BG62136B1 - Индолови производни - Google Patents

Индолови производни Download PDF

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Publication number
BG62136B1
BG62136B1 BG99111A BG9911194A BG62136B1 BG 62136 B1 BG62136 B1 BG 62136B1 BG 99111 A BG99111 A BG 99111A BG 9911194 A BG9911194 A BG 9911194A BG 62136 B1 BG62136 B1 BG 62136B1
Authority
BG
Bulgaria
Prior art keywords
formula
ethenyl
dichloroindole
group
compound
Prior art date
Application number
BG99111A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG99111A (bg
Inventor
Alfredo Cugola
Giovanni Gavira
Simone Giacobbe
Original Assignee
Glaxo S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo S.P.A. filed Critical Glaxo S.P.A.
Publication of BG99111A publication Critical patent/BG99111A/bg
Publication of BG62136B1 publication Critical patent/BG62136B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
BG99111A 1992-04-16 1994-10-14 Индолови производни BG62136B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929208492A GB9208492D0 (en) 1992-04-16 1992-04-16 Heterocyclic compounds
PCT/EP1993/000938 WO1993021153A1 (en) 1992-04-16 1993-04-15 Indole-2-carboxylic acid derivatives

Publications (2)

Publication Number Publication Date
BG99111A BG99111A (bg) 1995-05-31
BG62136B1 true BG62136B1 (bg) 1999-03-31

Family

ID=10714220

Family Applications (1)

Application Number Title Priority Date Filing Date
BG99111A BG62136B1 (bg) 1992-04-16 1994-10-14 Индолови производни

Country Status (41)

Country Link
US (4) US5373018A (Sortimente)
EP (1) EP0568136A1 (Sortimente)
JP (2) JPH07505407A (Sortimente)
KR (1) KR100264114B1 (Sortimente)
CN (1) CN1042331C (Sortimente)
AP (1) AP480A (Sortimente)
AT (1) AT403917B (Sortimente)
AU (1) AU666927B2 (Sortimente)
BE (1) BE1006343A5 (Sortimente)
BG (1) BG62136B1 (Sortimente)
BR (1) BR1100323A (Sortimente)
CA (3) CA2094073A1 (Sortimente)
CH (1) CH685630A5 (Sortimente)
CY (1) CY2038B1 (Sortimente)
CZ (1) CZ285799B6 (Sortimente)
DK (1) DK169890B1 (Sortimente)
ES (1) ES2105924B1 (Sortimente)
FI (1) FI106198B (Sortimente)
FR (1) FR2690919B1 (Sortimente)
GB (2) GB9208492D0 (Sortimente)
GE (1) GEP19991704B (Sortimente)
GR (1) GR1001619B (Sortimente)
HK (1) HK95797A (Sortimente)
HU (2) HU217964B (Sortimente)
IL (1) IL105412A (Sortimente)
IS (1) IS3994A (Sortimente)
IT (1) IT1265325B1 (Sortimente)
LU (1) LU88248A1 (Sortimente)
MX (1) MX9302195A (Sortimente)
MY (1) MY112232A (Sortimente)
NO (1) NO301879B1 (Sortimente)
NZ (1) NZ247413A (Sortimente)
OA (1) OA10103A (Sortimente)
PL (1) PL176451B1 (Sortimente)
RO (1) RO113242B1 (Sortimente)
RU (1) RU2129544C1 (Sortimente)
SE (1) SE504336C2 (Sortimente)
SK (1) SK281941B6 (Sortimente)
TW (1) TW224457B (Sortimente)
WO (1) WO1993021153A1 (Sortimente)
ZA (1) ZA932642B (Sortimente)

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GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
AU681402B2 (en) * 1993-05-27 1997-08-28 Aventis Inc. 3-(indol-3-yl) propenoic acid derivatives and as NMDA antagonists
US5519048A (en) * 1993-05-27 1996-05-21 Merrell Pharmaceuticals Inc. 3-(indol-3-yl)-propenoic acid derivatives and pharmaceutical compositions thereof
GB9319243D0 (en) * 1993-09-17 1993-11-03 Glaxo Spa Heterocyclic compounds
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
TW280819B (Sortimente) * 1993-11-17 1996-07-11 Sumitomo Pharma
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
GB9502695D0 (en) * 1995-02-11 1995-03-29 Glaxo Spa Pharmaceutical composition
GB9504361D0 (en) * 1995-03-04 1995-04-26 Glaxo Spa Heterocyclic compounds
WO1998011892A1 (en) * 1996-09-17 1998-03-26 The Regents Of The University Of California Positive ampa receptor modulation to enhance brain neurotrophic factor expression
AU732997B2 (en) * 1996-09-30 2001-05-03 Aventis Pharmaceuticals Inc. NMDA (N-methyl-D-aspartate) antagonists
US5922752A (en) * 1997-06-11 1999-07-13 Hoechst Marion Roussell, Inc. NMDA (n-methyl-d-aspartate) antagonists
ID27825A (id) * 1998-03-26 2001-04-26 Fujisawa Pharmaceutical Co Sediaan lepas lambat
EP1306378A4 (en) * 2000-07-31 2005-02-09 Dainippon Pharmaceutical Co DRUGS AGAINST DEMENTIA CONTAINING 2-ARYL-8-OXODIHYDROPURINE DERIVATIVES AS AN ACTIVE INGREDIENT
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
WO2003049702A2 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands and their use in treatments
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
DE10306202A1 (de) * 2003-02-13 2004-08-26 Grünenthal GmbH Arzneimittel enthaltend substituierte 2-Aryl-Aminoessigsäure-Verbindungen und/oder substituierte 2-Heteroaryl-Aminoessigsäure-Verbindungen
JP2006526612A (ja) * 2003-06-05 2006-11-24 ファイザー・プロダクツ・インク ベータ−ラクタマーゼ阻害剤・プロドラッグ
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
ATE473967T1 (de) * 2003-11-26 2010-07-15 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
WO2005066135A2 (en) * 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole daao inhibitors
RU2281755C2 (ru) * 2004-04-19 2006-08-20 Пятигорская государственная фармацевтическая академия Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для ректального применения
US20060002999A1 (en) * 2004-06-17 2006-01-05 Forest Laboratories, Inc. Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
AU2006264317B2 (en) 2005-07-06 2012-02-23 Sunovion Pharmaceuticals Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
CN104276955A (zh) 2006-01-06 2015-01-14 赛诺维信制药公司 基于四氢萘酮的单胺再摄取抑制剂
NZ569630A (en) * 2006-01-06 2011-09-30 Sepracor Inc Cycloalkylamines as monoamine reuptake inhibitors
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
EP1942104A1 (en) 2006-12-20 2008-07-09 sanofi-aventis Heteroarylcyclopropanecarboxamides and their use as pharmaceuticals
MX2009007410A (es) * 2007-01-18 2009-09-09 Sepracor Inc Inhibidores de d-aminoacido oxidasa.
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
WO2008151156A1 (en) 2007-05-31 2008-12-11 Sepracor Inc. Phenyl substituted cycloalkylamines as monoamine reuptake inhibitors
WO2009151498A2 (en) * 2008-03-28 2009-12-17 Forest Laboratories Holdings Limited Memantine formulations
WO2010017418A1 (en) * 2008-08-07 2010-02-11 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
KR20110126132A (ko) * 2009-03-10 2011-11-22 산텐 세이야꾸 가부시키가이샤 4,6-디클로로-1η-인돌-2-카르복실산 유도체 또는 이의 염을 유효 성분으로서 함유하는 시신경 장애의 예방 또는 치료제
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US9737531B2 (en) 2012-07-12 2017-08-22 Glytech, Llc Composition and method for treatment of depression and psychosis in humans
USRE49340E1 (en) 2014-04-30 2022-12-20 Yufeng Jane Tseng Use of known compounds as D-amino acid oxidase inhibitors
CA3207747A1 (en) 2016-09-14 2018-03-22 Yufeng Jane Tseng Novel substituted benzimidazole derivatives as d-amino acid oxidase (daao) inhibitors
WO2018229744A1 (en) 2017-06-12 2018-12-20 Glytech Llc. Treatment of depression with nmda antagonists and d2/5ht2a or selective 5ht2a antagonists
CN112707874A (zh) * 2020-12-29 2021-04-27 广东中科药物研究有限公司 一种抗病毒化合物及其制备方法

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US3010971A (en) * 1960-08-04 1961-11-28 Smith Kline French Lab Cyclopropylamine derivatives and processes for their preparation
DK500285A (da) * 1984-11-02 1986-05-03 Glaxo Group Ltd Cephalosporinantibiotika
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
PT93943A (pt) * 1989-05-05 1991-02-08 Searle & Co Processo para a preparacao de composicoes contendo compostos indole-2-carboxilato para tratamento de perturbacoes do snc
DE69118539T2 (de) * 1990-07-16 1996-09-19 Merrell Dow Pharmaceuticals Inc., Cincinnati, Ohio Exzitatorische Aminosäureantagonisten
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity

Also Published As

Publication number Publication date
HU217964B (hu) 2000-05-28
DK169890B1 (da) 1995-03-27
WO1993021153A1 (en) 1993-10-28
HK95797A (en) 1997-08-08
GEP19991704B (en) 1999-08-05
ATA75293A (de) 1997-11-15
JPH07505407A (ja) 1995-06-15
FI944800L (fi) 1994-10-12
CH685630A5 (fr) 1995-08-31
GR1001619B (el) 1994-07-29
MX9302195A (es) 1994-03-31
IL105412A0 (en) 1993-08-18
SE504336C2 (sv) 1997-01-13
FI106198B (fi) 2000-12-15
GB2266091A (en) 1993-10-20
RO113242B1 (ro) 1998-05-29
NZ247413A (en) 1995-12-21
CN1042331C (zh) 1999-03-03
US5373018A (en) 1994-12-13
SK124194A3 (en) 1995-05-10
GB9307808D0 (en) 1993-06-02
GB9208492D0 (en) 1992-06-03
TW224457B (Sortimente) 1994-06-01
CZ254394A3 (en) 1995-07-12
BG99111A (bg) 1995-05-31
FR2690919A1 (fr) 1993-11-12
CZ285799B6 (cs) 1999-11-17
DK43193A (da) 1993-10-17
DK43193D0 (da) 1993-04-15
US5510367A (en) 1996-04-23
CA2094076A1 (en) 1993-10-17
IT1265325B1 (it) 1996-10-31
RU94045915A (ru) 1996-09-10
SE9301241L (sv) 1993-10-17
CN1085212A (zh) 1994-04-13
ITRM930236A0 (it) 1993-04-15
US5374648A (en) 1994-12-20
LU88248A1 (fr) 1994-03-01
CA2094075A1 (en) 1993-10-17
FR2690919B1 (fr) 1995-05-05
NO943913L (no) 1994-12-14
IL105412A (en) 1998-02-22
BE1006343A5 (fr) 1994-07-26
OA10103A (en) 1996-12-18
CA2094073A1 (en) 1993-10-17
AP9300524A0 (en) 1993-04-30
PL176451B1 (pl) 1999-05-31
SE9301241D0 (sv) 1993-04-15
CY2038B1 (en) 1998-04-30
KR100264114B1 (ko) 2000-11-01
AU666927B2 (en) 1996-02-29
ZA932642B (en) 1994-01-10
HU9402975D0 (en) 1995-02-28
ITRM930236A1 (it) 1994-10-15
GB2266091B (en) 1995-08-09
RU2129544C1 (ru) 1999-04-27
AP480A (en) 1996-03-22
AU3692393A (en) 1993-10-21
US5374649A (en) 1994-12-20
AT403917B (de) 1998-06-25
HUT70526A (en) 1995-10-30
EP0568136A1 (en) 1993-11-03
HU211826A9 (en) 1995-12-28
MY112232A (en) 2001-05-31
ES2105924B1 (es) 1998-07-01
IS3994A (is) 1993-10-17
NO943913D0 (no) 1994-10-14
FI944800A0 (fi) 1994-10-12
JPH0649027A (ja) 1994-02-22
NO301879B1 (no) 1997-12-22
ES2105924A1 (es) 1997-10-16
BR1100323A (pt) 2000-06-27
SK281941B6 (sk) 2001-09-11

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