FI954612A0 - Uusia imidatsolidiinejä, jotka on substituoitu heterosyklillä, niiden valmistusmenetelmä ja -välituotetteita, niiden käyttö lääkkeinä ja niitä sisältävät farmaseuttiset koostumukset - Google Patents

Uusia imidatsolidiinejä, jotka on substituoitu heterosyklillä, niiden valmistusmenetelmä ja -välituotetteita, niiden käyttö lääkkeinä ja niitä sisältävät farmaseuttiset koostumukset

Info

Publication number
FI954612A0
FI954612A0 FI954612A FI954612A FI954612A0 FI 954612 A0 FI954612 A0 FI 954612A0 FI 954612 A FI954612 A FI 954612A FI 954612 A FI954612 A FI 954612A FI 954612 A0 FI954612 A0 FI 954612A0
Authority
FI
Finland
Prior art keywords
opt
substd
pharmaceuticals
intermediates
novel
Prior art date
Application number
FI954612A
Other languages
English (en)
Swedish (sv)
Other versions
FI954612A (fi
FI111259B (fi
Inventor
Andre Claussner
Francois Goubet
Jean-Georges Teutsch
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Publication of FI954612A0 publication Critical patent/FI954612A0/fi
Publication of FI954612A publication Critical patent/FI954612A/fi
Application granted granted Critical
Publication of FI111259B publication Critical patent/FI111259B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
FI954612A 1994-09-29 1995-09-28 Uusia imidatsolidiinijohdannaisia, niiden valmistusmenetelmä, niiden käyttö lääkkeinä ja niitä sisältävät farmaseuttiset koostumukset FI111259B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9411649A FR2725206B1 (fr) 1994-09-29 1994-09-29 Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR9411649 1994-09-29

Publications (3)

Publication Number Publication Date
FI954612A0 true FI954612A0 (fi) 1995-09-28
FI954612A FI954612A (fi) 1996-03-30
FI111259B FI111259B (fi) 2003-06-30

Family

ID=9467411

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954612A FI111259B (fi) 1994-09-29 1995-09-28 Uusia imidatsolidiinijohdannaisia, niiden valmistusmenetelmä, niiden käyttö lääkkeinä ja niitä sisältävät farmaseuttiset koostumukset

Country Status (19)

Country Link
US (3) US5646172A (fi)
EP (1) EP0704448B1 (fi)
JP (1) JPH0899977A (fi)
CN (1) CN1055471C (fi)
AT (1) ATE210134T1 (fi)
AU (1) AU707569B2 (fi)
BR (1) BR9504205A (fi)
CA (1) CA2159425A1 (fi)
DE (1) DE69524344T2 (fi)
DK (1) DK0704448T3 (fi)
ES (1) ES2169112T3 (fi)
FI (1) FI111259B (fi)
FR (1) FR2725206B1 (fi)
HU (1) HU222564B1 (fi)
IL (1) IL114939A (fi)
PT (1) PT704448E (fi)
RU (1) RU2170231C2 (fi)
UA (1) UA48937C2 (fi)
ZA (1) ZA957568B (fi)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
FR2742749B1 (fr) * 1995-12-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
DE19632126A1 (de) * 1996-08-09 1998-02-12 Bayer Ag Phenylsubstituierte cyclische Ketoenole
US20020142993A1 (en) * 2000-10-12 2002-10-03 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of bicyclic compounds
CA2579609A1 (en) * 2003-09-10 2005-03-17 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
CA2550447A1 (en) * 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
NZ550102A (en) * 2004-02-24 2010-10-29 Univ California Methods and materials for assessing prostate cancer therapies and compounds (thiohydantoine derivatives)
ATE541571T1 (de) 2005-05-13 2012-02-15 Univ California Diarylhydantoin-verbindung
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
WO2007011833A2 (en) * 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
PT2656841T (pt) * 2006-03-27 2016-09-28 Univ California Modulador do recetor de androgénios para o tratamento de cancro da próstata e doenças associadas ao recetor de androgénios
KR101600230B1 (ko) 2006-03-29 2016-03-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 디아릴티오히단토인 화합물
GB0610765D0 (en) * 2006-05-31 2006-07-12 Proskelia Sas Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
CA2662776A1 (en) * 2006-09-07 2008-03-13 Merck And Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
EP2220050A2 (en) 2007-10-26 2010-08-25 The Regents Of The University Of California Diarylhydantoin compounds as androgen receptor modulators
BR112012004919A2 (pt) 2009-09-04 2019-09-24 Univ Vanderbilt potencializadores alostericos de mglur4, composição e metodos de tratamentos de disfunção neurologica
EP2475647B1 (en) * 2009-09-10 2015-11-04 Suzhou Kintor Pharmaceuticals, Inc. Androgen receptor antagonists and uses thereof
ES2668380T3 (es) 2010-02-16 2018-05-17 Aragon Pharmaceuticals, Inc. Moduladores de receptores de andrógenos y sus usos
RU2434851C1 (ru) * 2010-07-22 2011-11-27 Александр Васильевич Иващенко Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
BR112013023028B1 (pt) 2011-03-10 2021-09-21 Suzhou Kintor Pharmaceuticals, Inc Composto de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica e formulação farmacêutica tópica
SI3305285T1 (sl) 2012-09-26 2021-03-31 Aragon Pharmaceuticals, Inc. Anti-androgeni za zdravljenje proti kastraciji odpornega ne-metastatskega raka
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
EP3696276A1 (en) 2013-02-25 2020-08-19 Novartis AG Novel androgen receptor mutation
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
WO2018037310A1 (en) 2016-08-20 2018-03-01 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
JOP20200076A1 (ar) 2017-10-16 2020-04-30 Aragon Pharmaceuticals Inc مضادات أندروجين لعلاج سرطان البروستاتا غير النقيلي المقاوم للاستئصال

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS421179Y1 (fi) * 1964-03-13 1967-01-24
JPS4623738Y1 (fi) * 1968-05-29 1971-08-16
DE2126532A1 (de) * 1971-05-28 1972-12-07 Merck Patent Gmbh, 6100 Darmstadt Neue Derivate der 6-Aminopenicillansäure und Verfahren zu ihrer Herstellung
FR2329276A1 (fr) * 1975-10-29 1977-05-27 Roussel Uclaf Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
US4320135A (en) * 1980-05-19 1982-03-16 Sandoz, Inc. Inhibiting growth hormone secretion with 5,5-substituted hydantoin derivatives
EP0091596B1 (de) * 1982-04-08 1991-09-11 Shell Internationale Researchmaatschappij B.V. Neue Hydantoine, ihre Herstellung und Verwendung
US5221675A (en) * 1989-12-15 1993-06-22 Abbott Laboratories Aza-spirocyclic compounds that enhance cholinergic neurotransmission
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
FR2694290B1 (fr) * 1992-07-08 1994-09-02 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
ES2169112T3 (es) 2002-07-01
BR9504205A (pt) 1996-08-06
FI954612A (fi) 1996-03-30
FR2725206B1 (fr) 1996-12-06
US5705654A (en) 1998-01-06
IL114939A0 (en) 1995-12-08
JPH0899977A (ja) 1996-04-16
UA48937C2 (uk) 2002-09-16
EP0704448A1 (fr) 1996-04-03
PT704448E (pt) 2002-05-31
EP0704448B1 (fr) 2001-12-05
CA2159425A1 (fr) 1996-03-30
RU2170231C2 (ru) 2001-07-10
FI111259B (fi) 2003-06-30
ZA957568B (en) 1996-09-09
IL114939A (en) 2005-11-20
CN1127753A (zh) 1996-07-31
US5646172A (en) 1997-07-08
HUT72748A (en) 1996-05-28
HU222564B1 (hu) 2003-08-28
DE69524344T2 (de) 2002-08-22
ATE210134T1 (de) 2001-12-15
AU3292195A (en) 1996-04-18
DE69524344D1 (de) 2002-01-17
CN1055471C (zh) 2000-08-16
HU9502841D0 (en) 1995-11-28
US5958936A (en) 1999-09-28
AU707569B2 (en) 1999-07-15
DK0704448T3 (da) 2002-03-25
FR2725206A1 (fr) 1996-04-05

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Legal Events

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Owner name: HOECHST MARION ROUSSEL