BG63945B1 - Тропанови производни, тяхното получаване и приложение - Google Patents

Тропанови производни, тяхното получаване и приложение Download PDF

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Publication number
BG63945B1
BG63945B1 BG102637A BG10263798A BG63945B1 BG 63945 B1 BG63945 B1 BG 63945B1 BG 102637 A BG102637 A BG 102637A BG 10263798 A BG10263798 A BG 10263798A BG 63945 B1 BG63945 B1 BG 63945B1
Authority
BG
Bulgaria
Prior art keywords
tropane
dichlorophenyl
chlorophenyl
ethoxymethyl
normethyl
Prior art date
Application number
BG102637A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102637A (en
Inventor
Jorgen Scheel-Krueger
Peter Moldt
Frank Waetjen
Original Assignee
Neurosearch A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch A/S filed Critical Neurosearch A/S
Publication of BG102637A publication Critical patent/BG102637A/xx
Publication of BG63945B1 publication Critical patent/BG63945B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
BG102637A 1996-02-22 1998-07-15 Тропанови производни, тяхното получаване и приложение BG63945B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK19496 1996-02-22
PCT/EP1997/000850 WO1997030997A1 (en) 1996-02-22 1997-02-21 Tropane-derivatives, their preparation and use

Publications (2)

Publication Number Publication Date
BG102637A BG102637A (en) 1999-06-30
BG63945B1 true BG63945B1 (bg) 2003-07-31

Family

ID=8090830

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102637A BG63945B1 (bg) 1996-02-22 1998-07-15 Тропанови производни, тяхното получаване и приложение

Country Status (32)

Country Link
US (3) US6288079B1 (ko)
EP (2) EP1130020A1 (ko)
JP (1) JP3238414B2 (ko)
KR (1) KR100446571B1 (ko)
CN (1) CN1077574C (ko)
AT (1) ATE203023T1 (ko)
AU (1) AU720358B2 (ko)
BG (1) BG63945B1 (ko)
BR (1) BR9707636A (ko)
CA (1) CA2244773C (ko)
CZ (1) CZ287007B6 (ko)
DE (1) DE69705608T2 (ko)
DK (1) DK0885220T3 (ko)
EE (1) EE04751B1 (ko)
ES (1) ES2159839T3 (ko)
GR (1) GR3036829T3 (ko)
HK (1) HK1018957A1 (ko)
HU (1) HU228356B1 (ko)
IL (1) IL125146A (ko)
IS (1) IS1824B (ko)
NO (1) NO318731B1 (ko)
NZ (1) NZ330886A (ko)
PL (1) PL185132B1 (ko)
PT (1) PT885220E (ko)
RU (1) RU2167876C2 (ko)
SG (1) SG99853A1 (ko)
SI (1) SI0885220T1 (ko)
SK (1) SK281813B6 (ko)
TR (1) TR199801641T2 (ko)
UA (1) UA49872C2 (ko)
WO (1) WO1997030997A1 (ko)
ZA (1) ZA971525B (ko)

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HK1018957A1 (en) 2000-01-14
NO983877L (no) 1998-08-21
WO1997030997A1 (en) 1997-08-28
RU2167876C2 (ru) 2001-05-27
AU1794097A (en) 1997-09-10
KR100446571B1 (ko) 2004-11-03
CN1077574C (zh) 2002-01-09
EP0885220A1 (en) 1998-12-23
CA2244773A1 (en) 1997-08-28
PL328503A1 (en) 1999-02-01
TR199801641T2 (xx) 1998-11-23
IS1824B (is) 2002-10-01
HU228356B1 (en) 2013-03-28
US20010018444A1 (en) 2001-08-30
EP1130020A1 (en) 2001-09-05
ES2159839T3 (es) 2001-10-16
NO318731B1 (no) 2005-05-02
BG102637A (en) 1999-06-30
HUP9901199A3 (en) 2001-02-28
SK92998A3 (en) 1998-11-04
CZ252098A3 (cs) 1998-11-11
GR3036829T3 (en) 2002-01-31
SI0885220T1 (en) 2001-12-31
CN1211982A (zh) 1999-03-24
EE9800254A (et) 1999-02-15
PT885220E (pt) 2001-11-30
US6395748B2 (en) 2002-05-28
EE04751B1 (et) 2006-12-15
AU720358B2 (en) 2000-06-01
DE69705608T2 (de) 2002-05-16
KR19990087127A (ko) 1999-12-15
IL125146A (en) 2002-03-10
NZ330886A (en) 1999-02-25
CZ287007B6 (en) 2000-08-16
IL125146A0 (en) 1999-01-26
PL185132B1 (pl) 2003-02-28
US6288079B1 (en) 2001-09-11
NO983877D0 (no) 1998-08-21
BR9707636A (pt) 1999-07-27
HUP9901199A2 (hu) 1999-08-30
JP2000504739A (ja) 2000-04-18
IS4825A (is) 1998-08-17
DE69705608D1 (de) 2001-08-16
CA2244773C (en) 2006-01-03
SG99853A1 (en) 2003-11-27
UA49872C2 (uk) 2002-10-15
US20020128284A1 (en) 2002-09-12
ZA971525B (en) 1997-10-21
SK281813B6 (sk) 2001-08-06
JP3238414B2 (ja) 2001-12-17
ATE203023T1 (de) 2001-07-15
DK0885220T3 (da) 2001-10-15
EP0885220B1 (en) 2001-07-11

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