FI942112A - AIDS:n hoidossa käyttökelpoisia HIV-proteaasi-inhibiittoreita - Google Patents
AIDS:n hoidossa käyttökelpoisia HIV-proteaasi-inhibiittoreita Download PDFInfo
- Publication number
- FI942112A FI942112A FI942112A FI942112A FI942112A FI 942112 A FI942112 A FI 942112A FI 942112 A FI942112 A FI 942112A FI 942112 A FI942112 A FI 942112A FI 942112 A FI942112 A FI 942112A
- Authority
- FI
- Finland
- Prior art keywords
- opt
- substd
- aryl
- halo
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78950891A | 1991-11-08 | 1991-11-08 | |
| US78950891 | 1991-11-08 | ||
| US88382592A | 1992-05-15 | 1992-05-15 | |
| US88382592 | 1992-05-15 | ||
| US9209444 | 1992-11-03 | ||
| PCT/US1992/009444 WO1993009096A1 (en) | 1991-11-08 | 1992-11-03 | Hiv protease inhibitors useful for the treatment of aids |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI942112A true FI942112A (fi) | 1994-05-06 |
| FI942112A0 FI942112A0 (fi) | 1994-05-06 |
| FI106025B FI106025B (fi) | 2000-11-15 |
Family
ID=27120923
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI942112A FI106025B (fi) | 1991-11-08 | 1994-05-06 | Menetelmä uusien terapeuttisesti käyttökelpoisten N-(2-hydroksi-indanyyli)-5-piperatsinyylipentaaniamidijohdannaisten valmistamiseksi |
| FI981591A FI981591A (fi) | 1991-11-08 | 1998-07-10 | AIDS:n hoidossa käyttökelpoisia HIV-proteaasi-inhibiittoreita |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI981591A FI981591A (fi) | 1991-11-08 | 1998-07-10 | AIDS:n hoidossa käyttökelpoisia HIV-proteaasi-inhibiittoreita |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP0541168B1 (fi) |
| JP (1) | JPH0733373B2 (fi) |
| KR (1) | KR100273623B1 (fi) |
| AT (1) | ATE163926T1 (fi) |
| AU (1) | AU659234B2 (fi) |
| BG (1) | BG61725B1 (fi) |
| CA (2) | CA2195027C (fi) |
| CY (1) | CY2090B1 (fi) |
| CZ (1) | CZ287610B6 (fi) |
| DE (1) | DE69224703T2 (fi) |
| DK (1) | DK0541168T3 (fi) |
| ES (1) | ES2112880T3 (fi) |
| FI (2) | FI106025B (fi) |
| GR (1) | GR3026334T3 (fi) |
| HK (1) | HK1006060A1 (fi) |
| HU (1) | HU220866B1 (fi) |
| IL (1) | IL103613A (fi) |
| LV (1) | LV12208B (fi) |
| NO (1) | NO303383B1 (fi) |
| NZ (1) | NZ244986A (fi) |
| PL (1) | PL171340B1 (fi) |
| RO (1) | RO115726B1 (fi) |
| RU (1) | RU2131416C1 (fi) |
| SG (1) | SG52731A1 (fi) |
| SK (1) | SK281864B6 (fi) |
| UA (1) | UA45945C2 (fi) |
| WO (1) | WO1993009096A1 (fi) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040122000A1 (en) | 1981-01-07 | 2004-06-24 | Vertex Pharmaceuticals Incorporated. | Inhibitors of aspartyl protease |
| US6878728B1 (en) | 1999-06-11 | 2005-04-12 | Vertex Pharmaceutical Incorporated | Inhibitors of aspartyl protease |
| USH1649H (en) | 1987-07-31 | 1997-05-06 | Barrish; Joel C. | HIV protease inhibitor combinations |
| US5413999A (en) * | 1991-11-08 | 1995-05-09 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| ATE253050T1 (de) | 1992-03-11 | 2003-11-15 | Narhex Ltd | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| EP0633881B1 (en) | 1992-03-11 | 2003-10-29 | Narhex Limited | Amine derivatives of oxo- and hydroxy-substitued hydrocarbons |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| US7141609B2 (en) | 1992-08-25 | 2006-11-28 | G.D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| PT810209E (pt) | 1992-08-25 | 2002-09-30 | Searle & Co | Hidroxietilamino-sulfonamidas de alfa- e beta-aminoacidos uteis como inibidores de protease retroviral |
| US5783701A (en) | 1992-09-08 | 1998-07-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
| US5430150A (en) * | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
| IL110255A (en) * | 1993-07-16 | 1998-12-06 | Merck & Co Inc | Creation and resolution of 2 tert-butylcarboxamidopiprazine |
| US5463067A (en) * | 1993-07-16 | 1995-10-31 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| IL110752A (en) * | 1993-09-13 | 2000-07-26 | Abbott Lab | Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor |
| US5559158A (en) * | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
| IL111584A0 (en) * | 1993-11-18 | 1995-01-24 | Merck & Co Inc | Prodrugs of an inhibitor of hiv protease and pharmaceutical compositions containing them |
| US5455351A (en) * | 1993-12-13 | 1995-10-03 | Abbott Laboratories | Retroviral protease inhibiting piperazine compounds |
| ATE215952T1 (de) * | 1993-12-15 | 2002-04-15 | Merck & Co Inc | Hiv-proteaseinhibitoren |
| US5428167A (en) * | 1994-01-14 | 1995-06-27 | American Cyanamid Company | Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds |
| US5733882A (en) * | 1994-01-17 | 1998-03-31 | Smithkline Beecham Corporation | Retroviral protease inhibitors |
| TW472047B (en) * | 1994-02-04 | 2002-01-11 | Merck & Co Inc | Process for making HIV protease inhibitors |
| US5728840A (en) * | 1994-03-04 | 1998-03-17 | Merck & Co., Inc. | Process for making an epoxide |
| TW380137B (en) * | 1994-03-04 | 2000-01-21 | Merck & Co Inc | Process for making an epoxide |
| ATE184594T1 (de) * | 1994-03-07 | 1999-10-15 | Vertex Pharma | Sulfonamidderivate als aspartylprotease- inhibitoren |
| US5420353A (en) * | 1994-03-11 | 1995-05-30 | Merck & Co., Inc. | Regiospecific process to make cis-1-amino-2-alkanol from epoxide |
| US5449830A (en) * | 1994-03-11 | 1995-09-12 | Marck & Co., Inc. | Regiospecific processes to make CIS-1-Amino-2-Alkanol from Diol or Halohydrin |
| CA2186023C (en) * | 1994-04-20 | 2006-11-07 | Walter Brieden | Process for preparing 2-piperazine carboxylic acid derivatives |
| KR100389151B1 (ko) * | 1994-04-22 | 2003-10-04 | 고에이 가가쿠 고교 가부시키가이샤 | 광학활성N-tert-부틸-2-피페라진카르복시아미드의제조방법및그라세미화법 |
| UA49803C2 (uk) * | 1994-06-03 | 2002-10-15 | Дж.Д. Сьорль Енд Ко | Спосіб лікування ретровірусних інфекцій |
| US5476874A (en) * | 1994-06-22 | 1995-12-19 | Merck & Co., Inc. | New HIV protease inhibitors |
| GB2292146A (en) * | 1994-08-11 | 1996-02-14 | Merck & Co Inc | HIV protease inhibitors useful for the treatment of AIDS |
| IL114808A (en) * | 1994-08-11 | 1999-10-28 | Merck & Co Inc | Combinations of protease inhibitors for the treatment of hiv infection and aids |
| US5612217A (en) * | 1994-10-25 | 1997-03-18 | Merck & Co., Inc. | Streptomyces sp. MA 7074 (ATCC 55605) used for microbial synthesis of HIV protease inhibitors |
| AU702122B2 (en) * | 1994-10-25 | 1999-02-11 | Merck & Co., Inc. | Microbial synthesis of HIV protease inhibitors |
| DE4446025A1 (de) * | 1994-12-22 | 1996-06-27 | Basf Ag | 2-Caroxamido-1,4,5,6-tetrahydropyrazine |
| JPH11500425A (ja) * | 1995-01-23 | 1999-01-12 | ロンザ アーゲー | １，４，５，６−テトラヒドロピラジン−２−カルボキサミドの製造方法 |
| US5508404A (en) * | 1995-03-15 | 1996-04-16 | Merck & Co., Inc. | Reductive amination process |
| US5618937A (en) * | 1995-03-15 | 1997-04-08 | Merck & Co., Inc. | Process to make HIV protease inhibitor from (2S)-4-picolyl-2-piperazine-t-butylcarboxamide |
| US5691372A (en) * | 1995-04-19 | 1997-11-25 | Vertex Pharmaceuticals Incorporated | Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease |
| US5612484A (en) * | 1995-05-18 | 1997-03-18 | Merck & Co., Inc. | Process for making HIV protease inhibitors |
| US5605819A (en) * | 1995-05-19 | 1997-02-25 | Merck & Co., Inc. | Quantitative conversion of indene to (1S,2R) indene oxide and (1S,2R)-indandiol by combination of haloperoxidase bioconversion and chemical steps |
| EP0744401B1 (de) * | 1995-05-23 | 2001-11-21 | Lonza Ag | Verfahren zur Herstellung von optisch aktiven 2-Piperazincarbonsäurederivaten |
| US6004957A (en) * | 1995-06-07 | 1999-12-21 | Vertex Pharmaceuticals, Incorporated | Sulfonamide inhibitors of aspartyl protease |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| DK0861085T3 (da) | 1995-11-13 | 2005-11-21 | Vitaleech Bioscience N V | Antivirale isolater opnået fra igler |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| MY126358A (en) * | 1996-03-22 | 2006-09-29 | Glaxo Group Ltd | Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs |
| CA2201218C (en) * | 1996-04-23 | 2004-09-28 | Rudolf Fuchs | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives |
| DE19620494A1 (de) * | 1996-05-21 | 1997-11-27 | Basf Ag | 1-(Halogenalkanoyl)-2-carboxamido-1,4,5,6-tetrahydropyrazine |
| US5747540A (en) * | 1996-10-21 | 1998-05-05 | Merck & Co., Inc. | HIV protease inhibitors useful for the treatment of AIDS |
| US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| ZA9710071B (en) * | 1996-11-21 | 1998-05-25 | Abbott Lab | Pharmaceutical composition. |
| US6645961B1 (en) | 1997-03-07 | 2003-11-11 | Merck & Co., Inc. | Dry granulation formulation for an HIV protease inhibitor |
| US6436989B1 (en) | 1997-12-24 | 2002-08-20 | Vertex Pharmaceuticals, Incorporated | Prodrugs of aspartyl protease inhibitors |
| CA2331756A1 (en) * | 1998-05-15 | 1999-11-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| WO1999065870A2 (en) | 1998-06-19 | 1999-12-23 | Vertex Pharmaceuticals Incorporated | Sulfonamide inhibitors of aspartyl protease |
| US6538006B1 (en) | 1998-07-08 | 2003-03-25 | Pharmacia Corporation | Retroviral protease inhibitors |
| WO2000048466A2 (en) * | 1999-02-19 | 2000-08-24 | Oklahoma Medical Research Foundation | Protease inhibitors that overcome drug resistance |
| AU777824B2 (en) | 1999-11-24 | 2004-11-04 | Merck Sharp & Dohme Corp. | Gamma-hydroxy-2-(fluoroalkylaminocarbonyl)-1- piperazinepentanamides as HIV protease inhibitors |
| PT1248600E (pt) | 2000-01-19 | 2008-08-25 | Abbott Lab | Formulações farmacêuticas melhoradas de inibidores da protease do vih |
| MXPA04003244A (es) * | 2001-10-05 | 2004-07-08 | Elan Pharm Inc | Alilamidas utiles para tratamiento de enfermedad de alzheimer. |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| US7037913B2 (en) * | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
| AU2008226823B2 (en) | 2007-03-12 | 2014-03-13 | Nektar Therapeutics | Oligomer-protease inhibitor conjugates |
| EP2262538B1 (en) | 2008-03-12 | 2014-12-10 | Nektar Therapeutics | Oligomer-amino acid conjugate |
| WO2010144869A2 (en) | 2009-06-12 | 2010-12-16 | Nektar Therapeutics | Protease inhibitors |
| WO2015013835A1 (en) | 2013-07-31 | 2015-02-05 | Merck Sharp & Dohme Corp. | Piperazine derivatives as hiv protease inhibitors |
| CN107074904B (zh) | 2014-10-23 | 2022-12-23 | 深圳华大智造科技股份有限公司 | 信号约束测序(scs)和用于信号约束测序的核苷酸类似物 |
| US20230218644A1 (en) | 2020-04-16 | 2023-07-13 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| CA2032259A1 (en) * | 1989-12-18 | 1991-06-19 | Wayne J. Thompson | Hiv protease inhibitors useful for the treatment of aids |
-
1992
- 1992-11-02 IL IL10361392A patent/IL103613A/en not_active IP Right Cessation
- 1992-11-02 CA CA002195027A patent/CA2195027C/en not_active Expired - Lifetime
- 1992-11-02 CA CA002081970A patent/CA2081970C/en not_active Expired - Lifetime
- 1992-11-02 DK DK92203357.6T patent/DK0541168T3/da active
- 1992-11-02 AT AT92203357T patent/ATE163926T1/de active
- 1992-11-02 DE DE69224703T patent/DE69224703T2/de not_active Expired - Lifetime
- 1992-11-02 ES ES92203357T patent/ES2112880T3/es not_active Expired - Lifetime
- 1992-11-02 EP EP92203357A patent/EP0541168B1/en not_active Expired - Lifetime
- 1992-11-02 SG SG1996008456A patent/SG52731A1/en unknown
- 1992-11-02 NZ NZ244986A patent/NZ244986A/en not_active IP Right Cessation
- 1992-11-03 HU HU9401424A patent/HU220866B1/hu unknown
- 1992-11-03 PL PL92303600A patent/PL171340B1/pl unknown
- 1992-11-03 RO RO94-00763A patent/RO115726B1/ro unknown
- 1992-11-03 CZ CZ19941110A patent/CZ287610B6/cs not_active IP Right Cessation
- 1992-11-03 UA UA94005497A patent/UA45945C2/uk unknown
- 1992-11-03 RU RU94027563A patent/RU2131416C1/ru active
- 1992-11-03 SK SK523-94A patent/SK281864B6/sk not_active IP Right Cessation
- 1992-11-03 WO PCT/US1992/009444 patent/WO1993009096A1/en active IP Right Grant
- 1992-11-03 KR KR1019940701535A patent/KR100273623B1/ko not_active IP Right Cessation
- 1992-11-06 AU AU28199/92A patent/AU659234B2/en not_active Expired
- 1992-11-09 JP JP4340891A patent/JPH0733373B2/ja not_active Expired - Lifetime
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1994
- 1994-05-03 BG BG98745A patent/BG61725B1/bg unknown
- 1994-05-06 NO NO941696A patent/NO303383B1/no not_active IP Right Cessation
- 1994-05-06 FI FI942112A patent/FI106025B/fi not_active IP Right Cessation
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1998
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- 1998-06-12 HK HK98105213A patent/HK1006060A1/xx not_active IP Right Cessation
- 1998-06-17 CY CY9800011A patent/CY2090B1/xx unknown
- 1998-07-10 FI FI981591A patent/FI981591A/fi not_active Application Discontinuation
- 1998-10-26 LV LVP-98-235A patent/LV12208B/en unknown
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| PC | Transfer of assignment of patent |
Owner name: MERCK SHARP & DOHME CORP. Free format text: MERCK SHARP & DOHME CORP. |
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| PC | Transfer of assignment of patent |
Owner name: MERCK SHARP & DOHME CORP. |
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| MA | Patent expired |