BR0313545B1 - processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila - Google Patents

processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila

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Publication number
BR0313545B1
BR0313545B1 BRPI0313545A BR0313545A BR0313545B1 BR 0313545 B1 BR0313545 B1 BR 0313545B1 BR PI0313545 A BRPI0313545 A BR PI0313545A BR 0313545 A BR0313545 A BR 0313545A BR 0313545 B1 BR0313545 B1 BR 0313545B1
Authority
BR
Brazil
Prior art keywords
amino
cyanoethenyl
processes
benzonitrile
dimethylphenyl
Prior art date
Application number
BRPI0313545A
Other languages
English (en)
Other versions
BRPI0313545B1 (pt
BR0313545A (pt
Inventor
Petrus Anna Maria Jozef Medaer Bart
Philippe Robert Schils Didier
Therese Jeanne Pasquier Elisabeth
Heeres Jan
Josephus Maria Willems Joannes
Emile Georges Guillemont Jérôme
Adrian Jan Janssen Paul
Gerardus George Leenders Ruben
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR0313545A publication Critical patent/BR0313545A/pt
Publication of BRPI0313545B1 publication Critical patent/BRPI0313545B1/pt
Publication of BR0313545B1 publication Critical patent/BR0313545B1/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/20—Preparation of carboxylic acid nitriles by dehydration of carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

processos para a preparação de 4-[[4-[[4(2-cianoetenil)-2,6-dimetilfenil]amino]-2pirimidinili]amino]benzonitrila. a presente invenção refere-se a processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila de fórmula (i), (iii) um n-óxido, um sal de adição de ácido farmaceuticamente aceitável, uma amina quaternária ou uma forma estereoquimicamente isomérica da mesma, onde os referidos processos compreendem a) reagir 4-(2-cianoetenil)-2,6-dimetilbenzenamina com um intermediário de fórmula (iii) na presença de um solvente adequado; b) reagir um intermediário de fórmula (iv) (iv) com acrilonitrila na presença de um catalisador de paládio adequado, uma base adequada e um solvente adequado; c) desidratar a amida correspondente do composto de fórmula (i).
BRPI0313545A 2002-08-09 2003-08-07 processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila BR0313545B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02078306.4 2002-08-09
EP02078306 2002-08-09
PCT/EP2003/050366 WO2004016581A1 (en) 2002-08-09 2003-08-07 Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Publications (3)

Publication Number Publication Date
BR0313545A BR0313545A (pt) 2005-07-12
BRPI0313545B1 BRPI0313545B1 (pt) 2021-07-27
BR0313545B1 true BR0313545B1 (pt) 2021-07-27

Family

ID=31725448

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0313545A BR0313545B1 (pt) 2002-08-09 2003-08-07 processos para a preparação de 4-[[4-[[4-(2-cianoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrila

Country Status (27)

Country Link
US (3) US7399856B2 (pt)
EP (1) EP1529032B1 (pt)
JP (1) JP4822707B2 (pt)
KR (2) KR101140785B1 (pt)
CN (4) CN101481356B (pt)
AR (1) AR040964A1 (pt)
AU (1) AU2003266413B2 (pt)
BR (1) BR0313545B1 (pt)
CA (2) CA2686429C (pt)
CL (1) CL2010000284A1 (pt)
CY (1) CY1114428T1 (pt)
DK (1) DK1529032T3 (pt)
EA (1) EA007953B1 (pt)
ES (1) ES2422196T3 (pt)
HK (4) HK1129671A1 (pt)
HR (1) HRP20050104B1 (pt)
IL (1) IL166710A (pt)
IS (1) IS2980B (pt)
MX (1) MXPA05001541A (pt)
MY (1) MY144894A (pt)
NO (1) NO330013B1 (pt)
NZ (1) NZ538611A (pt)
PL (1) PL208533B1 (pt)
PT (1) PT1529032E (pt)
SI (1) SI1529032T1 (pt)
TW (1) TWI314146B (pt)
WO (1) WO2004016581A1 (pt)

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Also Published As

Publication number Publication date
CY1114428T1 (el) 2016-08-31
PL208533B1 (pl) 2011-05-31
IL166710A (en) 2010-12-30
HK1129671A1 (en) 2009-12-04
ES2422196T3 (es) 2013-09-09
US20060167253A1 (en) 2006-07-27
JP4822707B2 (ja) 2011-11-24
NZ538611A (en) 2007-03-30
HRP20050104B1 (hr) 2014-02-14
SI1529032T1 (sl) 2013-08-30
NO20050524L (no) 2005-02-01
HK1081527A1 (en) 2006-05-19
EA007953B1 (ru) 2007-02-27
IS2980B (is) 2017-09-15
EP1529032B1 (en) 2013-04-24
KR20050040906A (ko) 2005-05-03
CN1681774A (zh) 2005-10-12
JP2005537303A (ja) 2005-12-08
KR101140785B1 (ko) 2012-05-03
US7399856B2 (en) 2008-07-15
US7705148B2 (en) 2010-04-27
CN102702111A (zh) 2012-10-03
CA2493794C (en) 2010-05-25
CL2010000284A1 (es) 2010-08-20
TWI314146B (en) 2009-09-01
KR101086678B1 (ko) 2011-11-25
US20070191407A1 (en) 2007-08-16
CN101481356A (zh) 2009-07-15
US20080167464A1 (en) 2008-07-10
CN101481356B (zh) 2012-07-11
NO330013B1 (no) 2011-02-07
CA2686429C (en) 2010-11-16
CN102702111B (zh) 2014-12-17
HK1161869A1 (en) 2012-08-10
HK1174922A1 (en) 2013-06-21
PL373679A1 (en) 2005-09-05
EA200500325A1 (ru) 2005-06-30
PT1529032E (pt) 2013-07-11
IL166710A0 (en) 2006-01-15
KR20100127889A (ko) 2010-12-06
HRP20050104A2 (en) 2006-03-31
DK1529032T3 (da) 2013-07-08
TW200418810A (en) 2004-10-01
MXPA05001541A (es) 2005-04-19
AU2003266413B2 (en) 2009-04-02
EP1529032A1 (en) 2005-05-11
US7563922B2 (en) 2009-07-21
BR0313545A (pt) 2005-07-12
CA2493794A1 (en) 2004-02-26
CN102225902A (zh) 2011-10-26
AU2003266413A1 (en) 2004-03-03
CA2686429A1 (en) 2004-02-26
AR040964A1 (es) 2005-04-27
CN102225902B (zh) 2013-04-24
MY144894A (en) 2011-11-30
WO2004016581A1 (en) 2004-02-26
IS7621A (is) 2004-12-29
CN100554245C (zh) 2009-10-28

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