ATE127807T1 - N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. - Google Patents

N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Info

Publication number
ATE127807T1
ATE127807T1 AT90110676T AT90110676T ATE127807T1 AT E127807 T1 ATE127807 T1 AT E127807T1 AT 90110676 T AT90110676 T AT 90110676T AT 90110676 T AT90110676 T AT 90110676T AT E127807 T1 ATE127807 T1 AT E127807T1
Authority
AT
Austria
Prior art keywords
lower alkyl
heteroaryl
aryl
purine
amines
Prior art date
Application number
AT90110676T
Other languages
English (en)
Inventor
Richard Charles Effland
Joseph Thomas Klein
Larry Davis
Gordon Edward Olson
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE127807T1 publication Critical patent/ATE127807T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Television Signal Processing For Recording (AREA)
AT90110676T 1989-06-09 1990-06-06 N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. ATE127807T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,837 US5017578A (en) 1989-06-09 1989-06-09 N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents

Publications (1)

Publication Number Publication Date
ATE127807T1 true ATE127807T1 (de) 1995-09-15

Family

ID=23431950

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90110676T ATE127807T1 (de) 1989-06-09 1990-06-06 N-heteroaryl-purin-6-amine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.

Country Status (21)

Country Link
US (1) US5017578A (de)
EP (1) EP0402752B1 (de)
JP (1) JPH06102663B2 (de)
KR (2) KR100199524B1 (de)
CN (1) CN1029968C (de)
AT (1) ATE127807T1 (de)
AU (1) AU636351B2 (de)
CA (1) CA2018563C (de)
DE (1) DE69022294T2 (de)
DK (1) DK0402752T3 (de)
ES (1) ES2078267T3 (de)
FI (1) FI902850A0 (de)
GR (1) GR3017743T3 (de)
HU (1) HU207320B (de)
IE (1) IE68433B1 (de)
IL (1) IL94665A (de)
MX (1) MX21088A (de)
NO (1) NO902555L (de)
NZ (1) NZ233970A (de)
PT (1) PT94297B (de)
ZA (1) ZA904443B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432164A (en) * 1991-10-24 1995-07-11 Novo Nordisk A/S C2,N6 -disubstituted adenosine derivatives
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5589467A (en) * 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
JP3355237B2 (ja) * 1993-10-15 2002-12-09 呉羽化学工業株式会社 Ｎ−（置換アミノ）ピロール誘導体、その製造方法及び除草剤
BR9507683A (pt) * 1994-05-10 1997-09-23 Sandoz Ag Derivados de adenosina
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
JP2007502776A (ja) * 2003-08-15 2007-02-15 アイアールエム・リミテッド・ライアビリティ・カンパニー Ｒｔｋ阻害剤としての６−置換アニリノプリン類
CN100447143C (zh) * 2003-08-15 2008-12-31 Irm责任有限公司 作为rtk抑制剂的6-取代的苯胺基嘌呤
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
EP2063905B1 (de) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Behandlungen von lebererkrankungen durch verabreichung von konjugaten aus rezeptor-assoziierten proteinen
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN104744470A (zh) * 2014-10-31 2015-07-01 合肥平光制药有限公司 一种茶碱的合成方法
WO2017160922A1 (en) 2016-03-16 2017-09-21 Kalyra Pharmaceuticals, Inc. Analgesic compounds
CN106632339B (zh) * 2016-12-16 2018-11-27 温州医科大学 一种6-取代-9h-嘌呤类衍生物及其制备方法和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016378A (en) * 1959-07-01 1962-01-09 Thomae Gmbh Dr K Amino-substituted purine derivatives
US3796700A (en) * 1970-06-30 1974-03-12 Takedo Chem Ind Ltd Adenosine derivatives and the production thereof
JPS4935635B1 (de) * 1970-12-28 1974-09-25
US3936454A (en) * 1973-08-14 1976-02-03 Warner-Lambert Company 5-Amino-4-chloro-6-(substituted amino)-pyrimidines
US3862189A (en) * 1973-08-14 1975-01-21 Warner Lambert Co Aralkyl-substituted purines and pyrimidines as antianginal bronchodilator agents
JPS57171998A (en) * 1981-04-15 1982-10-22 Fujisawa Pharmaceut Co Ltd Adenosine derivative and its salt, preparation thereof and medicinal composition containing the same
US4514405A (en) * 1981-09-17 1985-04-30 Merck Patent Gesellschaft Mit Beschrankter Haftung Use of adenosine derivatives as anticonvulsants
DE3406533A1 (de) * 1984-02-23 1985-08-29 Boehringer Mannheim Gmbh, 6800 Mannheim Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten
AU582359B2 (en) * 1984-04-18 1989-03-23 Nelson Research & Development Company N-6 substituted adenosine derivatives as cardiac vasodilators
US4657897A (en) * 1984-06-22 1987-04-14 Warner-Lambert Company N6 -substituted adenosines for treating pain
CA1254888A (en) * 1984-10-26 1989-05-30 Bharat Trivedi N.sup.6-bicycloadenosines
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
US4780452A (en) * 1986-09-08 1988-10-25 Burroughs Wellcome Co. F-substituted-3-β-D-ribofuranosyl-3H-imidazo[4,5-b]pyridines and pharmaceutical compositions thereof

Also Published As

Publication number Publication date
KR100199524B1 (ko) 1999-06-15
KR100210179B1 (ko) 1999-07-15
JPH0324080A (ja) 1991-02-01
DE69022294T2 (de) 1996-03-14
HU903768D0 (en) 1990-11-28
PT94297B (pt) 1997-01-31
IE902077L (en) 1990-12-09
CA2018563C (en) 2000-09-19
IL94665A (en) 1994-06-24
AU636351B2 (en) 1993-04-29
CA2018563A1 (en) 1990-12-09
MX21088A (es) 1993-11-01
AU5691990A (en) 1990-12-13
NZ233970A (en) 1993-02-25
US5017578A (en) 1991-05-21
CN1029968C (zh) 1995-10-11
CN1047866A (zh) 1990-12-19
DK0402752T3 (da) 1996-01-15
EP0402752B1 (de) 1995-09-13
HUT54156A (en) 1991-01-28
IL94665A0 (en) 1991-04-15
PT94297A (pt) 1991-02-08
ZA904443B (en) 1991-03-27
DE69022294D1 (de) 1995-10-19
KR910000730A (ko) 1991-01-30
ES2078267T3 (es) 1995-12-16
GR3017743T3 (en) 1996-01-31
JPH06102663B2 (ja) 1994-12-14
NO902555D0 (no) 1990-06-08
NO902555L (no) 1990-12-10
EP0402752A1 (de) 1990-12-19
HU207320B (en) 1993-03-29
IE68433B1 (en) 1996-06-12
FI902850A0 (fi) 1990-06-07

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee