ES2054309T3 - Compuestos de urea sustituida y su preparacion y uso. - Google Patents
Compuestos de urea sustituida y su preparacion y uso.Info
- Publication number
- ES2054309T3 ES2054309T3 ES90610056T ES90610056T ES2054309T3 ES 2054309 T3 ES2054309 T3 ES 2054309T3 ES 90610056 T ES90610056 T ES 90610056T ES 90610056 T ES90610056 T ES 90610056T ES 2054309 T3 ES2054309 T3 ES 2054309T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- formula
- alkyl
- compound
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical class NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- -1 urea compound Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- 101100517202 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) NRPS1 gene Proteins 0.000 abstract 1
- 101150035904 PES1 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
Un método para preparar un compuesto de urea de la fórmula (I): (I) en el que: R 1 es un grupo de fórmula (II) ó (III) (II) (III) donde n es 2 ó 3, pes1 ó 2, q es 1 a 3,y R 4 es H, alquilo (C1 C7) o cicloalquilo (C3 C6); y en el que R 2 es 1,2,4 oxadiazol 5 ilo sustituido con alquilo (C1 C8), alquenilo (C2 C8), alquinilo (C2 C8), cicloalquilo (C3 C7), bencilo, fenilo, alcoxi (C1 C6), alquiltio (C1 C6), o amino; o bien en el que R 2 esC R 6 =NOR 7 , siendo R 6 hidrógeno o metilo y R 7 alquilo (C1 C6) que puede estar sustituido con cicloalquilo (C3 C7); y en el que R 3 es hidrógeno, halógeno, nitro, trifluorometilo, alquilo (C1 C6) ó alcoxi(C1 C6), caracterizado por: a) reaccionar un compuesto de fórmula (V): (V) con un compuestodefórmula (VI) J -R 1 donde R 1 , R 2 , R 3 son como se ha definido arriba; R 8 es COQ, donde Q es un grupo desplazable por un nucleófilo; R 8 y R 9 conjuntamente son =C=O, ó R 8 es hidrógeno (cuando R 9 es hidrógeno), y cuando R 8 es COQ, ó R 8 NR 9 es N=C=O, J es NH2, o uno de sus derivados reactivos o cuando R 8 es hidrógeno, J es un grupo que contiene un grupo carbonilo activado capaz de formar una unión CO N con el compuesto de fórmula (V).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK443489A DK443489D0 (da) | 1989-09-08 | 1989-09-08 | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2054309T3 true ES2054309T3 (es) | 1994-08-01 |
Family
ID=8133482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90610056T Expired - Lifetime ES2054309T3 (es) | 1989-09-08 | 1990-09-06 | Compuestos de urea sustituida y su preparacion y uso. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5330990A (es) |
| EP (2) | EP0491770A1 (es) |
| JP (1) | JPH05505171A (es) |
| AT (1) | ATE106885T1 (es) |
| AU (1) | AU639487B2 (es) |
| CA (1) | CA2066696A1 (es) |
| DE (1) | DE69009646T2 (es) |
| DK (2) | DK443489D0 (es) |
| ES (1) | ES2054309T3 (es) |
| FI (1) | FI921005A0 (es) |
| HU (1) | HU208433B (es) |
| IE (1) | IE69266B1 (es) |
| IL (1) | IL95440A (es) |
| NO (1) | NO300460B1 (es) |
| NZ (1) | NZ235117A (es) |
| PT (1) | PT95248B (es) |
| WO (1) | WO1991003475A1 (es) |
| ZA (1) | ZA907111B (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8922622D0 (en) * | 1989-10-07 | 1989-11-22 | Wyeth John & Brother Ltd | Aroylureas |
| DK40890D0 (da) * | 1990-02-16 | 1990-02-16 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
| GB9106571D0 (en) * | 1991-03-27 | 1991-05-15 | Erba Carlo Spa | Derivatives of substituted imidazol-2-one and process for their preparation |
| FR2677019B1 (fr) * | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
| GB9120628D0 (en) * | 1991-09-27 | 1991-11-06 | Fujisawa Pharmaceutical Co | Pyrrolobenzoxazine derivatives and process for preparation thereof |
| GB9121835D0 (en) * | 1991-10-15 | 1991-11-27 | Smithkline Beecham Plc | Pharmaceuticals |
| NZ251687A (en) * | 1992-03-31 | 1995-12-21 | Glaxo Group Ltd | Oxadiazol- and thiadiazol- phenylcarbamates and -phenylureas and pharmaceutical compositions thereof |
| GB9206989D0 (en) * | 1992-03-31 | 1992-05-13 | Glaxo Group Ltd | Chemical compounds |
| GB9214184D0 (en) * | 1992-07-03 | 1992-08-12 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9307400D0 (en) * | 1993-04-08 | 1993-06-02 | Smithkline Beecham Plc | Compounds |
| US5773459A (en) * | 1995-06-07 | 1998-06-30 | Sugen, Inc. | Urea- and thiourea-type compounds |
| US6676925B1 (en) | 1996-03-20 | 2004-01-13 | Wake Forest University | Sigma-2 receptors as biomarkers of tumor cell proliferation |
| US6113877A (en) * | 1996-03-20 | 2000-09-05 | Wake Forest University | σ-2 receptors as biomarkers of tumor cell proliferation |
| DE19643037A1 (de) * | 1996-10-18 | 1998-04-23 | Boehringer Ingelheim Kg | Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel |
| US6660529B2 (en) * | 1998-07-28 | 2003-12-09 | Pe Corporation | Heteroaryl substituted benzothiazole dioxetanes |
| US6693202B1 (en) | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
| UA73543C2 (uk) | 1999-12-07 | 2005-08-15 | Тераванс, Інк. | Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором |
| AU783095B2 (en) | 1999-12-07 | 2005-09-22 | Theravance Biopharma R&D Ip, Llc | Carbamate derivatives having muscarinic receptor antagonist activity |
| CA2407520C (en) | 2000-04-27 | 2010-02-02 | Wake Forest University Health Sciences | Sigma-2 receptors as biomarkers of tumor cell proliferation |
| US20050069976A1 (en) * | 2001-02-14 | 2005-03-31 | Peter Lind | Protein-coupled receptor |
| PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
| CA2543858C (en) | 2003-11-21 | 2014-04-15 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| AU2021311131A1 (en) | 2020-07-24 | 2023-03-23 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0158265A2 (en) | 1984-04-13 | 1985-10-16 | Beecham Group Plc | Benzamide and anilide derivatives |
| EP0235878A3 (en) * | 1986-01-16 | 1989-06-14 | Beecham Group Plc | Novel compounds |
| IE62231B1 (en) | 1987-12-24 | 1995-01-11 | Wyeth John & Brother Ltd | Heterocyclic compounds |
| DK40890D0 (da) * | 1990-02-16 | 1990-02-16 | Ferrosan As | Substituerede urinstofforbindelser, deres fremstilling og anvendelse |
-
1989
- 1989-09-08 DK DK443489A patent/DK443489D0/da not_active Application Discontinuation
-
1990
- 1990-08-21 IL IL9544090A patent/IL95440A/en not_active IP Right Cessation
- 1990-08-24 IE IE308290A patent/IE69266B1/en not_active IP Right Cessation
- 1990-08-31 NZ NZ235117A patent/NZ235117A/en unknown
- 1990-09-06 ES ES90610056T patent/ES2054309T3/es not_active Expired - Lifetime
- 1990-09-06 DK DK90610056.5T patent/DK0419397T3/da active
- 1990-09-06 EP EP90913477A patent/EP0491770A1/en active Pending
- 1990-09-06 WO PCT/DK1990/000232 patent/WO1991003475A1/en not_active Application Discontinuation
- 1990-09-06 JP JP2512602A patent/JPH05505171A/ja active Pending
- 1990-09-06 EP EP90610056A patent/EP0419397B1/en not_active Expired - Lifetime
- 1990-09-06 DE DE69009646T patent/DE69009646T2/de not_active Expired - Fee Related
- 1990-09-06 HU HU92776A patent/HU208433B/hu not_active IP Right Cessation
- 1990-09-06 CA CA002066696A patent/CA2066696A1/en not_active Abandoned
- 1990-09-06 ZA ZA907111A patent/ZA907111B/xx unknown
- 1990-09-06 AT AT90610056T patent/ATE106885T1/de not_active IP Right Cessation
- 1990-09-06 AU AU63414/90A patent/AU639487B2/en not_active Ceased
- 1990-09-07 PT PT95248A patent/PT95248B/pt not_active IP Right Cessation
-
1992
- 1992-03-03 NO NO920833A patent/NO300460B1/no unknown
- 1992-03-06 FI FI921005A patent/FI921005A0/fi not_active Application Discontinuation
- 1992-09-17 US US07/947,073 patent/US5330990A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0491770A1 (en) | 1992-07-01 |
| IL95440A (en) | 1994-07-31 |
| NO920833D0 (no) | 1992-03-03 |
| DE69009646T2 (de) | 1995-01-12 |
| NZ235117A (en) | 1993-02-25 |
| DK0419397T3 (da) | 1994-10-10 |
| NO300460B1 (no) | 1997-06-02 |
| IE69266B1 (en) | 1996-08-21 |
| CA2066696A1 (en) | 1991-03-09 |
| IL95440A0 (en) | 1991-06-30 |
| DE69009646D1 (de) | 1994-07-14 |
| HU208433B (en) | 1993-10-28 |
| DK443489D0 (da) | 1989-09-08 |
| US5330990A (en) | 1994-07-19 |
| IE903082A1 (en) | 1991-03-13 |
| JPH05505171A (ja) | 1993-08-05 |
| NO920833L (no) | 1992-03-03 |
| AU639487B2 (en) | 1993-07-29 |
| HU9200776D0 (en) | 1992-08-28 |
| EP0419397B1 (en) | 1994-06-08 |
| AU6341490A (en) | 1991-04-08 |
| EP0419397A1 (en) | 1991-03-27 |
| FI921005A0 (fi) | 1992-03-06 |
| PT95248B (pt) | 1997-06-30 |
| HUT61019A (en) | 1992-11-30 |
| WO1991003475A1 (en) | 1991-03-21 |
| PT95248A (pt) | 1991-05-22 |
| ZA907111B (en) | 1991-07-31 |
| ATE106885T1 (de) | 1994-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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