ES2137638T3 - Derivados del indol, del indazol y del bencisoxazol para el tratamiento de la esquizofrenia. - Google Patents

Derivados del indol, del indazol y del bencisoxazol para el tratamiento de la esquizofrenia.

Info

Publication number
ES2137638T3
ES2137638T3 ES96401208T ES96401208T ES2137638T3 ES 2137638 T3 ES2137638 T3 ES 2137638T3 ES 96401208 T ES96401208 T ES 96401208T ES 96401208 T ES96401208 T ES 96401208T ES 2137638 T3 ES2137638 T3 ES 2137638T3
Authority
ES
Spain
Prior art keywords
pyrrolidin
indol
ylü
alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96401208T
Other languages
English (en)
Inventor
Gilbert Lavielle
Olivier Muller
Mark Millan
Valerie Audinot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2137638T3 publication Critical patent/ES2137638T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Indole Compounds (AREA)

Abstract

COMPUESTO DE FORMULA (I) EN LA QUE R 1 REPRESENTA UN ATOMO DE HIDROGENO, DE HALOGENO, UN GRUPO ALQUILO, ALCOXI, TRIHALOGENOMETILO O HIDROXI, R{SUB,2} REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUILO, FENILO SUSTITUIDO O NO, REPRESENTA, O BIEN REPRESENTA -O-N=, 1 INFERIOR O IGUALA N INFERIOR O IGUAL A 6, REPRESENTA UNO CUALQUIERA DE LOS GRUPOS DEFINIDOS EN LA DESCRIPCION, SUS ISOMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO O A UNA BASE FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES96401208T 1995-06-07 1996-06-06 Derivados del indol, del indazol y del bencisoxazol para el tratamiento de la esquizofrenia. Expired - Lifetime ES2137638T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506663A FR2735129B1 (fr) 1995-06-07 1995-06-07 Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2137638T3 true ES2137638T3 (es) 1999-12-16

Family

ID=9479672

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96401208T Expired - Lifetime ES2137638T3 (es) 1995-06-07 1996-06-06 Derivados del indol, del indazol y del bencisoxazol para el tratamiento de la esquizofrenia.

Country Status (15)

Country Link
US (1) US5703070A (es)
EP (1) EP0747379B1 (es)
JP (1) JPH08333362A (es)
CN (1) CN1060772C (es)
AT (1) ATE183183T1 (es)
AU (1) AU702285B2 (es)
CA (1) CA2178302C (es)
DE (1) DE69603667T2 (es)
DK (1) DK0747379T3 (es)
ES (1) ES2137638T3 (es)
FR (1) FR2735129B1 (es)
GR (1) GR3031051T3 (es)
NO (1) NO309090B1 (es)
NZ (1) NZ286756A (es)
ZA (1) ZA964842B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6187774B1 (en) * 1996-03-04 2001-02-13 Yoshitomi Pharmaceutical Industries, Ltd. Fused heterocyclic compounds and pharmaceutical applications thereof
GB9718712D0 (en) * 1997-09-03 1997-11-12 Merck Sharp & Dohme Theraputic Agents
GB9718833D0 (en) * 1997-09-04 1997-11-12 Merck Sharp & Dohme Therapeutic agents
GB9805716D0 (en) * 1998-03-17 1998-05-13 Merck Sharp & Dohme Therapeutic agents
GB9815317D0 (en) * 1998-07-15 1998-09-16 Merck Sharp & Dohme Therapeutic agents
GB9816263D0 (en) 1998-07-24 1998-09-23 Merck Sharp & Dohme Therapeutic agents
US6627645B2 (en) * 2000-04-28 2003-09-30 Acadia Pharmaceuticals, Inc. Muscarinic agonists
AU2003248091A1 (en) * 2002-07-19 2004-02-09 Meiji Dairies Corporation Indole derivatives and drugs containing the same
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
US8569282B2 (en) 2007-12-11 2013-10-29 Cytopathfinder, Inc. Carboxamide compounds and their use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2708913A1 (de) * 1976-03-04 1977-09-08 Hoechst Ag Benzoylpiperidyalkyl-indole und verwandte verbindungen
JPH0615529B2 (ja) * 1985-04-01 1994-03-02 エーザイ株式会社 新規ピペリジン誘導体
US5030639A (en) * 1987-07-13 1991-07-09 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
US4980365A (en) * 1987-07-13 1990-12-25 Hoechst-Roussel Pharmaceuticals Inc. N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents
FR2644786B1 (fr) * 1989-03-21 1993-12-31 Adir Cie Nouveaux derives fluoro-4 benzoiques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2654104B1 (fr) * 1989-11-07 1992-01-03 Adir Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2716680B1 (fr) * 1994-02-25 1996-04-05 Adir Nouveaux dérivés de benzodioxane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
FR2735129A1 (fr) 1996-12-13
CN1143642A (zh) 1997-02-26
CA2178302C (fr) 2002-02-26
AU5473596A (en) 1996-12-19
EP0747379B1 (fr) 1999-08-11
DK0747379T3 (da) 2000-01-31
ATE183183T1 (de) 1999-08-15
DE69603667T2 (de) 2000-03-09
CA2178302A1 (fr) 1996-12-08
NO962360L (no) 1996-12-09
GR3031051T3 (en) 1999-12-31
NO962360D0 (no) 1996-06-06
EP0747379A1 (fr) 1996-12-11
ZA964842B (en) 1997-01-07
US5703070A (en) 1997-12-30
NZ286756A (en) 1997-08-22
CN1060772C (zh) 2001-01-17
AU702285B2 (en) 1999-02-18
FR2735129B1 (fr) 1997-07-11
JPH08333362A (ja) 1996-12-17
NO309090B1 (no) 2000-12-11
DE69603667D1 (de) 1999-09-16

Similar Documents

Publication Publication Date Title
ES2116801T3 (es) Empleo de derivados de adamantano para el tratamiento de tinnitus.
UY23657A1 (es) Procedimiento para la preparacion de derivados de indol
PT91417A (pt) Processo para a preparacao de derivados indolicos
NO20023995D0 (no) 2-okso-1-pyrrolidinderivater, fremgangsmåte for fremstilling og anvendelse av disse
NO965334D0 (no) Nye 4,6-diarylpyrimidin-derivater og salter derav
ES2137638T3 (es) Derivados del indol, del indazol y del bencisoxazol para el tratamiento de la esquizofrenia.
ES2156287T3 (es) Derivados de difenilmetilen piperidina.
PE41796A1 (es) Compuesto activo en el receptor de serotonina 5-ht, util en el tratamiento de enfermedades del s.n.c.
DE69323667T2 (de) 4-substituierte 1,2,4-Triazolderivate
DE60102171D1 (de) Ketolidantibiotika
PT655243E (pt) Derivados da melatonina para utilizacao no tratamento de disturbios do sono
NO913543D0 (no) Fremgangsmaate for fremstilling av 3-(1h-indazol-3-yl)-4-pyridinaminer og mellomprodukter, og anvendelse som medikamenter.
ES2181387T3 (es) Derivados de azetidinocarboxamida para el tratamiento de trastornos del sistema nervioso central.
IT1313583B1 (it) Derivati 2-amminotetralinici per la terapia del glaucoma.
GT200100120A (es) Derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 747379

Country of ref document: ES