BG64624B1 - (бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства - Google Patents

(бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства Download PDF

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Publication number
BG64624B1
BG64624B1 BG104372A BG10437200A BG64624B1 BG 64624 B1 BG64624 B1 BG 64624B1 BG 104372 A BG104372 A BG 104372A BG 10437200 A BG10437200 A BG 10437200A BG 64624 B1 BG64624 B1 BG 64624B1
Authority
BG
Bulgaria
Prior art keywords
formula
alkyl
hydrogen
radical
compounds
Prior art date
Application number
BG104372A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104372A (en
Inventor
Piet Wigerinck
Wim Verschueren
Marc SCHROVEN
Bruyn Marcel De
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG104372A publication Critical patent/BG104372A/xx
Publication of BG64624B1 publication Critical patent/BG64624B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BG104372A 1997-12-05 2000-04-24 (бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства BG64624B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97203808 1997-12-05

Publications (2)

Publication Number Publication Date
BG104372A BG104372A (en) 2000-12-29
BG64624B1 true BG64624B1 (bg) 2005-09-30

Family

ID=8229014

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104372A BG64624B1 (bg) 1997-12-05 2000-04-24 (бензодиоксанови, бензофуранови или бензопиранови) производни, притежаващи фундусни релаксиращи свойства

Country Status (32)

Country Link
US (4) US6133277A (pl)
EP (1) EP1036073B8 (pl)
JP (1) JP2001525407A (pl)
KR (1) KR100591605B1 (pl)
CN (1) CN1155597C (pl)
AR (1) AR017195A1 (pl)
AT (1) ATE334125T1 (pl)
AU (1) AU748669B2 (pl)
BG (1) BG64624B1 (pl)
BR (1) BR9814256A (pl)
CA (1) CA2311669C (pl)
CO (1) CO5011114A1 (pl)
CZ (1) CZ297895B6 (pl)
DE (1) DE69835372T2 (pl)
EA (1) EA003365B1 (pl)
EE (1) EE04438B1 (pl)
ES (1) ES2270541T3 (pl)
HK (1) HK1028400A1 (pl)
HR (1) HRP20000340B1 (pl)
HU (1) HU224813B1 (pl)
ID (1) ID24616A (pl)
IL (1) IL136529A (pl)
MY (1) MY124586A (pl)
NO (1) NO320727B1 (pl)
NZ (1) NZ503603A (pl)
PL (1) PL191144B1 (pl)
SK (1) SK286268B6 (pl)
TR (1) TR200001542T2 (pl)
TW (1) TW577886B (pl)
UA (1) UA70308C2 (pl)
WO (1) WO1999029687A1 (pl)
ZA (1) ZA9811081B (pl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6133277A (en) * 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties
CZ20014167A3 (cs) * 1999-06-02 2002-06-12 Janssen Pharmaceutica N. V. Pyrrolidinylem, piperidinylem nebo homopiperidinylem substituované deriváty benzodioxanu, benzofuranu nebo benzopyranu
HUP0201404A3 (en) * 1999-06-02 2005-02-28 Janssen Pharmaceutica Nv Aminoalkyl substituted benzodioxan, benzofuran or benzopyran derivatives, pharmaceutical compositions containing them and their use and process for their preparations
JO2352B1 (en) 2000-06-22 2006-12-12 جانسين فارماسيوتيكا ان. في Compounds for the treatment of non-adaptation of the bottom of the uterus
JO2654B1 (en) * 2000-09-04 2012-06-17 شركة جانسين فارماسوتيكا ان. في Multiple aryl caroxa amides are useful as lipid - lowering agents
JO2409B1 (en) 2000-11-21 2007-06-17 شركة جانسين فارماسوتيكا ان. في Second-phenyl carboxy amides are useful as lipid-lowering agents
US6688079B2 (en) 2001-04-18 2004-02-10 Kraft Foods Holdings, Inc. Method for manufacturing flexible packages having slide closures
JPWO2003040382A1 (ja) * 2001-11-09 2005-03-03 株式会社カネカ 光学活性クロマン誘導体の製造法および中間体
ES2199086B1 (es) 2002-07-31 2005-06-01 Cepa Schwarz Pharma Sl Nuevos derivados de cicloalcanodionas, procedimiento para su preparacion y sus aplicaciones farmacologicas.
US7071821B2 (en) * 2003-05-14 2006-07-04 Bellsouth Intellectual Property Corporation Method and system for alerting a person to a situation
ITTO20030140U1 (it) * 2003-09-16 2005-03-17 Interfila Srl Matita cosmetica
US7470798B2 (en) 2003-09-19 2008-12-30 Edison Pharmaceuticals, Inc. 7,8-bicycloalkyl-chroman derivatives
EP1687277B1 (en) 2003-11-20 2018-04-04 Janssen Pharmaceutica NV 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
MXPA06005686A (es) 2003-11-20 2006-08-17 Janssen Pharmaceutica Nv 2-quinolinonas y 2-quinoxalinonas 7-fenilaquilo sustituidas como inhibidores de la poli(adp-ribosa)polimerasa.
ES2238015B1 (es) * 2004-01-30 2006-11-01 Cepa Schwarz Pharma, S.L. Derivados de cicloalcanodionas con actividad neuroprotectora.
US7803795B2 (en) 2004-06-30 2010-09-28 Janssen Pharmaceutica N.V. Phthalazine derivatives as parp inhibitors
UA86237C2 (uk) 2004-06-30 2009-04-10 Янссен Фармацевтика Н.В. Похідні заміщеного 2-алкілхіназолінону як інгібітори parp
CN1980913B (zh) 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
DE102004032277A1 (de) * 2004-07-02 2006-01-19 Basell Polyolefine Gmbh Verfahren zur racemoselektiven Synthese von ansa-Metallocenen
CA2597616A1 (en) 2005-02-17 2006-08-24 Wyeth Cycloalkylfused indole, benzothiophene, benzofuran and indene derivatives
TW200716595A (en) * 2005-04-22 2007-05-01 Wyeth Corp Chromane and chromene derivatives and uses thereof
WO2008015538A2 (en) * 2006-07-31 2008-02-07 Schwarz Pharma S.L. Use of diaza- and thiaza-cycloalkanediones for preventing and/or treating pain and /or migraine
US20080033050A1 (en) 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US8503431B2 (en) * 2006-08-25 2013-08-06 Wireless Wonders Ltd. Mobile phone related indirect communication system and method
EP2134691B1 (en) 2007-03-08 2012-01-25 Janssen Pharmaceutica, N.V. Quinolinone derivatives as parp and tank inhibitors
JP5017703B2 (ja) * 2007-05-16 2012-09-05 住友ゴム工業株式会社 ビードエイペックスおよびタイヤ
US8404713B2 (en) 2007-10-26 2013-03-26 Janssen Pharmaceutica Nv Quinolinone derivatives as PARP inhibitors
AU2009228945B2 (en) 2008-03-27 2013-05-02 Janssen Pharmaceutica Nv Quinazolinone derivatives as tubulin polymerization inhibitors
CN101981013B (zh) 2008-03-27 2013-05-29 詹森药业有限公司 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
HUE046172T2 (hu) 2012-02-24 2020-02-28 Lupin Ltd Szubsztituált krománvegyületek mint kalcium-szenzor receptor modulátorok
US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
DE102013207163B4 (de) 2013-04-19 2022-09-22 Adidas Ag Schuhoberteil
DE102014220087B4 (de) 2014-10-02 2016-05-12 Adidas Ag Flachgestricktes Schuhoberteil für Sportschuhe
US20190290656A1 (en) 2015-12-30 2019-09-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Pt(iv) prodrugs

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2400094A1 (de) * 1973-01-04 1974-07-18 Janssen Pharmaceutica Nv 1-geschweifte klammer auf 1- eckige klammer auf 2-(1,4-benzodioxan-2-yl) -2-hydroxyaethyl eckige klammer zu -4-piperidyl geschweifte klammer zu -2-benzimidazolinone, verfahren zu iherer herstellung und arzneimittel
US5137901A (en) * 1988-07-28 1992-08-11 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
EP0546388A1 (de) * 1991-12-09 1993-06-16 Bayer Ag Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems
WO1993017017A1 (en) * 1992-02-27 1993-09-02 Janssen Pharmaceutica N.V. [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
WO1995005383A1 (en) * 1993-08-19 1995-02-23 Janssen Pharmaceutica N.V. Vasocontrictive dihydrobenzopyran derivatives
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
WO1997028157A1 (fr) * 1996-02-01 1997-08-07 Pierre Fabre Medicament Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US3929801A (en) * 1973-11-20 1975-12-30 Janssen Pharmaceutica Nv 2-Benzimidazolinones
GB1599296A (en) * 1977-07-06 1981-09-30 Brewster D L Ice making machine
GR71865B (pl) * 1978-03-20 1983-07-07 Ciba Geigy
DE2852945A1 (de) * 1978-12-07 1980-06-26 Boehringer Sohn Ingelheim Benzodioxanyl-hydroxyaethylpiperidyl- imidazolidinone, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4329348A (en) * 1979-02-26 1982-05-11 Ciba-Geigy Corporation N-Oxacyclic-alkylpiperidines as psychostimulants
US4239348A (en) * 1979-11-30 1980-12-16 Hughes Aircraft Company High resolution AC silicon MOS light-valve substrate
DE4319038A1 (de) * 1993-06-08 1994-12-15 Bayer Ag Verwendung von teilweise bekannten substituierten Chromanen als Arzneimittel, neue Wirkstoffe und Verfahren zu ihrer Herstellung
US5696653A (en) * 1996-12-13 1997-12-09 Phase Metrics Tooling for holding a head gimbal assembly
US6133277A (en) 1997-12-05 2000-10-17 Janssen Pharmaceutica N.V. (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2400094A1 (de) * 1973-01-04 1974-07-18 Janssen Pharmaceutica Nv 1-geschweifte klammer auf 1- eckige klammer auf 2-(1,4-benzodioxan-2-yl) -2-hydroxyaethyl eckige klammer zu -4-piperidyl geschweifte klammer zu -2-benzimidazolinone, verfahren zu iherer herstellung und arzneimittel
US5137901A (en) * 1988-07-28 1992-08-11 Bayer Aktiengesellschaft Substituted aminomethyltetralins and their heterocyclic analogues
EP0546388A1 (de) * 1991-12-09 1993-06-16 Bayer Ag Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems
WO1993017017A1 (en) * 1992-02-27 1993-09-02 Janssen Pharmaceutica N.V. [(benzodioxan, benzofuran or benzopyran)-alkylamino] alkyl substituted guanidines as selective vascoconstrictors
WO1995005383A1 (en) * 1993-08-19 1995-02-23 Janssen Pharmaceutica N.V. Vasocontrictive dihydrobenzopyran derivatives
US5541199A (en) * 1995-06-02 1996-07-30 American Home Products Corporation Chroman-2-ylmethylamino derivatives
WO1997028157A1 (fr) * 1996-02-01 1997-08-07 Pierre Fabre Medicament Nouveaux derives de la piperidine substitues en position 4 par un groupe imidazolidin-2-on-1-yl-ethyl, tetrahydropyrimidin-2-on-1-yl-ethyl, et 1,3-dia-zepin-2-on-1-yl-ethyl, et leurs applications comme antagonistes des recepteurs alpha-2 adrenergiques

Also Published As

Publication number Publication date
BR9814256A (pt) 2000-10-03
PL341007A1 (en) 2001-03-12
NO20002074D0 (no) 2000-04-19
TW577886B (en) 2004-03-01
TR200001542T2 (tr) 2001-01-22
EA003365B1 (ru) 2003-04-24
CA2311669A1 (en) 1999-06-17
HU224813B1 (en) 2006-02-28
US20030083365A1 (en) 2003-05-01
BG104372A (en) 2000-12-29
WO1999029687A8 (en) 2000-04-13
IL136529A (en) 2003-03-12
ES2270541T3 (es) 2007-04-01
EP1036073A1 (en) 2000-09-20
IL136529A0 (en) 2001-06-14
AR017195A1 (es) 2001-08-22
NO20002074L (no) 2000-06-02
KR20010031010A (ko) 2001-04-16
ATE334125T1 (de) 2006-08-15
KR100591605B1 (ko) 2006-06-20
DE69835372T2 (de) 2007-08-09
HRP20000340A2 (en) 2001-04-30
EP1036073B1 (en) 2006-07-26
US6495547B1 (en) 2002-12-17
SK8032000A3 (en) 2001-02-12
AU748669B2 (en) 2002-06-06
ID24616A (id) 2000-07-27
SK286268B6 (sk) 2008-06-06
AU2412799A (en) 1999-06-28
ZA9811081B (en) 2000-06-22
US20030149093A1 (en) 2003-08-07
CA2311669C (en) 2010-04-27
HUP0004492A2 (hu) 2002-03-28
US6747045B2 (en) 2004-06-08
UA70308C2 (uk) 2004-10-15
NO320727B1 (no) 2006-01-23
CZ20002018A3 (cs) 2000-10-11
EP1036073B8 (en) 2006-11-15
CN1155597C (zh) 2004-06-30
EA200000616A1 (ru) 2000-12-25
WO1999029687A1 (en) 1999-06-17
HK1028400A1 (en) 2001-02-16
EE200000328A (et) 2001-08-15
DE69835372D1 (de) 2006-09-07
CZ297895B6 (cs) 2007-04-25
EE04438B1 (et) 2005-02-15
CO5011114A1 (es) 2001-02-28
PL191144B1 (pl) 2006-03-31
JP2001525407A (ja) 2001-12-11
CN1280577A (zh) 2001-01-17
HUP0004492A3 (en) 2002-04-29
NZ503603A (en) 2001-10-26
MY124586A (en) 2006-06-30
US6852714B2 (en) 2005-02-08
US6133277A (en) 2000-10-17
HRP20000340B1 (en) 2008-12-31

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