DE69524344T2 - Heterocyclisch substituierte Imidazolidine, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zubereitungen - Google Patents
Heterocyclisch substituierte Imidazolidine, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische ZubereitungenInfo
- Publication number
- DE69524344T2 DE69524344T2 DE69524344T DE69524344T DE69524344T2 DE 69524344 T2 DE69524344 T2 DE 69524344T2 DE 69524344 T DE69524344 T DE 69524344T DE 69524344 T DE69524344 T DE 69524344T DE 69524344 T2 DE69524344 T2 DE 69524344T2
- Authority
- DE
- Germany
- Prior art keywords
- opt
- substd
- medicaments
- intermediates
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9411649A FR2725206B1 (fr) | 1994-09-29 | 1994-09-29 | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69524344D1 DE69524344D1 (de) | 2002-01-17 |
DE69524344T2 true DE69524344T2 (de) | 2002-08-22 |
Family
ID=9467411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69524344T Expired - Fee Related DE69524344T2 (de) | 1994-09-29 | 1995-09-28 | Heterocyclisch substituierte Imidazolidine, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Verwendung als Arzneimittel und diese enthaltende pharmazeutische Zubereitungen |
Country Status (19)
Country | Link |
---|---|
US (3) | US5646172A (de) |
EP (1) | EP0704448B1 (de) |
JP (1) | JPH0899977A (de) |
CN (1) | CN1055471C (de) |
AT (1) | ATE210134T1 (de) |
AU (1) | AU707569B2 (de) |
BR (1) | BR9504205A (de) |
CA (1) | CA2159425A1 (de) |
DE (1) | DE69524344T2 (de) |
DK (1) | DK0704448T3 (de) |
ES (1) | ES2169112T3 (de) |
FI (1) | FI111259B (de) |
FR (1) | FR2725206B1 (de) |
HU (1) | HU222564B1 (de) |
IL (1) | IL114939A (de) |
PT (1) | PT704448E (de) |
RU (1) | RU2170231C2 (de) |
UA (1) | UA48937C2 (de) |
ZA (1) | ZA957568B (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2741342B1 (fr) * | 1995-11-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques |
FR2742749B1 (fr) * | 1995-12-22 | 1998-02-06 | Roussel Uclaf | Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques |
DE19632126A1 (de) * | 1996-08-09 | 1998-02-12 | Bayer Ag | Phenylsubstituierte cyclische Ketoenole |
US20020142993A1 (en) * | 2000-10-12 | 2002-10-03 | Dr. Reddy's Laboratories Ltd. | Pharmaceutically acceptable salts of bicyclic compounds |
CA2579609A1 (en) * | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
ATE502298T1 (de) * | 2003-12-19 | 2011-04-15 | Univ California | Verfahren und materialien zur beurteilung von prostatakrebstherapien |
AU2005232526B2 (en) * | 2004-02-24 | 2011-06-23 | The Regents Of The University Of California | Methods and materials for assessing prostate cancer therapies and compounds |
US7709517B2 (en) * | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
KR101169832B1 (ko) | 2005-05-13 | 2012-07-30 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴히단토인 화합물 |
JP2009502786A (ja) * | 2005-07-18 | 2009-01-29 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病を治療するためのスピロピペリジンβ−セクレターゼ阻害剤 |
EP3412290B1 (de) * | 2006-03-27 | 2021-03-03 | The Regents of The University of California | Androgenrezeptor-modulator zur behandlung von prostatakrebs und androgenrezeptor-assoziierte erkrankungen |
CN101460467B (zh) | 2006-03-29 | 2012-09-19 | 加利福尼亚大学董事会 | 二芳基硫代乙内酰脲化合物 |
GB0610765D0 (en) * | 2006-05-31 | 2006-07-12 | Proskelia Sas | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
US8168667B2 (en) | 2006-05-31 | 2012-05-01 | Galapagos Nv | Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such |
WO2008030412A2 (en) * | 2006-09-07 | 2008-03-13 | Merck & Co., Inc. | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease |
JP5535925B2 (ja) | 2007-10-26 | 2014-07-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | アンドロゲン受容体調節物質としてのジアリールヒダントイン化合物 |
WO2011029104A1 (en) | 2009-09-04 | 2011-03-10 | Vanderbilt University | Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
JP5659232B2 (ja) * | 2009-09-10 | 2015-01-28 | トン、ヨウヂ | アンドロゲン受容体アンタゴニストおよびその使用 |
SI3124481T1 (en) | 2010-02-16 | 2018-06-29 | Aragon Pharmaceuticals, Inc. | Androgen receptor modulators and their use |
RU2434851C1 (ru) * | 2010-07-22 | 2011-11-27 | Александр Васильевич Иващенко | Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения |
CN103608333B (zh) | 2011-03-10 | 2016-01-06 | 苏州开拓药业有限公司 | 雄激素受体拮抗剂及其用途 |
MY180834A (en) | 2012-09-26 | 2020-12-10 | Aragon Pharmaceuticals Inc | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
EP3696276A1 (de) | 2013-02-25 | 2020-08-19 | Novartis AG | Neuartige androgenrezeptormutation |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
US20190209469A1 (en) | 2016-08-20 | 2019-07-11 | Ftf Pharma Private Limited | Pharmaceutical composition comprising an androgen receptor inhibitor |
AU2018351714A1 (en) | 2017-10-16 | 2020-04-30 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS421179Y1 (de) * | 1964-03-13 | 1967-01-24 | ||
JPS4623738Y1 (de) * | 1968-05-29 | 1971-08-16 | ||
DE2126532A1 (de) * | 1971-05-28 | 1972-12-07 | Merck Patent Gmbh, 6100 Darmstadt | Neue Derivate der 6-Aminopenicillansäure und Verfahren zu ihrer Herstellung |
FR2329276A1 (fr) * | 1975-10-29 | 1977-05-27 | Roussel Uclaf | Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant |
US4320135A (en) * | 1980-05-19 | 1982-03-16 | Sandoz, Inc. | Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives |
EP0091596B1 (de) * | 1982-04-08 | 1991-09-11 | Shell Internationale Researchmaatschappij B.V. | Neue Hydantoine, ihre Herstellung und Verwendung |
US5221675A (en) * | 1989-12-15 | 1993-06-22 | Abbott Laboratories | Aza-spirocyclic compounds that enhance cholinergic neurotransmission |
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
FR2694290B1 (fr) * | 1992-07-08 | 1994-09-02 | Roussel Uclaf | Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant. |
-
1994
- 1994-09-29 FR FR9411649A patent/FR2725206B1/fr not_active Expired - Fee Related
-
1995
- 1995-08-15 IL IL11493995A patent/IL114939A/xx not_active IP Right Cessation
- 1995-09-07 US US08/524,508 patent/US5646172A/en not_active Expired - Fee Related
- 1995-09-08 ZA ZA957568A patent/ZA957568B/xx unknown
- 1995-09-27 JP JP7272076A patent/JPH0899977A/ja active Pending
- 1995-09-27 UA UA95094318A patent/UA48937C2/uk unknown
- 1995-09-28 DK DK95402174T patent/DK0704448T3/da active
- 1995-09-28 CN CN95117799A patent/CN1055471C/zh not_active Expired - Fee Related
- 1995-09-28 EP EP95402174A patent/EP0704448B1/de not_active Expired - Lifetime
- 1995-09-28 ES ES95402174T patent/ES2169112T3/es not_active Expired - Lifetime
- 1995-09-28 RU RU95116592/04A patent/RU2170231C2/ru not_active IP Right Cessation
- 1995-09-28 BR BR9504205A patent/BR9504205A/pt active Search and Examination
- 1995-09-28 AU AU32921/95A patent/AU707569B2/en not_active Ceased
- 1995-09-28 FI FI954612A patent/FI111259B/fi active
- 1995-09-28 DE DE69524344T patent/DE69524344T2/de not_active Expired - Fee Related
- 1995-09-28 PT PT95402174T patent/PT704448E/pt unknown
- 1995-09-28 HU HU9502841A patent/HU222564B1/hu not_active IP Right Cessation
- 1995-09-28 CA CA002159425A patent/CA2159425A1/fr not_active Abandoned
- 1995-09-28 AT AT95402174T patent/ATE210134T1/de not_active IP Right Cessation
-
1996
- 1996-08-12 US US08/695,690 patent/US5705654A/en not_active Expired - Fee Related
-
1997
- 1997-09-23 US US08/935,708 patent/US5958936A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2159425A1 (fr) | 1996-03-30 |
DE69524344D1 (de) | 2002-01-17 |
AU707569B2 (en) | 1999-07-15 |
UA48937C2 (uk) | 2002-09-16 |
ES2169112T3 (es) | 2002-07-01 |
FI954612A0 (fi) | 1995-09-28 |
US5705654A (en) | 1998-01-06 |
HU222564B1 (hu) | 2003-08-28 |
US5958936A (en) | 1999-09-28 |
FR2725206A1 (fr) | 1996-04-05 |
JPH0899977A (ja) | 1996-04-16 |
EP0704448A1 (de) | 1996-04-03 |
CN1055471C (zh) | 2000-08-16 |
PT704448E (pt) | 2002-05-31 |
ATE210134T1 (de) | 2001-12-15 |
ZA957568B (en) | 1996-09-09 |
HU9502841D0 (en) | 1995-11-28 |
IL114939A0 (en) | 1995-12-08 |
HUT72748A (en) | 1996-05-28 |
US5646172A (en) | 1997-07-08 |
FR2725206B1 (fr) | 1996-12-06 |
CN1127753A (zh) | 1996-07-31 |
IL114939A (en) | 2005-11-20 |
RU2170231C2 (ru) | 2001-07-10 |
AU3292195A (en) | 1996-04-18 |
FI954612A (fi) | 1996-03-30 |
EP0704448B1 (de) | 2001-12-05 |
DK0704448T3 (da) | 2002-03-25 |
FI111259B (fi) | 2003-06-30 |
BR9504205A (pt) | 1996-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |