NO994340L - FremgangsmÕte for fremstilling av 2-[[(2-pyridinyl)metyl]sulfinyl]-1H-benzimidazoler samt nye forbindelser til anvendelse for dette formÕl - Google Patents
FremgangsmÕte for fremstilling av 2-[[(2-pyridinyl)metyl]sulfinyl]-1H-benzimidazoler samt nye forbindelser til anvendelse for dette formÕlInfo
- Publication number
- NO994340L NO994340L NO994340A NO994340A NO994340L NO 994340 L NO994340 L NO 994340L NO 994340 A NO994340 A NO 994340A NO 994340 A NO994340 A NO 994340A NO 994340 L NO994340 L NO 994340L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- sulfinyl
- pyridinyl
- och3
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
2-[[(2-pyridinyl) metyl] sulfinyl]-IH-benzimidazolderivater med generell formel (V), hvor R2 betegner H, OCH3, OCHF2 eller CF3, R3 betegner H, CH3 eller OCH3/ R4 betegner H, OCH3, OCH2CF3, halogen eller nitro, R5 betegner H, CH3 eller OCH3, og N er O eller l, eller salter derav,- fremstilles ved en ny fremgangsmåte som foregår via nye mellomprodukter med generell formel (I), (II), (III) og (Va) hvor R1 betegner forgrenet eller rettkjedet Cj. 8-alkyl, C3.8-sykloalkyl, aryl, aralkyl med ^gC-atomer i alkyldelen, eller en 5-6-leddet heterosyklisk gruppe med 1,2 eller 3 heteroatomer utvalgt fra nitrogen, svovel og oksygen i den heterosykliske ring. Forbindelsene med formel (V) er biologisk aktive og/eller kan anvendes som mellomprodukter ved syntese av biologisk aktive forbindelser. (V) (D R« (Va)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK25097 | 1997-03-07 | ||
PCT/DK1998/000059 WO1998040378A1 (en) | 1997-03-07 | 1998-02-16 | Process for the preparation of 2-[[(2-pyridinyl)methyl]sulfinyl]-1h-benzimidazoles and novel compounds of use for such purpose |
Publications (2)
Publication Number | Publication Date |
---|---|
NO994340D0 NO994340D0 (no) | 1999-09-07 |
NO994340L true NO994340L (no) | 1999-09-07 |
Family
ID=8091429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO994340A NO994340L (no) | 1997-03-07 | 1999-09-07 | FremgangsmÕte for fremstilling av 2-[[(2-pyridinyl)metyl]sulfinyl]-1H-benzimidazoler samt nye forbindelser til anvendelse for dette formÕl |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0968205A1 (no) |
AU (1) | AU5982298A (no) |
HR (1) | HRP980115A2 (no) |
NO (1) | NO994340L (no) |
WO (1) | WO1998040378A1 (no) |
ZA (1) | ZA981732B (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE510643C2 (sv) * | 1997-06-27 | 1999-06-14 | Astra Ab | Termodynamiskt stabil omeprazol natrium form B |
US6191148B1 (en) | 1998-08-11 | 2001-02-20 | Merck & Co., Inc. | Omerazole process and compositions thereof |
US6166213A (en) * | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
US20020128232A1 (en) * | 2000-10-12 | 2002-09-12 | Henderson Scott A. | Heterocyclic angiogenesis inhibitors |
CA2510849A1 (en) | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
EP1615913A2 (en) | 2003-06-10 | 2006-01-18 | Teva Pharmaceutical Industries Limited | Process for preparing 2-(pyridinyl)methyl sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole |
SE0400410D0 (sv) | 2004-02-20 | 2004-02-20 | Astrazeneca Ab | New compounds |
DE602007005077D1 (de) * | 2006-10-30 | 2010-04-15 | Dipharma Francis Srl | Verfahren zur Herstellung von Pyridinmethylsulphinylverbindungen |
EP2022789A1 (en) * | 2007-08-06 | 2009-02-11 | Farmaprojects, S.A. | Process for the preparation of a gastric acid secretion inhibitor |
CN102964336B (zh) * | 2012-11-29 | 2014-08-06 | 寿光富康制药有限公司 | 质子泵抑制剂的精制方法及其n-氧化物的还原方法 |
CN103044401A (zh) * | 2012-12-21 | 2013-04-17 | 北京华禧联合科技发展有限公司 | 苯并咪唑类化合物的制备方法 |
CN103951651B (zh) * | 2014-03-24 | 2018-11-30 | 翰宇药业(武汉)有限公司 | 雷贝拉唑相关物d的合成方法 |
CN105111187B (zh) * | 2015-08-07 | 2017-08-25 | 齐鲁天和惠世制药有限公司 | 一种泮托拉唑钠氮氧化杂质的制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DD231787A1 (de) * | 1984-08-10 | 1986-01-08 | Akad Wissenschaften Ddr | Verfahren zur herstellung von omega-substituierten bzw. omega, omega-disubstituierten 2-methylthio-benzimidazolderivaten |
ES2026761A6 (es) * | 1990-10-31 | 1992-05-01 | Genesis Para La Investigacion | Procedimiento de obtencion del omeprazol. |
-
1998
- 1998-02-16 AU AU59822/98A patent/AU5982298A/en not_active Abandoned
- 1998-02-16 WO PCT/DK1998/000059 patent/WO1998040378A1/en not_active Application Discontinuation
- 1998-02-16 EP EP98902961A patent/EP0968205A1/en not_active Withdrawn
- 1998-03-02 ZA ZA981732A patent/ZA981732B/xx unknown
- 1998-03-06 HR HR0250/97A patent/HRP980115A2/hr not_active Application Discontinuation
-
1999
- 1999-09-07 NO NO994340A patent/NO994340L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO994340D0 (no) | 1999-09-07 |
EP0968205A1 (en) | 2000-01-05 |
HRP980115A2 (en) | 1999-02-28 |
WO1998040378A1 (en) | 1998-09-17 |
ZA981732B (en) | 1998-09-07 |
AU5982298A (en) | 1998-09-29 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |