BG64597B1 - Метод за синтез на хлоропуринови междинни съединения - Google Patents

Метод за синтез на хлоропуринови междинни съединения Download PDF

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Publication number
BG64597B1
BG64597B1 BG104352A BG10435200A BG64597B1 BG 64597 B1 BG64597 B1 BG 64597B1 BG 104352 A BG104352 A BG 104352A BG 10435200 A BG10435200 A BG 10435200A BG 64597 B1 BG64597 B1 BG 64597B1
Authority
BG
Bulgaria
Prior art keywords
formula
compound
acid
pms
carried out
Prior art date
Application number
BG104352A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104352A (en
Inventor
Martin Jones
Christopher Wallis
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of BG104352A publication Critical patent/BG104352A/xx
Publication of BG64597B1 publication Critical patent/BG64597B1/bg

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/40Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BG104352A 1997-10-14 2000-04-18 Метод за синтез на хлоропуринови междинни съединения BG64597B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9721780.6A GB9721780D0 (en) 1997-10-14 1997-10-14 Process for the synthesis of chloropurine intermediates

Publications (2)

Publication Number Publication Date
BG104352A BG104352A (en) 2001-02-28
BG64597B1 true BG64597B1 (bg) 2005-08-31

Family

ID=10820547

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104352A BG64597B1 (bg) 1997-10-14 2000-04-18 Метод за синтез на хлоропуринови междинни съединения

Country Status (44)

Country Link
US (1) US6646125B1 (is)
EP (1) EP1023292B1 (is)
JP (1) JP4531250B2 (is)
KR (1) KR100543845B1 (is)
CN (1) CN1160354C (is)
AP (1) AP1182A (is)
AR (1) AR014921A1 (is)
AT (1) ATE249461T1 (is)
AU (1) AU738462B2 (is)
BG (1) BG64597B1 (is)
BR (1) BR9813048B1 (is)
CA (1) CA2306958C (is)
CO (1) CO4980899A1 (is)
CZ (1) CZ294482B6 (is)
DE (1) DE69818084T2 (is)
DK (1) DK1023292T3 (is)
EA (1) EA003183B1 (is)
EE (1) EE04059B1 (is)
EG (1) EG21730A (is)
ES (1) ES2205553T3 (is)
GB (1) GB9721780D0 (is)
GE (1) GEP20022679B (is)
HK (1) HK1027807A1 (is)
HR (1) HRP20000216B1 (is)
HU (1) HUP0003984A3 (is)
ID (1) ID24927A (is)
IL (1) IL135323A (is)
IN (1) IN184590B (is)
IS (1) IS2195B (is)
MA (1) MA24676A1 (is)
MY (1) MY127470A (is)
NO (1) NO325030B1 (is)
NZ (1) NZ503679A (is)
OA (1) OA11370A (is)
PE (1) PE121899A1 (is)
PL (1) PL188477B1 (is)
PT (1) PT1023292E (is)
RS (1) RS49710B (is)
SK (1) SK285331B6 (is)
TR (1) TR200000976T2 (is)
TW (1) TW436488B (is)
UA (1) UA54550C2 (is)
WO (1) WO1999019327A1 (is)
ZA (1) ZA989338B (is)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ298144B6 (cs) 1997-11-27 2007-07-04 Lonza Ag Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu
FR2849030A1 (fr) * 2002-12-20 2004-06-25 Isochem Sa Procede de preparation des n-(2-amino-4, 6-dihalogenopyrimidin-5-yl) formamides
GB0320738D0 (en) 2003-09-04 2003-10-08 Glaxo Group Ltd Novel process
CN100465174C (zh) * 2006-06-13 2009-03-04 中国科学院上海有机化学研究所 制备光学纯阿巴卡韦的方法
KR101109476B1 (ko) * 2009-06-26 2012-01-31 현대제철 주식회사 실린더 교체용 지그장치
KR20170078868A (ko) 2010-01-27 2017-07-07 비이브 헬쓰케어 컴퍼니 항바이러스 치료
CN104672239A (zh) * 2013-11-26 2015-06-03 上海迪赛诺化学制药有限公司 一种采用一锅法制备阿巴卡韦式v中间体的工艺

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217320A (en) * 1988-01-20 1989-10-25 Univ Minnesota Dideoxydidehydrocarbocyclic nucleosides
EP0434450A2 (en) * 1989-12-22 1991-06-26 The Wellcome Foundation Limited Therapeutic nucleosides
WO1991015490A1 (en) * 1990-04-06 1991-10-17 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
WO1995021161A1 (en) * 1994-02-04 1995-08-10 The Wellcome Foundation Limited Chloropyrimide intermediates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4268672A (en) * 1977-02-09 1981-05-19 The Regents Of The University Of Minnesota Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ コムパニ− 神経弛緩剤、1‐フルオロフェニルブチル‐4‐(5‐ハロ‐2‐ピリミジニル)ピペラジン誘導体
US5631370A (en) * 1988-01-20 1997-05-20 Regents Of The University Of Minnesota Optically-active isomers of dideoxycarbocyclic nucleosides
NZ229453A (en) * 1988-06-10 1991-08-27 Univ Minnesota & Southern Rese A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
US5329008A (en) * 1993-04-07 1994-07-12 Glaxo Inc. Synthesis of a 3,4-dihydroxy-1-cyclopentanylpurinone
SK284810B6 (sk) * 1997-05-13 2005-12-01 Lonza Ag Spôsob výroby (1S,4R)- alebo (1R,4S)-4-(2-amino-6-chlór-9-H- purín-9-yl)-2-cyklopentén-1-metanolu

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2217320A (en) * 1988-01-20 1989-10-25 Univ Minnesota Dideoxydidehydrocarbocyclic nucleosides
EP0434450A2 (en) * 1989-12-22 1991-06-26 The Wellcome Foundation Limited Therapeutic nucleosides
WO1991015490A1 (en) * 1990-04-06 1991-10-17 Glaxo Inc. Synthesis of purine substituted cyclopentene derivatives
WO1995021161A1 (en) * 1994-02-04 1995-08-10 The Wellcome Foundation Limited Chloropyrimide intermediates

Also Published As

Publication number Publication date
AR014921A1 (es) 2001-04-11
MY127470A (en) 2006-12-29
CA2306958C (en) 2007-09-04
JP2001519432A (ja) 2001-10-23
EE04059B1 (et) 2003-06-16
TR200000976T2 (tr) 2000-11-21
AU9547698A (en) 1999-05-03
HUP0003984A2 (hu) 2001-04-28
KR20010015744A (ko) 2001-02-26
NO325030B1 (no) 2008-01-21
HRP20000216B1 (en) 2002-08-31
NZ503679A (en) 2002-09-27
PL188477B1 (pl) 2005-02-28
UA54550C2 (uk) 2003-03-17
NO20001896L (no) 2000-06-13
EA200000318A1 (ru) 2000-12-25
RS49710B (sr) 2007-12-31
DK1023292T3 (da) 2003-11-10
MA24676A1 (fr) 1999-07-01
EP1023292B1 (en) 2003-09-10
CZ20001367A3 (cs) 2000-10-11
DE69818084D1 (de) 2003-10-16
IL135323A0 (en) 2001-05-20
SK5362000A3 (en) 2001-03-12
EA003183B1 (ru) 2003-02-27
CA2306958A1 (en) 1999-04-22
IN184590B (is) 2000-09-09
WO1999019327A1 (en) 1999-04-22
DE69818084T2 (de) 2004-07-15
CZ294482B6 (cs) 2005-01-12
IS5423A (is) 2000-03-28
KR100543845B1 (ko) 2006-01-23
YU20200A (sh) 2003-02-28
BG104352A (en) 2001-02-28
PE121899A1 (es) 1999-12-20
HUP0003984A3 (en) 2002-12-28
AP2000001790A0 (en) 2000-06-30
JP4531250B2 (ja) 2010-08-25
US6646125B1 (en) 2003-11-11
ID24927A (id) 2000-08-31
OA11370A (en) 2004-01-27
HRP20000216A2 (en) 2000-08-31
EG21730A (en) 2002-02-27
IS2195B (is) 2007-01-15
SK285331B6 (sk) 2006-11-03
CO4980899A1 (es) 2000-11-27
CN1160354C (zh) 2004-08-04
BR9813048A (pt) 2000-08-15
EP1023292A1 (en) 2000-08-02
NO20001896D0 (no) 2000-04-12
CN1281457A (zh) 2001-01-24
HK1027807A1 (en) 2001-01-23
PT1023292E (pt) 2004-02-27
IL135323A (en) 2004-07-25
BR9813048B1 (pt) 2010-07-13
ES2205553T3 (es) 2004-05-01
TW436488B (en) 2001-05-28
GEP20022679B (en) 2002-04-25
ATE249461T1 (de) 2003-09-15
PL339904A1 (en) 2001-01-15
GB9721780D0 (en) 1997-12-10
ZA989338B (en) 2000-04-13
EE200000162A (et) 2001-04-16
AU738462B2 (en) 2001-09-20
AP1182A (en) 2003-06-18

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