BG61039B1 - Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му - Google Patents

Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му Download PDF

Info

Publication number
BG61039B1
BG61039B1 BG96651A BG9665192A BG61039B1 BG 61039 B1 BG61039 B1 BG 61039B1 BG 96651 A BG96651 A BG 96651A BG 9665192 A BG9665192 A BG 9665192A BG 61039 B1 BG61039 B1 BG 61039B1
Authority
BG
Bulgaria
Prior art keywords
medium
fermenter
cell
concentration
culture
Prior art date
Application number
BG96651A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG96651A (bg
Inventor
Michael Metz
Original Assignee
Mueller & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mueller & Co Kg filed Critical Mueller & Co Kg
Publication of BG96651A publication Critical patent/BG96651A/bg
Publication of BG61039B1 publication Critical patent/BG61039B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/10—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by centrifugation ; Cyclones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
BG96651A 1990-11-23 1992-07-20 Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му BG61039B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4037325A DE4037325A1 (de) 1990-11-23 1990-11-23 Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchfuehrung des verfahrens
PCT/EP1991/002189 WO1992009683A1 (de) 1990-11-23 1991-11-21 Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchführung des verfahrens

Publications (2)

Publication Number Publication Date
BG96651A BG96651A (bg) 1993-12-24
BG61039B1 true BG61039B1 (bg) 1996-09-30

Family

ID=6418808

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96651A BG61039B1 (bg) 1990-11-23 1992-07-20 Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му

Country Status (17)

Country Link
US (1) US5981260A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0487867B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH05503635A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR920703786A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE138684T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU672745B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG61039B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR9106024A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2074466C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ283799B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE4037325A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0487867T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2090199T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI101083B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT65380A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO303230B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO1992009683A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1080761C (zh) * 1993-12-24 2002-03-13 Basf公司 2－酮基－l－古洛糖酸的改良性生产方法
DE9419230U1 (de) * 1994-12-02 1995-03-09 Forschungszentrum Jülich GmbH, 52428 Jülich Anordnung für fed-batch-Prozeßuntersuchungen in einer Schüttelkolbenserie
FI100338B (fi) * 1995-07-18 1997-11-14 Danisco Sugar Finland Oy Menetelmä puhtaan maitohapon valmistamiseksi
DE19718608A1 (de) * 1997-05-02 1998-11-05 Ireks Gmbh Verfahren zur Herstellung von Milchsäure
US7879593B2 (en) 1999-12-16 2011-02-01 Whiteman G Robert Fermentation systems, methods and apparatus
US9969633B2 (en) * 1999-12-16 2018-05-15 Robert Whiteman Systems and methods for treating oil, fat and grease in collection systems
US20020117445A1 (en) * 1999-12-16 2002-08-29 Whiteman G. Robert Fermentation systems, methods, and apparatus
DE60124780T2 (de) * 2000-12-20 2007-10-11 Bayer Pharmaceuticals Corp., West Haven Vorrichtung und verfahren zur serienvermehrung von säugerzellen zum animpfen
JP3958089B2 (ja) * 2002-03-26 2007-08-15 有限会社新世紀発酵研究所 嫌気性菌の連続培養法
US7081361B2 (en) * 2003-08-07 2006-07-25 Nch Corporation Biomass generator
US7435581B2 (en) * 2003-11-26 2008-10-14 Broadley-James Corporation Integrated bio-reactor monitor and control system
US7635586B2 (en) 2003-11-26 2009-12-22 Broadley-James Corporation Integrated bio-reactor monitor and control system
US20080305213A1 (en) * 2007-06-11 2008-12-11 Kerry Group Services International, Ltd. Method and composition for preparing cured meat products
EP2398887A1 (en) * 2009-02-18 2011-12-28 Universiti Sains Malaysia A solid state fermentation (ssf) system
US8961893B2 (en) 2009-07-07 2015-02-24 Nch Corporation Automated chemical diluter system having disposable components
US8551762B2 (en) 2009-07-07 2013-10-08 Nch Corporation System and apparatus for feeding, solubilizing, growing and discharging a biological material
SG10201510640QA (en) 2009-10-26 2016-01-28 Hoffmann La Roche Method For The Production Of A Glycosylated Immunoglobulin
US8969067B2 (en) 2010-05-20 2015-03-03 Pond Biofuels Inc. Process for growing biomass by modulating supply of gas to reaction zone
US8940520B2 (en) 2010-05-20 2015-01-27 Pond Biofuels Inc. Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply
US20120156669A1 (en) 2010-05-20 2012-06-21 Pond Biofuels Inc. Biomass Production
US8889400B2 (en) 2010-05-20 2014-11-18 Pond Biofuels Inc. Diluting exhaust gas being supplied to bioreactor
US11512278B2 (en) 2010-05-20 2022-11-29 Pond Technologies Inc. Biomass production
US20120276633A1 (en) 2011-04-27 2012-11-01 Pond Biofuels Inc. Supplying treated exhaust gases for effecting growth of phototrophic biomass
US9534261B2 (en) 2012-10-24 2017-01-03 Pond Biofuels Inc. Recovering off-gas from photobioreactor
DE102018120885B4 (de) * 2018-08-27 2020-06-18 Sartorius Stedim Biotech Gmbh Vorrichtung und Verfahren zur kontrollierten Zuführung von Substrat

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591455A (en) * 1968-02-14 1971-07-06 Nalco Chemical Co Continuous microbial process
DE1953430A1 (de) * 1968-10-25 1970-04-30 Tanabe Seiyaku Co Verfahren zur kontinuierlichen Fermentation mit Hilfe von aeroben Mikroorganismen
GB1290444A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1970-02-02 1972-09-27
US3857757A (en) * 1972-11-30 1974-12-31 Gen Electric Means for the oxygen/temperature control of aerobic fermentations
US4105804A (en) * 1973-01-31 1978-08-08 Gyozo Terui Method for separation of bacteria cells from culture broth
US3956482A (en) * 1973-06-25 1976-05-11 W. R. Grace & Co. Milk production
FR2259903A1 (en) * 1974-02-05 1975-08-29 Univ Moskovsk Continuous propagation of micro-organisms in a closed circuit - with accurately controlled process parameters and uniformity in operation
GB1545766A (en) * 1975-07-22 1979-05-16 Novo Industri As Process for the production of a glucose isomerase product by fermentation
GB1514425A (en) * 1976-02-20 1978-06-14 Gist Brocades Nv Vinegar production and other fermentation processes
CH621363A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1976-05-18 1981-01-30 Mueller Hans Dr Ing Fa
US4167450A (en) * 1977-07-13 1979-09-11 University Of New Hampshire Method and apparatus for the production of secondary metabolites by the maintenance-state cultivation of microorganisms
US4357424A (en) * 1979-12-13 1982-11-02 Sim-Chem Limited Process for the continuous production of fermentation alcohol
EP0046344B1 (en) * 1980-08-19 1985-06-19 Imperial Chemical Industries Plc Fermentation process
US4342835A (en) * 1980-10-03 1982-08-03 Provesta Corporation Fermentation process and apparatus
DE3049381A1 (de) * 1980-12-29 1982-07-29 Rudolf 8034 Germering Schanze Verfahren zur herstellung von ammoniumlactat enthaltenden mischungen, waessriges ammoniumlactat und vorrichtung zur durchfuehrung des verfahrens
FR2505359B1 (fr) * 1981-05-08 1985-07-05 Air Liquide Procede et installation de fabrication de microorganismes
US4399223A (en) * 1981-07-07 1983-08-16 Phillips Petroleum Company Cellular product separation
SU1024514A1 (ru) * 1981-07-28 1983-06-23 Всесоюзный Научно-Исследовательский Биотехнический Институт Способ культивировани водородных бактерий
DE3323205A1 (de) * 1983-06-28 1985-01-17 Carl Schleicher & Schuell Gmbh & Co Kg, 3352 Einbeck Einrichtung u. kontinuierliches verfahren zur filtration, sterilisation von fermentationsloesungen, kultur von mikroorganismen sowie fuer die fraktinierung von komponenten unterschiedlicher molekulargewichte auf membranen
CA1232050A (en) * 1984-02-28 1988-01-26 James A. Zeitlin Fermentation control system
US4680267A (en) * 1985-03-01 1987-07-14 New Brunswick Scientific Company, Inc. Fermentor control system
FR2611742B1 (fr) * 1987-03-02 1990-01-05 Lyonnaise Eaux Procede de production de cultures enrichies en microorganismes et/ou en metabolites resultant de ces cultures, appareillage pour la mise en oeuvre de ce procede et application de ce dernier, notamment a l'ensemencement et au reensemencement des nitrificateurs et bassins de traitement des eaux
DE3733748A1 (de) * 1987-10-06 1989-04-20 Westphal Kg Georg Verfahren zur gewinnung von ethanol und biomasse aus vergorener maische
CA1293217C (en) * 1987-11-09 1991-12-17 Sooyoung Stanford Lee Controlled growth rate fermentation
US4885241A (en) * 1988-10-13 1989-12-05 University Of Queensland Ethanol production by zymomonas cultured in yeast-conditioned media
US4985355A (en) * 1988-10-13 1991-01-15 University Of Queensland Ethanol production by zymomonas cultured in yeast-conditioned media

Also Published As

Publication number Publication date
BG96651A (bg) 1993-12-24
ATE138684T1 (de) 1996-06-15
JPH05503635A (ja) 1993-06-17
ES2090199T3 (es) 1996-10-16
FI922172A7 (fi) 1992-05-24
AU672745B2 (en) 1996-10-17
EP0487867B1 (de) 1996-05-29
US5981260A (en) 1999-11-09
CA2074466A1 (en) 1992-05-24
CA2074466C (en) 2007-07-03
DE4037325C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-08-19
FI101083B (fi) 1998-04-15
WO1992009683A1 (de) 1992-06-11
AU8946691A (en) 1992-06-25
EP0487867A1 (de) 1992-06-03
NO922887L (no) 1992-09-11
FI922172A0 (fi) 1992-05-13
DE59107860D1 (de) 1996-07-04
BR9106024A (pt) 1993-03-02
HUT65380A (en) 1994-05-02
CS188392A3 (en) 1992-12-16
NO303230B1 (no) 1998-06-15
NO922887D0 (no) 1992-07-21
HU9202189D0 (en) 1992-12-28
CZ283799B6 (cs) 1998-06-17
KR920703786A (ko) 1992-12-18
DK0487867T3 (da) 1996-10-07
DE4037325A1 (de) 1992-05-27

Similar Documents

Publication Publication Date Title
BG61039B1 (bg) Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му
CN103497891B (zh) 一种微生物固态制种及发酵装置
CN114806864A (zh) 一种固态发酵酶制剂的制备装置及其制备方法
JPWO2007032265A1 (ja) アルコール生産細菌の連続培養装置及びその方法
EP2678436B1 (en) Method for preventing bacterial infection in a fermentation process
JP2011092041A (ja) エタノール生産微生物の連続培養発酵装置
KR20020034944A (ko) 발효 공정의 최적화
US20240174970A1 (en) Method for operating a bioprocess installation
CN109295118B (zh) 一种丙酸杆菌的循环发酵方法
CN115074220B (zh) 一种模块化微生物菌剂培养及自动投加装置
CN117511713A (zh) 一种微生物培养基全自动发酵罐及其发酵方法
Macauley‐Patrick et al. Modes of fermenter operation
CN101586133A (zh) 阿维菌素批发酵优化工艺
CN104946501B (zh) 一种醋酸发酵扩培酸蒸工艺及系统
RU2105059C1 (ru) Способ получения биомассы и устройство для его осуществления
CN105936885A (zh) 一种基于在线监控碱液消耗率的乳酸菌高细胞密度培养方法
US20140141469A1 (en) Methods of producing human hemoglobin in a bioreactor
CN205040612U (zh) 一种基于plc的蔬菜发酵系统
CN221917959U (zh) 白酒酿造微生物厌氧发酵罐
CN223373074U (zh) 一种酵素生产系统
JPH02174674A (ja) 乳酸菌の培養方法
EP3674392A1 (en) Process and plant for growth of microorganisms and use thereof
KR20150094722A (ko) 폐수 처리로부터 나온 바이오매스에 대한 배치 공급식 공정에서 폴리히드록시알카노에이트(pha)의 생산성 증가 방법
CN107058415A (zh) 一种添加海藻糖酶提高谷氨酸发酵糖酸转化率的方法
WO2025068592A2 (en) Bioreactor system and method for agricultural production of fermented feed