DE69405729T2 - 1,4-benzoxazinderivate als kalium kanalaktivatoren - Google Patents

1,4-benzoxazinderivate als kalium kanalaktivatoren

Info

Publication number
DE69405729T2
DE69405729T2 DE69405729T DE69405729T DE69405729T2 DE 69405729 T2 DE69405729 T2 DE 69405729T2 DE 69405729 T DE69405729 T DE 69405729T DE 69405729 T DE69405729 T DE 69405729T DE 69405729 T2 DE69405729 T2 DE 69405729T2
Authority
DE
Germany
Prior art keywords
benzoxazine derivatives
potassium activators
activators
potassium
benzoxazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69405729T
Other languages
English (en)
Other versions
DE69405729D1 (de
Inventor
Frederick Brown
Keith Russell
Paul Warwick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69405729D1 publication Critical patent/DE69405729D1/de
Application granted granted Critical
Publication of DE69405729T2 publication Critical patent/DE69405729T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69405729T 1993-05-12 1994-05-04 1,4-benzoxazinderivate als kalium kanalaktivatoren Expired - Fee Related DE69405729T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939309716A GB9309716D0 (en) 1993-05-12 1993-05-12 Heterocyclic derivatives
PCT/GB1994/000951 WO1994026739A1 (en) 1993-05-12 1994-05-04 1,4-benzoxazine derivatives as potassium channel openers

Publications (2)

Publication Number Publication Date
DE69405729D1 DE69405729D1 (de) 1997-10-23
DE69405729T2 true DE69405729T2 (de) 1998-01-08

Family

ID=10735294

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69405729T Expired - Fee Related DE69405729T2 (de) 1993-05-12 1994-05-04 1,4-benzoxazinderivate als kalium kanalaktivatoren

Country Status (9)

Country Link
US (2) US5486515A (de)
EP (1) EP0698022B1 (de)
JP (1) JP3523257B2 (de)
AU (1) AU6579494A (de)
DE (1) DE69405729T2 (de)
ES (1) ES2107212T3 (de)
GB (1) GB9309716D0 (de)
HU (1) HU9501708D0 (de)
WO (1) WO1994026739A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives
GB9607458D0 (en) * 1996-04-10 1996-06-12 Zeneca Ltd Enzymatic process for stereoselective preparation of therapeutic amides
US6083986A (en) * 1996-07-26 2000-07-04 Icagen, Inc. Potassium channel inhibitors
US6333337B1 (en) 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
GB9804648D0 (en) 1998-03-06 1998-04-29 Zeneca Ltd Chemical compounds
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
GB9811427D0 (en) 1998-05-29 1998-07-22 Zeneca Ltd Chemical compounds
US6455554B1 (en) 1999-06-07 2002-09-24 Targacept, Inc. Oxopyridinyl pharmaceutical compositions and methods for use
PL353887A1 (en) 1999-09-04 2003-12-15 Astrazeneca Abastrazeneca Ab Substituted n-phenyl 2-hydroxy-2-methyl-3,3,3-trifluoropropanamide derivatives which elevate pyruvate dehydrogenase activity
ES2307528T3 (es) 1999-09-04 2008-12-01 Astrazeneca Ab Amidas como inhibidores para la piruvato deshidrogenasa.
JP2003508514A (ja) 1999-09-04 2003-03-04 アストラゼネカ アクチボラグ 化学的化合物
US6458794B2 (en) 1999-12-21 2002-10-01 Icagen, Inc. Potassium channel inhibitors
US6566380B2 (en) 2000-07-25 2003-05-20 Icagen, Inc. Potassium channel inhibitors
US6620849B2 (en) 2000-07-26 2003-09-16 Icafen, Inc. Potassium channel inhibitors
US6849634B2 (en) 2000-12-21 2005-02-01 Icagen Potassium channel inhibitors
JP2004528335A (ja) 2001-04-23 2004-09-16 アストラゼネカ アクチボラグ 血管新生の治療に使用のベンゾオキサジノン誘導体
GB0120471D0 (en) * 2001-08-23 2001-10-17 Astrazeneca Ab Chemical compounds
JP2007536302A (ja) * 2004-05-05 2007-12-13 エフ．ホフマン−ラ　ロシュ　アーゲー ５−ｈｔ６受容体、５−ｈｔ２ａ受容体、又はその両方の調節に有用なアリールスルホニルベンゾジオキサン類
US7378415B2 (en) 2004-09-30 2008-05-27 Roche Palo Alto Llc Benzoxazine and quinoxaline derivatives and uses thereof
SI2794600T1 (en) 2011-12-22 2018-03-30 Novartis Ag 2,3-Dihydro-benzo (1,4) oxazine derivatives and related compounds as phosphoinositide-3 kinase inhibitors (PI3K) for the treatment, e.g. rheumatoid arthritis
CN112511569B (zh) * 2021-02-07 2021-05-11 杭州筋斗腾云科技有限公司 网络资源访问请求的处理方法、系统及计算机设备

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192208A (en) * 1962-07-31 1965-06-29 Lilly Co Eli Novel substituted morpholines and piperazines and processes for their synthesis
US3225042A (en) * 1962-07-31 1965-12-21 Lilly Co Eli Hydroxymorpholines
US3763153A (en) * 1972-02-22 1973-10-02 Squibb & Sons Inc Benzothiazines
US3821377A (en) * 1972-02-22 1974-06-28 Squibb & Sons Inc Anti-inflammatory agents
JPS62178577A (ja) * 1986-02-03 1987-08-05 Daikin Ind Ltd 含フツ素複素環化合物
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
TW224941B (de) * 1989-11-08 1994-06-11 Yamanouchi Pharma Co Ltd
CN1060467A (zh) * 1990-09-25 1992-04-22 武田药品工业株式会社 1，3-苯并嗪衍生物、其生产方法和用途
CA2061179A1 (en) * 1991-02-18 1992-08-19 Ryuji Tsuzuki Oxzazinobenzazole compounds
AU1493092A (en) * 1991-04-18 1992-10-22 Ortho Pharmaceutical Corporation (+) and (-) enantiomers of 5-aliphatic-6-(benzoxazinyl- or benzothiazinyl)-2,3,4,5-tetrahydropyridazin-3-ones
AU4761693A (en) * 1992-08-17 1994-03-15 Chugai Seiyaku Kabushiki Kaisha Benzopyran and benzoxazine derivatives
GB9309716D0 (en) * 1993-05-12 1993-06-23 Zeneca Ltd Heterocyclic derivatives

Also Published As

Publication number Publication date
US5486515A (en) 1996-01-23
AU6579494A (en) 1994-12-12
JPH08510226A (ja) 1996-10-29
EP0698022A1 (de) 1996-02-28
HU9501708D0 (en) 1996-03-28
DE69405729D1 (de) 1997-10-23
US5700798A (en) 1997-12-23
ES2107212T3 (es) 1997-11-16
EP0698022B1 (de) 1997-09-17
JP3523257B2 (ja) 2004-04-26
WO1994026739A1 (en) 1994-11-24
GB9309716D0 (en) 1993-06-23

Similar Documents

Publication Publication Date Title
DE69405729T2 (de) 1,4-benzoxazinderivate als kalium kanalaktivatoren
ATE204865T1 (de) Optisch aktive 2-imidazoline-5-one-derivate als fungizide
NL350032I1 (nl) Pyrazool-4-yl-benzoylderivaten de toepassing ervan als herbiciden.
DE59501802D1 (de) Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
DE69610822T2 (de) Indolderivate als 5-ht rezeptorantagoniste
DE59511103D1 (de) 1-h-3-aryl-pyrrolidin-2,4-dion-derivate als schädlingsbekämpfungsmittel
DE69105836D1 (de) Bleichmittelzusammensetzung.
DE59100656D1 (de) Bohrfutter.
NL300304I1 (nl) Pleuromutilinderivaten als anti-bacteriele middelen.
NL300122I1 (nl) Androtenonderivaat.
DE69017066D1 (de) 3-Substituierte-2-Oxindolderivate als Entzündungshemmender.
DE69202078D1 (de) Werkstückhalter.
ATE296800T1 (de) Sulfonylamino-carbonsäure-n-arylamide als guanylatcyclase-aktivatoren
DE69428724T2 (de) Drehautomat
DE69409124T2 (de) Bleichaktivatoren
FR2701164B1 (fr) Photodétecteur.
BR9609310A (pt) Derivados de 1,3-OXA(TIA)ZINA
KR950017018U (ko) 천공기
ATE108789T1 (de) Benzoxazinderivate.
TR27956A (tr) Hidroksietil-azolil türevleri.
DE69418656D1 (de) 2-acyloxycephemderivate als elastaseinhibitoren
KR960700235A (ko) 신규 치환 티오세미카르바존 유도체(Novel Substituted Thiosemicarbazone Derivatives)
DE59007345D1 (de) Triphendioxazinfarbstoffe.
KR950005817U (ko) 드릴 머신
FI932549A0 (fi) Haollfast, enhetligt, plastbaserat kompositmaterial och foerfaranden foerframstaellning daerav

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB

8339 Ceased/non-payment of the annual fee