ATE210134T1 - Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen - Google Patents

Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen

Info

Publication number
ATE210134T1
ATE210134T1 AT95402174T AT95402174T ATE210134T1 AT E210134 T1 ATE210134 T1 AT E210134T1 AT 95402174 T AT95402174 T AT 95402174T AT 95402174 T AT95402174 T AT 95402174T AT E210134 T1 ATE210134 T1 AT E210134T1
Authority
AT
Austria
Prior art keywords
opt
substd
products
production
pharmaceutical preparations
Prior art date
Application number
AT95402174T
Other languages
English (en)
Inventor
Andre Claussner
Francois Goubet
Jean-Georges Teutsch
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE210134T1 publication Critical patent/ATE210134T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT95402174T 1994-09-29 1995-09-28 Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen ATE210134T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9411649A FR2725206B1 (fr) 1994-09-29 1994-09-29 Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
ATE210134T1 true ATE210134T1 (de) 2001-12-15

Family

ID=9467411

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95402174T ATE210134T1 (de) 1994-09-29 1995-09-28 Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen

Country Status (19)

Country Link
US (3) US5646172A (de)
EP (1) EP0704448B1 (de)
JP (1) JPH0899977A (de)
CN (1) CN1055471C (de)
AT (1) ATE210134T1 (de)
AU (1) AU707569B2 (de)
BR (1) BR9504205A (de)
CA (1) CA2159425A1 (de)
DE (1) DE69524344T2 (de)
DK (1) DK0704448T3 (de)
ES (1) ES2169112T3 (de)
FI (1) FI111259B (de)
FR (1) FR2725206B1 (de)
HU (1) HU222564B1 (de)
IL (1) IL114939A (de)
PT (1) PT704448E (de)
RU (1) RU2170231C2 (de)
UA (1) UA48937C2 (de)
ZA (1) ZA957568B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
FR2742749B1 (fr) * 1995-12-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
DE19632126A1 (de) * 1996-08-09 1998-02-12 Bayer Ag Phenylsubstituierte cyclische Ketoenole
US20020142993A1 (en) * 2000-10-12 2002-10-03 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of bicyclic compounds
EP1786816A4 (de) * 2003-09-10 2009-11-04 Virochem Pharma Inc Spirohydantoinverbindungen und -verfahren zur modulation von chemokin-rezeptoraktivität
EP2299266A1 (de) * 2003-12-19 2011-03-23 The Regents of the University of California Verfahren und Materialien zur Beurteilung von Prostatakrebstherapien
US7718684B2 (en) * 2004-02-24 2010-05-18 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
DK2444085T3 (en) 2005-05-13 2015-04-27 Univ California Diarylhydantoinforbindelser as androgenreceptorantagonister for treating cancer
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
WO2007011810A1 (en) * 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
DK2656841T3 (en) 2006-03-27 2016-12-05 Univ California Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES
RU2449993C2 (ru) 2006-03-29 2012-05-10 Те Риджентс Оф Те Юниверсити Оф Калифорния Диарилтиогидантоиновые соединения
GB0610765D0 (en) * 2006-05-31 2006-07-12 Proskelia Sas Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
JP2010502705A (ja) * 2006-09-07 2010-01-28 メルク エンド カムパニー インコーポレーテッド アルツハイマー病の治療用としてのスピロピペリジンベータセクレターゼ阻害剤
CA2966280A1 (en) 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds
US8779157B2 (en) 2009-09-04 2014-07-15 Vanderbilt University MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
WO2011029392A1 (en) 2009-09-10 2011-03-17 Youzhi Tong Androgen receptor antagonists and uses thereof
WO2011103202A2 (en) 2010-02-16 2011-08-25 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
RU2434851C1 (ru) * 2010-07-22 2011-11-27 Александр Васильевич Иващенко Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
CA2829322C (en) * 2011-03-10 2017-01-10 Suzhou Kintor Pharmaceuticals, Inc. Substituted thioimidazolidinone androgen receptor antagonists and uses thereof
KR20220025231A (ko) 2012-09-26 2022-03-03 아라곤 파마슈티컬스, 인코포레이티드 비전이성 거세 저항성 전립선암 치료용 항안드로겐
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
WO2014130932A2 (en) 2013-02-25 2014-08-28 Novartis Ag Novel androgen receptor mutation
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US20190209469A1 (en) 2016-08-20 2019-07-11 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
KR20200070334A (ko) 2017-10-16 2020-06-17 아라곤 파마슈티컬스, 인코포레이티드 비-전이성 거세-저항성 전립선암의 치료를 위한 항-안드로겐

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS421179Y1 (de) * 1964-03-13 1967-01-24
JPS4623738Y1 (de) * 1968-05-29 1971-08-16
DE2126532A1 (de) * 1971-05-28 1972-12-07 Merck Patent Gmbh, 6100 Darmstadt Neue Derivate der 6-Aminopenicillansäure und Verfahren zu ihrer Herstellung
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
US4320135A (en) * 1980-05-19 1982-03-16 Sandoz, Inc. Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
US5221675A (en) * 1989-12-15 1993-06-22 Abbott Laboratories Aza-spirocyclic compounds that enhance cholinergic neurotransmission
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
US5646172A (en) 1997-07-08
IL114939A (en) 2005-11-20
JPH0899977A (ja) 1996-04-16
CN1127753A (zh) 1996-07-31
PT704448E (pt) 2002-05-31
BR9504205A (pt) 1996-08-06
FR2725206B1 (fr) 1996-12-06
HU222564B1 (hu) 2003-08-28
ES2169112T3 (es) 2002-07-01
AU707569B2 (en) 1999-07-15
AU3292195A (en) 1996-04-18
ZA957568B (en) 1996-09-09
IL114939A0 (en) 1995-12-08
UA48937C2 (uk) 2002-09-16
RU2170231C2 (ru) 2001-07-10
HU9502841D0 (en) 1995-11-28
FR2725206A1 (fr) 1996-04-05
US5705654A (en) 1998-01-06
EP0704448B1 (de) 2001-12-05
CA2159425A1 (fr) 1996-03-30
DE69524344D1 (de) 2002-01-17
CN1055471C (zh) 2000-08-16
EP0704448A1 (de) 1996-04-03
DK0704448T3 (da) 2002-03-25
DE69524344T2 (de) 2002-08-22
FI954612A (fi) 1996-03-30
FI954612A0 (fi) 1995-09-28
US5958936A (en) 1999-09-28
HUT72748A (en) 1996-05-28
FI111259B (fi) 2003-06-30

Similar Documents

Publication Publication Date Title
ATE210134T1 (de) Heterocyclisch substituierte imidazolidine, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen
ATE128975T1 (de) Harnstoffderivate, verfahren zu ihrer herstellung und diese enthaltende medikamente.
DE3778800D1 (de) Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel.
ATE141277T1 (de) Neue phosphonobernsteinsäurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE50011034D1 (de) N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE58901510D1 (de) 6-phenyldihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
DE3777852D1 (de) Dekahydrochinolinderivate, verfahren zu ihrer herstellung, zwischenprodukte zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende zubereitungen.
ATE127807T1 (de) N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
EP0369263A3 (de) Präparate zur topischen Behandlung von Hautkrankheiten
ATE122042T1 (de) Pyrazoloisoquinoline-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
HUP9801442A2 (hu) Fenil-ecetsav-származékok, eljárás és intermedierek előállításukhoz, valamint inszekticidként, akaricidként, nematocidként és fungicidként való alkalmazásuk
DE3882438D1 (de) Alkansulfonanilid-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzung.
DK0637583T3 (da) 1-Aryloxy-3-alkylamino-2-propanol-nitratestere, anvendelse heraf og tilsvarende farmaceutisk præparat
ATE171704T1 (de) Optisch wirksame alkylendioxybenzolderivate und ihre verwendung als arzneimittel
ATE88460T1 (de) Verbindungen zur behandlung von harninkontinenz.
ATE238660T1 (de) Triazolyloxybenzyl-alkoxyacrylsäureester, verfahren zu ihrer herstellung und ihre verwendung
ATE123776T1 (de) Aminoalkylchromone, verfahren zu ihrer herstellung und diese enthaltende zusammensetzungen.
IE800900L (en) Pyrrolidinyl-benzoic acid derivatives.
DE68922605D1 (de) Verfahren zur Herstellung von (-)2-(2-(2-Aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorphenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridin, und Zwischenprodukt zu dessen Herstellung.
ATE121724T1 (de) Neue salze der 2-(2,6-dichloranilino)- phenylessigsäure, verfahren zu ihrer herstellung und ihre verwendung für topisch anwendbare pharmazeutische zubereitungen.
PT87954A (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de dioxopiperidina, com efeito antipsicotico
ATE281453T1 (de) 4-amino-2-ureido-pyrimidin-5-carbonsäureamide, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
ATE119888T1 (de) 5-(amino)-triazolylcarbothioamidderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel sowie verwendung der ersteren.
ATE165829T1 (de) Nootrope wirkstoffe
DE2963724D1 (en) Clavulanic acid derivatives, their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee