido 7-oxo-4,7-dihidrotien[2,3-b[piridin-6-carboxilico 3-sustituido que son utiles como antivirales
AR038294A1 (es) 2002-01-14 2005-01-12 Upjohn Co Oxotieno(3,2-b)piridincarboxamidas como agentes antivirales
AU2003222077A1 (en) * 2002-04-22 2003-11-03 Pharmacia And Upjohn Company A trifluoroacetic acid process to prepare (2,3-b)pyridine intermediates
US7399856B2 (en) 2002-08-09 2008-07-15 Janssen Pharmaceutica N.V. Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-2pyrimidinyl]amino]benzonitrile
WO2004019940A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019939A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019932A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004019933A1 (en) * 2002-08-30 2004-03-11 Pharmacia & Upjohn Company Method of preventing or treating atherosclerosis or restenosis
WO2004106345A2 (en) * 2002-09-04 2004-12-09 Pharmacia & Upjohn Company Heteroaryl-ethanolamine derivatives as antiviral agents
WO2004022568A1 (en) * 2002-09-04 2004-03-18 Pharmacia & Upjohn Company Llc Aryl-ethanolamine derivatives as antiviral agents
AU2003269950A1 (en) * 2002-09-04 2004-03-29 Pharmacia & Upjohn Company Llc Heteroaryl-ethanolamine derivatives as antiviral agents
US6831081B2 (en) * 2002-09-04 2004-12-14 Pharmacia & Upjohn 4-Oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
WO2005003140A1 (en) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides as antiviral agents
US20070208015A1 (en) * 2004-04-13 2007-09-06 Astex Therapeutics, Ltd. 5-Morpholinylmethylthiophenyl Pharmaceutical Compounds As P38 MAP Kinase Modulators
SE0401578D0 (sv) 2004-06-18 2004-06-18 Active Biotech Ab Novel compounds
WO2006093518A2 (en) * 2004-06-25 2006-09-08 Apath, Llc Thienyl compounds for treating virus-related conditions
AP3069A (en) * 2009-02-27 2014-12-31 Siga Technologies Inc Thienopyridine derivatives for the treatment and prvention of dengue virus infection
AU2017221404A1 (en) 2016-02-16 2018-08-23 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
US10899759B2 (en) 2016-09-30 2021-01-26 Vanderbilt University Positive allosteric modulators of the muscarinic acetylcholine receptor M1
US11072610B2 (en) 2018-09-12 2021-07-27 Novartis Ag Antiviral pyridopyrazinedione compounds
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CN115073489B (zh) * 2021-03-15 2023-11-28 同济大学 一种噻吩骈吡啶酮类化合物、制备方法及一种抗真菌药物

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Also Published As

Publication number Publication date
TWI222451B (en) 2004-10-21
ZA200107255B (en) 2002-12-02
HUP0200324A2 (en) 2002-06-29
AU759875B2 (en) 2003-05-01
DE60000611T2 (de) 2003-06-26
US6239142B1 (en) 2001-05-29
WO2000053610A2 (en) 2000-09-14
DK1159279T3 (da) 2003-02-17
HUP0200324A3 (en) 2003-07-28
SK12582001A3 (sk) 2002-02-05
EA200100955A1 (ru) 2002-02-28
NZ513758A (en) 2001-09-28
EP1159279A2 (en) 2001-12-05
NO20014363L (no) 2001-11-08
PT1159279E (pt) 2003-02-28
IL145005A0 (en) 2002-06-30
CZ20013028A3 (cs) 2002-03-13
US6495683B2 (en) 2002-12-17
BR0008804A (pt) 2002-04-16
CA2366609A1 (en) 2000-09-14
KR20010102543A (ko) 2001-11-15
WO2000053610A3 (en) 2001-01-25
HK1045518A1 (zh) 2002-11-29
CN1347417A (zh) 2002-05-01
DE60000611D1 (en) 2002-11-21
EA003607B1 (ru) 2003-06-26
JP2002539130A (ja) 2002-11-19
EP1159279B1 (en) 2002-10-16
PL350651A1 (en) 2003-01-27
ATE226208T1 (de) 2002-11-15
NO20014363D0 (no) 2001-09-07
AU3516200A (en) 2000-09-28
US20020006937A1 (en) 2002-01-17

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