BG64473B1 - Използване на сибутраминови аналози за предотвратяване развитието на диабет - Google Patents

Използване на сибутраминови аналози за предотвратяване развитието на диабет Download PDF

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Publication number
BG64473B1
BG64473B1 BG103277A BG10327799A BG64473B1 BG 64473 B1 BG64473 B1 BG 64473B1 BG 103277 A BG103277 A BG 103277A BG 10327799 A BG10327799 A BG 10327799A BG 64473 B1 BG64473 B1 BG 64473B1
Authority
BG
Bulgaria
Prior art keywords
insulin
formula
compound
dependent diabetes
diabetes mellitus
Prior art date
Application number
BG103277A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103277A (en
Inventor
Clifford Bailey
Robert Jones
Helen Jackson
Original Assignee
Knoll Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll Aktiengesellschaft filed Critical Knoll Aktiengesellschaft
Publication of BG103277A publication Critical patent/BG103277A/xx
Publication of BG64473B1 publication Critical patent/BG64473B1/bg

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Electrotherapy Devices (AREA)
BG103277A 1996-09-21 1999-03-24 Използване на сибутраминови аналози за предотвратяване развитието на диабет BG64473B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9619757.9A GB9619757D0 (en) 1996-09-21 1996-09-21 Chemical process

Publications (2)

Publication Number Publication Date
BG103277A BG103277A (en) 2000-01-31
BG64473B1 true BG64473B1 (bg) 2005-04-30

Family

ID=10800326

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103277A BG64473B1 (bg) 1996-09-21 1999-03-24 Използване на сибутраминови аналози за предотвратяване развитието на диабет

Country Status (26)

Country Link
US (3) US6174925B1 (pt)
EP (1) EP0927028A1 (pt)
JP (1) JP2001503737A (pt)
KR (1) KR20000048501A (pt)
CN (1) CN1237905A (pt)
AU (1) AU724488B2 (pt)
BG (1) BG64473B1 (pt)
BR (1) BR9711517A (pt)
CA (1) CA2266401C (pt)
CZ (1) CZ93699A3 (pt)
GB (1) GB9619757D0 (pt)
HR (1) HRP970505A2 (pt)
HU (1) HUP9904026A3 (pt)
ID (1) ID18320A (pt)
IL (1) IL128850A (pt)
MY (1) MY116150A (pt)
NO (1) NO991358D0 (pt)
NZ (1) NZ334580A (pt)
PL (1) PL332305A1 (pt)
RU (1) RU2245709C2 (pt)
SK (1) SK31999A3 (pt)
TR (1) TR199900618T2 (pt)
TW (1) TW580385B (pt)
UA (1) UA64726C2 (pt)
WO (1) WO1998011884A1 (pt)
ZA (1) ZA978450B (pt)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process
JP2000080047A (ja) * 1998-06-30 2000-03-21 Takeda Chem Ind Ltd 医 薬
DE69929996T2 (de) * 1998-06-30 2006-11-16 Takeda Pharmaceutical Co. Ltd. Pharmazeutisches mittel zur behandlung von diabetes
US6331571B1 (en) 1998-08-24 2001-12-18 Sepracor, Inc. Methods of treating and preventing attention deficit disorders
US6339106B1 (en) 1999-08-11 2002-01-15 Sepracor, Inc. Methods and compositions for the treatment and prevention of sexual dysfunction
US6476078B2 (en) * 1999-08-11 2002-11-05 Sepracor, Inc. Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction
US6974838B2 (en) 1998-08-24 2005-12-13 Sepracor Inc. Methods of treating or preventing pain using sibutramine metabolites
DZ2937A1 (fr) * 1998-11-12 2004-03-15 Smithkline Beecham Plc Compositions nouvelles de sensibilidants à l'insuline.
AU768994B2 (en) * 1998-11-12 2004-01-15 Smithkline Beecham Plc Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent
US20040102486A1 (en) * 1998-11-12 2004-05-27 Smithkline Beecham Corporation Novel method of treatment
US6696495B2 (en) 1998-12-02 2004-02-24 Snowden Pharmaceuticals, Llc Treatment of disorders secondary to organic impairments
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
US6552087B1 (en) 1999-03-19 2003-04-22 Abbott Gmbh & Co. Kg Therapeutic agent comprising (+)-sibutramine
US6723717B1 (en) 1999-06-01 2004-04-20 The University Of Texas Southwestern Medical Center Sulfur-containing thyroxane derivatives and their use as hair growth promotors
US6646005B1 (en) 1999-06-01 2003-11-11 The University Of Texas Southwestern Medical Center Method of treating hair loss using sulfonyl thyromimetic compounds
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
US6399826B1 (en) 1999-08-11 2002-06-04 Sepracor Inc. Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
WO2002083631A1 (en) * 2001-04-13 2002-10-24 Sepracor Inc. Methods of preparing didesmethylsibutramine and other sibutramine derivatives
WO2003105809A1 (en) 2002-06-17 2003-12-24 Themis Laboratories Private Limited Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them
BR0315084A (pt) * 2002-10-05 2005-08-16 Hanmi Pharm Ind Co Ltd Composição farmacêutica compreendendo hemiidrato cristalino de metanossulfonato de sibutramina
US20050131074A1 (en) * 2003-08-04 2005-06-16 Beckman Kristen M. Methods for treating metabolic syndrome
PE20050335A1 (es) * 2003-08-07 2005-06-01 Sb Pharmco Inc Forma de dosificacion oral que comprende 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona y procedimiento para la preparacion
GB0318824D0 (en) * 2003-08-11 2003-09-10 Glaxo Group Ltd Novel composition
NZ546337A (en) 2003-10-31 2009-03-31 Takeda Pharmaceutical Solid preparation comprising an insulin sensitizer such as pioglitazone hydrochloride, an insulin secretagogue such as glimepiride and a polyoxyethylene sorbitan fatty acid ester such as Polysorbate 80
KR100627687B1 (ko) * 2005-04-20 2006-09-25 주식회사 씨티씨바이오 시부트라민 유리염기 함유 조성물 및 이의 제조방법
RU2430913C2 (ru) * 2006-01-06 2011-10-10 Сепракор Инк. Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина
JP2010503709A (ja) 2006-09-15 2010-02-04 レビバ ファーマシューティカルズ，インコーポレーテッド シクロアルキルメチルアミンの合成、使用方法および組成物
KR100812538B1 (ko) * 2006-10-23 2008-03-11 한올제약주식회사 약물 제어방출형 메트포르민-글리메피리드 복합제제
BRPI0716002A2 (pt) * 2006-11-22 2013-07-30 Sk Chemicals Co Ltd complexo de inclusço, processo de preparaÇço de um complexo de inclusço e composiÇço de tratamento e prevenÇço de hipocondria e obesidade
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
AU2008232709C1 (en) 2007-03-28 2015-01-15 President And Fellows Of Harvard College Stitched polypeptides
WO2012003501A2 (en) 2010-07-02 2012-01-05 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TWI643868B (zh) 2011-10-18 2018-12-11 艾利倫治療公司 擬肽巨環化合物
US9238625B2 (en) 2011-12-30 2016-01-19 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using phenylcycloalkylmethylamine derivatives
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
MX2017011834A (es) 2015-03-20 2018-04-11 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098602A (en) * 1981-04-06 1982-11-24 Boots Co Plc Therapeutic agents
EP0230742A1 (en) * 1985-12-17 1987-08-05 The Boots Company PLC N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate and pharmaceutical compositions containing it
EP0282206A1 (en) * 1987-02-28 1988-09-14 The Boots Company PLC Arylcyclobutylalkylamine-derivative for the treatment of Parkinson's disease
US4939175A (en) * 1988-03-31 1990-07-03 The Boots Co. Plc Use of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
EP0397831A1 (en) * 1988-11-29 1990-11-22 Boots Co Plc TREATMENT OF OBESITAS.
WO1995020949A1 (en) * 1994-02-03 1995-08-10 Boots Pharmaceuticals, Inc. Improving glucose tolerance

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995010292A1 (en) 1993-10-14 1995-04-20 Biomedica California, Inc. Diabetes treatment and prophylaxis
GB9619757D0 (en) * 1996-09-21 1996-11-06 Knoll Ag Chemical process

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2098602A (en) * 1981-04-06 1982-11-24 Boots Co Plc Therapeutic agents
EP0230742A1 (en) * 1985-12-17 1987-08-05 The Boots Company PLC N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate and pharmaceutical compositions containing it
EP0282206A1 (en) * 1987-02-28 1988-09-14 The Boots Company PLC Arylcyclobutylalkylamine-derivative for the treatment of Parkinson's disease
US4939175A (en) * 1988-03-31 1990-07-03 The Boots Co. Plc Use of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine
EP0397831A1 (en) * 1988-11-29 1990-11-22 Boots Co Plc TREATMENT OF OBESITAS.
WO1995020949A1 (en) * 1994-02-03 1995-08-10 Boots Pharmaceuticals, Inc. Improving glucose tolerance

Also Published As

Publication number Publication date
ZA978450B (en) 1999-03-19
PL332305A1 (en) 1999-08-30
RU2245709C2 (ru) 2005-02-10
ID18320A (id) 1998-03-26
US6174925B1 (en) 2001-01-16
KR20000048501A (ko) 2000-07-25
AU724488B2 (en) 2000-09-21
TR199900618T2 (xx) 1999-06-21
UA64726C2 (uk) 2004-03-15
NZ334580A (en) 2000-09-29
WO1998011884A1 (en) 1998-03-26
NO991358L (no) 1999-03-19
TW580385B (en) 2004-03-21
IL128850A (en) 2003-07-31
CZ93699A3 (cs) 1999-08-11
CA2266401A1 (en) 1998-03-26
BG103277A (en) 2000-01-31
AU4774097A (en) 1998-04-14
EP0927028A1 (en) 1999-07-07
HUP9904026A3 (en) 2000-07-28
JP2001503737A (ja) 2001-03-21
IL128850A0 (en) 2000-01-31
GB9619757D0 (en) 1996-11-06
CN1237905A (zh) 1999-12-08
NO991358D0 (no) 1999-03-19
US20040077730A1 (en) 2004-04-22
MY116150A (en) 2003-11-28
HRP970505A2 (en) 1998-08-31
SK31999A3 (en) 1999-12-10
BR9711517A (pt) 1999-08-24
CA2266401C (en) 2007-01-30
HUP9904026A2 (hu) 2000-05-28
US6617360B1 (en) 2003-09-09

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