BG61725B1 - Hiv-протеазни инхибитори и използването им за лечение на спин - Google Patents
Hiv-протеазни инхибитори и използването им за лечение на спин Download PDFInfo
- Publication number
- BG61725B1 BG61725B1 BG98745A BG9874594A BG61725B1 BG 61725 B1 BG61725 B1 BG 61725B1 BG 98745 A BG98745 A BG 98745A BG 9874594 A BG9874594 A BG 9874594A BG 61725 B1 BG61725 B1 BG 61725B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- substituted
- unsubstituted
- hydroxy
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78950891A | 1991-11-08 | 1991-11-08 | |
US88382592A | 1992-05-15 | 1992-05-15 | |
PCT/US1992/009444 WO1993009096A1 (en) | 1991-11-08 | 1992-11-03 | Hiv protease inhibitors useful for the treatment of aids |
Publications (2)
Publication Number | Publication Date |
---|---|
BG98745A BG98745A (bg) | 1995-03-31 |
BG61725B1 true BG61725B1 (bg) | 1998-04-30 |
Family
ID=27120923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG98745A BG61725B1 (bg) | 1991-11-08 | 1994-05-03 | Hiv-протеазни инхибитори и използването им за лечение на спин |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0541168B1 (lv) |
JP (1) | JPH0733373B2 (lv) |
KR (1) | KR100273623B1 (lv) |
AT (1) | ATE163926T1 (lv) |
AU (1) | AU659234B2 (lv) |
BG (1) | BG61725B1 (lv) |
CA (2) | CA2081970C (lv) |
CY (1) | CY2090B1 (lv) |
CZ (1) | CZ287610B6 (lv) |
DE (1) | DE69224703T2 (lv) |
DK (1) | DK0541168T3 (lv) |
ES (1) | ES2112880T3 (lv) |
FI (2) | FI106025B (lv) |
GR (1) | GR3026334T3 (lv) |
HK (1) | HK1006060A1 (lv) |
HU (1) | HU220866B1 (lv) |
IL (1) | IL103613A (lv) |
LV (1) | LV12208B (lv) |
NO (1) | NO303383B1 (lv) |
NZ (1) | NZ244986A (lv) |
PL (1) | PL171340B1 (lv) |
RO (1) | RO115726B1 (lv) |
RU (1) | RU2131416C1 (lv) |
SG (1) | SG52731A1 (lv) |
SK (1) | SK281864B6 (lv) |
UA (1) | UA45945C2 (lv) |
WO (1) | WO1993009096A1 (lv) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
WO1993018006A1 (en) | 1992-03-11 | 1993-09-16 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
KR100336699B1 (ko) | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US5783701A (en) * | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
US5430150A (en) * | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
IL110255A (en) * | 1993-07-16 | 1998-12-06 | Merck & Co Inc | Creation and resolution of 2 tert-butylcarboxamidopiprazine |
IL110752A (en) * | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
US5559158A (en) * | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
IL111584A0 (en) * | 1993-11-18 | 1995-01-24 | Merck & Co Inc | Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them |
US5455351A (en) * | 1993-12-13 | 1995-10-03 | Abbott Laboratories | Retroviral protease inhibiting piperazine compounds |
ES2174921T3 (es) * | 1993-12-15 | 2002-11-16 | Merck & Co Inc | Inhibidores de la proteasa del vih. |
US5428167A (en) * | 1994-01-14 | 1995-06-27 | American Cyanamid Company | Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds |
US5733882A (en) * | 1994-01-17 | 1998-03-31 | Smithkline Beecham Corporation | Retroviral protease inhibitors |
TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
US5728840A (en) * | 1994-03-04 | 1998-03-17 | Merck & Co., Inc. | Process for making an epoxide |
TW380137B (en) * | 1994-03-04 | 2000-01-21 | Merck & Co Inc | Process for making an epoxide |
DE69512220T2 (de) * | 1994-03-07 | 2000-03-16 | Vertex Pharma | Sulfonamidderivate als aspartylprotease-inhibitoren |
US5420353A (en) * | 1994-03-11 | 1995-05-30 | Merck & Co., Inc. | Regiospecific process to make cis-1-amino-2-alkanol from epoxide |
US5449830A (en) * | 1994-03-11 | 1995-09-12 | Marck & Co., Inc. | Regiospecific processes to make CIS-1-Amino-2-Alkanol from Diol or Halohydrin |
EP0756593B1 (de) * | 1994-04-20 | 2000-09-20 | Lonza Ag | Verfahren zur herstellung von 2-piperazincarbonsäurederivaten |
ES2181774T3 (es) * | 1994-04-22 | 2003-03-01 | Koei Chemical Co | Procedimiento para producir n-terc-butil-2-piperazinocarboxamida. |
UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
US5476874A (en) * | 1994-06-22 | 1995-12-19 | Merck & Co., Inc. | New HIV protease inhibitors |
IL114808A (en) * | 1994-08-11 | 1999-10-28 | Merck & Co Inc | Combinations of protease inhibitors for the treatment of hiv infection and aids |
GB2292146A (en) * | 1994-08-11 | 1996-02-14 | Merck & Co Inc | HIV protease inhibitors useful for the treatment of AIDS |
US5612217A (en) * | 1994-10-25 | 1997-03-18 | Merck & Co., Inc. | Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors |
WO1996012492A1 (en) * | 1994-10-25 | 1996-05-02 | Merck & Co., Inc. | Microbial synthesis of hiv protease inhibitors |
DE4446025A1 (de) * | 1994-12-22 | 1996-06-27 | Basf Ag | 2-Caroxamido-1,4,5,6-tetrahydropyrazine |
DK0805803T3 (da) * | 1995-01-23 | 2003-02-17 | Lonza Ag | Fremgangsmåde til fremstilling af 1,4,5,6-tetrahydropyrazin-2-carboxylsyreamider |
US5508404A (en) * | 1995-03-15 | 1996-04-16 | Merck & Co., Inc. | Reductive amination process |
US5618937A (en) * | 1995-03-15 | 1997-04-08 | Merck & Co., Inc. | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
US5612484A (en) * | 1995-05-18 | 1997-03-18 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
US5605819A (en) * | 1995-05-19 | 1997-02-25 | Merck & Co., Inc. | Quantitative conversion of indene to (1S,2R) indene oxide and (1S,2R)-indandiol by combination of haloperoxidase bioconversion and chemical steps |
DK0744401T3 (da) * | 1995-05-23 | 2002-03-18 | Lonza Ag | Fremgangsmåde til fremstilling af optisk aktive 2-piperazincarboxylsyrederivater |
US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
US6270808B1 (en) | 1995-11-13 | 2001-08-07 | Gerard Voerman | Anti-viral isolates obtainable from leeches |
US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
MY126358A (en) * | 1996-03-22 | 2006-09-29 | Glaxo Group Ltd | Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs |
CA2201218C (en) * | 1996-04-23 | 2004-09-28 | Rudolf Fuchs | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives |
DE19620494A1 (de) * | 1996-05-21 | 1997-11-27 | Basf Ag | 1-(Halogenalkanoyl)-2-carboxamido-1,4,5,6-tetrahydropyrazine |
US5747540A (en) * | 1996-10-21 | 1998-05-05 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
ZA9710071B (en) * | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
US6645961B1 (en) | 1997-03-07 | 2003-11-11 | Merck & Co., Inc. | Dry granulation formulation for an HIV protease inhibitor |
US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
JP2002515501A (ja) * | 1998-05-15 | 2002-05-28 | アボット・ラボラトリーズ | レトロウイルスプロテアーゼの阻害化合物 |
US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
AP1717A (en) | 1998-06-19 | 2007-01-30 | Vertex Pharma | Sulfonamide inhibitors of aspartyl protease. |
WO2000002862A1 (en) | 1998-07-08 | 2000-01-20 | G.D. Searle & Co. | Retroviral protease inhibitors |
AU3369200A (en) * | 1999-02-19 | 2000-09-04 | Board Of Trustees Of The University Of Illinois, The | Protease inhibitors that overcome drug resistance |
CA2391643C (en) | 1999-11-24 | 2010-01-12 | Merck & Co., Inc. | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamides as hiv protease inhibitors |
ES2676151T3 (es) | 2000-01-19 | 2018-07-17 | Abbvie Inc. | Formulaciones farmacéuticas mejoradas |
EP1434580A2 (en) * | 2001-10-05 | 2004-07-07 | Elan Pharmaceuticals, Inc. | Allylamides useful in the treatment of alzheimer's disease |
JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
US7037913B2 (en) * | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
CN102816111B (zh) | 2007-03-12 | 2014-08-06 | 尼克塔治疗公司 | 低聚物-蛋白酶抑制剂偶联物 |
US9095620B2 (en) | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
WO2015013835A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
WO2016065248A1 (en) | 2014-10-23 | 2016-04-28 | Complete Genomics, Inc. | Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing |
US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
CA2032259A1 (en) * | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
-
1992
- 1992-11-02 ES ES92203357T patent/ES2112880T3/es not_active Expired - Lifetime
- 1992-11-02 AT AT92203357T patent/ATE163926T1/de active
- 1992-11-02 CA CA002081970A patent/CA2081970C/en not_active Expired - Lifetime
- 1992-11-02 SG SG1996008456A patent/SG52731A1/en unknown
- 1992-11-02 NZ NZ244986A patent/NZ244986A/en not_active IP Right Cessation
- 1992-11-02 DE DE69224703T patent/DE69224703T2/de not_active Expired - Lifetime
- 1992-11-02 DK DK92203357.6T patent/DK0541168T3/da active
- 1992-11-02 IL IL10361392A patent/IL103613A/en not_active IP Right Cessation
- 1992-11-02 CA CA002195027A patent/CA2195027C/en not_active Expired - Lifetime
- 1992-11-02 EP EP92203357A patent/EP0541168B1/en not_active Expired - Lifetime
- 1992-11-03 RU RU94027563A patent/RU2131416C1/ru active
- 1992-11-03 KR KR1019940701535A patent/KR100273623B1/ko not_active IP Right Cessation
- 1992-11-03 SK SK523-94A patent/SK281864B6/sk not_active IP Right Cessation
- 1992-11-03 CZ CZ19941110A patent/CZ287610B6/cs not_active IP Right Cessation
- 1992-11-03 PL PL92303600A patent/PL171340B1/pl unknown
- 1992-11-03 UA UA94005497A patent/UA45945C2/uk unknown
- 1992-11-03 HU HU9401424A patent/HU220866B1/hu unknown
- 1992-11-03 WO PCT/US1992/009444 patent/WO1993009096A1/en active IP Right Grant
- 1992-11-03 RO RO94-00763A patent/RO115726B1/ro unknown
- 1992-11-06 AU AU28199/92A patent/AU659234B2/en not_active Expired
- 1992-11-09 JP JP4340891A patent/JPH0733373B2/ja not_active Expired - Lifetime
-
1994
- 1994-05-03 BG BG98745A patent/BG61725B1/bg unknown
- 1994-05-06 NO NO941696A patent/NO303383B1/no not_active IP Right Cessation
- 1994-05-06 FI FI942112A patent/FI106025B/fi not_active IP Right Cessation
-
1998
- 1998-03-12 GR GR980400325T patent/GR3026334T3/el unknown
- 1998-06-12 HK HK98105213A patent/HK1006060A1/xx not_active IP Right Cessation
- 1998-06-17 CY CY9800011A patent/CY2090B1/xx unknown
- 1998-07-10 FI FI981591A patent/FI981591A/fi not_active Application Discontinuation
- 1998-10-26 LV LVP-98-235A patent/LV12208B/lv unknown
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