BG63938B1 - Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие - Google Patents

Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие Download PDF

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Publication number
BG63938B1
BG63938B1 BG103219A BG10321999A BG63938B1 BG 63938 B1 BG63938 B1 BG 63938B1 BG 103219 A BG103219 A BG 103219A BG 10321999 A BG10321999 A BG 10321999A BG 63938 B1 BG63938 B1 BG 63938B1
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Bulgaria
Prior art keywords
alkyl
unbranched
branched
hydrogen
phenyl
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BG103219A
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Bulgarian (bg)
English (en)
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BG103219A (bg
Inventor
Kurt Schromm
Ralf Anderskewitz
Ernst-Otto Renth
Franz Birke
Hans Jennewein
Christopher Meade
Original Assignee
Boehringer Ingelheim Pharma Kg
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Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg
Publication of BG103219A publication Critical patent/BG103219A/xx
Publication of BG63938B1 publication Critical patent/BG63938B1/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
BG103219A 1996-09-10 1999-03-01 Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие BG63938B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19636689A DE19636689A1 (de) 1996-09-10 1996-09-10 Neue Benzamidinderivate
PCT/EP1997/004921 WO1998011062A1 (de) 1996-09-10 1997-09-09 Benzamidinderivate und ihre verwendung als arzneimittel mit ltb4-antagonistischer wirkung

Publications (2)

Publication Number Publication Date
BG103219A BG103219A (bg) 1999-10-29
BG63938B1 true BG63938B1 (bg) 2003-07-31

Family

ID=7805125

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103219A BG63938B1 (bg) 1996-09-10 1999-03-01 Бензамидинови производни и използването им като лекарствени средства с ltb4-антагонистично действие

Country Status (30)

Country Link
US (2) US6197824B1 (cs)
EP (2) EP1203764B1 (cs)
JP (2) JP4150427B2 (cs)
KR (1) KR20000036005A (cs)
CN (1) CN1104412C (cs)
AR (1) AR009741A1 (cs)
AT (2) ATE224363T1 (cs)
AU (1) AU727900B2 (cs)
BG (1) BG63938B1 (cs)
BR (1) BR9712816A (cs)
CA (1) CA2262566C (cs)
CO (1) CO4900032A1 (cs)
CZ (1) CZ297252B6 (cs)
DE (3) DE19636689A1 (cs)
DK (1) DK0929516T3 (cs)
EA (1) EA003245B1 (cs)
EE (1) EE04431B1 (cs)
ES (1) ES2184131T3 (cs)
HU (1) HUP9904367A3 (cs)
IL (1) IL128144A (cs)
NO (1) NO312239B1 (cs)
NZ (1) NZ334895A (cs)
PL (1) PL188012B1 (cs)
PT (1) PT929516E (cs)
SK (1) SK282432B6 (cs)
TR (1) TR199900501T2 (cs)
TW (1) TW378200B (cs)
UA (1) UA60315C2 (cs)
WO (1) WO1998011062A1 (cs)
ZA (1) ZA978045B (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9814983A (pt) * 1997-11-20 2000-10-03 Teijin Ltd Derivado de bifenil-amidina, pró-medicamento; inibidor de coagulação sanguìnea, e, agentes profilático e terapêutico para trombose ou êmbolo.
NZ511927A (en) 1998-12-14 2004-02-27 F Phenylglycine derivatives
DE19948428A1 (de) * 1999-10-07 2001-04-12 Boehringer Ingelheim Pharma Neuer LTB¶4¶-Antagonist, Verfahren zu dessen Herstellung und dessen Verwendung als Arzneimittel
US6291531B1 (en) * 1999-10-07 2001-09-18 Boehringer Ingelheim Pharma Kg LTB4 antagonist, processes for the preparation thereof and its use as a pharmaceutical composition
DE10052658A1 (de) * 2000-10-24 2002-05-02 Boehringer Ingelheim Pharma Neue Pyranosidderivate
US6489359B2 (en) 2000-10-24 2002-12-03 Boehringer Ingelheim Pharma Kg Sulphoxybenzamides
US6528491B2 (en) 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
DE10052333A1 (de) * 2000-10-24 2002-05-02 Boehringer Ingelheim Pharma Neue Sulfooxybenzamide
US6608054B2 (en) * 2001-03-20 2003-08-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and endothelin antagonists
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
AU4239302A (en) * 2001-06-28 2003-01-02 Pfizer Products Inc. Benzoic acid substituted benzopyrans for the treatment of atherosclerosis
US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist
EP1408943B1 (de) * 2001-07-14 2005-06-29 Boehringer Ingelheim Pharma GmbH & Co.KG Arzneimittelformulierung enthaltend einen ltb4 antagonisten und einen netzmittel
IL160208A0 (en) * 2001-08-31 2004-07-25 Neurochem Int Ltd Amidine derivatives for treating amyloidosis
DE10213350A1 (de) * 2002-03-26 2003-10-16 Boehringer Ingelheim Pharma Verwendung von LTB¶4¶Antagonisten in der Tiermedizin
US6921752B2 (en) * 2002-03-26 2005-07-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Use of LTB4 antagonists in veterinary medicine
RS20050390A (sr) * 2002-11-26 2008-04-04 Boehringer Ingelheim Pharma Gmbh. & Co.Kg., Farmaceutska kompozicija koja obuhvata ltb4 antagonist i koks-2 inhibitor ili kombinovani koks1/2 inhibitor
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
EP1773333A4 (en) * 2004-07-05 2010-04-21 Dong Wha Pharm Co Ltd COMPOSITION FOR THE PREVENTION AND TREATMENT OF ALLERGIC INFLAMMATORY DISEASES
KR20060017929A (ko) * 2004-08-04 2006-02-28 동화약품공업주식회사 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물
US8679288B2 (en) * 2008-06-09 2014-03-25 Lam Research Corporation Showerhead electrode assemblies for plasma processing apparatuses
CN106831611B (zh) * 2017-01-23 2019-06-21 北京化工大学 一种偕胺肟类化合物及其在制备抑制癌细胞增殖药的应用
CA3063334A1 (en) 2017-05-12 2019-12-05 Riken Modified class a gpcr binding compound
EP3856234A4 (en) * 2018-09-24 2022-07-06 The University of British Columbia MODULATION OF GRANZYME K ACTIVITY IN THE TREATMENT OF SKIN CONDITIONS

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
US5246965A (en) 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
WO1993016036A1 (de) * 1992-02-05 1993-08-19 Boehringer Ingelheim Kg Neue amidinderivate, ihre herstellung und verwendung als arzneimittel mit ltb4-antagonischer wirkung
DE4219158A1 (de) 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4424714A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff
DE4424713A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DE19546452A1 (de) 1995-12-13 1997-06-19 Boehringer Ingelheim Kg Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
TR199900501T2 (xx) 1999-07-21
CZ297252B6 (cs) 2006-10-11
KR20000036005A (ko) 2000-06-26
ES2184131T3 (es) 2003-04-01
PL188012B1 (pl) 2004-11-30
CN1230174A (zh) 1999-09-29
PT929516E (pt) 2003-01-31
EP1203764B1 (de) 2004-05-12
ATE266630T1 (de) 2004-05-15
CA2262566A1 (en) 1998-03-19
NO312239B1 (no) 2002-04-15
EP0929516B1 (de) 2002-09-18
TW378200B (en) 2000-01-01
EA199900279A1 (ru) 1999-08-26
CN1104412C (zh) 2003-04-02
AU727900B2 (en) 2001-01-04
BR9712816A (pt) 1999-11-23
EP0929516A1 (de) 1999-07-21
SK29699A3 (en) 2000-03-13
CO4900032A1 (es) 2000-03-27
IL128144A0 (en) 1999-11-30
ATE224363T1 (de) 2002-10-15
JP4150427B2 (ja) 2008-09-17
US6197824B1 (en) 2001-03-06
PL332136A1 (en) 1999-08-30
BG103219A (bg) 1999-10-29
UA60315C2 (uk) 2003-10-15
JP2008266333A (ja) 2008-11-06
EE04431B1 (et) 2005-02-15
NO991131L (no) 1999-03-09
US6265612B1 (en) 2001-07-24
EE9900086A (et) 1999-10-15
HUP9904367A2 (hu) 2000-05-28
JP2001504087A (ja) 2001-03-27
HK1020564A1 (en) 2000-05-12
DK0929516T3 (da) 2003-01-13
AU4383897A (en) 1998-04-02
DE59711625D1 (de) 2004-06-17
HUP9904367A3 (en) 2001-11-28
DE59708278D1 (de) 2002-10-24
CZ82299A3 (cs) 1999-09-15
JP4288299B2 (ja) 2009-07-01
WO1998011062A1 (de) 1998-03-19
NZ334895A (en) 2000-09-29
EP1203764A1 (de) 2002-05-08
IL128144A (en) 2004-07-25
ZA978045B (en) 1998-03-10
NO991131D0 (no) 1999-03-09
SK282432B6 (sk) 2002-02-05
DE19636689A1 (de) 1998-03-12
CA2262566C (en) 2006-07-11
EA003245B1 (ru) 2003-02-27
AR009741A1 (es) 2000-05-03

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