ES2107212T3 - Derivados de 1,4-benzoxazina como abridores de los canales de potasio. - Google Patents

Derivados de 1,4-benzoxazina como abridores de los canales de potasio.

Info

Publication number
ES2107212T3
ES2107212T3 ES94913764T ES94913764T ES2107212T3 ES 2107212 T3 ES2107212 T3 ES 2107212T3 ES 94913764 T ES94913764 T ES 94913764T ES 94913764 T ES94913764 T ES 94913764T ES 2107212 T3 ES2107212 T3 ES 2107212T3
Authority
ES
Spain
Prior art keywords
potassium channel
channel openers
benzoxazine derivatives
fluorated
sup
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94913764T
Other languages
English (en)
Inventor
Frederick Jeffrey Brown
Keith Russell
Paul James Warwick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2107212T3 publication Critical patent/ES2107212T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

COMPUESTOS DE FORMULA (I), DONDE R 1 Y R 2 SE SELECCIONAN INDEPENDIENTEMENTE DE (1-3C) ALQUILO QUE PUEDE SER SUSTITUIDO POR UNO O MAS GRUPOS FLUORADOS, SIEMPRE QUE AL MENOS UNO DE R{SUP,1} Y R{SUP,2} ESTE SUSTITUIDO POR AL MENOS UN GRUPO FLUORADO; Y QUE LAS SALES FARMACEUTICAMENTE ACEPTABLES SEAN UTILES COMO ABRIDORES DEL CANAL DE POTASIO PARA EL TRATAMIENTO DE LA INCONTINENCIA URINARIA. TAMBIEN SE PRESENTAN LAS COMPOSICIONES FARMACEUTICAS, LOS PROCESOS PARA LA PREPARACION DE LAS COMPOSICONES DE LA FORMULA (I) Y SUS COMPUESTOS INTERMEDIOS.
ES94913764T 1993-05-12 1994-05-04 Derivados de 1,4-benzoxazina como abridores de los canales de potasio. Expired - Lifetime ES2107212T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309716A GB9309716D0 (en) 1993-05-12 1993-05-12 Heterocyclic derivatives

Publications (1)

Publication Number Publication Date
ES2107212T3 true ES2107212T3 (es) 1997-11-16

Family

ID=10735294

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94913764T Expired - Lifetime ES2107212T3 (es) 1993-05-12 1994-05-04 Derivados de 1,4-benzoxazina como abridores de los canales de potasio.

Country Status (9)

Country Link
US (2) US5486515A (es)
EP (1) EP0698022B1 (es)
JP (1) JP3523257B2 (es)
AU (1) AU6579494A (es)
DE (1) DE69405729T2 (es)
ES (1) ES2107212T3 (es)
GB (1) GB9309716D0 (es)
HU (1) HU9501708D0 (es)
WO (1) WO1994026739A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
GB9607458D0 (en) 1996-04-10 1996-06-12 Zeneca Ltd Enzymatic process for stereoselective preparation of therapeutic amides
US6083986A (en) * 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
GB9804648D0 (en) 1998-03-06 1998-04-29 Zeneca Ltd Chemical compounds
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GB9811427D0 (en) 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
KR100692232B1 (ko) 1999-09-04 2007-03-09 아스트라제네카 아베 피루베이트 탈수소효소 활성을 증가시키는 치환된 ｎ-페닐2-히드록시-2-메틸-3,3,3-트리플루오로프로판아미드 유도체
ATE344237T1 (de) 1999-09-04 2006-11-15 Astrazeneca Ab Hydroxyacetamidobenzolsulfonamidderivate
JP2003508509A (ja) 1999-09-04 2003-03-04 アストラゼネカ アクチボラグ ピルビン酸デヒドロゲナーゼの阻害剤としてのアミド
WO2001046155A1 (en) 1999-12-21 2001-06-28 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) * 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6620849B2 (en) 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
WO2002085868A1 (en) 2001-04-23 2002-10-31 Astrazeneca Ab Benzoxazinone derivatives for use in the treatment of angiogenesis
GB0120471D0 (en) * 2001-08-23 2001-10-17 Astrazeneca Ab Chemical compounds
NZ550441A (en) * 2004-05-05 2009-07-31 Hoffmann La Roche Arylsulfonyl benzodioxanes useful for modulating the 5-HT6 receptor, the 5-HT2A receptor or both
US7378415B2 (en) 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
CR20200286A (es) 2011-12-22 2020-09-23 Novartis Ag DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294)
CN112511569B (zh) * 2021-02-07 2021-05-11 杭州筋斗腾云科技有限公司 网络资源访问请求的处理方法、系统及计算机设备

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192208A (en) * 1962-07-31 1965-06-29 Lilly Co Eli Novel substituted morpholines and piperazines and processes for their synthesis
US3225042A (en) * 1962-07-31 1965-12-21 Lilly Co Eli Hydroxymorpholines
US3821377A (en) * 1972-02-22 1974-06-28 Squibb & Sons Inc Anti-inflammatory agents
US3763153A (en) * 1972-02-22 1973-10-02 Squibb & Sons Inc Benzothiazines
JPS62178577A (ja) * 1986-02-03 1987-08-05 Daikin Ind Ltd 含フツ素複素環化合物
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
TW224941B (es) * 1989-11-08 1994-06-11 Yamanouchi Pharma Co Ltd
CN1060467A (zh) * 1990-09-25 1992-04-22 武田药品工业株式会社 1，3-苯并嗪衍生物、其生产方法和用途
CA2061179A1 (en) * 1991-02-18 1992-08-19 Ryuji Tsuzuki Oxzazinobenzazole compounds
AU1493092A (en) * 1991-04-18 1992-10-22 Ortho Pharmaceutical Corporation (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones
DE69328366T2 (de) * 1992-08-17 2000-08-10 Chugai Pharmaceutical Co Ltd Benzopyran und benzoxazin-derivate
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives

Also Published As

Publication number Publication date
WO1994026739A1 (en) 1994-11-24
DE69405729T2 (de) 1998-01-08
JPH08510226A (ja) 1996-10-29
AU6579494A (en) 1994-12-12
US5486515A (en) 1996-01-23
DE69405729D1 (de) 1997-10-23
JP3523257B2 (ja) 2004-04-26
EP0698022A1 (en) 1996-02-28
GB9309716D0 (en) 1993-06-23
EP0698022B1 (en) 1997-09-17
US5700798A (en) 1997-12-23
HU9501708D0 (en) 1996-03-28

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