UA48937C2 - Імідазолідини, заміщені гетероциклом, спосіб їх одержання і фармацевтична композиція, що їх містить - Google Patents

Імідазолідини, заміщені гетероциклом, спосіб їх одержання і фармацевтична композиція, що їх містить

Info

Publication number
UA48937C2
UA48937C2 UA95094318A UA95094318A UA48937C2 UA 48937 C2 UA48937 C2 UA 48937C2 UA 95094318 A UA95094318 A UA 95094318A UA 95094318 A UA95094318 A UA 95094318A UA 48937 C2 UA48937 C2 UA 48937C2
Authority
UA
Ukraine
Prior art keywords
synthesis
substances
pharmaceutical composition
optionally substituted
substituted
Prior art date
Application number
UA95094318A
Other languages
English (en)
Russian (ru)
Inventor
Андре Клосснер
Франсуа Губе
Жан-Жорж Тьотш
Original Assignee
Хьохст Маріон Руссель
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хьохст Маріон Руссель, Хехст Марион Руссель filed Critical Хьохст Маріон Руссель
Publication of UA48937C2 publication Critical patent/UA48937C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Предмет винаходу становлять, зокрема, сполуки формули (I) , (I) де • являє собою арильний радикал, який може бути заміщено на ціано-, нітро- радикали, атом галогену, трифторметильним, карбоксильним вільним, перетвореним на складний ефір або сіль, алкоксильним, алкілтіонільним радикалом; • являє собою атом кисню чи сірки, а - атом водню, алкільний, алкенільний, алкінільний, арильний або арилалкильний радикал, с можливістю заміщення; • являє собою атом кисню чи сірки або радикал ; • являє собою насичений гетероцикл, який включає , або , с можливістю заміщення. Описані сполуки мають антиандрогенну активність і можуть застосовуватись як лікарські засоби. Наведено також спосіб отримання таких імідазолідинів. Описано фармацевтичну комозицію на основі цих сполук.
UA95094318A 1994-09-29 1995-09-27 Імідазолідини, заміщені гетероциклом, спосіб їх одержання і фармацевтична композиція, що їх містить UA48937C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9411649A FR2725206B1 (fr) 1994-09-29 1994-09-29 Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Publications (1)

Publication Number Publication Date
UA48937C2 true UA48937C2 (uk) 2002-09-16

Family

ID=9467411

Family Applications (1)

Application Number Title Priority Date Filing Date
UA95094318A UA48937C2 (uk) 1994-09-29 1995-09-27 Імідазолідини, заміщені гетероциклом, спосіб їх одержання і фармацевтична композиція, що їх містить

Country Status (19)

Country Link
US (3) US5646172A (uk)
EP (1) EP0704448B1 (uk)
JP (1) JPH0899977A (uk)
CN (1) CN1055471C (uk)
AT (1) ATE210134T1 (uk)
AU (1) AU707569B2 (uk)
BR (1) BR9504205A (uk)
CA (1) CA2159425A1 (uk)
DE (1) DE69524344T2 (uk)
DK (1) DK0704448T3 (uk)
ES (1) ES2169112T3 (uk)
FI (1) FI111259B (uk)
FR (1) FR2725206B1 (uk)
HU (1) HU222564B1 (uk)
IL (1) IL114939A (uk)
PT (1) PT704448E (uk)
RU (1) RU2170231C2 (uk)
UA (1) UA48937C2 (uk)
ZA (1) ZA957568B (uk)

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FR2741342B1 (fr) * 1995-11-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines fluorees ou hydroxylees, procede, intermediaires de preparation, application comme medicaments, nouvelle utilisation et compositions pharmaceutiques
FR2742749B1 (fr) * 1995-12-22 1998-02-06 Roussel Uclaf Nouvelles phenylimidazolidines comportant notamment un radical nitrooxy ou carbonyloxy, procede et intermediaires de preparation, application comme medicaments, nouvelles utilisations et compositions pharmaceutiques
DE19632126A1 (de) * 1996-08-09 1998-02-12 Bayer Ag Phenylsubstituierte cyclische Ketoenole
US20020142993A1 (en) * 2000-10-12 2002-10-03 Dr. Reddy's Laboratories Ltd. Pharmaceutically acceptable salts of bicyclic compounds
IL158485A0 (en) * 2001-04-18 2004-05-12 Euro Celtique Sa Spiropyrazole compounds
RU2243227C1 (ru) * 2003-07-25 2004-12-27 Институт проблем химической физики РАН (dl)-1-гидрокси-3,7,7,9,9-пентаметил-1,4,8-триазаспиро [4,5] декан-2-он и способ его получения
EP1786816A4 (en) * 2003-09-10 2009-11-04 Virochem Pharma Inc SPIROHYDANTOIN COMPOUNDS AND METHODS FOR MODULATING CHEMOKINE RECEPTOR ACTIVITY
DE602004031881D1 (de) * 2003-12-19 2011-04-28 Univ California Verfahren und materialien zur beurteilung von prostatakrebstherapien
US7718684B2 (en) * 2004-02-24 2010-05-18 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
EP3106162A1 (en) 2005-05-13 2016-12-21 The Regents of the University of California Diarylhydantoin compounds as androgen receptor antagonists for treatment of cancer
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
WO2007011810A1 (en) * 2005-07-18 2007-01-25 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
EP2656842B1 (en) * 2006-03-27 2016-08-10 The Regents of The University of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
WO2007127010A2 (en) * 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
US8168667B2 (en) 2006-05-31 2012-05-01 Galapagos Nv Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
GB0610765D0 (en) * 2006-05-31 2006-07-12 Proskelia Sas Imidazolidine derivatives, uses therefor, preparation thereof and compositions comprising such
AU2007293416A1 (en) * 2006-09-07 2008-03-13 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
CA2966280A1 (en) 2007-10-26 2009-04-30 The Regents Of The University Of California Diarylhydantoin compounds
WO2011029104A1 (en) 2009-09-04 2011-03-10 Vanderbilt University Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
JP5659232B2 (ja) * 2009-09-10 2015-01-28 トン、ヨウヂ アンドロゲン受容体アンタゴニストおよびその使用
HUE037389T2 (hu) 2010-02-16 2018-08-28 Aragon Pharmaceuticals Inc Androgén receptor modulátorok és alkalmazásaik
RU2434851C1 (ru) * 2010-07-22 2011-11-27 Александр Васильевич Иващенко Циклические n, n'-диарилтиомочевины или n, n'-диарилмочевины - антагонисты андрогенных рецепторов, противораковое средство, способ получения и применения
WO2012119559A1 (en) 2011-03-10 2012-09-13 Suzhou Kintor Pharmaceuticals,Inc. Androgen receptor antagonists and uses thereof
ES2836424T3 (es) 2012-09-26 2021-06-25 Aragon Pharmaceuticals Inc Antiandrógenos para tratar el cáncer de próstata no metastásico y resistente a la castración
CA3105575A1 (en) 2013-01-15 2014-07-24 Aragon Pharmaceuticals, Inc. Androgen receptor modulator and uses thereof
WO2014130932A2 (en) 2013-02-25 2014-08-28 Novartis Ag Novel androgen receptor mutation
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
US20190209469A1 (en) 2016-08-20 2019-07-11 Ftf Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
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Also Published As

Publication number Publication date
PT704448E (pt) 2002-05-31
EP0704448B1 (fr) 2001-12-05
CN1055471C (zh) 2000-08-16
EP0704448A1 (fr) 1996-04-03
CN1127753A (zh) 1996-07-31
AU3292195A (en) 1996-04-18
FI954612L (fi) 1996-03-30
US5705654A (en) 1998-01-06
DE69524344T2 (de) 2002-08-22
FR2725206A1 (fr) 1996-04-05
FR2725206B1 (fr) 1996-12-06
ATE210134T1 (de) 2001-12-15
DK0704448T3 (da) 2002-03-25
ZA957568B (en) 1996-09-09
RU2170231C2 (ru) 2001-07-10
BR9504205A (pt) 1996-08-06
US5958936A (en) 1999-09-28
JPH0899977A (ja) 1996-04-16
DE69524344D1 (de) 2002-01-17
FI954612A0 (fi) 1995-09-28
US5646172A (en) 1997-07-08
FI111259B (fi) 2003-06-30
HU222564B1 (hu) 2003-08-28
IL114939A (en) 2005-11-20
AU707569B2 (en) 1999-07-15
HUT72748A (en) 1996-05-28
HU9502841D0 (en) 1995-11-28
CA2159425A1 (fr) 1996-03-30
IL114939A0 (en) 1995-12-08
ES2169112T3 (es) 2002-07-01

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