DE69603667D1 - Indol-, Indazol- und Benzisoxazolderivate zur Behandlung von Schizophrenia - Google Patents

Indol-, Indazol- und Benzisoxazolderivate zur Behandlung von Schizophrenia

Info

Publication number
DE69603667D1
DE69603667D1 DE69603667T DE69603667T DE69603667D1 DE 69603667 D1 DE69603667 D1 DE 69603667D1 DE 69603667 T DE69603667 T DE 69603667T DE 69603667 T DE69603667 T DE 69603667T DE 69603667 D1 DE69603667 D1 DE 69603667D1
Authority
DE
Germany
Prior art keywords
pyrrolidin
indazole
indole
benzisoxazole
ylü
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69603667T
Other languages
English (en)
Other versions
DE69603667T2 (de
Inventor
Gilbert Lavielle
Olivier Muller
Mark Millan
Valerie Audinot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Publication of DE69603667D1 publication Critical patent/DE69603667D1/de
Application granted granted Critical
Publication of DE69603667T2 publication Critical patent/DE69603667T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)
DE69603667T 1995-06-07 1996-06-06 Indol-, Indazol- und Benzisoxazolderivate zur Behandlung von Schizophrenia Expired - Fee Related DE69603667T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506663A FR2735129B1 (fr) 1995-06-07 1995-06-07 Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
DE69603667D1 true DE69603667D1 (de) 1999-09-16
DE69603667T2 DE69603667T2 (de) 2000-03-09

Family

ID=9479672

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69603667T Expired - Fee Related DE69603667T2 (de) 1995-06-07 1996-06-06 Indol-, Indazol- und Benzisoxazolderivate zur Behandlung von Schizophrenia

Country Status (15)

Country Link
US (1) US5703070A (de)
EP (1) EP0747379B1 (de)
JP (1) JPH08333362A (de)
CN (1) CN1060772C (de)
AT (1) ATE183183T1 (de)
AU (1) AU702285B2 (de)
CA (1) CA2178302C (de)
DE (1) DE69603667T2 (de)
DK (1) DK0747379T3 (de)
ES (1) ES2137638T3 (de)
FR (1) FR2735129B1 (de)
GR (1) GR3031051T3 (de)
NO (1) NO309090B1 (de)
NZ (1) NZ286756A (de)
ZA (1) ZA964842B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
GB9718712D0 (en) 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents
GB9718833D0 (en) * 1997-09-04 1997-11-12 Merck Sharp & Dohme Therapeutic agents
GB9805716D0 (en) * 1998-03-17 1998-05-13 Merck Sharp & Dohme Therapeutic agents
GB9815317D0 (en) * 1998-07-15 1998-09-16 Merck Sharp & Dohme Therapeutic agents
GB9816263D0 (en) 1998-07-24 1998-09-23 Merck Sharp & Dohme Therapeutic agents
BR0110420A (pt) * 2000-04-28 2003-07-01 Acadia Pharm Inc Agonistas muscarìnicos
EP1533299A4 (de) * 2002-07-19 2007-04-04 Meiji Dairies Corp Indolderivate und arzneimittel, die diese enthalten
US20100331298A1 (en) * 2007-12-10 2010-12-30 Cytopathfinder, Inc. Carboxamide Compounds and Their Use
RU2010128543A (ru) 2007-12-11 2012-01-20 Сайтопатфайндер, Инк. (Jp) Карбоксамидные соединения и их применение в качестве агонистов хемокиновых рецепторов

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2708913A1 (de) * 1976-03-04 1977-09-08 Hoechst Ag Benzoylpiperidyalkyl-indole und verwandte verbindungen
JPH0615529B2 (ja) * 1985-04-01 1994-03-02 エーザイ株式会社 新規ピペリジン誘導体
US5030639A (en) * 1987-07-13 1991-07-09 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2716680B1 (fr) * 1994-02-25 1996-04-05 Adir Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
JPH08333362A (ja) 1996-12-17
CN1060772C (zh) 2001-01-17
CN1143642A (zh) 1997-02-26
ATE183183T1 (de) 1999-08-15
NO309090B1 (no) 2000-12-11
EP0747379A1 (de) 1996-12-11
AU702285B2 (en) 1999-02-18
ZA964842B (en) 1997-01-07
AU5473596A (en) 1996-12-19
DE69603667T2 (de) 2000-03-09
ES2137638T3 (es) 1999-12-16
GR3031051T3 (en) 1999-12-31
CA2178302C (fr) 2002-02-26
FR2735129A1 (fr) 1996-12-13
DK0747379T3 (da) 2000-01-31
NZ286756A (en) 1997-08-22
CA2178302A1 (fr) 1996-12-08
US5703070A (en) 1997-12-30
FR2735129B1 (fr) 1997-07-11
NO962360D0 (no) 1996-06-06
NO962360L (no) 1996-12-09
EP0747379B1 (de) 1999-08-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR

8339 Ceased/non-payment of the annual fee