ATE41146T1 - Irreversible dopamin-b-hydroxylase-inhibitoren. - Google Patents

Irreversible dopamin-b-hydroxylase-inhibitoren.

Info

Publication number
ATE41146T1
ATE41146T1 AT86306923T AT86306923T ATE41146T1 AT E41146 T1 ATE41146 T1 AT E41146T1 AT 86306923 T AT86306923 T AT 86306923T AT 86306923 T AT86306923 T AT 86306923T AT E41146 T1 ATE41146 T1 AT E41146T1
Authority
AT
Austria
Prior art keywords
dopamine
irreversible
hydroxylase inhibitors
preparation
inhibitors
Prior art date
Application number
AT86306923T
Other languages
English (en)
Inventor
Pamela Anne Chambers
James Simpson Frazee
Carl Kaiser
Lawrence Ivan Kruse
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Application granted granted Critical
Publication of ATE41146T1 publication Critical patent/ATE41146T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT86306923T 1985-09-09 1986-09-08 Irreversible dopamin-b-hydroxylase-inhibitoren. ATE41146T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/773,694 US4760089A (en) 1985-09-09 1985-09-09 Irreversible dopamine-β-hydroxylase inhibitors
EP86306923A EP0219961B1 (de) 1985-09-09 1986-09-08 Irreversible Dopamin-B-Hydroxylase-Inhibitoren

Publications (1)

Publication Number Publication Date
ATE41146T1 true ATE41146T1 (de) 1989-03-15

Family

ID=25099026

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86306923T ATE41146T1 (de) 1985-09-09 1986-09-08 Irreversible dopamin-b-hydroxylase-inhibitoren.

Country Status (11)

Country Link
US (1) US4760089A (de)
EP (1) EP0219961B1 (de)
JP (1) JPS6261960A (de)
AT (1) ATE41146T1 (de)
AU (1) AU595232B2 (de)
DE (1) DE3662265D1 (de)
DK (1) DK421586A (de)
ES (1) ES2001775A6 (de)
GR (1) GR862290B (de)
PT (1) PT83316B (de)
ZA (1) ZA866808B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4760089A (en) * 1985-09-09 1988-07-26 Smithkline Beckman Corporation Irreversible dopamine-β-hydroxylase inhibitors
MTP1031B (en) * 1987-12-24 1990-10-04 Orion Yhtymae Oy New use of cathecol-o-methyl transferase (comt) inhibitors and their physiologically acceptable salts and esters
US5637767A (en) * 1995-06-07 1997-06-10 Warner-Lambert Company Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
KR20070004769A (ko) * 2004-02-27 2007-01-09 암젠 인코포레이션 대사 장애의 치료에 사용되는 화합물, 약제학적 조성물 및그 사용방법
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
CA2621949A1 (en) * 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
EP2001844A2 (de) * 2006-03-14 2008-12-17 Amgen, Inc Bicyclische carbonsäurederivate zur behandlung von stoffwechselerkrankungen
EP2064193A1 (de) * 2006-09-07 2009-06-03 Amgen, Inc Heterozyklische gpr40-modulatoren
CA2662242C (en) * 2006-09-07 2012-06-12 Amgen Inc. Benzo-fused compounds for use in treating metabolic disorders
CA2683751C (en) * 2007-04-16 2013-01-08 Amgen Inc. Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
CA2702047C (en) 2007-10-10 2012-04-17 Amgen Inc. Substituted biphenyl gpr40 modulators
US8450522B2 (en) * 2008-03-06 2013-05-28 Amgen Inc. Conformationally constrained carboxylic acid derivatives useful for treating metabolic disorders
CA2739888C (en) * 2008-10-15 2013-11-19 Amgen Inc. Spirocyclic gpr40 modulators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2757031C2 (de) * 1976-12-27 1981-11-26 Agency Of Industrial Science And Technology Verfahren zur Herstellung von Aldehyden und/oder Alkoholen aus einem Toluolderivat mit Ätherbindungen
DE2950608A1 (de) * 1978-12-29 1980-07-10 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung von 2-(3-phenoxy-phenyl)-propionsaeure
DE3144150A1 (de) * 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
US4496757A (en) * 1981-11-05 1985-01-29 Ciba-Geigy Corporation Ultraviolet-absorbing stabilizers substituted an aliphatic hydroxyl group
US4760089A (en) * 1985-09-09 1988-07-26 Smithkline Beckman Corporation Irreversible dopamine-β-hydroxylase inhibitors

Also Published As

Publication number Publication date
US4760089A (en) 1988-07-26
AU595232B2 (en) 1990-03-29
EP0219961A1 (de) 1987-04-29
DK421586A (da) 1987-03-10
DK421586D0 (da) 1986-09-03
EP0219961B1 (de) 1989-03-08
ZA866808B (en) 1987-08-26
JPS6261960A (ja) 1987-03-18
AU6216886A (en) 1987-03-12
ES2001775A6 (es) 1988-06-16
PT83316B (en) 1988-10-07
GR862290B (en) 1987-01-02
PT83316A (en) 1986-10-01
DE3662265D1 (en) 1989-04-13

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee